Gene info: ID 10640

Gene: EXOC5

GENE ID: 10640

Synonyms: HSEC10|PRO1912|SEC10|SEC10L1|SEC10P

Description: exocyst complex component 5

Gene type: protein-coding

Location: 14q22.3

dbXrefs: Ensembl:ENSG00000070367 MIM:604469 Vega:OTTHUMG00000171309 UniprotKB:O00471

RefSeq: NC_000014.9

Retrived from: SNP Mapped

SNPs: 32 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.031e-2 (AD) 2.724e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs17093036	chr14:57267302 (GRCh38.p7)	C>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs6573140	chr14:57266276 (GRCh38.p7)	T>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs10147752	chr14:57265552 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs11850616	chr14:57265255 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs10141911	chr14:57264133 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs10141811	chr14:57264030 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs716690	chr14:57261934 (GRCh38.p7)	C>A / C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs10133300	chr14:57256175 (GRCh38.p7)	G>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs7147218	chr14:57255339 (GRCh38.p7)	T>C / T>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs10130359	chr14:57249675 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs9323304	chr14:57245764 (GRCh38.p7)	A>C / A>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs6573137	chr14:57233186 (GRCh38.p7)	A>G / A>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs7155721	chr14:57230712 (GRCh38.p7)	A>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs10147790	chr14:57226318 (GRCh38.p7)	T>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs11846972	chr14:57222138 (GRCh38.p7)	A>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs1555788	chr14:57218454 (GRCh38.p7)	A>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs60328452	chr14:57217583 (GRCh38.p7)	A>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs10135879	chr14:57217416 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs4569162	chr14:57215062 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs10140993	chr14:57212739 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs10150771	chr14:57208467 (GRCh38.p7)	C>G / C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs10137379	chr14:57208149 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs7141911	chr14:57206153 (GRCh38.p7)	A>G / A>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs3742578	chr14:57205997 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs3742577	chr14:57205822 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs8003535	chr14:57205286 (GRCh38.p7)	G>A / G>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs7157608	chr14:57204497 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs4612984	chr14:57204241 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs10134311	chr14:57203324 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs11851015	chr14:57202815 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs10137456	chr14:57202285 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs10135064	chr14:57202141 (GRCh38.p7)	T>C / T>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MIB1	0.919
SMAD2	0.916
SERBP1	0.9
RAD21	0.892
TM9SF3	0.89
SMARCA5	0.887
UBL3	0.884
USP8	0.88
USP1	0.88
SYNCRIP	0.878

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.667
OR4F29	-0.66
PTGDR2	-0.205
NUTM2E	-0.187
RNF223	-0.185
NPIPA2	-0.181
RSPO1	-0.173
MUC6	-0.172
MMP23B	-0.169
OR4F16	-0.166

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C032668	1-nitropyrene	1-nitropyrene results in increased expression of EXOC5 mRNA	19041380
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of EXOC5 mRNA"	25614096
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EXOC5 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EXOC5 mRNA"	27188386
C032642	4-aminophenylarsenoxide	4-aminophenylarsenoxide binds to EXOC5 protein	26598702
C032642	4-aminophenylarsenoxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to EXOC5 protein]	26598702
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EXOC5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EXOC5 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of EXOC5 mRNA	21420995
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of EXOC5 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of EXOC5 mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to EXOC5 protein]	26598702
D001280	Atrazine	Atrazine results in decreased expression of EXOC5 mRNA	22378314
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EXOC5 mRNA"	19150397\|2001819
C006780	bisphenol A	bisphenol A affects the expression of EXOC5 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of EXOC5 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of EXOC5 gene	28505145
C006780	bisphenol A	bisphenol A results in increased expression of EXOC5 mRNA	26794494
C037123	cadmium sulfate	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of EXOC5 mRNA	18654764
C018021	cobaltous chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of EXOC5 mRNA	18654764
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of EXOC5 mRNA	17361019\|2126653
D002945	Cisplatin	Cisplatin results in decreased expression of EXOC5 mRNA	27392435
C000944	dicrotophos	dicrotophos results in decreased expression of EXOC5 mRNA	28302478
D004726	Endosulfan	Endosulfan results in increased expression of EXOC5 mRNA	26615145
D005419	Flavonoids	Flavonoids results in decreased expression of EXOC5 mRNA	18035473
C544151	jinfukang	jinfukang results in decreased expression of EXOC5 mRNA	27392435
C029891	lead chloride	[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of EXOC5 mRNA	18654764
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of EXOC5 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of EXOC5 mRNA	23649840
D010126	Ozone	Ozone results in increased expression of EXOC5 mRNA	28652203
D010795	Phthalic Acids	Phthalic Acids results in increased expression of EXOC5 mRNA	21061450
D010936	Plant Extracts	Plant Extracts results in increased expression of EXOC5 mRNA	23557933
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of EXOC5 mRNA	21334430
D011794	Quercetin	Quercetin results in decreased expression of EXOC5 mRNA	21632981
C009277	sodium arsenate	sodium arsenate results in decreased expression of EXOC5 mRNA	21795629
C009277	sodium arsenate	sodium arsenate results in increased expression of EXOC5 mRNA	21795629
D013853	Thioacetamide	Thioacetamide results in increased expression of EXOC5 mRNA	23411599
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EXOC5 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of EXOC5 mRNA	24935251\|2627250
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EXOC5 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of EXOC5 mRNA	23179753\|2627250
D014635	Valproic Acid	Valproic Acid results in decreased methylation of EXOC5 gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of EXOC5 gene	25560391
C088658	zoledronic acid	zoledronic acid results in increased expression of EXOC5 mRNA	20977926

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	21516116 25416956 25910212 26871637 27173435
GO:0017160	Ral GTPase binding	-	IPI	24056301
GO:0047485	protein N-terminus binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006887	exocytosis	-	IBA	21873635
GO:0006892	post-Golgi vesicle-mediated transport	-	TAS	9119050
GO:0006893	Golgi to plasma membrane transport	-	IBA	21873635
GO:0015031	protein transport	-	IEA	-
GO:0048278	vesicle docking	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000145	exocyst	-	IBA	21873635
GO:0005737	cytoplasm	-	TAS	9119050
GO:0005829	cytosol	-	TAS	-
GO:0030496	midbody	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1445148	Translocation of GLUT4 to the plasma membrane	IEA
R-HSA-1852241	Organelle biogenesis and maintenance	TAS
R-HSA-199991	Membrane Trafficking	IEA
R-HSA-264876	Insulin processing	TAS
R-HSA-2980736	Peptide hormone metabolism	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5617833	Cilium Assembly	TAS
R-HSA-5620916	VxPx cargo-targeting to cilium	TAS
R-HSA-5620920	Cargo trafficking to the periciliary membrane	TAS
R-HSA-5653656	Vesicle-mediated transport	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal