Gene: IGF2BP2

10644
IMP-2|IMP2|VICKZ2
insulin like growth factor 2 mRNA binding protein 2
protein-coding
3q27.2
Ensembl:ENSG00000073792 MIM:608289 Vega:OTTHUMG00000074025 UniprotKB:Q9Y6M1
NG_011602.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.445e-1 (AD)  4.061e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24960291chr3:185538892IGF2BP25.940e-9Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C9orf1350.797
HAS20.786
KIAA00400.784
AGTR10.763
PIRT0.754
WWTR10.736
ZNF1140.732
CD8B0.731
S100A30.722
CRNDE0.721

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCRT1-0.601
KCNQ4-0.584
EXTL1-0.583
NEUROD6-0.582
MPPED1-0.571
KCNA2-0.567
MGAT5B-0.553
ANKRD24-0.551
RTN4R-0.55
CA7-0.55

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of IGF2BP2 mRNA"19114083
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of IGF2BP2 mRNA"25710175
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of IGF2BP2 protein"25670856
D000082AcetaminophenAcetaminophen affects the expression of IGF2BP2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IGF2BP2 mRNA19770486
C006632arsenic trioxidearsenic trioxide results in decreased expression of IGF2BP2 mRNA22521957
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IGF2BP2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IGF2BP2 mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of IGF2BP2 mRNA"19150397
D004958EstradiolEstradiol results in increased expression of IGF2BP2 mRNA23019147
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of IGF2BP2 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of IGF2BP2 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of IGF2BP2 mRNA26496021
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGF2BP2 mRNA22079614
C584509C646 compoundC646 compound results in decreased expression of IGF2BP2 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IGF2BP2 protein24527689
C100187chloropicrinchloropicrin results in increased expression of IGF2BP2 mRNA26352163
D002737ChloropreneChloroprene results in increased expression of IGF2BP2 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of IGF2BP220938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of IGF2BP2 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IGF2BP2 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of IGF2BP2 mRNA19320972
D003300CopperCopper deficiency results in increased expression of IGF2BP2 mRNA26033743
D019327Copper SulfateCopper Sulfate results in increased expression of IGF2BP2 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of IGF2BP2 mRNA26577399
D002945CisplatinCisplatin results in decreased expression of IGF2BP2 mRNA19561079
D019422Dietary SucroseDietary Sucrose results in increased expression of IGF2BP2 mRNA26033743
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of IGF2BP220938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of IGF2BP2 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IGF2BP2 mRNA20938992
C039281furanfuran results in increased expression of IGF2BP2 mRNA27387713
D017313FenretinideFenretinide results in decreased expression of IGF2BP2 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of IGF2BP2 mRNA17183730
D007545IsoproterenolIsoproterenol results in increased expression of IGF2BP2 mRNA20003209
D007854LeadLead affects the splicing of IGF2BP2 mRNA28903495
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of IGF2BP2 mRNA21641980
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of IGF2BP220938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of IGF2BP2 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IGF2BP2 mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of IGF2BP2 mRNA24449571
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of IGF2BP2 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of IGF2BP2 promoter"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of IGF2BP2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IGF2BP2 mRNA"25554681
D009538NicotineNicotine results in increased expression of IGF2BP2 mRNA17997037
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IGF2BP2 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of IGF2BP2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of IGF2BP2 mRNA23811191
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of IGF2BP2 mRNA21334430
C059514resveratrolresveratrol results in increased expression of IGF2BP2 protein25505154
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of IGF2BP2 mRNA"21148743
D012822Silicon DioxideSilicon Dioxide results in increased expression of IGF2BP2 mRNA19073995
D018038Sodium SeleniteSodium Selenite results in decreased expression of IGF2BP2 mRNA18175754
D053260SootSoot results in increased expression of IGF2BP2 mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of IGF2BP2 mRNA21641980
D013605T-2 ToxinT-2 Toxin results in increased expression of IGF2BP2 mRNA26141394
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of IGF2BP2 mRNA"26179874
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of IGF2BP2 mRNA17183730
D014635Valproic AcidValproic Acid results in increased expression of IGF2BP2 mRNA19101580
D014635Valproic AcidValproic Acid results in increased methylation of IGF2BP2 gene29154799
C029297vinylidene chloridevinylidene chloride results in increased expression of IGF2BP2 mRNA26682919
D014810Vitamin EVitamin E results in decreased expression of IGF2BP2 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003730mRNA 3'-UTR binding-IDA20080952  
GO:0005515protein binding-IPI12674497  17289661  
GO:0045182translation regulator activity-ISS9891060  
GO:0048027mRNA 5'-UTR binding-IDA9891060  
GO ID GO Term Qualifier Evidence PubMed
GO:0009653anatomical structure morphogenesis-TAS9891060  
GO:0017148negative regulation of translation-ISS9891060  
GO:0042035regulation of cytokine biosynthetic process-IC9891060  
GO:0043488regulation of mRNA stability-TAS-  
GO:0051028mRNA transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA15618018  
GO:0005737cytoplasm-IDA15618018  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IDA15618018  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-428359Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNATAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20384434Combining genetic markers and clinical risk factors improves the risk assessment of impaired glucose metabolism. (2010 Apr)Ruchat SMAnn Med
19020324Clinical risk factors, DNA variants, and the development of type 2 diabetes. (2008 Nov 20)Lyssenko VN Engl J Med