Gene: CAMKK2

10645
CAMKK|CAMKKB
calcium/calmodulin dependent protein kinase kinase 2
protein-coding
12q24.31
Ensembl:ENSG00000110931 MIM:615002 Vega:OTTHUMG00000169156 UniprotKB:Q96RR4
NG_029409.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.192e-1 (AD)  2.839e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RIMS30.972
C1orf1150.97
LRRC40.962
ATP2B20.961
CACNB30.959
PRKCB0.958
SYNGR10.958
SCAMP50.957
RHOBTB20.957
MPPED10.956

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WWTR1-0.537
OR4F5-0.536
TFPI2-0.524
SNHG18-0.521
C9orf135-0.509
MYL3-0.506
IGF2BP2-0.506
ZNF114-0.504
KIAA0040-0.502
REST-0.501

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CAMKK2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CAMKK2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CAMKK2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CAMKK2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CAMKK2 mRNA"25510870
D000082AcetaminophenAcetaminophen affects the expression of CAMKK2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CAMKK2 gene27153756
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of and affects the localization of CAMKK2 protein22654108
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of CAMKK2 mRNA22654108
D001151ArsenicArsenic affects the methylation of CAMKK2 gene25304211
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of CAMKK2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to CAMKK2 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CAMKK2 mRNA21715664
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CAMKK2 mRNA22300585
D004958EstradiolEstradiol results in increased expression of CAMKK2 mRNA23019147
C006780bisphenol Abisphenol A results in decreased expression of CAMKK2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CAMKK2 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CAMKK2 mRNA25596134
D002118CalciumCAMKK2 protein affects the reaction [[Calcium co-treated with Ionomycin] results in increased phosphorylation of AKT1 protein]28634229
D002246Carbon DisulfideCarbon Disulfide results in increased expression of CAMKK2 protein27530093
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CAMKK2 mRNA17484886
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of CAMKK2 mRNA25596134
D002737ChloropreneChloroprene results in decreased expression of CAMKK2 mRNA23125180
C059262cidofovircidofovir results in increased expression of CAMKK2 mRNA25596134
D002922CiguatoxinsCiguatoxins affects the expression of CAMKK2 mRNA18353800
D004002Clodronic AcidClodronic Acid results in increased expression of CAMKK2 mRNA25596134
C055162clopidogrelclopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CAMKK2 mRNA]19172522
D003024ClozapineClozapine results in decreased expression of CAMKK2 protein19289156
D060729Coal AshCoal Ash results in increased expression of CAMKK2 mRNA19000753
C018021cobaltous chloridecobaltous chloride results in decreased expression of CAMKK2 mRNA19320972
D005576ColforsinColforsin results in increased expression of CAMKK2 mRNA16751804
D005576ColforsinColforsin affects the splicing of CAMKK2 exon22684629
D019327Copper SulfateCopper Sulfate results in decreased expression of CAMKK2 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of CAMKK2 mRNA26577399
D003891DesipramineDesipramine results in decreased expression of CAMKK2 mRNA15555640
D016190CarboplatinCAMKK2 protein affects the susceptibility to Carboplatin28634229
D002945CisplatinCisplatin results in decreased expression of CAMKK2 mRNA27594783
D002945CisplatinCisplatin results in increased expression of CAMKK2 mRNA25596134
D004041Dietary FatsDietary Fats promotes the reaction [imidacloprid results in decreased expression of CAMKK2 protein]27960282
D002117CalcitriolCAMKK2 mutant form inhibits the reaction [Calcitriol affects the localization of CAMP protein]19748465
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CAMKK2 mRNA"22485181
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CAMKK2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CAMKK2 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CAMKK2 mRNA23649840
D019833GenisteinGenistein results in decreased expression of CAMKK2 mRNA15378649
D006220HaloperidolHaloperidol results in decreased expression of CAMKK2 protein19289156
D007069IfosfamideIfosfamide results in increased expression of CAMKK2 mRNA25596134
C082359imidaclopridDietary Fats promotes the reaction [imidacloprid results in decreased expression of CAMKK2 protein]27960282
C082359imidaclopridimidacloprid results in decreased expression of CAMKK2 protein27960282
D015759IonomycinCAMKK2 protein affects the reaction [[Calcium co-treated with Ionomycin] results in increased phosphorylation of AKT1 protein]28634229
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CAMKK2 mRNA25613284
D007529IsoflavonesIsoflavones results in decreased expression of CAMKK2 mRNA17374662
D007545IsoproterenolIsoproterenol results in decreased phosphorylation of CAMKK2 protein27491814
D008070Lipopolysaccharidesclopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CAMKK2 mRNA]19172522
D008094LithiumLithium results in increased expression of CAMKK2 protein19289156
C025340manganese chloridemanganese chloride results in increased expression of CAMKK2 mRNA15295902
D008727MethotrexateMethotrexate affects the expression of CAMKK2 mRNA18502557
D008731MethoxychlorMethoxychlor results in increased methylation of CAMKK2 gene23303685
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CAMKK2 protein25809596
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CAMKK2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CAMKK2 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of CAMKK2 promoter"26251327
D015741MetriboloneMetribolone results in increased expression of CAMKK2 mRNA16751804
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of CAMKK2 mRNA"29244179
D010100OxygenOxygen deficiency affects the expression of CAMKK2 mRNA25596134
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CAMKK2 mRNA"25510870
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of CAMKK2 mRNA17560707
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of CAMKK2 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of CAMKK2 mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CAMKK2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of CAMKK2 mRNA18301758
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of CAMKK2 mRNA19162173
C045950propiconazolepropiconazole results in decreased expression of CAMKK2 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of CAMKK2 mRNA24780913
C496788PX-866CAMKK2 protein affects the susceptibility to PX-86628634229
D020891RacloprideRaclopride results in decreased expression of CAMKK2 protein19289156
D018967RisperidoneRisperidone results in decreased expression of CAMKK2 protein19289156
D012402RotenoneRotenone affects the expression of CAMKK2 mRNA23186747
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in decreased expression of CAMKK2 mRNA17540011
D019821SimvastatinCAMKK2 mutant form inhibits the reaction [Simvastatin results in increased activity of STK11 protein]19332549
D019821SimvastatinCAMKK2 mutant form inhibits the reaction [Simvastatin results in increased phosphorylation of STK11 protein]19332549
D019821SimvastatinSimvastatin results in increased phosphorylation of and results in increased activity of CAMKK2 protein19332549
C017947sodium arsenitesodium arsenite results in increased expression of CAMKK2 mRNA25089838
C017947sodium arsenitesodium arsenite results in increased expression of CAMKK2 protein25089838
D012999SomanSoman results in decreased expression of CAMKK2 mRNA19281266
C458525STO 609STO 609 results in decreased activity of CAMKK2 protein18482975
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CAMKK2 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CAMKK2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CAMKK2 mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CAMKK2 mRNA18796159
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CAMKK2 mRNA25613284
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CAMKK2 mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of CAMKK2 mRNA29154799
D014639VanadiumVanadium results in decreased expression of CAMKK2 mRNA19000753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004713protein tyrosine kinase activity-TAS11395482  
GO:0005509calcium ion binding-IDA11395482  
GO:0005516calmodulin binding-TAS11395482  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS11395482  
GO:0001934positive regulation of protein phosphorylation-IMP26103054  
GO:0006468protein phosphorylation-IDA11395482  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0019722calcium-mediated signaling-TAS11395482  
GO:0034614cellular response to reactive oxygen species-TAS26103054  
GO:0045859regulation of protein kinase activity-TAS11395482  
GO:0045893positive regulation of transcription, DNA-templated-TAS11395482  
GO:0046777protein autophosphorylation-IDA11395482  
GO:0061762CAMKK-AMPK signaling cascade-IMP26103054  
GO:1903599positive regulation of autophagy of mitochondrion-IC26103054  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IMP26103054  
GO:0005622intracellular-TAS11395482  
GO:0005829cytosol-IDA-  
GO:0042995cell projection-IEA-  
KEGG ID KEGG Term
hsa04920Adipocytokine signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28737528Genetic variants of increased waist circumference in psychosis. (2017 Dec)Hukic DSPsychiatr Genet