Gene: DMRT2

10655
-
doublesex and mab-3 related transcription factor 2
protein-coding
9p24.3
Ensembl:ENSG00000173253 MIM:604935 Vega:OTTHUMG00000019437 UniprotKB:Q9Y5R5
NG_017051.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.819e-3 (AD)  6.348e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6474550chr9:1052722 (GRCh38.p7)G>C / G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NIPAL40.917
NINJ20.911
GJB10.906
GPR620.898
TRIM590.897
KLK60.893
TMEM1250.892
SLC45A30.888
SMIM50.885
GALNT60.882

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.421
GPR153-0.399
WTIP-0.352
NEUROD1-0.352
LTK-0.35
GRB14-0.337
PCDH8-0.334
CNGB1-0.332
CHRNA2-0.328
BEAN1-0.327

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in increased expression of DMRT2 mRNA23792671
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of DMRT2 mRNA"25710175
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DMRT2 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of DMRT2 mRNA24449571
C015001arsenitearsenite results in increased methylation of DMRT2 promoter23974009
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of DMRT2 mRNA26377693
D004958EstradiolEstradiol results in decreased expression of DMRT2 mRNA17823450|1870914
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of DMRT2 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of DMRT2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of DMRT2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of DMRT2 gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of DMRT2 mRNA26079696
D003035Cobalt[tungsten carbide binds to Cobalt] which results in decreased expression of DMRT2 mRNA20105288
C018021cobaltous chloridecobaltous chloride results in decreased expression of DMRT2 mRNA20105288
D003687DehydroepiandrosteroneDehydroepiandrosterone results in decreased expression of DMRT2 mRNA18709148
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of DMRT2 mRNA28962523
D004026DieldrinDieldrin results in increased expression of DMRT2 mRNA23041725
D004041Dietary FatsDietary Fats results in decreased expression of DMRT2 mRNA18042831
D004397FonofosFonofos results in increased methylation of DMRT2 promoter22847954
D005839GentamicinsGentamicins results in decreased expression of DMRT2 mRNA22061828
D017313FenretinideFenretinide results in decreased expression of DMRT2 mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DMRT2 mRNA24796395
C008261lead acetatelead acetate results in decreased expression of DMRT2 mRNA21829687
D008713MethimazoleMethimazole results in decreased expression of DMRT2 mRNA22504374
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of DMRT2 protein24625837
D000073878Palm OilPalm Oil results in decreased expression of DMRT2 mRNA18042831
D010278ParathionParathion results in increased methylation of DMRT2 promoter22847954
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of DMRT2 mRNA18709148
C006253pirinixic acidpirinixic acid results in increased expression of DMRT2 mRNA23811191
D011192Potassium DichromatePotassium Dichromate results in decreased expression of DMRT2 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of DMRT2 mRNA22504374
C017947sodium arsenitesodium arsenite results in increased expression of DMRT2 mRNA28595984
C012568terbufosterbufos results in increased methylation of DMRT2 promoter22847954
D013893ThiramThiram results in increased expression of DMRT2 mRNA20530235
C009495titanium dioxidetitanium dioxide results in decreased expression of DMRT2 mRNA23557971
D014212TretinoinTretinoin results in decreased expression of DMRT2 mRNA20530235
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of DMRT2 mRNA19042947
C002802tungsten carbide[tungsten carbide binds to Cobalt] which results in decreased expression of DMRT2 mRNA20105288
D014635Valproic AcidValproic Acid affects the expression of DMRT2 mRNA17292431
C029297vinylidene chloridevinylidene chloride results in decreased expression of DMRT2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003674molecular_function-ND-  
GO:0042803protein homodimerization activity-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0008150biological_process-ND-  
GO:0014807regulation of somitogenesis-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0048706embryonic skeletal system development-IEA-  
GO:2000287positive regulation of myotome development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28355295Risk prediction of pulmonary tuberculosis using genetic and conventional risk factors in adult Korean population. (2017)Hong EPPLoS One