Gene: KHDRBS3

10656
Etle|SALP|SLM-2|SLM2|T-STAR|TSTAR|etoile
KH RNA binding domain containing, signal transduction associated 3
protein-coding
8q24.23
Ensembl:ENSG00000131773 MIM:610421 Vega:OTTHUMG00000164164 UniprotKB:O75525
NC_000008.11
PubMed|SNP Mapped
1   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.171e-1 (AD)  7.404e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6997956chr8:135472147 (GRCh38.p7)T>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBE2E20.938
TSPAN130.93
YWHAH0.927
FAM220A0.925
UBE2QL10.92
RTN30.919
GLS0.919
MAP2K40.918
RTN10.916
TBPL10.916

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.568
OR4F29-0.532
ASB4-0.447
LRAT-0.436
MBNL3-0.403
PARD3B-0.401
MYOM1-0.395
FZD10-0.388
ARHGEF5-0.385
REST-0.383

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of KHDRBS3 mRNA"19114083
D000082AcetaminophenAcetaminophen results in increased expression of KHDRBS3 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of KHDRBS3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of KHDRBS3 mRNA19770486
D000638AmiodaroneAmiodarone results in increased expression of KHDRBS3 mRNA24535564
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KHDRBS3 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KHDRBS3 mRNA19770486
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of KHDRBS3 mRNA26496021
D001622BetaineBetaine results in decreased expression of KHDRBS3 mRNA26391144
C006780bisphenol Abisphenol A results in decreased expression of KHDRBS3 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of KHDRBS3 mRNA27685785
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of KHDRBS3 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of KHDRBS3 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of KHDRBS3 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of KHDRBS3 mRNA17484886
C018021cobaltous chloridecobaltous chloride results in decreased expression of KHDRBS3 mRNA19320972
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of KHDRBS3 mRNA24690739
D003471CuprizoneCuprizone results in decreased expression of KHDRBS3 mRNA26577399
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of KHDRBS3 mRNA]27941970
D002945CisplatinCisplatin results in decreased expression of KHDRBS3 mRNA19561079
D004041Dietary FatsDietary Fats results in increased expression of KHDRBS3 mRNA18042831
C024629dimethyl phthalatedimethyl phthalate affects the expression of KHDRBS3 mRNA26924002
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of KHDRBS3 mRNA24690739
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of KHDRBS3 mRNA17555576
C039281furanfuran results in increased expression of KHDRBS3 mRNA27387713
D017313FenretinideFenretinide results in increased expression of KHDRBS3 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of KHDRBS3 mRNA26191083
D007854LeadLead affects the splicing of KHDRBS3 mRNA28903495
C045463leflunomideleflunomide results in increased expression of KHDRBS3 mRNA28988120
D008727MethotrexateMethotrexate results in increased expression of KHDRBS3 mRNA17379860
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of KHDRBS3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of KHDRBS3 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of KHDRBS3 mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of KHDRBS3 mRNA18042831
C046012pentanalpentanal results in increased expression of KHDRBS3 mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of KHDRBS3 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of KHDRBS3 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KHDRBS3 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of KHDRBS3 mRNA18301758|2081375
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of KHDRBS3 mRNA22714537
C017947sodium arsenitesodium arsenite results in increased expression of KHDRBS3 mRNA17879257
D013629TamoxifenTamoxifen affects the expression of KHDRBS3 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KHDRBS3 mRNA22574217
C009495titanium dioxidetitanium dioxide results in increased expression of KHDRBS3 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of KHDRBS3 mRNA25729387
D014520UrethaneUrethane results in increased expression of KHDRBS3 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of KHDRBS3 mRNA24935251|2800136
D014635Valproic AcidValproic Acid affects the expression of KHDRBS3 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of KHDRBS3 mRNA24535564
C025643vinclozolinvinclozolin results in increased expression of KHDRBS3 mRNA22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22681889  
GO:0003723RNA binding-IDA19561594  
GO:0005515protein binding-IPI10332027  10749975  16189514  20195357  25416956  25910212  
26871637  27107014  
GO:0017124SH3 domain binding-IEA-  
GO:0019904protein domain specific binding-IPI10332027  10749975  
GO:0042802identical protein binding-IDA10332027  10749975  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006397mRNA processing-IEA-  
GO:0048024regulation of mRNA splicing, via spliceosome-IEA-  
GO:0051259protein complex oligomerization-IDA10332027  10749975  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IMP10332027  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-8848021Signaling by PTK6TAS
R-HSA-8849468PTK6 Regulates Proteins Involved in RNA ProcessingTAS
R-HSA-9006927Signaling by Non-Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28542447Exploratory plasma proteomic analysis in a randomized crossover trial of aspirin among healthy men and women. (2017)Wang XPLoS One