Gene: CELF1

10658
BRUNOL2|CUG-BP|CUGBP|CUGBP1|EDEN-BP|NAB50|NAPOR|hNab50
CUGBP Elav-like family member 1
protein-coding
11p11.2
Ensembl:ENSG00000149187 MIM:601074 Vega:OTTHUMG00000166526 UniprotKB:Q92879
NC_000011.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.730e-1 (AD)  1.987e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MBD10.939
QRICH10.937
LARP4B0.932
CDK130.93
SMG70.93
AP1G10.927
GATAD2B0.927
GTF3C20.927
SEC16A0.925
SUPT7L0.925

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.709
OR4F29-0.678
SH2D1A-0.264
ANXA13-0.259
KLRC2-0.253
CTNNA3-0.252
TFPI2-0.225
KLRB1-0.225
C9orf153-0.225
CD8B-0.214

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CELF1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CELF1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CELF1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CELF1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CELF1 mRNA"25510870
D000082AcetaminophenAcetaminophen results in increased expression of CELF1 mRNA21420995
C014949acetylhydrazineacetylhydrazine results in decreased expression of CELF1 mRNA15282401
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CELF1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CELF1 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of CELF1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of CELF1 protein16483693
D001151ArsenicArsenic affects the methylation of CELF1 gene25304211
D001280AtrazineAtrazine results in increased expression of CELF1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of CELF1 mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CELF1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CELF1 mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of CELF1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of CELF1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of CELF1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CELF1 mRNA28628672
C018021cobaltous chloridecobaltous chloride results in decreased expression of CELF1 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of CELF1 mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of CELF1 mRNA22077320
D016572CyclosporineCyclosporine results in decreased expression of CELF1 mRNA20106945|2163298
D016572CyclosporineCyclosporine results in increased methylation of CELF1 promoter27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of CELF1 mRNA24317228
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CELF1 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CELF1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CELF1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CELF1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of CELF1 mRNA27594783
C118739entinostatentinostat results in decreased expression of CELF1 mRNA27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CELF1 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CELF1 mRNA17606305
D018120FinasterideFinasteride results in increased expression of CELF1 mRNA24136188
D005839GentamicinsGentamicins results in decreased expression of CELF1 mRNA22061828
C029424hydrazinehydrazine results in decreased expression of CELF1 mRNA15282401
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CELF1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CELF1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CELF1 mRNA28628672
D048628KetolidesKetolides analog results in decreased expression of CELF1 mRNA24967691
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CELF1 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CELF1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CELF1 mRNA"25554681
D010100OxygenOxygen deficiency results in increased expression of CELF1 mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of CELF1 mRNA]22629407
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CELF1 mRNA"25510870
D010634PhenobarbitalPhenobarbital affects the expression of CELF1 mRNA19159669
C006253pirinixic acidpirinixic acid results in decreased expression of CELF1 mRNA18445702|2381119
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of CELF1 mRNA19162173
C045950propiconazolepropiconazole results in decreased expression of CELF1 mRNA21278054
D011794QuercetinQuercetin results in increased expression of CELF1 mRNA21632981
C061133tamibarotenetamibarotene affects the expression of CELF1 mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CELF1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CELF1 mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CELF1 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CELF1 mRNA28065790
D014212TretinoinTretinoin results in decreased expression of CELF1 mRNA15498508
C057693troglitazonetroglitazone results in decreased expression of CELF1 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of CELF1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CELF1 mRNA19101580|2317975
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CELF1 gene25560391
C025643vinclozolinvinclozolin affects the expression of CELF1 mRNA19015723
D014750VincristineVincristine results in decreased expression of CELF1 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of CELF1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000900translation repressor activity, mRNA regulatory element binding-NAS10893231  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-IBA21873635  
GO:0003723RNA binding-IDA16946708  
GO:0003729mRNA binding-IBA21873635  
GO:0003729mRNA binding-IDA14726956  
GO:0005515protein binding-IPI16946708  
GO:0036002pre-mRNA binding-IDA11158314  
GO:0042835BRE binding-IDA10893231  
GO ID GO Term Qualifier Evidence PubMed
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IBA21873635  
GO:0006376mRNA splice site selection-IBA21873635  
GO:0006376mRNA splice site selection-IDA11158314  
GO:0006376mRNA splice site selection-ISS-  
GO:0006397mRNA processing-TAS8948631  
GO:0007281germ cell development-NAS10893231  
GO:0009792embryo development ending in birth or egg hatching-NAS10893231  
GO:0016246RNA interference-NAS10893231  
GO:0017148negative regulation of translation-IEA-  
GO:0043484regulation of RNA splicing-IDA16946708  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA11158314  
GO:0005634nucleus-NAS10893231  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0016020membrane-HDA19946888  
GO:1990904ribonucleoprotein complex-NAS10893231  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget
22649255Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males. (2012 Jul)Wernimont SMJ Nutr