Gene: CES1

1066
ACAT|CE-1|CEH|CES2|HMSE|HMSE1|PCE-1|REH|SES1|TGH|hCE-1
carboxylesterase 1
protein-coding
16q12.2
Ensembl:ENSG00000198848 MIM:114835 Vega:OTTHUMG00000176718 UniprotKB:P23141
NG_012057.1
PubMed
0   ANCO-SNPs
AD
2   
6.866e-1 (AD)  9.750e-1 (ND)   (Frontal_Cortex)
8.674e-1 (AD)  7.952e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04521981chr16:55850985CES1Gene body2.974e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC16A120.741
TNFAIP80.725
GJA50.718
BNC20.7
PDE3A0.695
TBX180.693
PALMD0.693
C70.691
SPTLC30.688
COL8A10.684

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGIX-0.453
ASPDH-0.451
RTN4R-0.449
BCL11A-0.446
NEUROD6-0.445
MYADML2-0.443
MARCH11-0.439
FBLL1-0.435
CHRNA4-0.429
HAS1-0.428

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00198OseltamivirSmall Molecule196618-13-0ApprovedTarget
DB00382TacrineSmall Molecule321-64-2Investigational|WithdrawnTarget
DB00454PethidineSmall Molecule57-42-1ApprovedTarget
DB00583L-CarnitineSmall Molecule541-15-1Approved|InvestigationalTarget
DB00647DextropropoxypheneSmall Molecule469-62-5Approved|Illicit|Investigational|WithdrawnTarget
DB00907CocaineSmall Molecule50-36-2Approved|IllicitTarget
DB01183NaloxoneSmall Molecule465-65-6ApprovedTarget
DB01452HeroinSmall Molecule561-27-3Approved|Illicit|InvestigationalTarget
DB01599ProbucolSmall Molecule23288-49-5Approved|InvestigationalTarget
DB02161Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl EsterSmall MoleculeExperimentalTarget
DB02659Cholic AcidSmall Molecule81-25-4ApprovedTarget
DB030564-Piperidino-PiperidineSmall MoleculeExperimentalTarget
DB03721N-acetyl-alpha-neuraminic acidSmall MoleculeExperimentalTarget
DB04509N-MethylnaloxoniumSmall MoleculeExperimentalTarget
DB04795ThenoyltrifluoroacetoneSmall Molecule326-91-0ExperimentalTarget
DB04838CyclandelateSmall Molecule456-59-7ApprovedTarget
DB06442AvasimibeSmall Molecule166518-60-1InvestigationalTarget
DB07821(1R)-1,2,2-trimethylpropyl (R)-methylphosphinateSmall MoleculeExperimentalTarget
DB08224(1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOLSmall MoleculeExperimentalTarget
DB11181HomatropineSmall Molecule87-00-3ApprovedTarget
DB00328IndomethacinSmall Molecule53-86-1Approved|InvestigationalEnzyme
DB00519TrandolaprilSmall Molecule87679-37-6ApprovedEnzyme
DB00675TamoxifenSmall Molecule10540-29-1ApprovedEnzyme
DB00688Mycophenolate mofetilSmall Molecule128794-94-5Approved|InvestigationalEnzyme
DB00758ClopidogrelSmall Molecule113665-84-2ApprovedEnzyme
DB00762IrinotecanSmall Molecule97682-44-5Approved|InvestigationalEnzyme
DB01086BenzocaineSmall Molecule94-09-7Approved|InvestigationalEnzyme
DB01101CapecitabineSmall Molecule154361-50-9Approved|InvestigationalEnzyme
DB01410CiclesonideSmall Molecule126544-47-6Approved|InvestigationalEnzyme
DB02161Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl EsterSmall MoleculeExperimentalEnzyme
DB03721N-acetyl-alpha-neuraminic acidSmall MoleculeExperimentalEnzyme
DB04509N-MethylnaloxoniumSmall MoleculeExperimentalEnzyme
DB06201RufinamideSmall Molecule106308-44-5ApprovedEnzyme
DB06693MevastatinSmall Molecule73573-88-3ExperimentalEnzyme
DB06695Dabigatran etexilateSmall Molecule211915-06-9ApprovedEnzyme
DB09269Phenylacetic acidSmall Molecule103-82-2ApprovedEnzyme
DB09342PropoxycaineSmall Molecule86-43-1ApprovedEnzyme
DB11362SelexipagSmall Molecule475086-01-2ApprovedEnzyme
ID Drug Name Action PubMed
C0340861,5-naphthalenediamine"1,5-naphthalenediamine affects the expression of CES1 mRNA"17114358
C0340861,5-naphthalenediamine"1,5-naphthalenediamine results in increased expression of CES1 mRNA"17311802
C1221281,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydroacridine"1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydroacridine results in decreased activity of CES1 protein"23123248
C0600802,2-bis(bromomethyl)-1,3-propanediol"2,2-bis(bromomethyl)-1,3-propanediol results in increased expression of CES1 mRNA"17311802
C07699627-hydroxycholesterol27-hydroxycholesterol inhibits the reaction [CES1 protein results in increased metabolism of bioresmethrin]19761868
C07699627-hydroxycholesterol27-hydroxycholesterol results in decreased activity of CES1 protein19761868
C0914232-chloromethylpyridine2-chloromethylpyridine results in increased expression of CES1 mRNA17311802
C5308882'-deoxy-N4-(2-(4-nitrophenyl)ethoxycarbonyl)-5-azacytidineCES1 protein affects the cleavage of and results in increased activity of 2'-deoxy-N4-(2-(4-nitrophenyl)ethoxycarbonyl)-5-azacytidine18499340
C0284052-naphtholCES1 protein affects the metabolism of 2-naphthol12837533
C0455732-nitrophenolCES1 protein affects the metabolism of 2-nitrophenol12837533
C1199712-nitrophenylacetic acidCES1 protein results in increased hydrolysis of 2-nitrophenylacetic acid23123248
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of and results in increased activity of CES1 protein alternative form19715681
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of CES1 mRNA alternative form19715681
C0188552-tert-butylhydroquinoneNFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of CES1 mRNA alternative form]19715681
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CES1 mRNA"19692669
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CES1 mRNA"18648102
C0821374-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide results in increased expression of CES1 mRNA15681896
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased activity of CES1 protein21878322
C0320784-methylumbelliferyl acetateAtropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]9311626
C0320784-methylumbelliferyl acetateCES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate9311626
C0320784-methylumbelliferyl acetateCocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]9311626
C0320784-methylumbelliferyl acetatetropacocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]9311626
C0542684-methylumbelliferyl heptanoateCES1 protein binds to and results in increased hydrolysis of 4-methylumbelliferyl heptanoate16282638
C0248364-nitrophenolCES1 protein affects the metabolism of 4-nitrophenol12837533
C0248364-nitrophenolCES1 protein results in increased chemical synthesis of 4-nitrophenol20097249
C0248364-nitrophenol[CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate] which results in increased chemical synthesis of 4-nitrophenol20097249
C0086424-nitrophenyl acetateAripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]20097249
C0086424-nitrophenyl acetateCES1 gene mutant form results in decreased metabolism of 4-nitrophenyl acetate18485328
C0086424-nitrophenyl acetateCES1 protein binds to and results in increased hydrolysis of 4-nitrophenyl acetate16282638
C0086424-nitrophenyl acetateCES1 protein results in increased hydrolysis of 4-nitrophenyl acetate10518925|2009724
C0086424-nitrophenyl acetate[CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate] which results in increased chemical synthesis of 4-nitrophenol20097249
C0086424-nitrophenyl acetateCES1 protein results in increased metabolism of 4-nitrophenyl acetate18485328
C0086424-nitrophenyl acetateFluoxetine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]20097249
C0086424-nitrophenyl acetatePerphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]20097249
C0086424-nitrophenyl acetateThioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]20097249
C1180084-nitrophenylacetic acidCES1 protein results in increased hydrolysis of 4-nitrophenylacetic acid11950785
C0335924-nitrophenyl butyrateCES1 protein binds to and results in increased hydrolysis of 4-nitrophenyl butyrate16282638
C0335924-nitrophenyl butyrateCES1 protein results in increased hydrolysis of 4-nitrophenyl butyrate11950785
C0500144-nitrophenyl laurateCES1 protein binds to and results in increased hydrolysis of 4-nitrophenyl laurate16282638
C0341064-nitrophenyloctanoateCES1 protein results in increased metabolism of 4-nitrophenyloctanoate15825828
C4182085'-deoxy-5-fluorocytidineCES1 protein results in increased chemical synthesis of 5'-deoxy-5-fluorocytidine15687373
C0269796-O-monoacetylmorphine6-O-monoacetylmorphine binds to CES1 protein9311626
C0269796-O-monoacetylmorphineCES1 protein results in increased chemical synthesis of 6-O-monoacetylmorphine8930175|9311626
C0269796-O-monoacetylmorphineCocaine inhibits the reaction [CES1 protein results in increased chemical synthesis of 6-O-monoacetylmorphine]8930175
C0108479-amino-6-chloro-2-methoxyacridine9-amino-6-chloro-2-methoxyacridine results in decreased activity of CES1 protein23123248
C0371129-deoxy-delta-9-prostaglandin D29-deoxy-delta-9-prostaglandin D2 results in decreased expression of CES1 mRNA11409902
D000082AcetaminophenAcetaminophen results in decreased expression of CES1 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of CES1 mRNA21163907|2223033
D000083AcetanilidesCES1 protein results in increased hydrolysis of Acetanilides8611161
D000117AcetylglucosamineAcetylglucosamine results in increased expression of CES1 mRNA18047607
C033116acetyl methyl tetramethyl tetralinacetyl methyl tetramethyl tetralin results in decreased activity of CES1 protein22489002
D000166AcridinesAcridines results in decreased activity of CES1 protein23123248
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CES1 mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in increased expression of CES1 protein26072098
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of CES1 protein26072098
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of CES1 mRNA21298039
D000638AmiodaroneAmiodarone results in increased expression of CES1 mRNA21163907
D000667AmpicillinAmpicillin results in increased expression of CES1 mRNA22609641
C036466aniracetamCES1 protein results in increased hydrolysis of aniracetam9300133
D016718Arachidonic AcidArachidonic Acid results in decreased activity of CES1 protein19761868
D016718Arachidonic Acid[CES1 protein results in increased hydrolysis of glyceryl 2-arachidonate] which results in increased chemical synthesis of Arachidonic Acid21049984
D000068180AripiprazoleAripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]20097249
D000068180AripiprazoleAripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]20097249
D000068180AripiprazoleAripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]20097249
D001194AsbestosAsbestos results in increased expression of CES1 mRNA22398240
D001241AspirinCES1 protein promotes the reaction [Aspirin results in increased expression of ACACA protein modified form]25743752
D001241AspirinCES1 protein promotes the reaction [Aspirin results in increased expression of PRKAA1 protein modified form]25743752
D001285AtropineAtropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]9311626
D001387AzinphosmethylAzinphosmethyl results in decreased activity of CES1 protein26790371
C547126AZM551248AZM551248 results in decreased expression of CES1 mRNA22323515
D001554BenzeneBenzene results in increased expression of CES1 mRNA17311802
C105430benzofuranbenzofuran affects the expression of CES1 mRNA17114358
C105430benzofuranbenzofuran results in increased expression of CES1 mRNA17311802
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of CES1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CES1 mRNA19770486|2012785
C005618benzoylecgonineCES1 protein results in increased chemical synthesis of benzoylecgonine9311626
D004958EstradiolEstradiol results in decreased expression of CES1 mRNA19484750
C018465bioallethrinCES1 protein results in increased metabolism of bioallethrin19249324
C002842bioresmethrin27-hydroxycholesterol inhibits the reaction [CES1 protein results in increased metabolism of bioresmethrin]19761868
C002842bioresmethrinCES1 protein results in increased hydrolysis of bioresmethrin16387282
C002842bioresmethrinCES1 protein results in increased metabolism of bioresmethrin19249324|1976186
C002842bioresmethrinCES1 protein results in increased hydrolysis of bioresmethrin16387282
C002842bioresmethrinCES1 protein results in increased hydrolysis of bioresmethrin16387282
C002842bioresmethrinCES1 protein results in increased hydrolysis of bioresmethrin16387282
C002887bis(4-nitrophenyl)phosphatebis(4-nitrophenyl)phosphate results in decreased activity of CES1 protein23123248
D017438Bisphenol A-Glycidyl MethacrylateBisphenol A-Glycidyl Methacrylate results in increased expression of CES1 mRNA21951919
D017438Bisphenol A-Glycidyl MethacrylateCAT protein inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in increased expression of CES1 mRNA]21951919
C006780bisphenol Abisphenol A results in increased expression of CES1 mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of CES1 mRNA25181051
D001761BleomycinBleomycin results in decreased expression of CES1 protein25933445
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of CES1 mRNA18227147
C018475butyraldehydebutyraldehyde results in decreased expression of CES1 mRNA26079696
D002104CadmiumCadmium results in increased activity of CES1 protein24915613
D000069287CapecitabineCES1 protein results in increased hydrolysis of and results in increased activity of Capecitabine15687373
D004390ChlorpyrifosChlorpyrifos results in decreased activity of CES1 protein26790371
D004390ChlorpyrifosChlorpyrifos results in decreased activity of CES1 protein24373905
D002784CholesterolCES1 protein results in increased metabolism of Cholesterol11015575|1277316
D002784CholesterolCholesterol results in increased expression of CES1 mRNA8049197
D002784CholesterolCES1 protein results in increased abundance of Cholesterol15825828
C039671ciglitazoneciglitazone results in decreased expression of CES1 mRNA11409902
D002922CiguatoxinsCiguatoxins affects the expression of CES1 mRNA18353800
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of CES1 mRNA19524605
D002994ClofibrateClofibrate results in increased expression of CES1 protein16470657
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CES1 mRNA17602206
C066444cocaethyleneCES1 protein results in increased chemical synthesis of cocaethylene12773168|9311626
D003042CocaineCES1 protein results in increased hydrolysis of Cocaine12679808|1277316
D003042CocaineCES1 protein results in increased metabolism of [Cocaine co-treated with Ethanol]12773168|9311626
D003042CocaineCocaine binds to CES1 protein9311626
D003042CocaineCocaine inhibits the reaction [CES1 protein results in increased chemical synthesis of 6-O-monoacetylmorphine]8930175
D003042CocaineCocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]9311626
D003042CocaineCocaine inhibits the reaction [CES1 protein results in increased hydrolysis of Heroin]8930175
D019327Copper SulfateCopper Sulfate results in increased expression of CES1 mRNA19549813
C030123coumarincoumarin results in increased expression of CES1 mRNA17311802
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES1 mRNA]18200517
C500528cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl estercyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester results in decreased activity of CES1 protein27659731
D016572CyclosporineCyclosporine results in increased expression of CES1 mRNA21163907
D016572CyclosporineCyclosporine results in decreased expression of CES1 mRNA19770486|2330838
D016572CyclosporineCyclosporine results in decreased expression of CES1 protein23308384
C037304cyhalothrinCES1 protein inhibits the reaction [cyhalothrin results in increased activity of NR1I2 protein]19249324
C037304cyhalothrinCES1 protein results in increased metabolism of cyhalothrin19249324
C089595cylindrospermopsincylindrospermopsin results in decreased expression of CES1 mRNA23726867
C017160cypermethrinCES1 protein results in increased hydrolysis of cypermethrin16359636
D000069439DasatinibDasatinib results in increased expression of CES1 mRNA20579391
C017180decamethrinCES1 protein affects the hydrolysis of decamethrin18983829
C017180decamethrinCES1 protein inhibits the reaction [decamethrin results in increased activity of NR1I2 protein]19249324
C017180decamethrinCES1 protein results in increased metabolism of decamethrin19249324
C014347decitabineCES1 protein results in increased abundance of decitabine18499340
C047759delaprilCES1 protein results in increased hydrolysis of and results in increased activity of delapril9300133
D003907DexamethasoneDexamethasone results in increased expression of CES1 mRNA25047013
D003907DexamethasoneDexamethasone results in increased expression of CES1 protein10640517
D003907DexamethasoneDexamethasone results in decreased expression of CES1 mRNA10640517
D003907DexamethasoneDexamethasone results in decreased expression of CES1 protein10640517
D015946Ethylene DibromideEthylene Dibromide results in increased expression of CES1 mRNA17311802
D004041Dietary FatsDietary Fats affects the expression of CES1 mRNA19680557
D004041Dietary FatsDietary Fats results in decreased expression of CES1 mRNA21852083
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CES1 mRNA17602206
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid] results in increased expression of CES1 mRNA18544905
D004052Diethylnitrosamine[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CES1 mRNA18253720
C066888dimethocaineCES1 protein results in increased hydrolysis of dimethocaine25445008
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of CES1 mRNA17547211
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of CES1 mRNA19524605
D0151175,8,11,14-Eicosatetraynoic Acid"5,8,11,14-Eicosatetraynoic Acid results in decreased expression of CES1 mRNA"11409902
C118739entinostatentinostat results in increased expression of CES1 mRNA27188386
D000431EthanolCES1 protein results in increased metabolism of [Cocaine co-treated with Ethanol]12773168|9311626
C042400ethylphenidateCES1 protein results in increased hydrolysis of ethylphenidate25445008
D000068338EverolimusEverolimus results in decreased activity of CES1 protein24727322
D005231Fatty Acids, Unsaturated"Fatty Acids, Unsaturated results in decreased activity of CES1 protein"19761868
D011345Fenofibrate[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CES1 mRNA18253720
C017690fenvalerateCES1 protein results in increased metabolism of fenvalerate19249324
D005473FluoxetineFluoxetine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]20097249
D005473FluoxetineFluoxetine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]20097249
C056933fumonisin B1fumonisin B1 results in increased expression of CES1 mRNA16221962
C033119galaxolidegalaxolide results in decreased activity of CES1 protein22489002
C546771gardiquimodgardiquimod results in increased expression of CES1 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CES1 mRNA]28003376
C094503glyceryl 2-arachidonateCES1 protein results in increased hydrolysis of glyceryl 2-arachidonate21049984
C094503glyceryl 2-arachidonate[CES1 protein results in increased hydrolysis of glyceryl 2-arachidonate] which results in increased chemical synthesis of Arachidonic Acid21049984
C094503glyceryl 2-arachidonate[JZL 184 results in decreased activity of CES1 protein] which results in decreased hydrolysis of glyceryl 2-arachidonate21049984
C094503glyceryl 2-arachidonate[Thiophenes results in decreased activity of CES1 protein] which results in decreased hydrolysis of glyceryl 2-arachidonate21049984
D003932HeroinCES1 protein results in decreased acetylation of Heroin9311626
D003932HeroinCES1 protein results in increased hydrolysis of Heroin12679808|1277316
D003932HeroinCocaine inhibits the reaction [CES1 protein results in increased hydrolysis of Heroin]8930175
D003932HeroinHeroin binds to CES1 protein9311626
C100236homatropineCES1 protein binds to and results in increased metabolism of homatropine12679808
C100236homatropinehomatropine binds to CES1 protein12773168
D017313FenretinideFenretinide results in decreased expression of CES1 mRNA28973697
C065166imidaprilCES1 protein results in increased hydrolysis of and results in increased activity of imidapril9300133
C051890irinotecanCES1 mRNA results in increased susceptibility to irinotecan15239142
C051890irinotecanCES1 protein results in increased hydrolysis of irinotecan15100172
C534333JZL 184JZL 184 results in decreased activity of CES1 protein21049984
C534333JZL 184[JZL 184 results in decreased activity of CES1 protein] which results in decreased hydrolysis of Dinoprost21049984
C534333JZL 184[JZL 184 results in decreased activity of CES1 protein] which results in decreased hydrolysis of glyceryl 2-arachidonate21049984
C534333JZL 184[JZL 184 results in decreased activity of CES1 protein] which results in decreased hydrolysis of prostaglandin E2 glyceryl ester21049984
C410337K 7174K 7174 results in increased expression of CES1 mRNA24086573
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid] results in increased expression of CES1 mRNA18544905
D008055LipidsCES1 protein binds to and results in increased hydrolysis of Lipids16282638
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CES1 mRNA21237253
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CES1 protein21237253
D008070Lipopolysaccharidesprolinedithiocarbamate inhibits the reaction [Lipopolysaccharides results in decreased expression of CES1 mRNA]21237253
D008070LipopolysaccharidesSB 203580 inhibits the reaction [Lipopolysaccharides results in decreased expression of CES1 mRNA]21237253
D008294MalathionMalathion results in increased expression of CES1 mRNA17311802
D008614MeperidineCES1 protein results in increased hydrolysis of Meperidine10381793
D008614MeperidineMeperidine binds to CES1 protein10381793
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of CES1 protein10640517
D008774MethylphenidateAripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]20097249
D008774MethylphenidateCES1 gene mutant form results in decreased metabolism of and results in increased abundance of Methylphenidate18485328
D008774MethylphenidateCES1 protein results in increased hydrolysis of Methylphenidate15082749|2009724
D008774Methylphenidate[CES1 protein results in increased hydrolysis of Methylphenidate] which results in increased chemical synthesis of ritalinic acid20097249
D008774MethylphenidateCES1 protein results in increased metabolism of Methylphenidate18485328
D008774MethylphenidateFluoxetine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]20097249
D008774MethylphenidatePerphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]20097249
D008774MethylphenidateThioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]20097249
D008774MethylphenidateAripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]20097249
C001801mitragynineCES1 protein results in increased hydrolysis of mitragynine25445008
C008588N-(1-naphthyl)ethylenediamineN-(1-naphthyl)ethylenediamine results in increased expression of CES1 mRNA17311802
D009270NaloxoneCES1 protein binds to and results in increased metabolism of Naloxone12679808
D009270NaloxoneNaloxone binds to CES1 protein12773168
D009532NickelNickel results in decreased expression of CES1 mRNA25583101
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of CES1 mRNA17616710
C066443N-methylolacrylamideN-methylolacrylamide results in increased expression of CES1 mRNA17311802
C025589ochratoxin Aochratoxin A results in decreased expression of CES1 mRNA16251485
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased activity of CES1 protein"15896444
D053139OseltamivirCES1 protein affects the hydrolysis of Oseltamivir18983829
D010171Palmitoyl Coenzyme ACES1 protein results in increased hydrolysis of Palmitoyl Coenzyme A8611161
D010261ParaoxonParaoxon results in decreased activity of CES1 protein11950785|2525084
C084656paricalcitol[Phosphorus co-treated with paricalcitol] results in increased expression of CES1 mRNA17715259
D010400Penicillin GPenicillin G results in increased expression of CES1 mRNA22609641
D010404Penicillin VPenicillin V results in increased expression of CES1 mRNA22609641
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of CES1 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of CES1 mRNA18281256|1942940
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CES1 mRNA26794494
D026023PermethrinCES1 protein affects the hydrolysis of Permethrin18983829
D026023PermethrinCES1 protein results in increased hydrolysis of Permethrin16359636|1638728
D026023PermethrinCES1 protein results in increased hydrolysis of Permethrin16387282
D026023PermethrinCES1 protein results in increased hydrolysis of Permethrin16387282
D026023PermethrinCES1 protein results in increased hydrolysis of Permethrin16387282
D010546PerphenazinePerphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]20097249
D010546PerphenazinePerphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]20097249
C576198phenethylcymserinephenethylcymserine results in decreased activity of CES1 protein23123248
D010634PhenobarbitalPhenobarbital results in increased expression of CES1 protein10640517
D010664Phenylmethylsulfonyl FluoridePhenylmethylsulfonyl Fluoride results in decreased activity of CES1 protein11950785
D010758Phosphorus[Phosphorus co-treated with paricalcitol] results in increased expression of CES1 mRNA17715259
C060836pioglitazonepioglitazone results in increased expression of CES1 mRNA15381068
C006253pirinixic acidpirinixic acid results in decreased expression of CES1 mRNA11409902
C006253pirinixic acidpirinixic acid results in increased expression of CES1 mRNA16221962|1742611
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of CES1 mRNA]20059764
D011192Potassium DichromatePotassium Dichromate affects the expression of CES1 mRNA23608068
D011374ProgesteroneProgesterone results in increased activity of CES1 protein8696951
C066229prolinedithiocarbamateprolinedithiocarbamate inhibits the reaction [Lipopolysaccharides results in decreased expression of CES1 mRNA]21237253
D011431DextropropoxypheneDextropropoxyphene binds to CES1 protein10381793
C518978prostaglandin E2 glyceryl esterCES1 protein results in increased hydrolysis of prostaglandin E2 glyceryl ester21049984
C518978prostaglandin E2 glyceryl ester[JZL 184 results in decreased activity of CES1 protein] which results in decreased hydrolysis of prostaglandin E2 glyceryl ester21049984
C518978prostaglandin E2 glyceryl ester[Thiophenes results in decreased activity of CES1 protein] which results in decreased hydrolysis of prostaglandin E2 glyceryl ester21049984
D015237DinoprostCES1 protein results in increased hydrolysis of Dinoprost21049984
D015237Dinoprost[JZL 184 results in decreased activity of CES1 protein] which results in decreased hydrolysis of Dinoprost21049984
D015237Dinoprost[Thiophenes results in decreased activity of CES1 protein] which results in decreased hydrolysis of Dinoprost21049984
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CES1 mRNA]28003376
C005805quintozenequintozene results in increased expression of CES1 mRNA17311802
D017257RamiprilCES1 protein results in increased hydrolysis of Ramipril25445008
D012293RifampinRifampin results in increased expression of CES1 protein10640517
C009189ritalinic acidCES1 protein results in increased chemical synthesis of ritalinic acid20097249
C009189ritalinic acid[CES1 protein results in increased hydrolysis of Methylphenidate] which results in increased chemical synthesis of ritalinic acid20097249
D000068836RivastigmineRivastigmine results in decreased activity of CES1 protein23123248
C089730rosiglitazonerosiglitazone results in increased expression of CES1 mRNA15381068
C100720RPR 121056CES1 protein results in increased hydrolysis of RPR 12105615100172
D012524SarinCES1 protein affects the metabolism of and results in decreased activity of Sarin12679808
C093642SB 203580SB 203580 inhibits the reaction [Lipopolysaccharides results in decreased expression of CES1 mRNA]21237253
D012643SeleniumSelenium results in increased expression of CES1 mRNA19244175
C002979selenomethylselenocysteineselenomethylselenocysteine results in increased expression of CES115897249
D020358Sodium CholateSodium Cholate results in increased expression of CES1 mRNA9565681
D012999SomanCES1 protein affects the metabolism of and results in decreased activity of Soman12679808
C016766sulforafanNFE2L2 protein affects the reaction [sulforafan results in increased expression of CES1 mRNA alternative form]19715681
C016766sulforafansulforafan promotes the reaction [NFE2L2 protein binds to CES1 promoter]19715681
C016766sulforafansulforafan promotes the reaction [[NFE2L2 protein binds to CES1 promoter] which results in increased expression of CES1 mRNA alternative form]19715681|1971568
C016766sulforafansulforafan results in increased expression of and results in increased activity of CES1 protein alternative form19715681
C016766sulforafansulforafan results in increased expression of CES1 mRNA26833863
C016766sulforafansulforafan results in increased expression of CES1 mRNA alternative form19715681
C009374tabunCES1 protein affects the metabolism of and results in decreased activity of tabun12679808
D013619TacrineTacrine analog results in decreased activity of CES1 protein12725862
D013619TacrineTacrine binds to CES1 protein12725862
C013698tallowtallow affects the expression of CES1 mRNA19680557
C069156temocaprilatCES1 protein results in increased chemical synthesis of temocaprilat15908471
C055603temocapril hydrochlorideCES1 protein results in increased hydrolysis of temocapril hydrochloride15908471|9300133
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CES1 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CES1 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CES1 protein25703434
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CES1 mRNA19770486
D013876ThiophenesThiophenes results in decreased activity of CES1 protein21049984
D013876Thiophenes[Thiophenes results in decreased activity of CES1 protein] which results in decreased hydrolysis of Dinoprost21049984
D013876Thiophenes[Thiophenes results in decreased activity of CES1 protein] which results in decreased hydrolysis of glyceryl 2-arachidonate21049984
D013876Thiophenes[Thiophenes results in decreased activity of CES1 protein] which results in decreased hydrolysis of prostaglandin E2 glyceryl ester21049984
D013881ThioridazineThioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]20097249
D013881ThioridazineThioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]20097249
D014028Tobacco Smoke PollutionNFE2L2 protein promotes the reaction [Tobacco Smoke Pollution affects the expression of CES1 mRNA]20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CES1 mRNA20133372
C412047tolserinetolserine results in decreased activity of CES1 protein23123248
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of CES1 mRNA19524605|2260964
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES1 mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of CES1 mRNA18200517
D014317Tritolyl PhosphatesTritolyl Phosphates results in decreased activity of CES1 protein23085349
C005862tropacocainetropacocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]9311626
D014635Valproic AcidValproic Acid results in decreased methylation of CES1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CES1 mRNA28001369
D014810Vitamin EVitamin E results in increased expression of CES1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004771sterol esterase activity-IBA21873635  
GO:0004771sterol esterase activity-IDA11015575  
GO:0004806triglyceride lipase activity-IBA21873635  
GO:0047374methylumbelliferyl-acetate deacetylase activity-IEA-  
GO:0052689carboxylic ester hydrolase activity-IBA21873635  
GO:0052689carboxylic ester hydrolase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006695cholesterol biosynthetic process-IDA11015575  
GO:0006805xenobiotic metabolic process-TAS-  
GO:0009636response to toxic substance-TAS1918003  
GO:0016042lipid catabolic process-IBA21873635  
GO:0030855epithelial cell differentiation-IDA21492153  
GO:0051791medium-chain fatty acid metabolic process-IDA11015575  
GO:0090122cholesterol ester hydrolysis involved in cholesterol transport-TAS11015575  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005829cytosol-IEA-  
KEGG ID KEGG Term
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26455281Novel candidate genes for alcoholism--transcriptomic analysis of prefrontal medial cortex, hippocampus and nucleus accumbens of Warsaw alcohol-preferring and non-preferring rats. (2015 Dec)Stankiewicz AMPharmacol Biochem Behav
24512105Association between copy number variation losses and alcohol dependence across African American and European American ethnic groups. (2014 May)Ulloa AEAlcohol Clin Exp Res