Gene: CXCR6

10663
BONZO|CD186|STRL33|TYMSTR
C-X-C motif chemokine receptor 6
protein-coding
3p21.31
Ensembl:ENSG00000172215 MIM:605163 Vega:OTTHUMG00000133448 UniprotKB:O00574
NC_000003.12
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.426e-1 (AD)  3.575e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAET1E0.733
NBEAL10.705
GPR1710.673
LMX1B0.662
OR13C30.654
DNASE1L30.651
MROH90.648
EOMES0.645
EBF10.635
NR2F2-AS10.633

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CKMT1A-0.428
MYADML2-0.422
LRTM2-0.42
DLK2-0.418
HAS1-0.417
KLHL35-0.415
THY1-0.415
FAM174B-0.412
ZNF575-0.41
VSTM5-0.407

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CXCR6 mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of CXCR6 mRNA26690555
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of CXCR6 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CXCR6 mRNA24449571
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CXCR6 mRNA27858113
D001554BenzeneBenzene results in increased expression of CXCR6 mRNA19162166
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CXCR6 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of CXCR6 mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CXCR6 mRNA27858113
D004958EstradiolEstradiol results in decreased expression of CXCR6 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of CXCR6 mRNA25181051
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CXCR6 mRNA27858113
D003520CyclophosphamideCyclophosphamide results in increased expression of CXCR6 mRNA21041162
D003907DexamethasoneDexamethasone results in increased expression of CXCR6 mRNA21041162
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CXCR6 mRNA21041162
C039281furanfuran results in increased expression of CXCR6 mRNA27387713
D008727MethotrexateMethotrexate results in decreased expression of CXCR6 mRNA24449571
D008727MethotrexateMethotrexate affects the expression of CXCR6 mRNA18502557
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of CXCR6 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CXCR6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CXCR6 mRNA"25554681|2562005
D009532NickelNickel results in increased expression of CXCR6 mRNA24768652|2558310
D017239PaclitaxelCXCR6 mRNA results in decreased susceptibility to Paclitaxel16322897
C009495titanium dioxidetitanium dioxide results in decreased expression of CXCR6 mRNA23557971
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CXCR6 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-TAS9166430  
GO:0015026coreceptor activity-IEA-  
GO:0016493C-C chemokine receptor activity-IBA21873635  
GO:0016494C-X-C chemokine receptor activity-IEA-  
GO:0019956chemokine binding-IBA21873635  
GO:0019957C-C chemokine binding-IBA21873635  
GO:0019958C-X-C chemokine binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006935chemotaxis-IBA21873635  
GO:0006935chemotaxis-IEA-  
GO:0006954inflammatory response-IEA-  
GO:0006955immune response-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007204positive regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0019079viral genome replication-TAS9230441  
GO:0019722calcium-mediated signaling-IBA21873635  
GO:0060326cell chemotaxis-IBA21873635  
GO:0070098chemokine-mediated signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9166430  
GO:0009897external side of plasma membrane-IBA21873635  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-380108Chemokine receptors bind chemokinesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28599467Association between CXCL16/CXCR6 expression and the clinicopathological features of patients with non-small cell lung cancer. (2017 Jun)Ke COncol Lett
29326688Cigarette Smoke Increases Endothelial CXCL16-Leukocyte CXCR6 Adhesion In Vitro and In Vivo. Potential Consequences in Chronic Obstructive Pulmonary Disease. (2017)Marques PFront Immunol
19729872Circulating soluble SR-PSOX/CXCL16 as a biomarker for acute coronary syndrome -comparison with high-sensitivity C-reactive protein. (2009 Oct)Mitsuoka HJ Atheroscler Thromb
29285224Soluble chemokine (C-X-C motif) ligand 16 (CXCL16) in urine as a novel biomarker candidate to identify high grade and muscle invasive urothelial carcinomas. (2017 Dec 1)Lang KOncotarget