Gene: FARS2

10667
COXPD14|FARS1|HSPC320|PheRS|SPG77
phenylalanyl-tRNA synthetase 2, mitochondrial
protein-coding
6p25.1
Ensembl:ENSG00000145982 MIM:611592 Vega:OTTHUMG00000014178 UniprotKB:O95363
NG_033003.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.514e-1 (AD)  4.539e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10484314chr6:5647854 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs9328308chr6:5513258 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00418528chr6:5463751FARS2Gene body6.712e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PJA10.907
IDH3B0.893
WIPI20.891
DCTN30.887
MAGEH10.887
SLC25A40.884
ASNA10.884
MRPL450.883
LRRC470.883
UBE2Z0.881

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.541
OR4F29-0.491
P2RY14-0.417
MTRNR2L6-0.404
IL18RAP-0.404
TFPI2-0.398
EBF1-0.395
KCNJ15-0.393
KLRB1-0.39
FZD10-0.388

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of FARS2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of FARS2 mRNA"21346803
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of FARS2 protein24140754
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FARS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FARS2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of FARS2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of FARS2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of FARS2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FARS2 mRNA21641981|2715375
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of FARS2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FARS2 mRNA19770486
D001280AtrazineAtrazine results in decreased expression of FARS2 mRNA22378314
D001554BenzeneBenzene results in decreased expression of FARS2 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FARS2 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FARS2 mRNA15034205|1977048
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FARS2 mRNA"20382639|2623829
C006780bisphenol Abisphenol A affects the expression of FARS2 mRNA21786754
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FARS2 gene20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of FARS2 mRNA19549813
C014347decitabinedecitabine affects the expression of FARS2 mRNA23300844
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FARS2 mRNA17361019
D002945CisplatinCisplatin affects the expression of FARS2 mRNA23300844
D002945CisplatinCisplatin results in decreased expression of FARS2 mRNA19561079
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of FARS2 mRNA"22485181
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FARS2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FARS2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FARS2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FARS2 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of FARS2 mRNA23649840
D018120FinasterideFinasteride results in increased expression of FARS2 mRNA24136188
D005472FluorouracilFluorouracil results in decreased expression of FARS2 mRNA16101138
D005485FlutamideFlutamide results in decreased expression of FARS2 mRNA24793618
D005485FlutamideFlutamide results in increased expression of FARS2 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FARS2 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of FARS2 mRNA23649840
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of FARS2 mRNA25613284
C544151jinfukangjinfukang results in increased expression of FARS2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FARS2 mRNA23086925
D048628KetolidesKetolides analog results in increased expression of FARS2 mRNA24967691
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FARS2 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of FARS2 mRNA26011545
D009151Mustard GasMustard Gas results in decreased expression of FARS2 mRNA25102026
C029938nickel sulfatenickel sulfate results in increased expression of FARS2 mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of FARS2 mRNA25729387
D010634PhenobarbitalPhenobarbital affects the expression of FARS2 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of FARS2 mRNA18445702
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FARS2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of FARS2 mRNA22079256
C045362prochlorazprochloraz results in increased expression of FARS2 mRNA21470553
D012999SomanSoman results in decreased expression of FARS2 mRNA19281266
D013311StreptozocinStreptozocin affects the expression of FARS2 mRNA18583417
D010042OuabainOuabain results in increased expression of FARS2 mRNA16412265
D013629TamoxifenTamoxifen affects the expression of FARS2 mRNA17555576
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of FARS2 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FARS2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FARS2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FARS2 mRNA15034205
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of FARS2 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of FARS2 mRNA25729387
D014303TrinitrotolueneTrinitrotoluene affects the expression of FARS2 mRNA21346803
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FARS2 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased methylation of FARS2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of FARS2 mRNA23179753|2627250

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000049tRNA binding-IDA10329163  
GO:0004826phenylalanine-tRNA ligase activity-IBA21873635  
GO:0004826phenylalanine-tRNA ligase activity-IDA10329163  
GO:0004826phenylalanine-tRNA ligase activity-TAS-  
GO:0005515protein binding-IPI25416956  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006418tRNA aminoacylation for protein translation-TAS-  
GO:0006432phenylalanyl-tRNA aminoacylation-IBA21873635  
GO:0006432phenylalanyl-tRNA aminoacylation-IDA10329163  
GO:0008033tRNA processing-IDA10329163  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-ISS-  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00970Aminoacyl-tRNA biosynthesis
Reactome ID Reactome Term Evidence
R-HSA-379724tRNA AminoacylationTAS
R-HSA-379726Mitochondrial tRNA aminoacylationTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-72766TranslationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal