Gene: TNFSF13B

10673
BAFF|BLYS|CD257|DTL|TALL-1|TALL1|THANK|TNFSF20|TNLG7A|ZTNF4
TNF superfamily member 13b
protein-coding
13q33.3
Ensembl:ENSG00000102524 MIM:603969 Vega:OTTHUMG00000017329 UniprotKB:Q9Y275
NG_029524.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.192e-1 (AD)  4.679e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFEC0.774
NOD20.755
CTSC0.746
IL150.742
FAM3B0.741
DENND2D0.74
BTN3A30.737
ARHGAP150.73
PDCD1LG20.729
DAPP10.728

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARSF-0.386
HHATL-0.374
HES6-0.36
OLIG1-0.358
HES5-0.346
SAPCD2-0.342
SNX22-0.342
ENHO-0.338
PYGM-0.329
ATP2C2-0.321

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB033161,4-Diethylene DioxideSmall MoleculeExperimentalTarget
DB04272Citric AcidSmall Molecule77-92-9Approved|NutraceuticalTarget
DB08879BelimumabBiotechDrug356547-88-1ApprovedTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of TNFSF13B mRNA"19095052
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of TNFSF13B mRNA"24172598
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of TNFSF13B mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TNFSF13B mRNA24449571
D001151ArsenicArsenic affects the methylation of TNFSF13B gene25304211
C006632arsenic trioxidearsenic trioxide affects the expression of TNFSF13B mRNA17530438
C015001arsenite[arsenite results in increased activity of [NFKB1 protein binds to RELB protein]] which results in increased expression of TNFSF13B mRNA18418899
C015001arsenitearsenite results in increased expression of TNFSF13B mRNA18418899
C015001arsenitearsenite results in decreased expression of TNFSF13B mRNA18191166
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TNFSF13B mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TNFSF13B mRNA"20382639
C006780bisphenol Abisphenol A results in decreased expression of TNFSF13B mRNA25181051
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of TNFSF13B mRNA28472532
D002922CiguatoxinsCiguatoxins affects the expression of TNFSF13B mRNA18353800
D003300CopperCopper deficiency results in increased expression of TNFSF13B mRNA26033743
D003436Croton OilCroton Oil results in increased expression of TNFSF13B mRNA19647056
D003703DemecolcineDemecolcine results in increased expression of TNFSF13B mRNA23649840
D003907DexamethasoneDexamethasone results in increased expression of TNFSF13B mRNA21041162
D019422Dietary SucroseDietary Sucrose results in increased expression of TNFSF13B mRNA26033743
D004237DiuronDiuron metabolite results in increased expression of TNFSF13B mRNA24172598
D005557FormaldehydeFormaldehyde results in increased expression of TNFSF13B mRNA23649840
D006025GlycosaminoglycansGlycosaminoglycans affects the reaction [TNFSF13B protein binds to and results in increased activity of TNFRSF13B protein]20807638
D006418HemeHeme metabolite results in decreased expression of TNFSF13B mRNA19191707
D017313FenretinideFenretinide results in increased expression of TNFSF13B mRNA16570282
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TNFSF13B mRNA26387944
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of TNFSF13B protein26590112
C008261lead acetatelead acetate results in increased expression of TNFSF13B mRNA20542052
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of TNFSF13B mRNA"24972896
D008070Lipopolysaccharides[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased expression of TNFSF13B mRNA21131560
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TNFSF13B mRNA26378955
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TNFSF13B mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TNFSF13B mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TNFSF13B mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TNFSF13B mRNA"25554681
D009532NickelNickel results in decreased expression of TNFSF13B mRNA23195993
D009532NickelNickel results in increased expression of TNFSF13B mRNA24768652|2558310
D017239PaclitaxelPaclitaxel results in increased expression of TNFSF13B mRNA18058816
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of TNFSF13B mRNA19095052
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of TNFSF13B mRNA23948077
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TNFSF13B mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of TNFSF13B mRNA17426115
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of TNFSF13B protein29175452
D011374ProgesteroneProgesterone results in increased expression of TNFSF13B mRNA21768398
D011374ProgesteroneTGFB1 protein promotes the reaction [Progesterone results in increased expression of TNFSF13B mRNA]21768398
D011441PropylthiouracilPropylthiouracil results in increased expression of TNFSF13B mRNA24780913
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TNFSF13B mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to RELB protein] which binds to TNFSF13B promoter]17900530
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of TNFSF13B mRNA17900530
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased expression of TNFSF13B mRNA21131560
D013849ThimerosalThimerosal results in increased expression of TNFSF13B mRNA27188386
C009495titanium dioxidetitanium dioxide results in increased expression of TNFSF13B mRNA23557971
C012589trichostatin Atrichostatin A results in increased expression of TNFSF13B mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of TNFSF13B mRNA23179753|2519280
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of TNFSF13B mRNA20370541
D019287Zinc SulfateZinc Sulfate results in increased expression of TNFSF13B mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-TAS10908663  
GO:0005125cytokine activity-IEA-  
GO:0005164tumor necrosis factor receptor binding-IEA-  
GO:0005515protein binding-IPI10801128  10880535  10956646  
GO ID GO Term Qualifier Evidence PubMed
GO:0001782B cell homeostasis-IEA-  
GO:0002636positive regulation of germinal center formation-IEA-  
GO:0006955immune response-IEA-  
GO:0007165signal transduction-TAS10908663  
GO:0008283cell proliferation-TAS10908663  
GO:0008284positive regulation of cell proliferation-TAS10359578  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0030890positive regulation of B cell proliferation-IMP17499850  
GO:0031295T cell costimulation-IEA-  
GO:0031296B cell costimulation-IEA-  
GO:0033209tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0042102positive regulation of T cell proliferation-IEA-  
GO:0048305immunoglobulin secretion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
GO:0005737cytoplasm-IDA19828625  
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-NAS12867412  
GO:0048471perinuclear region of cytoplasm-IDA19828625  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04672Intestinal immune network for IgA production
hsa05323Rheumatoid arthritis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5669034TNFs bind their physiological receptorsTAS
R-HSA-5676594TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23919740Comparison of circulating tumour necrosis factor superfamily cytokines in periodontitis patients undergoing supportive therapy: a case-controlled cross-sectional study comparing smokers and non-smokers in health and disease. (2013 Sep)Nile CJJ Clin Periodontol