Gene: EBP

10682
CDPX2|CHO2|CPX|CPXD|MEND
EBP, cholestenol delta-isomerase
protein-coding
Xp11.23
Ensembl:ENSG00000147155 MIM:300205 Vega:OTTHUMG00000034482 UniprotKB:Q15125
NG_007452.1
PubMed
0   ANCO-SNPs
OD|ND
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PHKG20.905
TUBB2A0.891
C6orf1360.89
LCMT10.89
AARSD10.889
AP2S10.887
TUBB0.885
ATP6V0B0.884
MRPL20.884
QPCTL0.883

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.583
OR4F29-0.546
MTRNR2L9-0.405
ASB4-0.398
FCGR3B-0.371
MTRNR2L10-0.368
MTRNR2L6-0.362
CXCR2-0.358
ARHGAP42-0.35
MTRNR2L8-0.35

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00675TamoxifenSmall Molecule10540-29-1ApprovedTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of EBP mRNA"19162173
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of EBP mRNA"19167446
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of EBP mRNA"28433925
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of EBP mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of EBP mRNA"21346803
C5756314-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile"4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile affects the expression of EBP mRNA"21218783
D000082AcetaminophenAcetaminophen results in decreased expression of EBP mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of EBP mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of EBP mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of EBP protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of EBP mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of EBP mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EBP mRNA16483693
D016718Arachidonic AcidArachidonic Acid results in decreased expression of EBP mRNA16704987
C519728archazolid Barchazolid B results in increased expression of EBP mRNA25218289
D001507BeclomethasoneBeclomethasone results in increased expression of EBP mRNA23656298
D001548Benzalkonium CompoundsBenzalkonium Compounds results in increased expression of EBP mRNA26919959
D004958EstradiolEstradiol results in decreased expression of EBP mRNA20106945
D004958EstradiolEstradiol results in increased expression of EBP mRNA16474171|1916744
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid affects the expression of EBP mRNA18192240
C053541bicalutamidebicalutamide results in decreased expression of EBP mRNA15638997
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of EBP mRNA25912373
C006780bisphenol Abisphenol A affects the expression of EBP mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of EBP mRNA16474171
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of EBP mRNA"28433925
C006780bisphenol Abisphenol A affects the expression of EBP mRNA21786754
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of EBP mRNA22079614
C027561butylbenzyl phthalatebutylbenzyl phthalate results in decreased expression of EBP mRNA26472102
C584509C646 compoundC646 compound results in increased expression of EBP mRNA26191083
D002104CadmiumCadmium results in decreased expression of EBP mRNA17547211
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of EBP mRNA17547211
D002110CaffeineCaffeine results in increased expression of EBP mRNA25868845
D002220CarbamazepineCarbamazepine affects the expression of EBP mRNA25979313
C026690cerous chloridecerous chloride affects the expression of EBP mRNA23139204
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of EBP mRNA27344345
D002793Cholic Acids[Cyclosporine co-treated with Cholic Acids] affects the expression of EBP mRNA27344345
D002793Cholic Acids[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of EBP mRNA27344345
C018021cobaltous chloridecobaltous chloride results in decreased expression of EBP mRNA24612858
C018021cobaltous chloridecobaltous chloride results in decreased expression of EBP mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of EBP mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of EBP mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of EBP mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of EBP mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of EBP mRNA19167446
D016572Cyclosporine[Cyclosporine co-treated with Cholic Acids] affects the expression of EBP mRNA27344345
D016572CyclosporineCyclosporine results in decreased expression of EBP mRNA20106945|2556210
D013759DronabinolDronabinol results in decreased expression of EBP mRNA18454173
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of EBP mRNA21266533|2647210
D002945CisplatinCisplatin results in increased expression of EBP mRNA27594783
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in decreased expression of EBP mRNA16498641
D004041Dietary FatsDietary Fats results in decreased expression of EBP mRNA15238619|1804283
D004041Dietary FatsDietary Fats results in increased expression of EBP mRNA18042831
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of EBP mRNA"28433925
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of EBP mRNA26472102
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of EBP mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of EBP mRNA19638242
C007379diethyl phthalatediethyl phthalate results in decreased expression of EBP mRNA26472102
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of EBP mRNA17547211
C034171di-n-pentyl phthalatedi-n-pentyl phthalate results in decreased expression of EBP mRNA26472102
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of EBP mRNA27344345
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of EBP mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EBP mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EBP mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of EBP mRNA23649840
D005411Flame RetardantsFlame Retardants results in decreased expression of EBP mRNA18534652
D005411Flame RetardantsFlame Retardants results in increased expression of EBP mRNA18534652
D005472FluorouracilEBP protein affects the susceptibility to Fluorouracil15548681|1621774
C061365flusilazoleflusilazole results in increased expression of EBP mRNA22382673
C061365flusilazoleflusilazole affects the expression of EBP mRNA22634333
D005485FlutamideFlutamide results in decreased expression of EBP mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of EBP mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of EBP mRNA19167457
C056933fumonisin B1fumonisin B1 results in decreased expression of EBP mRNA16221962
C039281furanfuran results in increased methylation of EBP gene22079235
D019833GenisteinGenistein results in increased expression of EBP mRNA16474171
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of EBP mRNA18534652
C089796hexabromocyclododecanehexabromocyclododecane results in increased expression of EBP mRNA18534652
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EBP mRNA25613284
C544151jinfukangjinfukang results in increased expression of EBP mRNA27392435
C410337K 7174K 7174 results in decreased expression of EBP mRNA24086573
D007649KetamineKetamine results in decreased expression of EBP mRNA20080153
D008752Methylene ChlorideMethylene Chloride affects the expression of EBP mRNA28392392
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of EBP mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of EBP mRNA23649840
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of EBP mRNA22087261
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of EBP mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of EBP mRNA"25620056
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of EBP mRNA27344345
C051752nefazodonenefazodone results in decreased expression of EBP mRNA24136188
C028007nickel monoxidenickel monoxide results in decreased expression of EBP mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of EBP mRNA20971185
D010126Ozone"[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of EBP mRNA"23246600
D000073878Palm OilPalm Oil results in decreased expression of EBP mRNA18042831
D000073878Palm OilPalm Oil results in increased expression of EBP mRNA18042831
D052638Particulate MatterParticulate Matter results in decreased expression of EBP mRNA24769257
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of EBP mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of EBP mRNA19162173
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of EBP mRNA17097637
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of EBP mRNA26678675
D010634PhenobarbitalPhenobarbital results in increased expression of EBP mRNA19162173
D010795Phthalic AcidsPhthalic Acids results in decreased expression of EBP mRNA15728792
D010894PiroxicamPiroxicam results in decreased expression of EBP mRNA21858171
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of EBP mRNA16474171
D011192Potassium DichromatePotassium Dichromate results in increased expression of EBP protein23718831
D011374ProgesteroneProgesterone results in increased expression of EBP mRNA23012394
D011374ProgesteroneProgesterone results in increased expression of EBP mRNA18070364
D011441PropylthiouracilPropylthiouracil results in decreased expression of EBP mRNA24780913
C010313pseudocumenepseudocumene results in decreased expression of EBP protein17337753
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride binds to EBP protein16033255
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of EBP mRNA19167446
D015474IsotretinoinIsotretinoin results in decreased expression of EBP mRNA20436886
C017947sodium arsenitesodium arsenite results in increased expression of EBP mRNA28595984
C016104sodium bichromatesodium bichromate results in decreased expression of EBP mRNA24612858
D013629TamoxifenTamoxifen affects the expression of EBP mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EBP mRNA21570461
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of EBP mRNA"28433925
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EBP mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EBP mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EBP mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EBP mRNA25613284
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of EBP mRNA28943392
C066340tolcaponetolcapone results in increased expression of EBP mRNA24136188
D001371trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride"trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in increased expression of EBP mRNA"26919959
D014212TretinoinTretinoin results in decreased expression of EBP mRNA20530235
C034613triacsin Ctriacsin C results in decreased expression of EBP mRNA16704987
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of EBP mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of EBP mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of EBP mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of EBP mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of EBP gene25560391
C025643vinclozolinvinclozolin results in decreased expression of EBP mRNA16498641
C025643vinclozolinvinclozolin results in increased expression of EBP mRNA22570695
D014874Water Pollutants, Chemical"[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of EBP mRNA"23246600
C088658zoledronic acidzoledronic acid results in increased expression of EBP mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000247C-8 sterol isomerase activity-IEA-  
GO:0004769steroid delta-isomerase activity-EXP10391218  10391219  
GO:0004769steroid delta-isomerase activity-IDA9894009  
GO:0004888transmembrane signaling receptor activity-TAS7706302  
GO:0005515protein binding-IPI25910212  
GO:0015238drug transmembrane transporter activity-TAS7706302  
GO:0047750cholestenol delta-isomerase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-TAS10391219  
GO:0006695cholesterol biosynthetic process-IDA9894009  
GO:0006855drug transmembrane transport-IEA-  
GO:0007165signal transduction-IEA-  
GO:0008203cholesterol metabolic process-TAS10391219  
GO:0030097hemopoiesis-IEA-  
GO:0033489cholesterol biosynthetic process via desmosterol-TAS-  
GO:0033490cholesterol biosynthetic process via lathosterol-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-IDA10406945  
GO:0005783endoplasmic reticulum-IDA10406945  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS7706302  
GO:0031410cytoplasmic vesicle-IEA-  
KEGG ID KEGG Term
hsa00100Steroid biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-191273Cholesterol biosynthesisTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-6807047Cholesterol biosynthesis via desmosterolTAS
R-HSA-6807062Cholesterol biosynthesis via lathosterolTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26740650Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons. (2016 Jan 6)Srinivasan RJ Neurosci
21697995Induction of the unfolded protein response by cigarette smoke is primarily an activating transcription factor 4-C/EBP homologous protein mediated process. (2011)Geraghty PInt J Chron Obstruct Pulmon Dis
21562127Lung epithelial CCAAT/enhancer-binding protein-beta is necessary for the integrity of inflammatory responses to cigarette smoke. (2011 Jul 15)Didon LAm J Respir Crit Care Med
23143154Cigarette smoke extract-induced adipogenesis in Graves' orbital fibroblasts is inhibited by quercetin via reduction in oxidative stress. (2013 Feb)Yoon JSJ Endocrinol
24053669Role of unfolded protein response dysregulation in oxidative injury of retinal pigment epithelial cells. (2014 May 10)Chen CAntioxid Redox Signal
28513228Relationship between CHOP/GADD153 and unstable human carotid atherosclerotic plaque. (2017 Dec)Wang SBr J Neurosurg
21595557Serum thyrotropin levels and blood pressure response to exercise in a population-based study. (2011 Aug)Lorbeer RThyroid
15821213Decreased CCAAT/enhancer binding protein transcription factor activity in chronic bronchitis and COPD. (2005 Apr)Didon LChest
21432382Evidence-based prevention (EBP): A review of cytochrome P450 expression in the bronchial epithelium and new approach to lung cancer prevention. (2006 May)Oyama TEnviron Health Prev Med
20966132YouTube as a source of quitting smoking information. (2011 Mar)Backinger CLTob Control
26511475Small airway epithelial-C/EBPbeta is increased in patients with advanced COPD. (2015 Oct 29)Mori MRespir Res