Gene: DLL3

10683
SCDO1
delta like canonical Notch ligand 3
protein-coding
19q13.2
Ensembl:ENSG00000090932 MIM:602768 Vega:OTTHUMG00000183067 UniprotKB:Q9NYJ7
NG_008256.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.779e-2 (AD)  1.763e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg15412721chr19:39995588DLL3Gene body4.409e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC27A50.749
TMEM1340.732
POLR2I0.711
DNPH10.707
NENF0.707
TAF100.704
RND20.703
ETFB0.7
ROMO10.695
ALKBH70.693

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.442
OR4F29-0.414
SIX4-0.292
SLC38A11-0.289
RGPD1-0.287
FILIP1L-0.286
KLHL38-0.283
TFAP2D-0.282
CCDC68-0.276
PHLDB2-0.275

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DLL3 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLL3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLL3 mRNA"27188386
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DLL3 mRNA16483693
D001151ArsenicArsenic affects the methylation of DLL3 gene25304211
D004958EstradiolEstradiol affects the expression of DLL3 mRNA22574217
C006780bisphenol Abisphenol A affects the expression of DLL3 mRNA25181051
C018021cobaltous chloridecobaltous chloride results in decreased expression of DLL3 mRNA19376846
D003300CopperCopper deficiency results in increased expression of DLL3 mRNA26033743
C014347decitabinedecitabine affects the expression of DLL3 mRNA23300844
D002945CisplatinCisplatin affects the expression of DLL3 mRNA23300844
D019422Dietary SucroseDietary Sucrose results in increased expression of DLL3 mRNA26033743
D005419FlavonoidsFlavonoids results in increased expression of DLL3 mRNA18035473
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of DLL3 mRNA21179406
C544151jinfukangjinfukang results in increased expression of DLL3 mRNA27392435
D007854LeadLead affects the expression of DLL3 mRNA28903495
D015122MercaptopurineMercaptopurine results in decreased expression of DLL3 mRNA23358152
D008713MethimazoleMethimazole results in decreased expression of DLL3 mRNA17403546
C004925methylmercuric chloridemethylmercuric chloride affects the expression of DLL3 mRNA20864626
C523799MRK 003MRK 003 results in increased expression of DLL3 mRNA21169257
C025589ochratoxin Aochratoxin A results in decreased expression of DLL3 mRNA21703336
C025589ochratoxin ASHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of DLL3 mRNA]21703336
C494474perchlorateperchlorate results in decreased expression of DLL3 mRNA17403546
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLL3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of DLL3 mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of DLL3 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of DLL3 mRNA24780913
D011441PropylthiouracilPropylthiouracil results in decreased expression of DLL3 mRNA17403546
C009250sevofluranesevoflurane results in increased expression of DLL3 mRNA26206149
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of DLL3 mRNA25895662
D014284TriiodothyronineTriiodothyronine affects the expression of DLL3 mRNA17403546
D013739TestosteroneTestosterone results in decreased expression of DLL3 mRNA19693291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DLL3 mRNA11752688
D014212TretinoinTretinoin results in decreased expression of DLL3 mRNA23724009
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DLL3 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of DLL3 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of DLL3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of DLL3 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DLL3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005112Notch binding-NAS10742114  
GO:0005509calcium ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-IMP10742114  
GO:0001756somitogenesis-IEA-  
GO:0007219Notch signaling pathway-IEA-  
GO:0007386compartment pattern specification-IEA-  
GO:0048339paraxial mesoderm development-IEA-  
GO:0050768negative regulation of neurogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-NAS10742114  
KEGG ID KEGG Term
hsa04330Notch signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29290251Prevalence of Delta-like protein 3 expression in patients with small cell lung cancer. (2018 Jan)Tanaka KLung Cancer
25962154Downregulation of notch signaling pathway in late preterm and term placentas from pregnancies complicated by preeclampsia. (2015)Fragkiadaki PPLoS One
29435295Identification of candidate responders for anti-PD-L1/PD-1 immunotherapy, Rova-T therapy, or EZH2 inhibitory therapy in small-cell lung cancer. (2018 Feb)Saito MMol Clin Oncol