Gene: RRH

10692
-
retinal pigment epithelium-derived rhodopsin homolog
protein-coding
4q25
Ensembl:ENSG00000180245 MIM:605224 Vega:OTTHUMG00000132045 UniprotKB:O14718
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
1.798e-1 (AD)  5.807e-1 (ND)   (Frontal_Cortex)
3.489e-1 (AD)  3.414e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRIT30.647
GEN10.635
ASTE10.629
STIL0.604
MED140.602
YTHDC20.602
SCYL30.601
NRF10.591
LRRC390.589
ZKSCAN40.589

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RSPO1-0.336
MTRNR2L9-0.329
MTRNR2L6-0.323
MTRNR2L10-0.31
KRTAP17-1-0.296
XCL2-0.291
KLRK1-0.29
KLRB1-0.29
GNG8-0.286
PPBP-0.283

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of RRH mRNA"25614096
D000082AcetaminophenAcetaminophen results in decreased expression of RRH mRNA17585979
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of RRH mRNA21298039
C006780bisphenol Abisphenol A results in decreased expression of RRH mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RRH gene28505145
D003300CopperCopper deficiency results in increased expression of RRH mRNA26033743
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of RRH mRNA22079256
D008727MethotrexateMethotrexate affects the expression of RRH mRNA18502557
D009532NickelNickel affects the expression of RRH mRNA14575637
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of RRH mRNA]14575637
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RRH mRNA"19013360
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of RRH mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of RRH mRNA22079256
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to RRH promoter]19654925
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of RRH mRNA]14575637
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of RRH gene25560391
D019287Zinc SulfateZinc Sulfate results in increased expression of RRH mRNA19013360

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-TAS9275222  
GO:0008020G-protein coupled photoreceptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-IEA-  
GO:0007601visual perception-IEA-  
GO:0007602phototransduction-IBA21873635  
GO:0007602phototransduction-IEA-  
GO:0009584detection of visible light-IEA-  
GO:0018298protein-chromophore linkage-IEA-  
GO:0071482cellular response to light stimulus-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001750photoreceptor outer segment-IBA21873635  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS9275222  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-419771OpsinsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
12661188Occupational exposures and gastrointestinal cancers among Finnish women. (2003 Mar)Weiderpass EJ Occup Environ Med