Gene: CORIN

10699
ATC2|CRN|Lrp4|PEE5|TMPRSS10
corin, serine peptidase
protein-coding
4p12
Ensembl:ENSG00000145244 MIM:605236 Vega:OTTHUMG00000099441 UniprotKB:Q9Y5Q5
NG_032679.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.804e-1 (AD)  3.667e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLAGL10.607
SRPK10.606
USP450.606
ZNF2300.598
FRAS10.598
SGCG0.598
SLC22A140.597
ABCA100.593
TXLNG0.591
NAA250.589

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNJ16-0.365
ENDOU-0.364
TNS3-0.349
PIPOX-0.33
DIAPH3-0.329
ACBD7-0.321
DIO2-0.319
C16orf74-0.315
S100A1-0.309
OLIG1-0.3

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of CORIN mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CORIN gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CORIN mRNA23630614
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of CORIN mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CORIN mRNA16483693
D001151ArsenicArsenic affects the methylation of CORIN gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of CORIN mRNA26705709
D001280AtrazineAtrazine results in decreased expression of CORIN mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CORIN mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CORIN mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CORIN mRNA]25566086
C006780bisphenol Abisphenol A results in increased expression of CORIN mRNA26063408
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of CORIN mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of CORIN mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CORIN gene28505145
D002104CadmiumCadmium results in decreased expression of CORIN mRNA24067728
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of CORIN promoter22457795
D003630DaunorubicinDaunorubicin results in decreased expression of CORIN mRNA26537877|2894005
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of CORIN mRNA28962523
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of CORIN mRNA24535843
D004317DoxorubicinDoxorubicin results in decreased expression of CORIN mRNA26537877|2894005
D004317DoxorubicinDoxorubicin results in increased expression of CORIN mRNA25896364
C039281furanfuran results in increased expression of CORIN mRNA25539665
D017313FenretinideFenretinide results in increased expression of CORIN mRNA28973697
D007545IsoproterenolIsoproterenol results in increased expression of CORIN mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CORIN mRNA26752646
D015122MercaptopurineMercaptopurine results in increased expression of CORIN mRNA23358152
D008942MitoxantroneMitoxantrone results in decreased expression of CORIN mRNA26537877|2894005
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CORIN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CORIN mRNA"27106021
D009532NickelNickel results in decreased expression of CORIN mRNA24768652
D010634PhenobarbitalPhenobarbital results in decreased expression of CORIN mRNA23091169
D010656PhenylephrinePhenylephrine results in increased expression of CORIN mRNA15191894
C006253pirinixic acidpirinixic acid results in increased expression of CORIN mRNA20813756
D011374ProgesteroneProgesterone results in increased expression of CORIN mRNA20864642|2179573
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in decreased expression of CORIN mRNA20613715
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in decreased expression of CORIN protein20613715
D013629TamoxifenTamoxifen results in increased expression of CORIN mRNA25123088
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of CORIN mRNA26496021
C010792testosterone undecanoatetestosterone undecanoate results in increased expression of CORIN mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CORIN mRNA21570461|2637764
D014212TretinoinTretinoin results in increased expression of CORIN mRNA21934132
C032910triadimefontriadimefon results in decreased expression of CORIN mRNA26705709
C005445triphenyl phosphatetriphenyl phosphate results in decreased expression of CORIN mRNA28934090
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CORIN gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of CORIN mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IDA10880574  
GO:0004252serine-type endopeptidase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003050regulation of systemic arterial blood pressure by atrial natriuretic peptide-IMP22437503  
GO:0003050regulation of systemic arterial blood pressure by atrial natriuretic peptide-ISS-  
GO:0007565female pregnancy-IMP22437503  
GO:0008217regulation of blood pressure-ISS-  
GO:0016486peptide hormone processing-IDA10880574  
GO:0035813regulation of renal sodium excretion-ISS-  
GO:1903779regulation of cardiac conduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IEA-  
GO:0015629actin cytoskeleton-IDA-  
GO:0016021integral component of membrane-IEA-  
GO:0016604nuclear body-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-397014Muscle contractionTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578768Physiological factorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27658255Serum Soluble Corin Deficiency Predicts Major Disability within 3 Months after Acute Stroke. (2016)Hu WPLoS One
26577631Association between serum corin levels and risk of acute myocardial infarction. (2016 Jan 15)Zhang SMClin Chim Acta
29391274Association of rs2271037 and rs3749585 polymorphisms in CORIN with susceptibility to hypertension in a Chinese Han population: A case-control study. (2018 Apr 20)Chen YLGene