Gene info: ID 107

Gene: ADCY1

GENE ID: 107

Synonyms: AC1|DFNB44

Description: adenylate cyclase 1

Gene type: protein-coding

Location: 7p12.3

dbXrefs: Ensembl:ENSG00000164742 MIM:103072 Vega:OTTHUMG00000155420 UniprotKB:Q08828

RefSeq: NG_034198.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.891e-1 (AD) 7.205e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg08619378	chr7:45616358	ADCY1	Gene body	1.347e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RIMS3	0.97
DLGAP1	0.961
ITPR1	0.956
TMEM151B	0.955
LRRC4	0.955
UNC13A	0.953
PRKCB	0.952
KIAA1549L	0.952
CNTNAP1	0.952
CAMKK2	0.951

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SNHG18	-0.565
ACAP1	-0.559
RAB13	-0.558
WWTR1	-0.539
MYL3	-0.538
ZNF114	-0.534
TGIF1	-0.533
AGTRAP	-0.53
HEY2	-0.53
HEBP2	-0.527

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00131	Adenosine monophosphate	Small Molecule	61-19-8	Approved\|Investigational\|Nutraceutical	Target
DB00171	ATP	Small Molecule	56-65-5	Investigational\|Nutraceutical	Target
DB09121	Aurothioglucose	Small Molecule	12192-57-3	Approved\|Withdrawn	Target

ID	Drug Name	Action	PubMed
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of ADCY1 mRNA	25596134
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ADCY1 mRNA	19933214
C008745	4,4'-bisphenol F	"4,4'-bisphenol F results in decreased expression of ADCY1 mRNA"	26186136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADCY1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADCY1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADCY1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADCY1 mRNA"	27188386
D000242	Cyclic AMP	ADCY1 protein results in increased abundance of Cyclic AMP	16914643
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of ADCY1 mRNA	24831965
D001280	Atrazine	Atrazine results in decreased expression of ADCY1 mRNA	25929836
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to ADCY1 promoter]	19654925
D004958	Estradiol	Estradiol results in increased expression of ADCY1 mRNA	23019147
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of ADCY1 mRNA	27685785
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ADCY1 mRNA	28628672
C006780	bisphenol A	bisphenol A results in increased expression of ADCY1 mRNA	27685785
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in decreased expression of ADCY1 mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased expression of ADCY1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of ADCY1 mRNA	29097150
D002220	Carbamazepine	Carbamazepine inhibits the reaction [Colforsin results in increased activity of ADCY1 protein]	19922557
D002220	Carbamazepine	Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY1 protein]	19922557
D002220	Carbamazepine	Carbamazepine results in decreased activity of ADCY1 protein	19922557
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of ADCY1 mRNA	17452286
D005576	Colforsin	Carbamazepine inhibits the reaction [Colforsin results in increased activity of ADCY1 protein]	19922557
D005576	Colforsin	Colforsin results in increased activity of ADCY1 protein	19922557
D016572	Cyclosporine	Cyclosporine results in decreased expression of ADCY1 mRNA	25596134
C017180	decamethrin	decamethrin results in decreased activity of ADCY1 protein	2957417
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ADCY1 mRNA	28628672
D003976	Diazinon	Diazinon results in decreased expression of ADCY1 mRNA	17452286
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of ADCY1 mRNA	28962523
D002945	Cisplatin	Cisplatin results in increased expression of ADCY1 mRNA	27392435
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of ADCY1 mRNA	26924002
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of ADCY1 mRNA	26033743
C058705	diethyl malate	diethyl malate affects the expression of ADCY1 mRNA	24814887
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of ADCY1 mRNA	15766595
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ADCY1 mRNA	29097150
D011345	Fenofibrate	Fenofibrate results in decreased expression of ADCY1 mRNA	25596134
D007052	Ibuprofen	Ibuprofen results in decreased expression of ADCY1 mRNA	25596134
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ADCY1 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ADCY1 mRNA	28628672
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of ADCY1 mRNA"	24972896
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of ADCY1 mRNA	28001369
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of ADCY1 mRNA	26924002
D009020	Morphine	[ADCY8 protein co-treated with ADCY1 protein] affects the susceptibility to Morphine	16914643
C464660	obeticholic acid	obeticholic acid results in increased expression of ADCY1 mRNA	27939613
D026023	Permethrin	Permethrin results in decreased activity of ADCY1 protein	2957417
D010578	Petroleum	Petroleum results in increased expression of ADCY1 mRNA	25208076
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADCY1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of ADCY1 mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in increased expression of ADCY1 mRNA	20813756
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of ADCY1 mRNA	28903501
D011374	Progesterone	Progesterone results in increased expression of ADCY1 mRNA	20864642
D011374	Progesterone	Progesterone results in increased expression of ADCY1 mRNA	19690047
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of ADCY1 mRNA	24780913
C089730	rosiglitazone	rosiglitazone results in decreased expression of ADCY1 mRNA	25596134
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of ADCY1 mRNA	25895662
C071262	SK&F 82958	Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY1 protein]	19922557
C071262	SK&F 82958	[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY1 protein	19922557
C017947	sodium arsenite	sodium arsenite results in increased expression of ADCY1 mRNA	17879257
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in decreased expression of ADCY1 mRNA	26496021
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ADCY1 mRNA	19933214
D014212	Tretinoin	Tretinoin results in decreased expression of ADCY1 mRNA	23724009
C012589	trichostatin A	trichostatin A results in decreased expression of ADCY1 mRNA	24935251
D017974	Uranium Compounds	Uranium Compounds results in increased expression of ADCY1 mRNA	19654044
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADCY1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of ADCY1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of ADCY1 mRNA	23179753\|2493525
D014635	Valproic Acid	Valproic Acid results in increased expression of ADCY1 mRNA	24935251
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of ADCY1 gene	25560391
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of ADCY1 mRNA	26682919
C111237	vorinostat	vorinostat results in decreased expression of ADCY1 mRNA	27188386
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased expression of ADCY1 mRNA"	25208076

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004016	adenylate cyclase activity	-	TAS	-
GO:0005516	calmodulin binding	-	IEA	-
GO:0005524	ATP binding	-	IEA	-
GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	-	ISS	-
GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	-	NAS	8314585
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003091	renal water homeostasis	-	TAS	-
GO:0006171	cAMP biosynthetic process	-	IBA	21873635
GO:0006171	cAMP biosynthetic process	-	ISS	-
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	-	IBA	21873635
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	-	ISS	-
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	-	IBA	21873635
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007409	axonogenesis	-	IEA	-
GO:0007420	brain development	-	IEA	-
GO:0007616	long-term memory	-	IEA	-
GO:0007623	circadian rhythm	-	IEA	-
GO:0010226	response to lithium ion	-	IEA	-
GO:0019933	cAMP-mediated signaling	-	IBA	21873635
GO:0019933	cAMP-mediated signaling	-	ISS	-
GO:0042752	regulation of circadian rhythm	-	ISS	-
GO:0071277	cellular response to calcium ion	-	ISS	-
GO:0071377	cellular response to glucagon stimulus	-	TAS	-
GO:1904322	cellular response to forskolin	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-
GO:0005737	cytoplasm	-	ISS	-
GO:0005886	plasma membrane	-	IDA	11549699
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	ISS	-
GO:0045121	membrane raft	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867

KEGG ID	KEGG Term
hsa00230	Purine metabolism
hsa04020	Calcium signaling pathway
hsa04062	Chemokine signaling pathway
hsa04114	Oocyte meiosis
hsa04270	Vascular smooth muscle contraction
hsa04540	Gap junction
hsa04720	Long-term potentiation
hsa04912	GnRH signaling pathway
hsa04914	Progesterone-mediated oocyte maturation
hsa04916	Melanogenesis
hsa04970	Salivary secretion
hsa04971	Gastric acid secretion
hsa04972	Pancreatic secretion
hsa04976	Bile secretion
hsa05142	Chagas disease (American trypanosomiasis)
hsa05146	Amoebiasis
hsa05414	Dilated cardiomyopathy

Reactome ID	Reactome Term	Evidence
R-HSA-111885	Opioid Signalling	TAS
R-HSA-111885	Opioid Signalling	IEA
R-HSA-111931	PKA-mediated phosphorylation of CREB	TAS
R-HSA-111933	Calmodulin induced events	TAS
R-HSA-111996	Ca-dependent events	TAS
R-HSA-111997	CaM pathway	TAS
R-HSA-112040	G-protein mediated events	TAS
R-HSA-112040	G-protein mediated events	IEA
R-HSA-112043	PLC beta mediated events	TAS
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	IEA
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112315	Transmission across Chemical Synapses	IEA
R-HSA-112316	Neuronal System	TAS
R-HSA-112316	Neuronal System	IEA
R-HSA-1430728	Metabolism	TAS
R-HSA-1489509	DAG and IP3 signaling	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-163359	Glucagon signaling in metabolic regulation	TAS
R-HSA-163615	PKA activation	TAS
R-HSA-163685	Integration of energy metabolism	TAS
R-HSA-164378	PKA activation in glucagon signalling	TAS
R-HSA-170660	Adenylate cyclase activating pathway	TAS
R-HSA-170670	Adenylate cyclase inhibitory pathway	TAS
R-HSA-170670	Adenylate cyclase inhibitory pathway	IEA
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-372790	Signaling by GPCR	IEA
R-HSA-382551	Transport of small molecules	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-388396	GPCR downstream signalling	IEA
R-HSA-418555	G alpha (s) signalling events	TAS
R-HSA-418555	G alpha (s) signalling events	IEA
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-418594	G alpha (i) signalling events	IEA
R-HSA-418597	G alpha (z) signalling events	IEA
R-HSA-418597	G alpha (z) signalling events	TAS
R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins	TAS
R-HSA-438064	Post NMDA receptor activation events	TAS
R-HSA-442720	CREB phosphorylation through the activation of Adenylate Cyclase	TAS
R-HSA-442755	Activation of NMDA receptor and postsynaptic events	TAS
R-HSA-445717	Aquaporin-mediated transport	TAS
R-HSA-5358351	Signaling by Hedgehog	TAS
R-HSA-5610787	Hedgehog 'off' state	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-977443	GABA receptor activation	TAS
R-HSA-977443	GABA receptor activation	IEA
R-HSA-977444	GABA B receptor activation	TAS
R-HSA-977444	GABA B receptor activation	IEA
R-HSA-991365	Activation of GABAB receptors	TAS
R-HSA-991365	Activation of GABAB receptors	IEA
R-HSA-997269	Inhibition of adenylate cyclase pathway	TAS
R-HSA-997269	Inhibition of adenylate cyclase pathway	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24884436	Chronic alcohol consumption from adolescence-to-adulthood in mice--hypothalamic gene expression changes in the dilated cardiomyopathy signaling pathway. (2014 May 9)	Zou H	BMC Neurosci
29032150	Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases. (2018 Jan 30)	Sundararajan T	Gene
23278386	Genetic markers of comorbid depression and alcoholism in women. (2013 Jun)	Procopio DO	Alcohol Clin Exp Res