Gene info: ID 1071

Gene: CETP

GENE ID: 1071

Synonyms: BPIFF|HDLCQ10

Description: cholesteryl ester transfer protein

Gene type: protein-coding

Location: 16q13

dbXrefs: Ensembl:ENSG00000087237 MIM:118470 Vega:OTTHUMG00000133279 UniprotKB:P11597

RefSeq: NG_008952.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 87

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.291e-2 (AD) 6.606e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PZP	0.564
IL2RB	0.558
FCRL3	0.548
KLRF1	0.543
HMCN1	0.54
MROH5	0.534
DPPA4	0.533
NMUR1	0.532
PROM1	0.531
C2orf83	0.526

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CADM1	-0.455
GDF10	-0.441
SLC1A4	-0.44
WFS1	-0.424
ADCY2	-0.42
CHST1	-0.418
SLC6A11	-0.415
KLHL21	-0.411
TMEM56	-0.41
LRRC8A	-0.405

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB06281	Torcetrapib	Small Molecule	262352-17-0	Investigational	Target

ID	Drug Name	Action	PubMed
C003585	22-hydroxycholesterol	22-hydroxycholesterol results in increased expression of CETP mRNA	16142410
C003585	22-hydroxycholesterol	[alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of CETP mRNA	16142410
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of CETP gene	27153756
C103303	alitretinoin	[alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of CETP mRNA	16142410
C103303	alitretinoin	[alitretinoin co-treated with TO-901317] results in increased expression of CETP mRNA	16142410
C103303	alitretinoin	alitretinoin results in increased expression of CETP mRNA	16142410
C530884	anacetrapib	anacetrapib results in decreased activity of CETP protein	18414186
C530884	anacetrapib	anacetrapib results in decreased activity of CETP protein	20645987\|2561724
C006632	arsenic trioxide	arsenic trioxide results in increased expression of CETP protein	27622732
D001629	Bezafibrate	Bezafibrate results in decreased activity of CETP protein	12754275
D001629	Bezafibrate	"[Bezafibrate results in decreased activity of CETP protein] affects the reaction [Bezafibrate results in increased abundance of Cholesterol, HDL]"	12754275
D001629	Bezafibrate	Bezafibrate inhibits the reaction [Cholesterol results in increased activity of CETP protein]	10406588
D001629	Bezafibrate	[Cholesterol co-treated with Probucol co-treated with Bezafibrate] results in increased activity of CETP protein	10406588
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of CETP mRNA	18804290
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CETP mRNA	18804290
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of CETP mRNA	18804290
D002784	Cholesterol	Teniposide promotes the reaction [CETP protein results in decreased abundance of Cholesterol]	25914138
D002784	Cholesterol	Bezafibrate inhibits the reaction [Cholesterol results in increased activity of CETP protein]	10406588
D002784	Cholesterol	[Cholesterol co-treated with Probucol co-treated with Bezafibrate] results in increased activity of CETP protein	10406588
D002784	Cholesterol	[Cholesterol co-treated with Probucol] results in increased activity of CETP protein	10406588
D002784	Cholesterol	Cholesterol results in increased activity of CETP protein	10406588
D002791	Cholesterol, Dietary	"Cholesterol, Dietary results in increased expression of CETP protein"	10519734
D008076	Cholesterol, HDL	"[Bezafibrate results in decreased activity of CETP protein] affects the reaction [Bezafibrate results in increased abundance of Cholesterol, HDL]"	12754275
D008076	Cholesterol, HDL	"CETP gene polymorphism affects the abundance of Cholesterol, HDL"	16030523
D008076	Cholesterol, HDL	"[CETP polymorphism affects the susceptibility to Simvastatin] which affects the abundance of Cholesterol, HDL"	17931083
D008076	Cholesterol, HDL	"CETP protein results in decreased abundance of Cholesterol, HDL"	25914138
D008076	Cholesterol, HDL	"Teniposide promotes the reaction [CETP protein results in decreased abundance of Cholesterol, HDL]"	25914138
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of CETP mRNA	24612858
C411602	dalcetrapib	dalcetrapib results in decreased activity of CETP protein	18414186
C411602	dalcetrapib	dalcetrapib results in decreased activity of CETP protein	20645987\|2561724
D005047	Etoposide	Etoposide promotes the reaction [NR1H2 protein results in increased expression of CETP mRNA]	25914138
D005047	Etoposide	Etoposide promotes the reaction [NR1H3 protein results in increased expression of CETP mRNA]	25914138
D005047	Etoposide	Etoposide promotes the reaction [RXRA protein results in increased expression of CETP mRNA]	25914138
D005047	Etoposide	Etoposide results in increased expression of CETP mRNA	25914138
D005047	Etoposide	Etoposide results in increased expression of CETP protein	25914138
D005047	Etoposide	NR1H2 mutant form inhibits the reaction [Etoposide results in increased expression of CETP mRNA]	25914138
D005047	Etoposide	NR1H3 mutant form inhibits the reaction [Etoposide results in increased expression of CETP mRNA]	25914138
D005047	Etoposide	[Tretinoin co-treated with Etoposide] results in increased expression of CETP mRNA	25914138
D005047	Etoposide	Tretinoin promotes the reaction [Etoposide promotes the reaction [RXRA protein results in increased expression of CETP mRNA]]	25914138
D005047	Etoposide	Tretinoin promotes the reaction [Etoposide results in increased expression of CETP protein]	25914138
C061365	flusilazole	flusilazole results in decreased expression of CETP mRNA	22382673
C061365	flusilazole	flusilazole results in increased expression of CETP mRNA	22382673
C065180	fluvastatin	[ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin	19773416
C065180	fluvastatin	[APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin	19773416
D005557	Formaldehyde	Formaldehyde results in increased expression of CETP mRNA	23649840
D005632	Fructose	Fructose results in increased expression of and results in increased activity of CETP protein	11476189
D005632	Fructose	Fructose results in increased expression of CETP mRNA	11476189
C473027	GW 3965	GW 3965 results in increased expression of CETP mRNA	19426978
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of CETP mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of CETP mRNA	23649840
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [APOA1 protein results in increased expression of CETP mRNA]	22056562
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [APOA1 protein results in increased secretion of CETP protein]	22056562
D019829	Nevirapine	Nevirapine results in increased expression of CETP protein	19667106
D059808	Polyphenols	Polyphenols results in decreased activity of CETP protein	16046716
D011341	Probucol	[Cholesterol co-treated with Probucol co-treated with Bezafibrate] results in increased activity of CETP protein	10406588
D011341	Probucol	[Cholesterol co-treated with Probucol] results in increased activity of CETP protein	10406588
D019821	Simvastatin	CETP polymorphism affects the susceptibility to Simvastatin	16038892\|1793108
D019821	Simvastatin	"[CETP polymorphism affects the susceptibility to Simvastatin] which affects the abundance of Cholesterol, HDL"	17931083
D019821	Simvastatin	[CETP polymorphism affects the susceptibility to Simvastatin] which affects the abundance of Triglycerides	17931083
D019821	Simvastatin	Simvastatin results in decreased expression of CETP protein	10519734
C009277	sodium arsenate	sodium arsenate results in decreased expression of CETP mRNA	23922661
C016104	sodium bichromate	sodium bichromate results in decreased expression of CETP mRNA	24612858
D013713	Teniposide	CETP protein promotes the reaction [Teniposide results in decreased abundance of Triglycerides]	25914138
D013713	Teniposide	NR1H2 mutant form inhibits the reaction [Teniposide results in increased expression of CETP mRNA]	25914138
D013713	Teniposide	NR1H3 mutant form inhibits the reaction [Teniposide results in increased expression of CETP mRNA]	25914138
D013713	Teniposide	Teniposide promotes the reaction [CETP protein results in decreased abundance of Cholesterol]	25914138
D013713	Teniposide	"Teniposide promotes the reaction [CETP protein results in decreased abundance of Cholesterol, HDL]"	25914138
D013713	Teniposide	Teniposide promotes the reaction [CETP protein results in decreased abundance of Triglycerides]	25914138
D013713	Teniposide	Teniposide promotes the reaction [NR1H2 protein results in increased expression of CETP mRNA]	25914138
D013713	Teniposide	Teniposide promotes the reaction [NR1H3 protein results in increased expression of CETP mRNA]	25914138
D013713	Teniposide	Teniposide promotes the reaction [RXRA protein results in increased expression of CETP mRNA]	25914138
D013713	Teniposide	Teniposide results in increased expression of and results in increased secretion of CETP protein	25914138
D013713	Teniposide	Teniposide results in increased expression of CETP mRNA	25914138
D013713	Teniposide	[Tretinoin co-treated with Teniposide] results in increased expression of CETP mRNA	25914138
D013713	Teniposide	Tretinoin promotes the reaction [Teniposide promotes the reaction [RXRA protein results in increased expression of CETP mRNA]]	25914138
D013713	Teniposide	Tretinoin promotes the reaction [Teniposide results in increased expression of CETP protein]	25914138
D013713	Teniposide	Teniposide promotes the reaction [CETP protein results in decreased expression of MTTP mRNA]	25914138
C423915	TO-901317	[alitretinoin co-treated with TO-901317] results in increased expression of CETP mRNA	16142410
C423915	TO-901317	TO-901317 results in increased expression of CETP mRNA	16142410\|1942697
C483909	torcetrapib	torcetrapib results in decreased activity of CETP protein	18414186\|2002678
C483909	torcetrapib	torcetrapib results in decreased activity of CETP protein	19164467\|2064598
D014108	Tosylphenylalanyl Chloromethyl Ketone	Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased expression of CETP mRNA]	22056562
D014108	Tosylphenylalanyl Chloromethyl Ketone	Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased secretion of CETP protein]	22056562
D014212	Tretinoin	[Tretinoin co-treated with Etoposide] results in increased expression of CETP mRNA	25914138
D014212	Tretinoin	[Tretinoin co-treated with Teniposide] results in increased expression of CETP mRNA	25914138
D014212	Tretinoin	Tretinoin promotes the reaction [Etoposide promotes the reaction [RXRA protein results in increased expression of CETP mRNA]]	25914138
D014212	Tretinoin	Tretinoin promotes the reaction [Etoposide results in increased expression of CETP protein]	25914138
D014212	Tretinoin	Tretinoin promotes the reaction [RXRA protein results in increased expression of CETP mRNA]	25914138
D014212	Tretinoin	Tretinoin promotes the reaction [Teniposide promotes the reaction [RXRA protein results in increased expression of CETP mRNA]]	25914138
D014212	Tretinoin	Tretinoin promotes the reaction [Teniposide results in increased expression of CETP protein]	25914138
D014212	Tretinoin	Tretinoin results in increased expression of CETP mRNA	25914138
D014280	Triglycerides	[CETP polymorphism affects the susceptibility to Simvastatin] which affects the abundance of Triglycerides	17931083
D014280	Triglycerides	CETP protein promotes the reaction [Teniposide results in decreased abundance of Triglycerides]	25914138
D014280	Triglycerides	CETP protein results in decreased abundance of Triglycerides	25914138
D014280	Triglycerides	Teniposide promotes the reaction [CETP protein results in decreased abundance of Triglycerides]	25914138
D014635	Valproic Acid	Valproic Acid results in increased methylation of CETP gene	29154799
D014750	Vincristine	Vincristine results in increased expression of CETP mRNA	23649840

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005319	lipid transporter activity	-	IDA	2833496
GO:0005548	phospholipid transporter activity	-	IDA	2833496
GO:0008289	lipid binding	-	IDA	3818596
GO:0015485	cholesterol binding	-	IDA	2833496
GO:0017127	cholesterol transporter activity	-	IDA	2833496 3600759 24293641
GO:0017129	triglyceride binding	-	IDA	2833496
GO:0031210	phosphatidylcholine binding	-	IDA	2833496

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006641	triglyceride metabolic process	-	IDA	2833496
GO:0006869	lipid transport	-	IDA	3818596
GO:0008203	cholesterol metabolic process	-	IDA	2833496
GO:0008203	cholesterol metabolic process	-	IMP	2586614
GO:0010745	negative regulation of macrophage derived foam cell differentiation	-	IC	16670775
GO:0010874	regulation of cholesterol efflux	-	IMP	16670775
GO:0015914	phospholipid transport	-	IDA	2833496
GO:0030301	cholesterol transport	-	IDA	2833496 24293641
GO:0034197	triglyceride transport	-	IDA	24293641
GO:0034372	very-low-density lipoprotein particle remodeling	-	IDA	2833496 24293641
GO:0034374	low-density lipoprotein particle remodeling	-	IDA	2833496
GO:0034374	low-density lipoprotein particle remodeling	-	TAS	-
GO:0034375	high-density lipoprotein particle remodeling	-	IDA	24293641
GO:0034375	high-density lipoprotein particle remodeling	-	IMP	2586614
GO:0034375	high-density lipoprotein particle remodeling	-	TAS	-
GO:0042632	cholesterol homeostasis	-	IMP	2586614
GO:0043691	reverse cholesterol transport	-	IC	7583561
GO:0046470	phosphatidylcholine metabolic process	-	IDA	2833496
GO:0055088	lipid homeostasis	-	IDA	3818596
GO:0055091	phospholipid homeostasis	-	IDA	2833496
GO:0070328	triglyceride homeostasis	-	IDA	2833496

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IDA	3104518 24293641
GO:0031982	vesicle	-	IDA	2833496
GO:0034364	high-density lipoprotein particle	-	IDA	3104518
GO:0070062	extracellular exosome	-	HDA	19056867 23533145

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-8963899	Plasma lipoprotein remodeling	TAS
R-HSA-8964041	LDL remodeling	TAS
R-HSA-8964058	HDL remodeling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
11888533	A prospective study of TaqIB polymorphism in the gene coding for cholesteryl ester transfer protein and risk of myocardial infarction in middle-aged men. (2002 Apr)	Liu S	Atherosclerosis
8566946	Sex difference in the regulation of plasma high density lipoprotein cholesterol by genetic and environmental factors. (1996 Feb)	Kauma H	Hum Genet
9670349	High-density lipoprotein cholesterol is related to the TaqIB cholesteryl ester transfer protein gene polymorphism and smoking, but not to moderate alcohol consumption in insulin-dependent diabetic men. (1998 May)	Dullaart RP	Scand J Clin Lab Invest
18187430	The lipoprotein lipase serine 447 stop polymorphism is associated with altered serum carotenoid concentrations in the Stanislas Family Study. (2007 Dec)	Herbeth B	J Am Coll Nutr
27478449	Serum CETP and PLTP activity in middle-aged men living in urban or rural area of the Lower Silesia region. PURE Poland sub-study. (2016 Aug 1)	Skoczynska A	Arch Med Sci
24608419	Elevated high-density lipoprotein cholesterol and age-related macular degeneration: the Alienor study. (2014)	Cougnard-Gregoire A	PLoS One
18480348	Targeting residual cardiovascular risk: raising high-density lipoprotein cholesterol levels. (2008 Jun)	Hausenloy DJ	Heart
12821213	Secondary prevention in coronary heart disease patients with low HDL: which options do we have? (2003 Jul)	Liem AH	Int J Cardiol
22003152	Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies. (2012 Jan)	Grallert H	Eur Heart J
15996208	An interaction between the TaqIB polymorphism of cholesterol ester transfer protein and smoking is associated with changes in plasma high-density lipoprotein cholesterol levels in Turks. (2005 Aug)	Hodoglugil U	Clin Genet
22235250	Quantile-specific penetrance of genes affecting lipoproteins, adiposity and height. (2012)	Williams PT	PLoS One
9555865	Molecular genetic study of Finns with hypoalphalipoproteinemia and hyperalphalipoproteinemia: a novel Gly230 Arg mutation (LCAT[Fin]) of lecithin:cholesterol acyltransferase (LCAT) accounts for 5% of cases with very low serum HDL cholesterol levels. (1998 Apr)	Miettinen HE	Arterioscler Thromb Vasc Biol
22941786	Relationship between atorvastatin dose and the harm caused by torcetrapib. (2012 Nov)	Barter PJ	J Lipid Res
24267222	Controlling for apolipoprotein A-I concentrations changes the inverse direction of the relationship between high HDL-C concentration and a measure of pre-clinical atherosclerosis. (2013 Dec)	Sung KC	Atherosclerosis
11714857	Genetic influences on lipid metabolism trait variability within the Stanislas Cohort. (2001 Nov)	Pallaud C	J Lipid Res
9387148	The effects of the cholesterol ester transfer protein gene and environmental factors on the plasma high density lipoprotein cholesterol levels in the Korean population. (1997 Oct 31)	Song GJ	Mol Cells
20430392	No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels. (2010 Aug)	Marques-Vidal P	Atherosclerosis
9084928	Interaction of the cholesteryl ester transfer protein I405V polymorphism with alcohol consumption in smoking and non-smoking healthy men, and the effect on plasma HDL cholesterol and apoAI concentration. (1997 Jan)	Gudnason V	Clin Genet
12519369	The association of cholesteryl ester transfer protein polymorphism with high-density lipoprotein cholesterol and coronary artery disease in Koreans. (2003 Jan)	Park KW	Clin Genet
22460205	Genetic variants at the APOE, lipoprotein lipase (LpL), cholesteryl ester transfer protein (CETP), and endothelial nitric oxide (eNOS) genes and coronary artery disease (CAD): CETP Taq1 B2B2 associates with lower risk of CAD in Asian Indians. (2010 Jun)	Bhanushali AA	J Community Genet
15655129	Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13,677 subjects. (2005 Jan 25)	Boekholdt SM	Circulation
15254877	Smoking prevents the intravascular remodeling of high-density lipoprotein particles: implications for reverse cholesterol transport. (2004 Jul)	Zaratin AC	Metabolism
16674961	The association between high-density lipoprotein cholesterol level and cholesteryl ester transfer protein TaqIB gene polymorphism is influenced by alcohol drinking in a population-based sample. (2007 Mar)	Tsujita Y	Atherosclerosis
14967821	A prospective study of HDL-C and cholesteryl ester transfer protein gene mutations and the risk of coronary heart disease in the elderly. (2004 May)	Curb JD	J Lipid Res
19056069	Association of the cholesteryl ester transfer protein Taq1 B2B2 genotype with higher high-density lipoprotein cholesterol concentrations and lower risk of coronary artery disease in a Tunisian population. (2008 Oct)	Rejeb J	Arch Cardiovasc Dis
18393253	[Association of CETP and CRP gene polymorphisms with non-valvular atrial fibrillation in Chinese Han population]. (2008 Apr)	Yang WY	Zhonghua Yi Xue Yi Chuan Xue Za Zhi
24283500	CETP gene polymorphisms and risk of coronary atherosclerosis in a Chinese population. (2013 Nov 27)	Wang J	Lipids Health Dis
19878569	Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis. (2009 Oct 30)	Chen SN	BMC Med Genet
27827461	Association and interaction of APOA5, BUD13, CETP, LIPA and health-related behavior with metabolic syndrome in a Taiwanese population. (2016 Nov 9)	Lin E	Sci Rep
25541553	Adiposity is associated with DNA methylation profile in adipose tissue. (2015 Aug)	Agha G	Int J Epidemiol
28209224	Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. (2017 Feb 21)	Webb TR	J Am Coll Cardiol
23950155	Association between the cholesteryl ester transfer protein gene and polypoidal choroidal vasculopathy. (2013 Sep 9)	Nakata I	Invest Ophthalmol Vis Sci
11359462	APOC3, CETP, fibrinogen, and MTHFR are genetic determinants of carotid intima-media thickness in healthy men (the Stanislas cohort). (2001 May)	Pallaud C	Clin Genet
20581105	Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population. (2010 Sep)	Corella D	J Lipid Res
28128572	[Genetic determination of dyslipidemia - What tell us the results of genome-wide association studies?] (Fall 2016)	Hubacek JA	Vnitr Lek
18956684	[Study on the correlation between CETP TaqIB, KCNE1 S38G and eNOS T-786C gene polymorphisms for predisposition and non-valvular atrial fibrillation]. (2008 May)	Xu LX	Zhonghua Liu Xing Bing Xue Za Zhi
17587762	Human cholestryl ester transfer protein (TaqIB) polymorphism among Filipinos with cardiovascular risk factors. (2007 Jun)	Sy RG	J Atheroscler Thromb
21589926	Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks. (2011 May 11)	Turner SD	PLoS One
16426594	The effect of the APOE polymorphism on HDL-C concentrations depends on the cholesterol ester transfer protein gene variation in a Southern European population. (2006 Apr)	Sorli JV	Clin Chim Acta
11575217	[APOC3, CETP, beta-fibrinogen and MTHFR are genetic determinants of carotid intim-media thickness (Stanislas cohort)]. (2001 Aug)	Pallaud C	Arch Mal Coeur Vaiss
25993681	Reassessing lipid metabolism and its potentialities in the prediction of cardiovascular risk. (2015 Apr)	Silva IT	Arch Endocrinol Metab
9102177	Heterogeneity at the CETP gene locus. Influence on plasma CETP concentrations and HDL cholesterol levels. (1997 Mar)	Kuivenhoven JA	Arterioscler Thromb Vasc Biol
9684753	Decreased postprandial high density lipoprotein cholesterol and apolipoproteins A-I and E in normolipidemic smoking men: relations with lipid transfer proteins and LCAT activities. (1998 Jul)	Mero N	J Lipid Res
10998464	Association of TaqIB polymorphism in the cholesteryl ester transfer protein gene with plasma lipid levels in a healthy Spanish population. (2000 Oct)	Corella D	Atherosclerosis
9392500	Cholesteryl ester transfer protein gene polymorphism is a determinant of HDL cholesterol and of the lipoprotein response to a lipid-lowering diet in type 1 diabetes. (1997 Dec)	Dullaart RP	Diabetes
23852759	Effects of cigarette smoking on HDL quantity and function: implications for atherosclerosis. (2013 Nov)	He BM	J Cell Biochem
17970962	Polymorphism in the cholesteryl ester transfer protein gene and the risk of early onset myocardial infarction among cigarette smokers. (2007 Oct)	Goldenberg I	Ann Noninvasive Electrocardiol
14563342	A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study. (2003 Oct)	Freeman DJ	Eur Heart J
1476558	Evaluation of plasma cholesteryl ester transfer protein (CETP) activity as a marker of alcoholism. (1992 Sep)	Hannuksela M	Alcohol Alcohol
17991668	Interaction between dietary fat intake and the cholesterol ester transfer protein TaqIB polymorphism in relation to HDL-cholesterol concentrations among US diabetic men. (2007 Nov)	Li TY	Am J Clin Nutr
19876761	Protective modulation of carotid atherosclerosis in hyperalphalipoproteinemic individuals. (2010 Jan)	Santiago FD	Int J Cardiovasc Imaging
25893111	Association of OCT derived drusen measurements with AMD associated-genotypic SNPs in Amish population. (2015)	Chavali VR	J Clin Med
10807749	Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: the Framingham study. (2000 May)	Ordovas JM	Arterioscler Thromb Vasc Biol
12820950	[Study on the distribution and association of cholesteryl ester transfer protein-TaqIB polymorphism and plasma concentration in general population]. (2003 Apr)	Liu J	Zhonghua Liu Xing Bing Xue Za Zhi
12033532	Association of human cholesteryl ester transfer protein-TaqI polymorphisms with serum HDL cholesterol levels in a normolipemic Japanese rural population. (2002 Mar)	Chen J	J Epidemiol
19103817	Targeting residual cardiovascular risk: raising high-density lipoprotein cholesterol levels. (2008 Nov)	Hausenloy DJ	Postgrad Med J
27899788	Serum Lipid Transfer Proteins in Hypothyreotic Patients Are Inversely Correlated with Thyroid-Stimulating Hormone (TSH) Levels. (2016 Nov 30)	Skoczynska A	Med Sci Monit
7857368	Relation of polymorphisms in the cholesteryl ester transfer protein gene to transfer protein activity and plasma lipoprotein levels in alcohol drinkers. (1994 Sep 30)	Hannuksela ML	Atherosclerosis
24376512	Gene-gene combination effect and interactions among ABCA1, APOA1, SR-B1, and CETP polymorphisms for serum high-density lipoprotein-cholesterol in the Japanese population. (2013)	Nakamura A	PLoS One
7907227	Regulation of plasma HDL cholesterol and subfraction distribution by genetic and environmental factors. Associations between the TaqI B RFLP in the CETP gene and smoking and obesity. (1994 Mar)	Freeman DJ	Arterioscler Thromb
15039035	Genetic risk factors for stroke and carotid atherosclerosis: insights into pathophysiology from candidate gene approaches. (2004 Apr)	Humphries SE	Lancet Neurol
28906356	Shared polymorphisms and modifiable behavior factors for myocardial infarction and high cholesterol in a retrospective population study. (2017 Sep)	Liang Y	Medicine (Baltimore)
20842556	High-density lipoprotein therapy: is there hope? (2010 Aug)	Bhatt KN	Curr Treat Options Cardiovasc Med
8971092	Macrovascular disease is associated with increased plasma apolipoprotein A-IV levels in NIDDM. (1997 Jan)	Verges BL	Diabetes
18221399	Glucocorticoid replacement is associated with hypertriglyceridaemia, elevated glucose and higher non-HDL cholesterol and may diminish the association of HDL cholesterol with the -629C>A CETP promoter polymorphism in GH-receiving hypopituitary patients. (2008 Sep)	Dullaart RP	Clin Endocrinol (Oxf)
15469403	Pharmacogenomics and drug response in cardiovascular disorders. (2004 Oct)	Siest G	Pharmacogenomics
7918308	Higher plasma lipid transfer protein activities and unfavorable lipoprotein changes in cigarette-smoking men. (1994 Oct)	Dullaart RP	Arterioscler Thromb
9543093	R451Q mutation in the cholesteryl ester transfer protein (CETP) gene is associated with high plasma CETP activity. (1998 Feb)	Kakko S	Atherosclerosis
7474298	CETP and LCAT activities are unrelated to smoking and moderate alcohol consumption in healthy normolipidemic men. (1995 Aug)	Ito T	Jpn Circ J
23758630	Association of CETP Taq1B and -629C > A polymorphisms with coronary artery disease and lipid levels in the multi-ethnic Singaporean population. (2013 Jun 8)	Lu Y	Lipids Health Dis
24615107	Relationship between the TaqI B polymorphism of the cholesterol ester transfer protein gene and atrial fibrillation in Han and Kazak populations. (2014 Feb 14)	Bakeyi M	Genet Mol Res
28167353	Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants. (2017 Mar)	Shahid SU	Atherosclerosis
2060438	Elevated cholesteryl ester transfer protein activity in IDDM men who smoke. Possible factor for unfavorable lipoprotein profile. (1991 Apr)	Dullaart RP	Diabetes Care
8281981	Smoking and plasma lipoproteins in man: effects on low density lipoprotein cholesterol levels and high density lipoprotein subfraction distribution. (1993 Oct)	Freeman DJ	Eur J Clin Invest
20799898	Cholesteryl ester transfer protein Taq1B polymorphism in an angiographically assessed Turkish population: no effects on coronary artery disease risk. (2010 Oct)	Tanrikulu-Kucuk S	Genet Test Mol Biomarkers
14669156	Association of cholesteryl ester transfer protein activity and TaqIB polymorphism with lipoprotein variations in Japanese subjects. (2003 Dec)	Ikewaki K	Metabolism
19784962	Association of cholesteryl ester transfer protein -629C > A polymorphism with high-density lipoprotein cholesterol levels in coronary artery disease patients. (2009 Oct)	Tanrikulu S	Cell Biochem Funct
28070240	Newer perspectives of coronary artery disease in young. (2016 Dec 26)	Aggarwal A	World J Cardiol
19822408	Association of Taq 1B CETP polymorphism with insulin and HOMA levels in the population of the Canary Islands. (2011 Jan)	Lopez-Rios L	Nutr Metab Cardiovasc Dis
21447678	Association of variants in the LIPC and ABCA1 genes with intermediate and large drusen and advanced age-related macular degeneration. (2011 Jun 28)	Yu Y	Invest Ophthalmol Vis Sci
8645374	CETP is a determinant of serum LDL-cholesterol but not HDL-cholesterol in healthy Japanese. (1996 Feb)	Kinoshita M	Atherosclerosis
15939053	CETP polymorphisms associated with HDL cholesterol may differ from those associated with cardiovascular disease. (2005 Jul)	Thompson JF	Atherosclerosis
12174215	Genetic and environmental determinants of plasma high density lipoprotein cholesterol and apolipoprotein AI concentrations in healthy middle-aged men. (2002 Mar)	Talmud PJ	Ann Hum Genet
18063597	Alcohol consumption, TaqIB polymorphism of cholesteryl ester transfer protein, high-density lipoprotein cholesterol, and risk of coronary heart disease in men and women. (2008 Jan)	Jensen MK	Eur Heart J
9726040	The effect of smoking on post-heparin lipoprotein and hepatic lipase, cholesteryl ester transfer protein and lecithin:cholesterol acyl transferase activities in human plasma. (1998 Jul)	Freeman DJ	Eur J Clin Invest
26820801	Serum CETP concentration is not associated with measures of body fat: The NEO study. (2016 Mar)	Blauw LL	Atherosclerosis
12889988	Moderate hyperalphalipoproteinaemia in a Brazilian population is related to lipoprotein lipase activity, apolipoprotein A-I concentration, age and body mass index. (2004 Jan)	Alarcon SB	Clin Sci (Lond)