Gene: TBR1

10716
TBR-1|TES-56
T-box, brain 1
protein-coding
2q24.2
Ensembl:ENSG00000136535 MIM:604616 Vega:OTTHUMG00000153888 UniprotKB:Q16650
NG_046904.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.758e-1 (AD)  6.707e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NOS1AP0.93
SATB20.923
PDE1A0.92
DIRAS20.916
IPCEF10.914
ZNF385B0.914
CHGA0.912
ELAVL40.911
TESPA10.911
SERPINF10.91

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EVA1A-0.569
ACAP1-0.56
ARHGEF5-0.557
LRAT-0.549
MDFI-0.548
TFPI2-0.524
SLC51B-0.505
WWTR1-0.502
EGFLAM-0.498
ZNF114-0.497

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of TBR1 mRNA"23829299
D000082AcetaminophenAcetaminophen results in increased expression of TBR1 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TBR1 gene27153756
D001151ArsenicArsenic results in increased methylation of TBR1 promoter21291286
C006780bisphenol Abisphenol A affects the methylation of TBR1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of TBR1 mRNA25181051
D005576ColforsinColforsin promotes the reaction [CASK protein modified form binds to TBR1 protein]20067577
C042080diisodecyl phthalatediisodecyl phthalate results in increased expression of TBR1 mRNA25270620
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TBR1 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of TBR1 mRNA22079256
D019833GenisteinGenistein results in decreased expression of TBR1 mRNA16169203
C517284monomethyl phthalatemonomethyl phthalate affects the expression of TBR1 mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of TBR1 mRNA15674844
C046012pentanalpentanal results in increased expression of TBR1 mRNA26079696
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of TBR1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of TBR1 mRNA22079256
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBR1 mRNA24058054
D014212TretinoinTretinoin results in decreased expression of TBR1 mRNA17045167
C012589trichostatin Atrichostatin A results in decreased expression of TBR1 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of TBR1 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of TBR1 mRNA17292431
D019287Zinc SulfateZinc Sulfate results in increased expression of TBR1 mRNA17506889

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0003700DNA-binding transcription factor activity-TAS7619531  
GO:0019901protein kinase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001661conditioned taste aversion-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007420brain development-TAS7619531  
GO:0010092specification of animal organ identity-IEA-  
GO:0021764amygdala development-IEA-  
GO:0021902commitment of neuronal cell to specific neuron type in forebrain-IEA-  
GO:0021987cerebral cortex development-IEA-  
GO:0030902hindbrain development-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:1902667regulation of axon guidance-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28158988Microsatellite polymorphisms associated with human behavioural and psychological phenotypes including a gene-environment interaction. (2017 Feb 3)Bagshaw ATBMC Med Genet