Gene: POLQ

10721
PRO0327
DNA polymerase theta
protein-coding
3q13.33
Ensembl:ENSG00000051341 MIM:604419 Vega:OTTHUMG00000159396 UniprotKB:O75417
NC_000003.12
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.766e-1 (AD)  8.176e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14535274chr3:121151186POLQ1.300e-13Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDKL10.753
RPAP20.747
USP280.744
PLEKHA50.739
DOPEY10.735
ZNF3820.732
PRSS510.732
ZFPM20.73
FAM13A0.727
CCDC390.719

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BCL7C-0.452
RBP1-0.451
S100A1-0.415
PAQR6-0.372
OLIG1-0.369
HEY2-0.364
MDFI-0.363
PLA2G5-0.354
HOMER3-0.351
METRN-0.348

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of POLQ mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of POLQ mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of POLQ mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of POLQ mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of POLQ mRNA"25510870
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of POLQ mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of POLQ mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of POLQ mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of POLQ mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of POLQ mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of POLQ mRNA22230336
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of POLQ mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of POLQ mRNA24449571
D001280AtrazineAtrazine results in decreased expression of POLQ mRNA22378314
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of POLQ mRNA"20018196|2038263
C006780bisphenol Abisphenol A results in decreased expression of POLQ mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of POLQ gene28505145
D002220CarbamazepineCarbamazepine affects the expression of POLQ mRNA24752500
D019327Copper SulfateCopper Sulfate results in decreased expression of POLQ mRNA19549813
D003375CoumestrolCoumestrol results in increased expression of POLQ mRNA19167446
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of POLQ mRNA21878529
D016572CyclosporineCyclosporine results in decreased expression of POLQ mRNA25562108
D000069439DasatinibDasatinib results in decreased expression of POLQ mRNA20579391
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of POLQ mRNA24317228
D003703DemecolcineDemecolcine results in increased expression of POLQ mRNA23649840
D002945CisplatinCisplatin results in increased expression of POLQ mRNA27594783
D002945CisplatinPOLQ results in decreased susceptibility to Cisplatin21883722
D004008DiclofenacDiclofenac affects the expression of POLQ mRNA24752500
D004041Dietary FatsDietary Fats results in increased expression of POLQ mRNA25016146
D002117CalcitriolCalcitriol results in decreased expression of POLQ mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of POLQ mRNA21592394
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of POLQ gene16724327
D005047EtoposidePOLQ results in decreased susceptibility to Etoposide21883722
C492448ICG 001ICG 001 results in decreased expression of POLQ mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of POLQ mRNA25613284
C544151jinfukangjinfukang results in increased expression of POLQ mRNA27392435
D007840LatexLatex analog results in increased expression of POLQ mRNA24768652
D007854LeadLead affects the expression of POLQ mRNA28903495
C008261lead acetatelead acetate results in increased expression of POLQ mRNA22641619
D016685MitomycinPOLQ results in decreased susceptibility to Mitomycin21883722
D009151Mustard GasMustard Gas results in decreased expression of POLQ mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of POLQ mRNA"25554681
D010100OxygenOxygen deficiency results in decreased expression of POLQ mRNA26516004
D010126OzoneOzone results in decreased expression of POLQ mRNA24336422
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of POLQ mRNA"25510870
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of POLQ mRNA18593933
D011192Potassium DichromatePotassium Dichromate results in decreased expression of POLQ mRNA23608068
D011794QuercetinQuercetin results in increased expression of POLQ mRNA21632981
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of POLQ mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of POLQ mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of POLQ mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of POLQ mRNA25613284
D013792ThalidomideThalidomide results in increased expression of POLQ mRNA28892372
D019284ThapsigarginThapsigargin results in decreased expression of POLQ mRNA22378314
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of POLQ mRNA"17951470
C012589trichostatin Atrichostatin A results in increased expression of POLQ mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of POLQ mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of POLQ mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of POLQ mRNA19140230
D014520UrethaneUrethane results in decreased expression of POLQ mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of POLQ mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of POLQ mRNA23179753|2627250
D014635Valproic AcidValproic Acid affects the expression of POLQ mRNA17963808
C025643vinclozolinvinclozolin results in decreased expression of POLQ mRNA23869203
D014750VincristineVincristine results in increased expression of POLQ mRNA23649840
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of POLQ mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IDA25642963  
GO:0003684damaged DNA binding-TAS10395804  
GO:0003887DNA-directed DNA polymerase activity-IBA21873635  
GO:0003887DNA-directed DNA polymerase activity-IDA14576298  25643323  
GO:0003887DNA-directed DNA polymerase activity-IMP22135286  
GO:0005515protein binding-IPI25642963  
GO:0005524ATP binding-IEA-  
GO:00084095'-3' exonuclease activity-IBA21873635  
GO:0043142single-stranded DNA-dependent ATPase activity-IDA14576298  
GO:00515755'-deoxyribose-5-phosphate lyase activity-IDA19188258  
GO ID GO Term Qualifier Evidence PubMed
GO:0000724double-strand break repair via homologous recombination-TAS-  
GO:0006261DNA-dependent DNA replication-IBA21873635  
GO:0006281DNA repair-TAS10395804  
GO:0006284base-excision repair-IDA19188258  
GO:0006302double-strand break repair-IDA22135286  
GO:0006974cellular response to DNA damage stimulus-IDA25642963  25643323  
GO:0016446somatic hypermutation of immunoglobulin genes-ISS-  
GO:0051260protein homooligomerization-IDA25643323  
GO:0071897DNA biosynthetic process-IEA-  
GO:0097681double-strand break repair via alternative nonhomologous end joining-IDA25643323  
GO:2000042negative regulation of double-strand break repair via homologous recombination-IDA25642963  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005694chromosome-IEA-  
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-5685939HDR through MMEJ (alt-NHEJ)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal