Gene: NFAT5

10725
NF-AT5|NFATL1|NFATZ|OREBP|TONEBP
nuclear factor of activated T cells 5
protein-coding
16q22.1
Ensembl:ENSG00000102908 MIM:604708 Vega:OTTHUMG00000137572 UniprotKB:O94916
NG_029600.1
PubMed|SNP Mapped
1   ANCO-SNPs
CD|ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.640e-1 (AD)  6.893e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10500553chr16:69651111 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDX60.918
UBE4A0.916
LNPEP0.914
ZNF7700.914
SHPRH0.91
PIAS10.905
TSTD20.9
SLC12A60.895
PHC30.877
DENND4A0.876

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.413
APOA1-0.409
BCL7C-0.408
KLRC3-0.391
RBP1-0.38
NRN1L-0.359
FAM229A-0.357
NANOGNB-0.352
HMX1-0.338
RARRES2-0.332

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in increased expression of NFAT5 mRNA"22101062
C0045042-bromoethylamine2-bromoethylamine inhibits the reaction [Sodium Chloride affects the localization of NFAT5 protein]20823374
C0045042-bromoethylamine2-bromoethylamine inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA]20823374
C0045042-bromoethylamine2-bromoethylamine inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 protein]20823374
C0045042-bromoethylamine2-bromoethylamine results in decreased expression of NFAT5 mRNA20823374
C0045042-bromoethylamine2-bromoethylamine results in decreased expression of NFAT5 protein20823374
C0261142-xylene2-xylene results in increased expression of NFAT5 mRNA20359517
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of NFAT5 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NFAT5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NFAT5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NFAT5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NFAT5 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of NFAT5 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NFAT5 mRNA19770486
D000493AllopurinolAllopurinol inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]23867654
D000493AllopurinolAllopurinol inhibits the reaction [Lipopolysaccharides results in increased expression of NFAT5 mRNA]23867654
D047310ApigeninApigenin inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA]26800359
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of NFAT5 mRNA"18687144
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of NFAT5 mRNA"19446018
D001554BenzeneBenzene results in increased expression of NFAT5 mRNA20359517
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NFAT5 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of NFAT5 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NFAT5 mRNA22228805
C090535benzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinalbenzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinal inhibits the reaction [Doxorubicin results in increased degradation of NFAT5 protein]17105721
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Doxorubicin results in increased degradation of NFAT5 protein]17105721
D004958EstradiolEstradiol results in decreased expression of NFAT5 mRNA21632981
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of NFAT5 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of NFAT5 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of NFAT5 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of NFAT5 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of NFAT5 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of NFAT5 mRNA27571134
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NFAT5 mRNA28628672
D001966BromineBromine results in increased expression of NFAT5 mRNA21391292
C018475butyraldehydebutyraldehyde results in decreased expression of NFAT5 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of NFAT5 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NFAT5 mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of NFAT5 mRNA24982889
D002330CarmustineNFAT5 mRNA affects the susceptibility to Carmustine16365179
C026690cerous chloridecerous chloride results in increased expression of NFAT5 mRNA23573234
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of NFAT5 mRNA16934159
D004390ChlorpyrifosChlorpyrifos results in decreased expression of NFAT5 mRNA18668222
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of NFAT5 mRNA20971185
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of NFAT5 mRNA15467011
D019327Copper SulfateCopper Sulfate results in increased expression of NFAT5 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of NFAT5 mRNA21632981
D013759DronabinolDronabinol results in increased expression of NFAT5 mRNA16597638
D003703DemecolcineDemecolcine results in increased expression of NFAT5 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of NFAT5 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of NFAT5 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NFAT5 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NFAT5 mRNA21266533
D002945CisplatinCisplatin results in increased expression of NFAT5 mRNA21151649
D004147DioxinsDioxins affects the expression of NFAT5 mRNA20463971
D004221DisulfiramDisulfiram results in decreased expression of NFAT5 mRNA20530235
D004317Doxorubicinbenzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinal inhibits the reaction [Doxorubicin results in increased degradation of NFAT5 protein]17105721
D004317Doxorubicinbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Doxorubicin results in increased degradation of NFAT5 protein]17105721
D004317DoxorubicinDoxorubicin affects the localization of NFAT5 protein17105721
D004317DoxorubicinDoxorubicin results in decreased activity of NFAT5 protein17105721
D004317DoxorubicinDoxorubicin results in increased degradation of and results in decreased expression of NFAT5 protein17105721
D004726EndosulfanEndosulfan results in increased expression of NFAT5 mRNA26615145
C004912ethylbenzeneethylbenzene results in increased expression of NFAT5 mRNA20359517
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of NFAT5 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of NFAT5 mRNA16111024|2364984
C001277geldanamycingeldanamycin results in increased expression of NFAT5 mRNA26705709
D019833GenisteinESR1 promotes the reaction [Genistein results in increased expression of NFAT5 protein]20884965
D019833GenisteinGenistein results in increased expression of NFAT5 protein20884965
D005839GentamicinsGentamicins results in increased expression of NFAT5 mRNA22061828
D017313FenretinideFenretinide results in increased expression of NFAT5 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of NFAT5 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of NFAT5 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of NFAT5 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NFAT5 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NFAT5 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of NFAT5 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of NFAT5 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NFAT5 mRNA28628672
C544151jinfukangjinfukang results in decreased expression of NFAT5 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of NFAT5 mRNA24796395
C410337K 7174K 7174 results in increased expression of NFAT5 mRNA24086573
D008070LipopolysaccharidesAllopurinol inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]23867654
D008070LipopolysaccharidesAllopurinol inhibits the reaction [Lipopolysaccharides results in increased expression of NFAT5 mRNA]23867654
D008070LipopolysaccharidesLipopolysaccharides affects the localization of NFAT5 protein23867654
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]23867654
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [Sodium Chloride affects the localization of NFAT5 protein]23867654
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA]23867654
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of NFAT5 mRNA21219332
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NFAT5 mRNA23867654
D008070LipopolysaccharidesRotenone inhibits the reaction [Sodium Chloride inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]]23867654
D008070LipopolysaccharidesSodium Chloride inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]23867654
D008070LipopolysaccharidesSodium Chloride promotes the reaction [Lipopolysaccharides affects the localization of NFAT5 protein]23867654
D008070LipopolysaccharidesSodium Chloride promotes the reaction [Lipopolysaccharides results in increased expression of NFAT5 mRNA]23867654
D047311LuteolinLuteolin inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA]26800359
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NFAT5 mRNA21641980
C030272maleic acidmaleic acid results in increased expression of NFAT5 mRNA28392987
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of NFAT5 mRNA22563483
D008353MannitolMannitol results in increased expression of NFAT5 mRNA23867654
D008694MethamphetamineMethamphetamine results in increased expression of NFAT5 mRNA26307267
D008727MethotrexateMethotrexate results in increased expression of NFAT5 mRNA17400583
D008752Methylene ChlorideMethylene Chloride results in increased expression of NFAT5 mRNA20359517
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NFAT5 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NFAT5 mRNA23649840
C030517myxothiazolmyxothiazol inhibits the reaction [Sodium Chloride results in increased activity of NFAT5 protein]16303854
C017557nickel subsulfidenickel subsulfide results in decreased expression of NFAT5 mRNA24952340
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of NFAT5 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of NFAT5 mRNA25729387
D010126OzoneOzone results in increased expression of NFAT5 mRNA27206323
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of NFAT5 mRNA22563483
D010269ParaquatParaquat results in increased expression of NFAT5 mRNA22563483
C410127PCB 180PCB 180 results in decreased expression of NFAT5 mRNA23829299
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of NFAT5 mRNA17097637
D010634PhenobarbitalPhenobarbital affects the expression of NFAT5 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NFAT5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of NFAT5 mRNA26272509
D010862PilocarpinePilocarpine results in decreased expression of NFAT5 mRNA21219332
C006253pirinixic acidpirinixic acid results in decreased expression of NFAT5 mRNA17950772
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of NFAT5 mRNA]17950772
D011374ProgesteroneProgesterone results in decreased expression of NFAT5 mRNA21371490
C428725pyridabenpyridaben results in increased expression of NFAT5 mRNA22563483
D011791QuartzQuartz results in increased expression of NFAT5 mRNA27917503
D011794QuercetinQuercetin inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA]26800359
D011794QuercetinQuercetin results in increased expression of NFAT5 mRNA21632981
D017382Reactive Oxygen Species[Sodium Chloride results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFAT5 protein16303854
C059514resveratrolresveratrol results in decreased expression of NFAT5 mRNA25667456
D012402RotenoneRotenone inhibits the reaction [Sodium Chloride results in increased activity of NFAT5 protein]16303854
D012402RotenoneRotenone inhibits the reaction [Sodium Chloride inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]]23867654
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of NFAT5 mRNA19244175
D012643SeleniumSelenium results in decreased expression of NFAT5 mRNA19244175
C009277sodium arsenatesodium arsenate results in increased expression of NFAT5 mRNA21795629
D012965Sodium ChlorideApigenin inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA]26800359
D012965Sodium ChlorideLuteolin inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA]26800359
D012965Sodium Chloridemyxothiazol inhibits the reaction [Sodium Chloride results in increased activity of NFAT5 protein]16303854
D012965Sodium ChlorideNFAT5 protein affects the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]26800359
D012965Sodium ChlorideNFAT5 protein affects the reaction [Sodium Chloride results in increased secretion of FGF2 protein]26800359
D012965Sodium ChlorideQuercetin inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA]26800359
D012965Sodium ChlorideRotenone inhibits the reaction [Sodium Chloride results in increased activity of NFAT5 protein]16303854
D012965Sodium Chloride[Sodium Chloride results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFAT5 protein16303854
D012965Sodium ChlorideSodium Chloride results in increased activity of NFAT5 protein16303854
D012965Sodium ChlorideSodium Chloride results in increased expression of NFAT5 mRNA26800359
D012965Sodium Chloride2-bromoethylamine inhibits the reaction [Sodium Chloride affects the localization of NFAT5 protein]20823374
D012965Sodium Chloride2-bromoethylamine inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA]20823374
D012965Sodium Chloride2-bromoethylamine inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 protein]20823374
D012965Sodium ChlorideLipopolysaccharides promotes the reaction [Sodium Chloride affects the localization of NFAT5 protein]23867654
D012965Sodium ChlorideLipopolysaccharides promotes the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA]23867654
D012965Sodium ChlorideRotenone inhibits the reaction [Sodium Chloride inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]]23867654
D012965Sodium ChlorideSodium Chloride affects the localization of NFAT5 protein20823374|2386765
D012965Sodium ChlorideSodium Chloride inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]23867654
D012965Sodium ChlorideSodium Chloride promotes the reaction [Lipopolysaccharides affects the localization of NFAT5 protein]23867654
D012965Sodium ChlorideSodium Chloride promotes the reaction [Lipopolysaccharides results in increased expression of NFAT5 mRNA]23867654
D012965Sodium ChlorideSodium Chloride results in increased expression of NFAT5 mRNA20823374|2386765
D012965Sodium ChlorideSodium Chloride results in increased expression of NFAT5 protein20823374
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NFAT5 mRNA21641980
C047246temozolomideNFAT5 mRNA affects the susceptibility to temozolomide16365179
C004648testosterone enanthatetestosterone enanthate results in increased expression of NFAT5 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NFAT5 mRNA18691609|2157046
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NFAT5 mRNA21354282
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NFAT5 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NFAT5 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of NFAT5 mRNA27188386
D013893ThiramThiram results in decreased expression of NFAT5 mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of NFAT5 mRNA27865774
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NFAT5 mRNA27404394
D014050TolueneToluene results in increased expression of NFAT5 mRNA20359517
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of NFAT5 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of NFAT5 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of NFAT5 mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased expression of NFAT5 mRNA20359517
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NFAT5 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of NFAT5 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NFAT5 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of NFAT5 mRNA28973697
D014520UrethaneUrethane results in increased expression of NFAT5 mRNA28818685
D014527Uric AcidNFAT5 gene SNP affects the abundance of Uric Acid23263486
D014750VincristineVincristine results in increased expression of NFAT5 mRNA23649840
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of NFAT5 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of NFAT5 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of NFAT5 mRNA27188386
C111237vorinostatvorinostat results in increased expression of NFAT5 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA11485737  11780147  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA11485737  
GO:0003682chromatin binding-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-TAS10051678  
GO:0005515protein binding-IPI22266867  
GO:0008134transcription factor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001816cytokine production-IBA21873635  
GO:0001816cytokine production-IEA-  
GO:0006366transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007165signal transduction-NAS10377394  
GO:0007588excretion-TAS10051678  
GO:0033173calcineurin-NFAT signaling cascade-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA11485737  
GO:0070884regulation of calcineurin-NFAT signaling cascade-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA12370307  
GO:0005654nucleoplasm-IDA-  
GO:0005667transcription factor complex-IBA21873635  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0044798nuclear transcription factor complex-IBA21873635  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26506053Transcriptomic and genetic studies identify NFAT5 as a candidate gene for cocaine dependence. (2015 Oct 27)Fernandez-Castillo NTransl Psychiatry
22199996Tumor necrosis factor-related genes and colon and rectal cancer. (2011)Slattery MLInt J Mol Epidemiol Genet