Gene: PTGES3

10728
P23|TEBP|cPGES
prostaglandin E synthase 3
protein-coding
12q13.3|12
Ensembl:ENSG00000110958 MIM:607061 Vega:OTTHUMG00000170217 UniprotKB:Q15185
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.993e-2 (AD)  6.410e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HSP90AA10.944
TCP10.934
DNAJA10.932
GPBP10.93
HSP90B10.926
DNAJB60.921
ST130.919
EIF2S20.916
UBE2D30.916
SNX30.91

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.742
OR4F29-0.735
KLRB1-0.207
C16orf97-0.206
HES5-0.202
IL2RB-0.192
XCL2-0.184
KLRF1-0.181
TCL1A-0.18
TTC16-0.18

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05036Grn163lSmall Molecule-InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PTGES3 mRNA"15215175
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of PTGES3 mRNA"19561079
C5350754-tosylcyclonovobiocic acid4-tosylcyclonovobiocic acid promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of PTGES3 protein]19118525
C5350754-tosylcyclonovobiocic acid4-tosylcyclonovobiocic acid results in increased cleavage of PTGES3 protein19118525
C5350767-tosylcyclonovobiocic acid7-tosylcyclonovobiocic acid results in increased cleavage of PTGES3 protein19118525
C5265509H-purine-9-propanamine, 6-amino-8-((6-iodo-1,3-benzodioxol-5-yl)thio)-N-(1-methylethyl)-"9H-purine-9-propanamine, 6-amino-8-((6-iodo-1,3-benzodioxol-5-yl)thio)-N-(1-methylethyl)- inhibits the reaction [HSP90AA1 protein binds to PTGES3 protein]"22895790
D015766Albendazole[Ivermectin co-treated with Albendazole] results in increased expression of PTGES3 mRNA16861626
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of PTGES3 mRNA12420312
C006632arsenic trioxidearsenic trioxide results in increased expression of PTGES3 mRNA20458559
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PTGES3 mRNA19770486|2156981
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PTGES3 mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PTGES3 mRNA"20382639
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde4-tosylcyclonovobiocic acid promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of PTGES3 protein]19118525
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of PTGES3 protein19118525
C044887beta-methylcholinebeta-methylcholine affects the expression of PTGES3 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of PTGES3 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of PTGES3 mRNA25181051
C016299chelerythrinechelerythrine results in increased cleavage of PTGES3 protein26124276
C100187chloropicrinchloropicrin results in increased expression of PTGES3 mRNA26352163
D004390ChlorpyrifosChlorpyrifos results in increased expression of PTGES3 mRNA26494550
D004390Chlorpyrifos[Malathion co-treated with Chlorpyrifos] results in decreased expression of PTGES3 mRNA26494550
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of PTGES3 mRNA24690739
D003300CopperPTGES3 protein binds to Copper15359738
D019327Copper SulfateCopper Sulfate results in increased expression of PTGES3 mRNA19549813
D003520CyclophosphamideCyclophosphamide results in increased expression of PTGES3 mRNA11599041
D016572CyclosporineCyclosporine results in increased expression of PTGES3 mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PTGES3 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of PTGES3 mRNA27392435
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of PTGES3 mRNA24690739
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of PTGES3 mRNA24534155
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PTGES3 protein23301498
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PTGES3 mRNA21179406
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of PTGES3 mRNA19376150
D007559Ivermectin[Ivermectin co-treated with Albendazole] results in increased expression of PTGES3 mRNA16861626
C544151jinfukangjinfukang results in decreased expression of PTGES3 mRNA27392435
C008261lead acetatelead acetate results in decreased expression of PTGES3 mRNA21829687
D008294Malathion[Malathion co-treated with Chlorpyrifos] results in decreased expression of PTGES3 mRNA26494550
D008294MalathionMalathion results in decreased expression of PTGES3 mRNA26494550
D008627Mercuric ChlorideMercuric Chloride results in increased expression of PTGES3 mRNA16507785
C576667N-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamideN-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide analog inhibits the reaction [HSP90AA1 protein binds to PTGES3 protein]22895790
C576667N-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamideN-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide analog inhibits the reaction [HSP90AB1 protein binds to PTGES3 protein]22895790
C576667N-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamideN-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide inhibits the reaction [HSP90AA1 protein binds to PTGES3 protein]22895790
C017557nickel subsulfidenickel subsulfide results in increased expression of PTGES3 mRNA21086188
D017239PaclitaxelPTGES3 protein affects the susceptibility to Paclitaxel16217747
D011794QuercetinQuercetin results in decreased expression of PTGES3 mRNA21632981
C059514resveratrolresveratrol results in increased expression of PTGES3 protein25505154
D012834SilverSilver results in increased expression of PTGES3 mRNA26014281
C017947sodium arsenitesodium arsenite results in decreased expression of PTGES3 protein21925251
C016104sodium bichromatesodium bichromate results in increased expression of PTGES3 mRNA12325037
D012965Sodium Chloride[AGT protein co-treated with Sodium Chloride] affects the expression of PTGES3 mRNA27225954
D019311StaurosporineStaurosporine results in increased cleavage of PTGES3 protein26124276
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PTGES3 mRNA21998131
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTGES3 mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PTGES3 mRNA22363418|2806579
D014241TrichloroethyleneTrichloroethylene results in decreased expression of PTGES3 mRNA15363585
D014501UraniumUranium affects the expression of PTGES3 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of PTGES3 mRNA15672453
C406224valdecoxibvaldecoxib results in increased expression of PTGES3 mRNA24136188
D014747VinblastinePTGES3 protein affects the susceptibility to Vinblastine16217747
C111237vorinostatvorinostat results in decreased expression of PTGES3 protein17593366|2054356

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003720telomerase activity-IDA12135483  
GO:0005515protein binding-IPI9817749  19875381  21183720  21988832  23741051  25036637  
27353360  
GO:0050220prostaglandin-E synthase activity-IBA21873635  
GO:0050220prostaglandin-E synthase activity-IDA10922363  
GO:0050220prostaglandin-E synthase activity-TAS-  
GO:0051082unfolded protein binding-IDA12077419  
GO:0051087chaperone binding-IBA21873635  
GO:0051879Hsp90 protein binding-IBA21873635  
GO:0051879Hsp90 protein binding-IPI10543959  10811660  19740745  
GO:0070182DNA polymerase binding-IPI10197982  19751963  
GO ID GO Term Qualifier Evidence PubMed
GO:0000723telomere maintenance-TAS12135483  
GO:0001516prostaglandin biosynthetic process-IBA21873635  
GO:0001516prostaglandin biosynthetic process-IDA10922363  
GO:0006457protein folding-IBA21873635  
GO:0006805xenobiotic metabolic process-TAS-  
GO:0007004telomere maintenance via telomerase-IBA21873635  
GO:0007004telomere maintenance via telomerase-IDA10197982  19740745  
GO:0007004telomere maintenance via telomerase-IMP19740745  
GO:0007165signal transduction-TAS8114727  
GO:0019371cyclooxygenase pathway-TAS-  
GO:0042327positive regulation of phosphorylation-IDA19740745  
GO:0050821protein stabilization-IMP10543959  10811660  
GO:0051085chaperone cofactor-dependent protein refolding-IDA12853476  
GO:0051131chaperone-mediated protein complex assembly-IBA21873635  
GO:0051131chaperone-mediated protein complex assembly-IMP10811660  
GO:0051973positive regulation of telomerase activity-IDA10197982  19740745  
GO:0051973positive regulation of telomerase activity-IMP19740745  
GO:1900034regulation of cellular response to heat-TAS-  
GO:1905323telomerase holoenzyme complex assembly-IBA21873635  
GO:1905323telomerase holoenzyme complex assembly-IDA10197982  
GO ID GO Term Qualifier Evidence PubMed
GO:0000781chromosome, telomeric region-IC12135483  
GO:0005634nucleus-HDA21630459  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005697telomerase holoenzyme complex-IDA12135483  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0032991protein-containing complex-IMP10543959  10811660  
GO:0101031chaperone complex-IDA29127155  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-2142753Arachidonic acid metabolismTAS
R-HSA-2162123Synthesis of Prostaglandins (PG) and Thromboxanes (TX)TAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3371497HSP90 chaperone cycle for steroid hormone receptors (SHR)TAS
R-HSA-3371511HSF1 activationTAS
R-HSA-3371556Cellular response to heat stressTAS
R-HSA-3371568Attenuation phaseTAS
R-HSA-3371571HSF1-dependent transactivationTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8937144Aryl hydrocarbon receptor signallingTAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-8978868Fatty acid metabolismTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27548026Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E2 in Normal Human Colon Tissue. (2016 Oct)Sidahmed ENutr Cancer