Gene: PLK4

10733
MCCRP2|SAK|STK18
polo like kinase 4
protein-coding
4q28.1
Ensembl:ENSG00000142731 MIM:605031 Vega:OTTHUMG00000133301 UniprotKB:O00444
NG_041821.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.514e-1 (AD)  4.411e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GSTCD0.763
MAP100.752
MFSD80.75
ZNF4410.75
ACADSB0.743
ZNF1360.737
ZNF430.737
KDM4D0.737
ARMCX50.735
AGL0.735

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC102A-0.418
C7orf61-0.415
HSPA1A-0.375
CELSR1-0.374
MIA-0.354
EPPIN-0.351
HSPB1-0.35
MTRNR2L10-0.349
SERTAD1-0.347
MTRNR2L9-0.347

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PLK4 mRNA"28903501
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PLK4 mRNA"25614096
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PLK4 mRNA"19167446
C0821644-methoxycinnamate methyl ester4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in increased expression of PLK4 mRNA]19442820
D000082AcetaminophenAcetaminophen results in decreased expression of PLK4 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of PLK4 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PLK4 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PLK4 mRNA23630614
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of PLK4 mRNA"22863853
D000880AnthraquinonesAnthraquinones analog results in decreased activity of PLK4 protein27473261
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PLK4 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of PLK4 mRNA26705709
C547126AZM551248AZM551248 results in increased expression of PLK4 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PLK4 mRNA20713471
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PLK4 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of PLK4 mRNA16474171|1916744
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of PLK4 mRNA]25210133
D004958EstradiolEstradiol affects the expression of PLK4 mRNA15598610
D004958EstradiolEstradiol results in increased expression of PLK4 mRNA25210133
C044887beta-methylcholinebeta-methylcholine affects the expression of PLK4 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of PLK4 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PLK4 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of PLK4 mRNA16474171
C006780bisphenol Abisphenol A results in increased expression of PLK4 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of PLK4 mRNA26982218
C006780bisphenol Abisphenol A results in increased expression of PLK4 mRNA25181051
C040048caffeic acidcaffeic acid promotes the reaction [Thapsigargin results in increased expression of PLK4 mRNA]19442820
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of PLK4 mRNA23650126
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of PLK4 mRNA26033743
D003300CopperCopper deficiency results in increased expression of PLK4 mRNA26033743
D003345CorticosteroneCorticosterone results in decreased expression of PLK4 mRNA15755911
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PLK4 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of PLK4 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of PLK4 mRNA19167446
D003471CuprizoneCuprizone results in decreased expression of PLK4 mRNA26577399|2752363
D003474CurcuminCurcumin analog results in increased expression of PLK4 mRNA26409325
D016572CyclosporineCyclosporine results in decreased expression of PLK4 mRNA20106945|2163298
D000069439DasatinibDasatinib results in decreased expression of PLK4 mRNA20579391
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PLK4 mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of PLK4 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of PLK4 mRNA]20032058
D003976DiazinonDiazinon affects the expression of PLK4 mRNA22546817
D002945CisplatinCisplatin promotes the reaction [Piroxicam results in decreased expression of PLK4 mRNA]21858171
C000944dicrotophosdicrotophos results in decreased expression of PLK4 mRNA28302478
D004026DieldrinDieldrin affects the expression of PLK4 mRNA22546817
D004041Dietary FatsDietary Fats results in increased expression of PLK4 mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of PLK4 mRNA]21852083
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of PLK4 mRNA26033743
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PLK4 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PLK4 mRNA]17854601
D002117CalcitriolCalcitriol results in decreased expression of PLK4 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of PLK4 mRNA21592394
C024629dimethyl phthalatedimethyl phthalate affects the expression of PLK4 mRNA26924002
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of PLK4 mRNA]"19442820
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PLK4 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLK4 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PLK4 mRNA17351261
C039281furanfuran results in increased expression of PLK4 mRNA25539665
D019833GenisteinGenistein results in increased expression of PLK4 mRNA16474171
D017313FenretinideFenretinide results in decreased expression of PLK4 mRNA28973697
D017313FenretinideFenretinide results in increased expression of PLK4 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of PLK4 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PLK4 mRNA25613284
C544151jinfukangjinfukang results in increased expression of PLK4 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PLK4 mRNA24796395
D007840LatexLatex analog results in increased expression of PLK4 mRNA24768652
C008261lead acetatelead acetate results in decreased expression of PLK4 mRNA21829687
C008261lead acetatelead acetate results in increased expression of PLK4 mRNA22641619
D008154LucanthoneLucanthone results in decreased expression of PLK4 mRNA21148553
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PLK4 mRNA21641980
D008627Mercuric ChlorideMercuric Chloride affects the expression of PLK4 mRNA20353558
D008727MethotrexateMethotrexate affects the expression of PLK4 mRNA18502557
D008748MethylcholanthreneMethylcholanthrene results in increased expression of PLK4 mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PLK4 mRNA26011545
D009151Mustard GasMustard Gas results in decreased expression of PLK4 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PLK4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PLK4 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of PLK4 mRNA19812364
C022838nickel chloridenickel chloride affects the expression of PLK4 mRNA22546817
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PLK4 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of PLK4 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of PLK4 mRNA26516004
D010126OzoneOzone results in increased expression of PLK4 mRNA12763052|1955522
D017239PaclitaxelPaclitaxel results in decreased expression of PLK4 mRNA15000894
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of PLK4 mRNA26678675
D010634PhenobarbitalPhenobarbital affects the expression of PLK4 mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of PLK4 mRNA12832660
D010894PiroxicamCisplatin promotes the reaction [Piroxicam results in decreased expression of PLK4 mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of PLK4 mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of PLK4 mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of PLK4 mRNA16474171
D011374ProgesteroneProgesterone affects the expression of PLK4 mRNA17251523
C005556propionaldehydepropionaldehyde results in decreased expression of PLK4 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of PLK4 mRNA24780913
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of PLK4 mRNA19167446
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of PLK4 mRNA]21852083
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PLK4 mRNA23806026
C016104sodium bichromatesodium bichromate affects the expression of PLK4 mRNA22110744
D053260SootSoot results in increased expression of PLK4 mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PLK4 mRNA21641980
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of PLK4 mRNA"26680231
C061133tamibarotenetamibarotene results in decreased expression of PLK4 mRNA15498508
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of PLK4 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of PLK4 mRNA21592394
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of PLK4 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PLK4 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLK4 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PLK4 mRNA25613284
D019284Thapsigargin4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in increased expression of PLK4 mRNA]19442820
D019284Thapsigargincaffeic acid promotes the reaction [Thapsigargin results in increased expression of PLK4 mRNA]19442820
D019284Thapsigargin"Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of PLK4 mRNA]"19442820
D019284ThapsigarginThapsigargin results in increased expression of PLK4 mRNA19442820
D013853ThioacetamideThioacetamide results in increased expression of PLK4 mRNA22659510
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PLK4 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of PLK4 mRNA25729387
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of PLK4 mRNA"17951470
D014212TretinoinTretinoin results in decreased expression of PLK4 mRNA15498508
C012589trichostatin Atrichostatin A results in decreased expression of PLK4 mRNA15901671
C012589trichostatin Atrichostatin A affects the expression of PLK4 mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of PLK4 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PLK4 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of PLK4 mRNA19140230
D014635Valproic AcidValproic Acid results in decreased expression of PLK4 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of PLK4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PLK4 mRNA23179753|2718838
C029297vinylidene chloridevinylidene chloride results in increased expression of PLK4 mRNA26682919
C111237vorinostatvorinostat results in increased expression of PLK4 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IDA21725316  27796307  
GO:0004674protein serine/threonine kinase activity-ISS-  
GO:0005515protein binding-IPI16189514  20348415  20852615  21059844  21725316  24997597  
25416956  25503564  26496610  26638075  26871637  27107014  
27796307  
GO:0005524ATP binding-IEA-  
GO:0042802identical protein binding-IPI16189514  24997597  25416956  27107012  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-TAS-  
GO:0006468protein phosphorylation-IDA27796307  
GO:0007099centriole replication-IMP21725316  22020124  
GO:0010389regulation of G2/M transition of mitotic cell cycle-TAS-  
GO:0046601positive regulation of centriole replication-IDA22349705  27796307  
GO:0046601positive regulation of centriole replication-IMP16244668  17681131  
GO:0060707trophoblast giant cell differentiation-ISS-  
GO:0097711ciliary basal body-plasma membrane docking-TAS-  
GO:0098535de novo centriole assembly involved in multi-ciliated epithelial cell differentiation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001741XY body-IEA-  
GO:0005730nucleolus-ISS-  
GO:0005813centrosome-IDA21399614  
GO:0005814centriole-IDA16244668  17681131  22020124  27796307  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0032154cleavage furrow-IEA-  
GO:0098536deuterosome-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionTAS
R-HSA-380259Loss of Nlp from mitotic centrosomesTAS
R-HSA-380270Recruitment of mitotic centrosome proteins and complexesTAS
R-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosomeTAS
R-HSA-380287Centrosome maturationTAS
R-HSA-380320Recruitment of NuMA to mitotic centrosomesTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5620912Anchoring of the basal body to the plasma membraneTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-8854518AURKA Activation by TPX2TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21324136Aberrant methylation of Polo-like kinase CpG islands in Plk4 heterozygous mice. (2011 Feb 15)Ward ABMC Cancer