Gene: STAG3

10734
-
stromal antigen 3
protein-coding
7q22.1
Ensembl:ENSG00000066923 MIM:608489 Vega:OTTHUMG00000155183 UniprotKB:Q9UJ98
NG_034114.1
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.548e-1 (AD)  9.867e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs79246196chr7:100185286 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCNI20.829
PVRIG0.79
LRCH30.784
P2RX70.779
TIAF10.769
ZNF4710.766
ZNF3970.757
PAN20.752
MDN10.747
ZNF8410.74

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNNT1-0.309
ENDOU-0.282
DIO2-0.277
OR4F29-0.268
PRSS27-0.263
PLA2G5-0.258
CXCL14-0.258
PRSS56-0.255
OR4F5-0.248
VAX2-0.246

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of STAG3 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAG3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAG3 mRNA"27188386
D020106AcrylamideAcrylamide results in increased expression of STAG3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of STAG3 mRNA22100608
D000643Ammonium ChlorideAmmonium Chloride affects the expression of STAG3 mRNA16483693
D001280AtrazineAtrazine results in increased expression of STAG3 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STAG3 mRNA17879257
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of STAG3 gene25435355
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of STAG3 mRNA26496021
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of STAG3 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of STAG3 mRNA27685785
C006780bisphenol Abisphenol A results in increased methylation of STAG3 promoter27312807
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of STAG3 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of STAG3 mRNA25181051
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of STAG3 mRNA28628672
D002945CisplatinCisplatin results in increased expression of STAG3 mRNA27392435
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of STAG3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STAG3 mRNA17942748
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of STAG3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of STAG3 mRNA28628672
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of STAG3 mRNA21427059
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of STAG3 mRNA"21148743
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of STAG3 mRNA25895662
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STAG3 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STAG3 mRNA17942748
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of STAG3 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of STAG3 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of STAG3 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of STAG3 mRNA21427059
D024483Vitamin K 3Vitamin K 3 results in increased expression of STAG3 mRNA25270620

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007130synaptonemal complex assembly-TAS10698974  
GO ID GO Term Qualifier Evidence PubMed
GO:0000775chromosome, centromeric region-IEA-  
GO:0000795synaptonemal complex-TAS10698974  
GO:0005615extracellular space-HDA22664934  
GO:0005634nucleus-TAS10698974  
GO:0030893meiotic cohesin complex-IDA21242291  
KEGG ID KEGG Term
hsa04114Oocyte meiosis
Reactome ID Reactome Term Evidence
R-HSA-1221632Meiotic synapsisIEA
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-1640170Cell CycleIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal