Gene: STAG2

10735
SA-2|SA2|SCC3B|bA517O1.1
stromal antigen 2
protein-coding
Xq25
Ensembl:ENSG00000101972 MIM:300826 Vega:OTTHUMG00000022725 UniprotKB:Q8N3U4
NG_033796.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF240.913
BBX0.908
GABPA0.897
EFCAB140.896
TWF10.896
RDX0.895
PAK20.893
IL6ST0.892
KTN10.889
TCF120.889

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.544
OR4F5-0.524
KCNG2-0.411
ADRA1D-0.407
ABCC12-0.387
NKX6-3-0.377
FBLN7-0.366
RHO-0.347
BHLHA9-0.346
PNPLA5-0.344

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of STAG2 mRNA"20453058
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of STAG2 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of STAG2 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of STAG2 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of STAG2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STAG2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of STAG2 mRNA"19150397|2001819
C006780bisphenol Abisphenol A affects the expression of STAG2 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of STAG2 mRNA18958704
D004390ChlorpyrifosChlorpyrifos results in decreased expression of STAG2 mRNA20350560
D003010ClorgylineClorgyline results in increased expression of STAG2 mRNA19691856
D019327Copper SulfateCopper Sulfate results in increased expression of STAG2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of STAG2 mRNA19770486
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of STAG2 mRNA23914054
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of STAG2 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of STAG2 mRNA28302478
D004726EndosulfanEndosulfan results in decreased expression of STAG2 mRNA28161397
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of STAG2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of STAG2 mRNA17555576
D005839GentamicinsGentamicins results in increased expression of STAG2 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of STAG2 mRNA24136188
D005947GlucoseGlucose results in decreased expression of STAG2 mRNA17178593
C089796hexabromocyclododecanehexabromocyclododecane affects the expression of STAG2 mRNA24680724
C492448ICG 001ICG 001 results in decreased expression of STAG2 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of STAG2 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of STAG2 mRNA27392435
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of STAG2 mRNA"24972896
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of STAG2 mRNA"18930950
D008713MethimazoleMethimazole results in increased expression of STAG2 mRNA22504374
D009151Mustard GasMustard Gas results in increased expression of STAG2 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of STAG2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of STAG2 mRNA"25554681
C025589ochratoxin Aochratoxin A results in increased expression of STAG2 mRNA23358140
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of STAG2 mRNA25729387
D010126OzoneOzone results in decreased expression of STAG2 mRNA12763052|1746015
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of STAG2 mRNA28973697
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of STAG2 mRNA27153767
D010634PhenobarbitalPhenobarbital affects the expression of STAG2 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of STAG2 mRNA23811191
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of STAG2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of STAG2 mRNA22079256
D011441PropylthiouracilPropylthiouracil results in increased expression of STAG2 mRNA22504374
D011794QuercetinQuercetin results in decreased expression of STAG2 mRNA23727915
C410733scriptaidscriptaid affects the expression of STAG2 mRNA18813790
D012643SeleniumSelenium results in decreased expression of STAG2 mRNA19244175
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of STAG2 mRNA"26680231
D013629TamoxifenTamoxifen affects the expression of STAG2 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STAG2 mRNA18691609|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of STAG2 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of STAG2 mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of STAG2 mRNA25613284
D013849ThimerosalThimerosal results in increased expression of STAG2 mRNA27188386
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of STAG2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of STAG2 mRNA25729387
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of STAG2 mRNA"26179874
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of STAG2 mRNA"18930950
D014635Valproic AcidValproic Acid affects the expression of STAG2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of STAG2 mRNA23179753|2718838
C025643vinclozolinvinclozolin results in decreased expression of STAG2 mRNA20566332
D014810Vitamin EVitamin E results in decreased expression of STAG2 mRNA19244175
C111237vorinostatvorinostat results in increased expression of STAG2 mRNA27188386
C088658zoledronic acidzoledronic acid results in decreased expression of STAG2 protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15737063  15855230  16682347  17112726  17113138  17349791  
17962804  18235444  19629043  20360068  20818333  22885700  
23242214  25173175  26496610  
GO ID GO Term Qualifier Evidence PubMed
GO:0007062sister chromatid cohesion-IMP15917200  
GO:0032876negative regulation of DNA endoreduplication-IMP15917200  
GO:0051301cell division-IEA-  
GO:0051321meiotic cell cycle-IEA-  
GO:1901673regulation of mitotic spindle assembly-IMP11590136  
GO ID GO Term Qualifier Evidence PubMed
GO:0000775chromosome, centromeric region-TAS-  
GO:0000785chromatin-IDA16682347  
GO:0005634nucleus-TAS9305759  
GO:0005654nucleoplasm-TAS-  
GO:0005694chromosome-TAS-  
GO:0005829cytosol-TAS-  
GO:0008278cohesin complex-IDA11590136  
GO:0016020membrane-HDA19946888  
GO:0016363nuclear matrix-IDA11590136  
GO:0097431mitotic spindle pole-IDA11590136  
KEGG ID KEGG Term
hsa04110Cell cycle
Reactome ID Reactome Term Evidence
R-HSA-1221632Meiotic synapsisIEA
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2468052Establishment of Sister Chromatid CohesionTAS
R-HSA-2470946Cohesin Loading onto ChromatinTAS
R-HSA-2500257Resolution of Sister Chromatid CohesionTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-2990846SUMOylationTAS
R-HSA-3108214SUMOylation of DNA damage response and repair proteinsTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68884Mitotic Telophase/CytokinesisTAS
R-HSA-68886M PhaseTAS
R-HSA-69242S PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28169993The evolving genomic landscape of urothelial carcinoma. (2017 Feb 7)Glaser APNat Rev Urol