Gene: MASP2

10747
MAP19|MASP-2|MASP1P1|sMAP
mannan binding lectin serine peptidase 2
protein-coding
1p36.22
Ensembl:ENSG00000009724 MIM:605102 Vega:OTTHUMG00000002121 UniprotKB:O00187
NG_007289.2
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.583e-1 (AD)  1.876e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNPC30.897
DOPEY10.895
GPATCH80.89
ZNF3820.884
ZNF5870.874
CCDC390.862
PRSS510.862
NEU30.852
CHD60.852
MPHOSPH90.85

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BCL7C-0.485
PPP1R14B-0.454
S100A1-0.431
RBP1-0.429
RAB13-0.423
VAX2-0.415
MDFI-0.414
PINLYP-0.401
EIF4EBP1-0.398
HEY2-0.393

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04527Beta-HydroxyasparagineSmall Molecule16712-79-1ExperimentalTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MASP2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MASP2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MASP2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MASP2 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MASP2 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MASP2 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of MASP2 mRNA"20406850
C496492abrineabrine results in decreased expression of MASP2 mRNA22595364
D020106AcrylamideAcrylamide results in decreased expression of MASP2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MASP2 mRNA27153756
D000638AmiodaroneAmiodarone affects the expression of MASP2 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MASP2 mRNA16483693
D001553BenzbromaroneBenzbromarone affects the expression of MASP2 mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MASP2 mRNA19770486
C006780bisphenol Abisphenol A results in increased expression of MASP2 mRNA26364221
C006780bisphenol Abisphenol A affects the expression of MASP2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of MASP2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MASP2 gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MASP2 mRNA12734012
D002509CephaloridineCephaloridine results in increased expression of MASP2 mRNA18500788
D002994ClofibrateClofibrate results in decreased expression of MASP2 mRNA17585979
D002994ClofibrateClofibrate affects the expression of MASP2 mRNA19483382
D019327Copper SulfateCopper Sulfate results in decreased expression of MASP2 mRNA19549813
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MASP2 mRNA21266533
D004041Dietary FatsDietary Fats results in decreased expression of MASP2 mRNA25016146
D005001EthionineEthionine affects the expression of MASP2 mRNA19483382
C082360fipronilfipronil results in decreased expression of MASP2 mRNA23962444
D005485FlutamideFlutamide results in decreased expression of MASP2 mRNA24136188
D005839GentamicinsGentamicins results in decreased expression of MASP2 mRNA22061828
C544151jinfukangjinfukang results in decreased expression of MASP2 mRNA27392435
C410337K 7174K 7174 results in decreased expression of MASP2 mRNA24086573
D008627Mercuric ChlorideMercuric Chloride affects the expression of MASP2 mRNA20353558
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MASP2 mRNA"20188158
D009853OmeprazoleOmeprazole affects the expression of MASP2 mRNA19483382
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MASP2 mRNA"25510870
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of MASP2 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of MASP2 mRNA17950772|2081375
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of MASP2 mRNA]17950772
C006253pirinixic acidpirinixic acid affects the expression of MASP2 mRNA19483382
D011441PropylthiouracilPropylthiouracil affects the expression of MASP2 mRNA19483382
D011794QuercetinQuercetin results in increased expression of MASP2 mRNA21565894
C089730rosiglitazonerosiglitazone results in decreased expression of MASP2 mRNA25572481
C016104sodium bichromatesodium bichromate results in decreased expression of MASP2 mRNA24612858
D012999SomanSoman results in increased expression of MASP2 mRNA19281266
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of MASP2 mRNA15885361
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MASP2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MASP2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MASP2 mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of MASP2 mRNA28973375
D013779TetrodotoxinTetrodotoxin results in increased expression of MASP2 mRNA26436198
D013853ThioacetamideThioacetamide affects the expression of MASP2 mRNA19483382
D013853ThioacetamideThioacetamide results in decreased expression of MASP2 mRNA23411599
D014520UrethaneUrethane results in decreased expression of MASP2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of MASP2 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MASP2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001855complement component C4b binding-IDA22949645  
GO:0004252serine-type endopeptidase activity-IBA21873635  
GO:0004252serine-type endopeptidase activity-IDA9087411  
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI10946292  11907111  
GO:0008233peptidase activity-IDA10946292  12538697  
GO:0048306calcium-dependent protein binding-IPI12421953  
GO ID GO Term Qualifier Evidence PubMed
GO:0001867complement activation, lectin pathway-IDA9087411  17182967  
GO:0001867complement activation, lectin pathway-TAS-  
GO:0006508proteolysis-IEA-  
GO:0006956complement activation-TAS-  
GO:0006958complement activation, classical pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
hsa05150Staphylococcus aureus infection
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-166662Lectin pathway of complement activationTAS
R-HSA-166663Initial triggering of complementTAS
R-HSA-166786Creation of C4 and C2 activatorsTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-2855086Ficolins bind to repetitive carbohydrate structures on the target cell surfaceTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28303635Incident microalbuminuria and complement factor mannan-binding lectin-associated protein 19 in people with newly diagnosed type 1 diabetes. (2017 Jul)Ostergaard JADiabetes Metab Res Rev
24632598Association of MASP-2 levels and MASP2 gene polymorphisms with rheumatoid arthritis in patients and their relatives. (2014)Goeldner IPLoS One