Gene: CHL1

10752
CALL|L1CAM2
cell adhesion molecule L1 like
protein-coding
3p26.3
Ensembl:ENSG00000134121 MIM:607416 Vega:OTTHUMG00000090601 UniprotKB:O00533
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.080e-1 (AD)  3.941e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GRIA20.97
SCN2A0.966
NCKAP10.964
WDR470.964
LZTFL10.963
KIF3A0.963
ADAM220.962
PPFIA20.961
PNMA20.961
NRXN10.961

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.541
OR4F5-0.496
HEY2-0.482
CNN2-0.475
RAI14-0.464
TFPI2-0.45
FZD10-0.446
RNF135-0.445
RUNX3-0.44
MYL3-0.438

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CHL1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHL1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHL1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHL1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of CHL1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CHL1 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of CHL1 mRNA24449571
C547126AZM551248AZM551248 results in decreased expression of CHL1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CHL1 mRNA23735875
C006780bisphenol Abisphenol A results in increased expression of CHL1 mRNA29097150
D003024ClozapineClozapine results in decreased expression of CHL1 mRNA14647396
D003471CuprizoneCuprizone results in decreased expression of CHL1 mRNA26577399
D004008DiclofenacDiclofenac results in increased expression of CHL1 mRNA26934552
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CHL1 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of CHL1 mRNA23649840
D006220HaloperidolHaloperidol results in decreased expression of CHL1 mRNA14647396
D007854LeadLead affects the splicing of CHL1 mRNA28903495
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CHL1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CHL1 mRNA23649840
C500085muraglitazarmuraglitazar results in decreased expression of CHL1 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CHL1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CHL1 mRNA"25554681
D009532NickelNickel affects the expression of CHL1 mRNA14575637
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of CHL1 mRNA]14575637
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CHL1 mRNA25658374
D017374ParoxetineCHL1 affects the susceptibility to Paroxetine21332311
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CHL1 mRNA27614199
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CHL1 mRNA19710929
D011192Potassium DichromatePotassium Dichromate results in increased expression of CHL1 mRNA23608068
C089730rosiglitazonerosiglitazone results in decreased expression of CHL1 mRNA21515302
D053260SootSoot results in increased expression of CHL1 mRNA22461453|2655175
C501413tesaglitazartesaglitazar results in decreased expression of CHL1 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CHL1 mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CHL1 promoter]19654925
C009495titanium dioxidetitanium dioxide results in increased expression of CHL1 mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CHL1 mRNA20133372
C011559tributyltintributyltin results in decreased expression of CHL1 mRNA27614199
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHL1 mRNA"27188386
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of CHL1 mRNA]14575637
C012589trichostatin Atrichostatin A results in increased expression of CHL1 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CHL1 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of CHL1 mRNA21515302
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHL1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CHL1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CHL1 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CHL1 gene25560391
C025643vinclozolinvinclozolin affects the expression of CHL1 mRNA19015723
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHL1 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of CHL1 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001764neuron migration-IEA-  
GO:0007155cell adhesion-IEA-  
GO:0007165signal transduction-TAS9799093  
GO:0007411axon guidance-IEA-  
GO:0008344adult locomotory behavior-IEA-  
GO:0031103axon regeneration-IEA-  
GO:0035640exploration behavior-IEA-  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0050890cognition-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0030425dendrite-IEA-  
GO:0045177apical part of cell-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-373760L1CAM interactionsIEA
R-HSA-422475Axon guidanceIEA
R-HSA-447041CHL1 interactionsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29568376CHL1 gene polymorphisms increase lung cancer susceptibility. (2018 Mar 2)Tian WOncotarget