Gene: NES

10763
Nbla00170
nestin
protein-coding
1q23.1
Ensembl:ENSG00000132688 MIM:600915 Vega:OTTHUMG00000034299 UniprotKB:P48681
NG_012300.1
PubMed
0   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.989e-1 (AD)  3.366e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VASP0.795
MYO1C0.781
PTBP10.78
ORAI10.775
STK100.772
CDH50.77
ITGA50.767
TLN10.765
SLC43A30.765
ESAM0.762

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FGF9-0.396
SLC7A4-0.396
MYADML2-0.395
PPEF1-0.393
KCNB2-0.391
FAM19A1-0.391
ABCC12-0.389
ST6GALNAC5-0.389
SMIM18-0.389
CDH8-0.382

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of NES mRNA"26377693
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of NES protein"15212945
C1202272-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of NES mRNA"20865013
C0127292-amino-4-phosphonobutyric acid2-amino-4-phosphonobutyric acid results in increased expression of NES protein16806298
C0127292-amino-4-phosphonobutyric acidGlycine Agents inhibits the reaction [2-amino-4-phosphonobutyric acid results in increased expression of NES protein]16806298
C0125873,5,6-trichloro-2-pyridinol"3,5,6-trichloro-2-pyridinol affects the expression of NES mRNA"25137620
C0125873,5,6-trichloro-2-pyridinol"3,5,6-trichloro-2-pyridinol results in decreased expression of NES mRNA"23220036
C0125873,5,6-trichloro-2-pyridinol"3,5,6-trichloro-2-pyridinol results in increased expression of NES mRNA"23220036
C0179063-dinitrobenzene3-dinitrobenzene affects the expression of NES mRNA24140754
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of NES mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of NES mRNA"25670856
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NES mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NES mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NES mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NES mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of NES mRNA25064622
D000082AcetaminophenAcetaminophen affects the expression of NES mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NES mRNA22100608
D000638AmiodaroneAmiodarone affects the expression of NES mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NES mRNA16483693
D001151ArsenicArsenic results in decreased expression of NES mRNA25922126
D001151ArsenicArsenic results in increased methylation of NES gene25922126
C006632arsenic trioxidearsenic trioxide results in increased expression of NES mRNA22521957
D001205Ascorbic AcidAscorbic Acid results in decreased expression of NES protein15372504
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of NES mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NES mRNA21569818|2222880
D004958EstradiolEstradiol results in increased expression of NES mRNA27271280
D004958EstradiolEstradiol results in increased expression of NES protein27271280
C006780bisphenol Abisphenol A results in decreased expression of NES mRNA27271280|2927551
C006780bisphenol Abisphenol A results in decreased expression of NES protein27271280
C006780bisphenol Abisphenol A results in increased expression of NES mRNA27685785
C006780bisphenol AIGF1 protein affects the reaction [bisphenol A results in decreased expression of NES protein]27271280
C006780bisphenol AIGF1 protein inhibits the reaction [bisphenol A results in decreased expression of NES mRNA]27271280
C006780bisphenol Abisphenol A results in decreased expression of NES mRNA24090592
C006780bisphenol Abisphenol A affects the expression of NES mRNA25181051|2538157
C006780bisphenol Abisphenol A results in decreased expression of NES mRNA25381574|2596372
C006780bisphenol ACurcumin inhibits the reaction [bisphenol A results in decreased expression of NES mRNA]25963729
C032036bromobenzenebromobenzene results in increased expression of NES mRNA12628495
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of NES mRNA15003993
C018475butyraldehydebutyraldehyde results in increased expression of NES mRNA26079696
D002104CadmiumCadmium results in decreased expression of NES mRNA25922126
D002104CadmiumCadmium results in increased methylation of NES gene25922126
D002235CarbofuranCarbofuran results in decreased expression of NES mRNA22240977|2898298
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of NES mRNA19395590
D002330CarmustineCarmustine results in increased expression of NES protein17572393
D002330CarmustineMelatonin inhibits the reaction [Carmustine results in increased expression of NES protein]17572393
C473711Chir 99021"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of NES mRNA"20865013
D002746ChlorpromazineChlorpromazine affects the expression of NES mRNA25064622
D004390ChlorpyrifosChlorpyrifos results in decreased expression of NES mRNA25137620
D004390ChlorpyrifosChlorpyrifos results in increased expression of NES mRNA23220036|2601842
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NES gene20938992
D003033Coal TarCoal Tar results in increased expression of NES mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of NES mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of NES mRNA16772336
C018021cobaltous chloridecobaltous chloride results in decreased expression of NES protein16772336
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of NES mRNA20971185
D003300CopperCopper deficiency results in increased expression of NES mRNA26033743
D019327Copper SulfateCopper Sulfate results in increased expression of NES mRNA19549813
D003471CuprizoneCuprizone results in increased expression of NES mRNA27523638
D003474CurcuminCurcumin inhibits the reaction [bisphenol A results in decreased expression of NES mRNA]25963729
D003474CurcuminCurcumin results in increased expression of NES mRNA25963729
D016572CyclosporineCyclosporine affects the expression of NES mRNA25064622
D016572CyclosporineCyclosporine results in increased expression of NES mRNA25562108
D003561CytarabineCytarabine results in decreased expression of NES protein21198554
D003561CytarabineCytarabine results in increased expression of NES mRNA21198554
C014347decitabinedecitabine affects the expression of NES mRNA25922126
C014347decitabinedecitabine results in decreased methylation of NES gene19415779
C014347decitabinedecitabine results in increased acetylation of NES enhancer19415779
C014347decitabinedecitabine results in increased expression of NES mRNA19415779
D003676DeferoxamineDeferoxamine results in decreased expression of NES mRNA16772336
D003891DesipramineDesipramine results in increased expression of NES mRNA17510525
D003907DexamethasoneDexamethasone results in decreased expression of NES protein22048647
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NES mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NES mRNA21266533
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in increased expression of NES mRNA20705681
D002945Cisplatin[Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of NES mRNA21342274
D002945Cisplatin[Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of NES protein21342274
D002945CisplatinCisplatin results in decreased expression of NES mRNA22023808
C000944dicrotophosdicrotophos results in increased expression of NES mRNA28302478
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in decreased expression of NES mRNA22105179
D004237DiuronDiuron results in increased expression of NES mRNA21551480
C060311eckoleckol results in decreased expression of NES protein21514314
D000431EthanolEthanol results in increased expression of NES mRNA19460430
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NES mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NES mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NES mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of NES mRNA29097150
D005013EthosuximideEthosuximide inhibits the reaction [APP protein modified form results in decreased expression of NES mRNA]26420483
D005013EthosuximideEthosuximide results in increased expression of NES mRNA26420483
C540355fenamidonefenamidone results in increased expression of NES mRNA27029645
D005472FluorouracilFluorouracil results in decreased expression of NES mRNA26272751
D005472FluorouracilFluorouracil results in decreased expression of NES protein21296659
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NES gene20938992
C039281furanfuran results in decreased expression of NES mRNA25539665
C039281furanfuran results in increased expression of NES mRNA27387713
C001277geldanamycingeldanamycin results in increased expression of NES mRNA26705709
D018684Glycine AgentsGlycine Agents inhibits the reaction [2-amino-4-phosphonobutyric acid results in increased expression of NES protein]16806298
D017313FenretinideFenretinide results in increased expression of NES mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of NES mRNA26846883
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of NES mRNA17997286
D006861Hydrogen PeroxideSodium Selenite inhibits the reaction [Hydrogen Peroxide results in decreased expression of NES mRNA]17997286
C492448ICG 001ICG 001 results in decreased expression of NES mRNA26191083
D007545IsoproterenolIsoproterenol results in decreased expression of NES mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NES mRNA24796395|2683047
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NES protein26067464
D007649KetamineKetamine results in decreased expression of NES mRNA20080153
D007854LeadLead affects the expression of NES mRNA28903495
C008261lead acetatelead acetate results in increased expression of NES mRNA24260418
D018021Lithium ChlorideLithium Chloride results in increased expression of NES mRNA26272751
C010480lupeollupeol results in decreased expression of NES protein20979057
D008550MelatoninMelatonin results in decreased expression of NES protein21269327
D008550MelatoninMelatonin inhibits the reaction [Carmustine results in increased expression of NES protein]17572393
D008550MelatoninMelatonin results in decreased expression of NES protein16369854
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NES gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NES mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NES mRNA22555245
C004925methylmercuric chloridemethylmercuric chloride affects the expression of NES mRNA20864626
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NES mRNA19651682
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of NES mRNA26011545
D008770MethylnitrosoureaMethylnitrosourea results in increased methylation of NES gene25922126
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of NES protein18155124
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of NES protein26558463
C091888monoisoamyl-2,3-dimercaptosuccinate"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of NES mRNA]"19615344
C091888monoisoamyl-2,3-dimercaptosuccinate"monoisoamyl-2,3-dimercaptosuccinate results in increased expression of NES mRNA"19615344
D009020MorphineMorphine results in decreased expression of NES mRNA26877219
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NES mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of NES mRNA19812364
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of NES mRNA20971185
C025589ochratoxin Aochratoxin A results in decreased expression of NES mRNA21703336
C025589ochratoxin ASHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of NES mRNA]21703336
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of NES mRNA"25137620
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of NES mRNA"23220036
D010100OxygenOxygen deficiency results in decreased expression of NES mRNA26516004
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in increased expression of NES mRNA20705681
D010261ParaoxonParaoxon results in increased expression of NES mRNA27117976
D010269ParaquatParaquat affects the expression of NES mRNA25064622
D010269ParaquatParaquat results in decreased expression of NES mRNA25314302
D010400Penicillin GPenicillin G affects the expression of NES mRNA25137620
D010400Penicillin GPenicillin G results in increased expression of NES protein16137769|1636985
D010433PentylenetetrazolePentylenetetrazole affects the expression of NES mRNA21503142
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of NES mRNA25510869
D010672PhenytoinPhenytoin results in decreased expression of NES mRNA26272751
D011374ProgesteroneProgesterone results in decreased expression of NES mRNA21795739
D011374ProgesteroneProgesterone results in decreased expression of NES mRNA20726854
C513428pyrachlostrobinpyrachlostrobin results in increased expression of NES mRNA27029645
D011794QuercetinQuercetin results in decreased expression of NES protein22422628
D011794QuercetinQuercetin affects the expression of NES mRNA18178720
C059514resveratrolresveratrol results in decreased expression of NES mRNA22692956
C059514resveratrolresveratrol results in decreased expression of NES protein18089832|2269295
C059514resveratrolresveratrol results in increased expression of NES protein24464877
D012439SaccharinSaccharin results in increased expression of NES mRNA26272751
D012834SilverSilver results in increased expression of NES mRNA27131904
C017947sodium arsenite"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of NES mRNA]"19615344
C017947sodium arsenitesodium arsenite affects the methylation of NES gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of NES mRNA19615344
C017947sodium arsenitesodium arsenite results in decreased expression of NES protein23219847
D018038Sodium SeleniteSodium Selenite inhibits the reaction [Hydrogen Peroxide results in decreased expression of NES mRNA]17997286
D012999SomanSoman results in increased expression of NES mRNA19281266
D053260SootSoot results in increased expression of NES mRNA26551751
D013311StreptozocinINS protein inhibits the reaction [Streptozocin results in decreased expression of NES mRNA]19388005
D013311StreptozocinStreptozocin results in decreased expression of NES mRNA19388005
D013311StreptozocinStreptozocin results in decreased expression of NES protein19388005
C105686SU 5402"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of NES mRNA"20865013
C021751tanshinonetanshinone results in decreased expression of NES mRNA16955220
C021751tanshinonetanshinone results in decreased expression of NES protein16955220
C004648testosterone enanthatetestosterone enanthate affects the expression of NES mRNA17440010
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NES mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NES mRNA17942748|2892240
D013752TetracyclineTetracycline affects the expression of NES mRNA25064622
D019284ThapsigarginThapsigargin results in decreased expression of NES mRNA22378314
D013849ThimerosalThimerosal results in decreased expression of NES mRNA27188386
D013853ThioacetamideThioacetamide affects the expression of NES mRNA25064622
D014212Tretinoin[NTF3 protein co-treated with Tretinoin] results in increased expression of NES protein16996685
D014212TretinoinTretinoin results in increased expression of NES mRNA18599177
D014212TretinoinTretinoin results in decreased expression of NES mRNA26272751
D014212TretinoinTretinoin results in increased expression of NES mRNA25137620
D014212TretinoinTretinoin results in increased expression of NES protein16806298|1706435
D014212TretinoinTretinoin results in decreased expression of NES protein16944780
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NES mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of NES mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in decreased methylation of NES gene19415779
C012589trichostatin Atrichostatin A results in increased acetylation of NES enhancer19415779
C012589trichostatin Atrichostatin A results in increased expression of NES mRNA19415779
C040533trimethyltin chloridetrimethyltin chloride results in increased expression of NES mRNA19651682
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NES mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of NES mRNA22378314
D014520UrethaneUrethane results in decreased expression of NES mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of NES mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of NES mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NES mRNA23527032
D014635Valproic AcidValproic Acid results in increased expression of NES mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of NES gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of NES mRNA26272751
D014635Valproic AcidValproic Acid results in increased expression of NES mRNA25137620
D014635Valproic AcidValproic Acid results in increased expression of NES mRNA19651682|2356265
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NES mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of NES mRNA26272509|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005198structural molecule activity-IEA-  
GO:0019215intermediate filament binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-IDA19384922  
GO:0007417central nervous system development-NAS9917366  
GO:0007420brain development-ISS-  
GO:0030844positive regulation of intermediate filament depolymerization-ISS-  
GO:0031076embryonic camera-type eye development-ISS-  
GO:0032091negative regulation of protein binding-IDA21185309  
GO:0043086negative regulation of catalytic activity-IDA21185309  
GO:0072089stem cell proliferation-IMP19384922  
GO:2000179positive regulation of neural precursor cell proliferation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA19384922  
GO:0005882intermediate filament-NAS9917366  
GO:0045111intermediate filament cytoskeleton-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28360656Night Eating Syndrome in Major Depression and Anxiety Disorders. (2014 Dec)Kucukgoncu SNoro Psikiyatr Ars