Gene: IQGAP2

10788
-
IQ motif containing GTPase activating protein 2
protein-coding
5q13.3
Ensembl:ENSG00000145703 MIM:605401 Vega:OTTHUMG00000162432 UniprotKB:Q13576
NG_053128.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.397e-1 (AD)  5.061e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10942782chr5:76485465 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08595501chr5:75878300IQGAP23.880e-8Tobacco smoking28225026

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SAMD90.797
FAM3B0.786
KYNU0.773
FRRS10.773
ARHGAP150.767
TLR30.765
SIGLEC70.763
SP1400.761
CYTIP0.759
IL150.754

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAGHL-0.34
FEZF2-0.326
KRTAP5-7-0.325
MYADML2-0.313
NEUROG2-0.305
MYH7B-0.304
HHATL-0.295
PNPLA7-0.287
CCDC78-0.287
TMEM191C-0.285

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of IQGAP2 mRNA"23962555
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of IQGAP2 mRNA]"19467301
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IQGAP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IQGAP2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of IQGAP2 mRNA21420995|2906747
D016604Aflatoxin B1Aflatoxin B1 affects the expression of IQGAP2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of IQGAP2 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of IQGAP2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of IQGAP2 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of IQGAP2 mRNA21757418
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of IQGAP2 mRNA"17331233
D001241AspirinAspirin results in increased expression of IQGAP2 mRNA15456535
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IQGAP2 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IQGAP2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IQGAP2 mRNA22300585
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of IQGAP2 mRNA"26238291
C006780bisphenol Abisphenol A affects the expression of IQGAP2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of IQGAP2 mRNA26063408
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of IQGAP2 mRNA22079614
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of IQGAP2 mRNA24982889
D019256Cadmium ChlorideCadmium Chloride affects the expression of IQGAP2 mRNA18804290
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of IQGAP2 mRNA28472532
D002994ClofibrateClofibrate affects the expression of IQGAP2 mRNA16081524
D003035Cobalt[tungsten carbide binds to Cobalt] which results in decreased expression of IQGAP2 mRNA20105288
C018021cobaltous chloridecobaltous chloride results in decreased expression of IQGAP2 mRNA20105288
D019327Copper SulfateCopper Sulfate results in decreased expression of IQGAP2 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of IQGAP2 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in decreased expression of IQGAP2 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of IQGAP2 mRNA19770486
D003976DiazinonDiazinon results in increased methylation of IQGAP2 gene22964155
C016366dibenzothiophenedibenzothiophene results in increased expression of IQGAP2 mRNA23656968
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of IQGAP2 mRNA21266533
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of IQGAP2 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of IQGAP2 mRNA19467301|2501614
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of IQGAP2 mRNA26464624
D004610Ellagic AcidEllagic Acid results in increased expression of IQGAP2 mRNA12002526
C118739entinostatentinostat results in increased expression of IQGAP2 mRNA27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of IQGAP2 mRNA23649840
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of IQGAP2 mRNA]15016801
D005557FormaldehydeFormaldehyde results in decreased expression of IQGAP2 mRNA23649840
D019833GenisteinGenistein results in decreased expression of IQGAP2 mRNA15378649
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of IQGAP2 mRNA22634610
D006046Gold[Gold co-treated with Polyethylene Glycols] results in decreased expression of IQGAP2 mRNA19695318
D017313FenretinideFenretinide results in decreased expression of IQGAP2 mRNA28973697
D017313FenretinideFenretinide results in increased expression of IQGAP2 mRNA28973697
D007213IndomethacinIndomethacin results in decreased expression of IQGAP2 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IQGAP2 mRNA25613284
D007529IsoflavonesIsoflavones results in decreased expression of IQGAP2 mRNA17374662
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IQGAP2 mRNA26752646
C410337K 7174K 7174 results in decreased expression of IQGAP2 mRNA24086573
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of IQGAP2 mRNA"24972896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IQGAP2 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IQGAP2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of IQGAP2 mRNA"20188158
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of IQGAP2 mRNA22401849
C029938nickel sulfatenickel sulfate results in increased expression of IQGAP2 mRNA22714537
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IQGAP2 mRNA"19013360
D010126Ozone"[Water Pollutants, Chemical co-treated with Ozone] results in decreased expression of IQGAP2 mRNA"23246600
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of IQGAP2 mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of IQGAP2 mRNA18804290
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of IQGAP2 mRNA17097637
D010634PhenobarbitalPhenobarbital affects the expression of IQGAP2 mRNA23091169
D011092Polyethylene Glycols[Gold co-treated with Polyethylene Glycols] results in decreased expression of IQGAP2 mRNA19695318
D011374ProgesteroneProgesterone results in increased expression of IQGAP2 mRNA21795739
D011794QuercetinQuercetin results in decreased expression of IQGAP2 mRNA21632981
C059514resveratrolresveratrol results in decreased expression of IQGAP2 mRNA18586690
D012834SilverSilver results in decreased expression of IQGAP2 mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of IQGAP2 gene28589171
D012969Sodium FluorideSodium Fluoride results in decreased expression of IQGAP2 protein28918527
D018038Sodium SeleniteSodium Selenite results in increased expression of IQGAP2 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IQGAP2 mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IQGAP2 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of IQGAP2 gene26756918
D014212TretinoinTretinoin results in increased expression of IQGAP2 mRNA23830798
C002802tungsten carbide[tungsten carbide binds to Cobalt] which results in decreased expression of IQGAP2 mRNA20105288
C002802tungsten carbidetungsten carbide results in decreased expression of IQGAP2 mRNA20105288
D014501UraniumUranium affects the expression of IQGAP2 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of IQGAP2 mRNA15672453
D014520UrethaneUrethane results in decreased expression of IQGAP2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IQGAP2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of IQGAP2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of IQGAP2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of IQGAP2 mRNA23179753|2627250
D014750VincristineVincristine results in decreased expression of IQGAP2 mRNA23649840
C111237vorinostatvorinostat results in increased expression of IQGAP2 mRNA27188386
D014874Water Pollutants, Chemical"[Water Pollutants, Chemical co-treated with Ozone] results in decreased expression of IQGAP2 mRNA"23246600
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of IQGAP2 mRNA"23246600
D019287Zinc SulfateZinc Sulfate results in increased expression of IQGAP2 mRNA19013360

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-TAS8756646  
GO:0005095GTPase inhibitor activity-TAS8756646  
GO:0005515protein binding-IPI17314511  17353931  
GO:0005516calmodulin binding-IPI21299499  
GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding-IDA22493426  
GO:0017048Rho GTPase binding-IDA12515716  
GO:0048365Rac GTPase binding-IDA12515716  
GO:0051015actin filament binding-IDA12515716  
GO:0071933Arp2/3 complex binding-IDA12515716  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS8756646  
GO:0034260negative regulation of GTPase activity-IEA-  
GO:0034314Arp2/3 complex-mediated actin nucleation-IDA12515716  
GO:0043312neutrophil degranulation-TAS-  
GO:0070493thrombin-activated receptor signaling pathway-IDA12515716  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA12515716  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0005902microvillus-IEA-  
GO:0009986cell surface-IDA12515716  
GO:0015629actin cytoskeleton-TAS8756646  
GO:0030027lamellipodium-IDA12515716  
GO:0030175filopodium-IDA12515716  
GO:0030667secretory granule membrane-TAS-  
GO:0031941filamentous actincolocalizes_withIDA12515716  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-5626467RHO GTPases activate IQGAPsTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal