Gene: ZNF460

10794
HZF8|ZNF272
zinc finger protein 460
protein-coding
19q13.43
Ensembl:ENSG00000197714 MIM:604755 Vega:OTTHUMG00000183222 UniprotKB:Q14592
NC_000019.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.832e-1 (AD)  9.118e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3746228chr19:57292994 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZBTB200.832
NBEAL10.775
AGO20.766
OMP0.733
LONRF30.713
ZNF4830.704
ZNF8050.691
PCDHGA80.686
PRR260.685
NUTM10.684

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHST8-0.313
CRYBA2-0.277
C11orf80-0.261
HENMT1-0.258
MYCNOS-0.253
ACRV1-0.251
RASGEF1C-0.242
GLYATL2-0.239
GPD1-0.237
SMIM18-0.237

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D004958EstradiolEstradiol results in increased expression of ZNF460 mRNA23019147
C006780bisphenol Abisphenol A results in decreased expression of ZNF460 mRNA24901218|2768578
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ZNF460 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ZNF460 mRNA27594783
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ZNF460 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of ZNF460 mRNA27392435
C045463leflunomideleflunomide results in increased expression of ZNF460 mRNA28988120
C031389resorcinolresorcinol results in decreased expression of ZNF460 mRNA22623647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZNF460 mRNA22574217
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ZNF460 mRNA28065790
C012589trichostatin Atrichostatin A results in decreased expression of ZNF460 mRNA28542535
D014520UrethaneUrethane results in increased expression of ZNF460 mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal