Gene info: ID 108

Gene: ADCY2

GENE ID: 108

Synonyms: AC2|HBAC2

Description: adenylate cyclase 2

Gene type: protein-coding

Location: 5p15.31

dbXrefs: Ensembl:ENSG00000078295 MIM:103071 Vega:OTTHUMG00000090476 UniprotKB:Q08462

RefSeq: NG_046913.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 2

Sherlock p-value : NA (AD) 3.648e-1 (ND) (Frontal_Cortex)

Pascal p-value : 7.186e-1 (AD) 4.700e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FMN2	0.885
ITSN1	0.872
LSAMP	0.858
PTPRF	0.858
CTNNA2	0.854
PRKCA	0.854
AGPAT3	0.853
PC	0.851
NTM	0.85
SLC1A4	0.85

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.629
OR4F29	-0.571
GADL1	-0.485
DPPA4	-0.484
CD3G	-0.479
CD2	-0.47
TBX21	-0.467
LY9	-0.467
FOXI2	-0.464
FCRL1	-0.459

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB02587	Colforsin	Small Molecule	66575-29-9	Experimental\|Investigational	Target
DB06843	2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE	Small Molecule		Experimental	Target
DB09121	Aurothioglucose	Small Molecule	12192-57-3	Approved\|Withdrawn	Target

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ADCY2 mRNA"	27291303
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ADCY2 mRNA"	19114083
C008745	4,4'-bisphenol F	"4,4'-bisphenol F results in decreased expression of ADCY2 mRNA"	26186136
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of ADCY2 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCY2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCY2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCY2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCY2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCY2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCY2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCY2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCY2 mRNA"	27188386
D020106	Acrylamide	Acrylamide results in decreased expression of ADCY2 mRNA	28959563
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ADCY2 mRNA	16483693
D001151	Arsenic	Arsenic affects the methylation of ADCY2 gene	25304211
C547126	AZM551248	AZM551248 results in decreased expression of ADCY2 mRNA	22323515
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of ADCY2 mRNA	26186136
C006780	bisphenol A	bisphenol A results in increased expression of ADCY2 mRNA	27685785
C006780	bisphenol A	bisphenol A results in decreased expression of ADCY2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of ADCY2 mRNA	26141625
C006780	bisphenol A	bisphenol A results in increased methylation of ADCY2 gene	28505145
C055494	caffeic acid phenethyl ester	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ADCY2 mRNA	20360939
D002220	Carbamazepine	Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY2 protein]	19922557
D002713	Chlorine	[Ozone co-treated with Chlorine] results in increased expression of ADCY2 mRNA	18636392
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADCY2 mRNA	20938992
D002994	Clofibrate	Clofibrate results in decreased expression of ADCY2 mRNA	17585979
D003042	Cocaine	Cocaine affects the expression of ADCY2 mRNA	20187946
D003300	Copper	[Copper co-treated with Dietary Sucrose] results in increased expression of ADCY2 mRNA	26033743
D003300	Copper	Copper deficiency results in increased expression of ADCY2 mRNA	26033743
D003976	Diazinon	Diazinon results in decreased expression of ADCY2 mRNA	17452286
D019422	Dietary Sucrose	[Copper co-treated with Dietary Sucrose] results in increased expression of ADCY2 mRNA	26033743
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of ADCY2 mRNA	26033743
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ADCY2 mRNA	20360939
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ADCY2 mRNA"	22485181
C118739	entinostat	entinostat results in increased expression of ADCY2 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCY2 mRNA"	27188386
C514340	estradiol-17-benzoate	[Genistein co-treated with estradiol-17-benzoate co-treated with Progesterone] results in increased expression of ADCY2 protein	26529183
C514340	estradiol-17-benzoate	[Genistein co-treated with estradiol-17-benzoate] results in increased expression of ADCY2 protein	26529183
D000431	Ethanol	Ethanol results in increased expression of ADCY2 mRNA	20655511
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADCY2 mRNA	17942748
D005419	Flavonoids	Flavonoids results in increased expression of ADCY2 mRNA	18035473
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADCY2 mRNA	20938992
D004397	Fonofos	Fonofos results in increased methylation of ADCY2 promoter	22847954
D019833	Genistein	[Genistein co-treated with estradiol-17-benzoate co-treated with Progesterone] results in increased expression of ADCY2 protein	26529183
D019833	Genistein	[Genistein co-treated with estradiol-17-benzoate] results in increased expression of ADCY2 protein	26529183
D007657	Ketone Bodies	Ketone Bodies results in increased expression of ADCY2 mRNA	16807920
D007854	Lead	Lead affects the expression of ADCY2 mRNA	28903495
C042720	mercuric bromide	mercuric bromide results in increased expression of ADCY2 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCY2 mRNA"	27188386
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADCY2 mRNA	20938992
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of ADCY2 mRNA	23649840
D009532	Nickel	Nickel results in decreased expression of ADCY2 mRNA	24768652\|2558310
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of ADCY2 mRNA	25729387
D010126	Ozone	[Ozone co-treated with Chlorine] results in increased expression of ADCY2 mRNA	18636392
D010278	Parathion	Parathion results in increased methylation of ADCY2 promoter	22847954
D010575	Pesticides	Pesticides results in decreased methylation of ADCY2 gene	28396702
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCY2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of ADCY2 mRNA	26272509
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ADCY2 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of ADCY2 mRNA	20813756
D011374	Progesterone	[Genistein co-treated with estradiol-17-benzoate co-treated with Progesterone] results in increased expression of ADCY2 protein	26529183
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of ADCY2 mRNA	16079270
D012643	Selenium	[Selenium co-treated with Vitamin E] results in increased expression of ADCY2 mRNA	19244175
D012643	Selenium	Selenium results in decreased expression of ADCY2 mRNA	19244175
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of ADCY2 mRNA	22431001
C071262	SK&F 82958	Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY2 protein]	19922557
C071262	SK&F 82958	[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY2 protein	19922557
C017947	sodium arsenite	sodium arsenite results in decreased expression of ADCY2 protein	21925251
C012568	terbufos	terbufos results in increased methylation of ADCY2 promoter	22847954
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADCY2 mRNA	17942748
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of ADCY2 mRNA	25729387
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADCY2 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of ADCY2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of ADCY2 mRNA	23179753\|2438349
C066075	vanadium pentoxide	vanadium pentoxide affects the expression of ADCY2 mRNA	26210822
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in increased expression of ADCY2 mRNA	19244175
C111237	vorinostat	vorinostat results in decreased expression of ADCY2 mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000287	magnesium ion binding	-	ISS	-
GO:0004016	adenylate cyclase activity	-	ISS	-
GO:0004016	adenylate cyclase activity	-	NAS	1427768
GO:0005524	ATP binding	-	IEA	-
GO:0008179	adenylate cyclase binding	-	ISS	-
GO:0030145	manganese ion binding	-	ISS	-
GO:0046982	protein heterodimerization activity	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003091	renal water homeostasis	-	TAS	-
GO:0006171	cAMP biosynthetic process	-	ISS	-
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	-	ISS	-
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	-	ISS	-
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	-	TAS	-
GO:0019933	cAMP-mediated signaling	-	ISS	-
GO:0071377	cellular response to glucagon stimulus	-	TAS	-
GO:1904322	cellular response to forskolin	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005622	intracellular	-	ISS	-
GO:0005737	cytoplasm	-	IDA	11549699
GO:0005886	plasma membrane	-	IDA	11549699
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	ISS	-
GO:0016020	membrane	-	ISS	-
GO:0030425	dendrite	-	ISS	-
GO:0045121	membrane raft	-	ISS	-

KEGG ID	KEGG Term
hsa00230	Purine metabolism
hsa04020	Calcium signaling pathway
hsa04062	Chemokine signaling pathway
hsa04114	Oocyte meiosis
hsa04270	Vascular smooth muscle contraction
hsa04540	Gap junction
hsa04912	GnRH signaling pathway
hsa04914	Progesterone-mediated oocyte maturation
hsa04916	Melanogenesis
hsa04970	Salivary secretion
hsa04971	Gastric acid secretion
hsa04972	Pancreatic secretion
hsa04976	Bile secretion
hsa05414	Dilated cardiomyopathy

Reactome ID	Reactome Term	Evidence
R-HSA-111885	Opioid Signalling	TAS
R-HSA-111885	Opioid Signalling	IEA
R-HSA-111931	PKA-mediated phosphorylation of CREB	TAS
R-HSA-111933	Calmodulin induced events	TAS
R-HSA-111996	Ca-dependent events	TAS
R-HSA-111997	CaM pathway	TAS
R-HSA-112040	G-protein mediated events	TAS
R-HSA-112040	G-protein mediated events	IEA
R-HSA-112043	PLC beta mediated events	TAS
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	IEA
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112315	Transmission across Chemical Synapses	IEA
R-HSA-112316	Neuronal System	TAS
R-HSA-112316	Neuronal System	IEA
R-HSA-1430728	Metabolism	TAS
R-HSA-1489509	DAG and IP3 signaling	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-163359	Glucagon signaling in metabolic regulation	TAS
R-HSA-163615	PKA activation	TAS
R-HSA-163685	Integration of energy metabolism	TAS
R-HSA-164378	PKA activation in glucagon signalling	TAS
R-HSA-170660	Adenylate cyclase activating pathway	TAS
R-HSA-170670	Adenylate cyclase inhibitory pathway	TAS
R-HSA-170670	Adenylate cyclase inhibitory pathway	IEA
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-372790	Signaling by GPCR	IEA
R-HSA-382551	Transport of small molecules	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-388396	GPCR downstream signalling	IEA
R-HSA-418555	G alpha (s) signalling events	TAS
R-HSA-418555	G alpha (s) signalling events	IEA
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-418594	G alpha (i) signalling events	IEA
R-HSA-418597	G alpha (z) signalling events	IEA
R-HSA-418597	G alpha (z) signalling events	TAS
R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins	TAS
R-HSA-445717	Aquaporin-mediated transport	TAS
R-HSA-5358351	Signaling by Hedgehog	TAS
R-HSA-5610787	Hedgehog 'off' state	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-977443	GABA receptor activation	TAS
R-HSA-977443	GABA receptor activation	IEA
R-HSA-977444	GABA B receptor activation	TAS
R-HSA-977444	GABA B receptor activation	IEA
R-HSA-991365	Activation of GABAB receptors	TAS
R-HSA-991365	Activation of GABAB receptors	IEA
R-HSA-997269	Inhibition of adenylate cyclase pathway	TAS
R-HSA-997269	Inhibition of adenylate cyclase pathway	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23278386	Genetic markers of comorbid depression and alcoholism in women. (2013 Jun)	Procopio DO	Alcohol Clin Exp Res
22461431	CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland. (2012 Aug)	Hardin M	Am J Respir Cell Mol Biol