Gene: CYSLTR1

10800
CYSLT1|CYSLT1R|CYSLTR|HMTMF81
cysteinyl leukotriene receptor 1
protein-coding
Xq21.1
Ensembl:ENSG00000173198 MIM:300201 Vega:OTTHUMG00000021889 UniprotKB:Q9Y271
NG_012809.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PGM50.763
MPEG10.758
HMCN10.758
DPEP20.736
COL14A10.736
PDE5A0.731
KCNE30.727
ATP2A30.72
OLFML2A0.715
LEPR0.714

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM43B-0.404
GDF10-0.387
GNB1L-0.379
C9orf24-0.367
ASPDH-0.367
SOX15-0.356
MESP1-0.351
BGLAP-0.348
RND1-0.347
KLHL26-0.345

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00471MontelukastSmall Molecule158966-92-8ApprovedTarget
DB00549ZafirlukastSmall Molecule107753-78-6Approved|InvestigationalTarget
DB00587CinalukastSmall Molecule128312-51-6ApprovedTarget
DB00716NedocromilSmall Molecule69049-73-6Approved|InvestigationalTarget
DB01411PranlukastSmall Molecule103177-37-3Approved|InvestigationalTarget
DB08855Leukotriene C4Small Molecule72025-60-6Experimental|InvestigationalTarget
DB11858Leukotriene D4Small Molecule73836-78-9InvestigationalTarget
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of CYSLTR1 mRNA19933214
C5023062-4-(3-(1H-1,2,3,4-tetraazol-5-yl)propoxy)phenethyl-1,3-isoindolinedione"2-4-(3-(1H-1,2,3,4-tetraazol-5-yl)propoxy)phenethyl-1,3-isoindolinedione binds to and results in decreased activity of CYSLTR1 protein"12031336
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of CYSLTR1 mRNA19191707
C010395acetylsalicylic acid lysinateacetylsalicylic acid lysinate inhibits the reaction [IL4 results in increased expression of CYSLTR1 mRNA]19767084
C006303acivicinacivicin inhibits the reaction [LY 171883 inhibits the reaction [Leukotriene C4 results in increased activity of CYSLTR1 protein]]1651863
C006303acivicinacivicin inhibits the reaction [zafirlukast inhibits the reaction [Leukotriene C4 results in increased activity of CYSLTR1 protein]]1651863
C006303acivicinacivicin promotes the reaction [Leukotriene C4 results in increased activity of CYSLTR1 protein]1651863
C049740alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanolalpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]14718577
C049740alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanolalpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [montelukast binds to and results in decreased activity of CYSLTR1 protein]14718577
C049740alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanolalpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [verlukast binds to and results in decreased activity of CYSLTR1 protein]14718577
C049740alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanolalpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [zafirlukast binds to and results in decreased activity of CYSLTR1 protein]14718577
C049740alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanolalpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol binds to and results in decreased activity of CYSLTR1 protein19837106
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CYSLTR1 mRNA16483693
D001194AsbestosAsbestos results in decreased expression of CYSLTR1 mRNA22398240
D001241AspirinAspirin inhibits the reaction [IL4 results in increased expression of CYSLTR1 mRNA]19767084
D001241AspirinAspirin results in increased expression of CYSLTR1 mRNA17641958
D001241AspirinCYSLTR1 gene SNP affects the susceptibility to Aspirin20485159
D001241AspirinCYSLTR1 SNP affects the susceptibility to Aspirin16630147|1837986
C071435BAY u9773BAY u9773 binds to and results in decreased activity of CYSLTR1 protein18651869
C071435BAY u9773BAY u9773 binds to and results in increased activity of CYSLTR1 protein9797038
C071435BAY u9773BAY u9773 inhibits the reaction [CYSLTR1 protein results in increased susceptibility to Leukotriene D4]9797038
C071435BAY u9773BAY u9773 inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]18651869
C071435BAY u9773CYSLTR1 protein results in increased susceptibility to BAY u97739797038
C071435BAY u9773ICI 198615 inhibits the reaction [CYSLTR1 protein results in increased susceptibility to BAY u9773]9797038
C071435BAY u9773BAY u9773 binds to and results in decreased activity of CYSLTR1 protein10851239|1109380
C071435BAY u9773BAY u9773 binds to and results in increased activity of CYSLTR1 protein14718577
C071435BAY u9773BAY u9773 binds to CYSLTR1 protein10825389
C071435BAY u9773BAY u9773 inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]14718577
C071435BAY u9773BAY u9773 inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]11093801
C071435BAY u9773BAY u9773 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]10825389
C071435BAY u9773BAY u9773 binds to and results in decreased activity of CYSLTR1 protein15888248
D001507BeclomethasoneBeclomethasone results in increased expression of CYSLTR1 mRNA23656298
D004958EstradiolEstradiol results in increased expression of CYSLTR1 mRNA19484750
D001622BetaineBetaine results in increased expression of CYSLTR1 mRNA26391144
C006780bisphenol Abisphenol A results in decreased expression of CYSLTR1 mRNA25181051
D002118CalciumBAY u9773 inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]11093801
D002118Calcium[CP 199330 binds to and results in decreased activity of CYSLTR1 protein] which affects the abundance of Calcium10509933
D002118Calcium[CP 199331 binds to and results in decreased activity of CYSLTR1 protein] which affects the abundance of Calcium10509933
D002118Calcium[CP 265298 binds to and results in decreased activity of CYSLTR1 protein] which results in decreased abundance of Calcium9934474
D002118Calcium[CP 288886 binds to and results in decreased activity of CYSLTR1 protein] which results in decreased abundance of Calcium9934474
D002118CalciumCYSLTR1 protein promotes the reaction [Leukotriene D4 results in increased abundance of Calcium]15990778
D002118Calcium[Leukotriene C4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium10391245|1046255
D002118Calcium[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium10391245|1046255
D002118Calcium[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium18704935
D002118Calcium[Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium10462554|1285384
D002118Calciummontelukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]10462554|1285384
D002118Calciummontelukast inhibits the reaction [[Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]20083671
D002118Calciumpobilukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]10462554
D002118Calcium[pranlukast binds to and results in decreased activity of CYSLTR1 protein] which affects the abundance of Calcium10509933
D002118Calciumpranlukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]10462554
D002118Calcium[Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium20083671
D002118Calciumverlukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]8014876
D002118Calcium[zafirlukast binds to and results in decreased activity of CYSLTR1 protein] which affects the abundance of Calcium10509933
D002118Calciumzafirlukast inhibits the reaction [CYSLTR1 protein promotes the reaction [Leukotriene D4 results in increased abundance of Calcium]]15990778
D002118Calciumzafirlukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]10462554|1285384
D002118Calciumzafirlukast inhibits the reaction [[Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]20083671
D002118Calcium[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium11705452|1579279
C112382CGP 57698CGP 57698 binds to CYSLTR1 protein10825389
C112382CGP 57698CGP 57698 inhibits the reaction [Leukotriene C4 binds to CYSLTR1 protein]10825389
C112382CGP 57698CGP 57698 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]10825389
D002737ChloropreneChloroprene results in decreased expression of CYSLTR1 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CYSLTR1 mRNA20938992
C122098CP 199330CP 199330 binds to and results in decreased activity of CYSLTR1 protein10509933
C122098CP 199330[CP 199330 binds to and results in decreased activity of CYSLTR1 protein] which affects the abundance of Calcium10509933
C122099CP 199331CP 199331 binds to and results in decreased activity of CYSLTR1 protein10509933
C122099CP 199331[CP 199331 binds to and results in decreased activity of CYSLTR1 protein] which affects the abundance of Calcium10509933
C118020CP 265298CP 265298 binds to and results in decreased activity of CYSLTR1 protein9934474
C118020CP 265298CP 265298 binds to and results in decreased activity of CYSLTR1 protein9934474
C118020CP 265298[CP 265298 binds to and results in decreased activity of CYSLTR1 protein] which results in decreased abundance of Calcium9934474
C118021CP 288886CP 288886 binds to and results in decreased activity of CYSLTR1 protein9934474
C118021CP 288886CP 288886 binds to and results in decreased activity of CYSLTR1 protein9934474
C118021CP 288886[CP 288886 binds to and results in decreased activity of CYSLTR1 protein] which results in decreased abundance of Calcium9934474
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CYSLTR1 mRNA17361019
C083427(E)-3-((((6-(2-carboxyethenyl)-5-((8-(4-methoxyphenyl)octyl)oxy)-2-pyridinyl)methyl)thio)methyl)benzoic acid(E)-3-((((6-(2-carboxyethenyl)-5-((8-(4-methoxyphenyl)octyl)oxy)-2-pyridinyl)methyl)thio)methyl)benzoic acid binds to CYSLTR1 protein10477044
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CYSLTR1 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CYSLTR1 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of CYSLTR1 mRNA23649840
C006312FPL 55712FPL 55712 inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]9620942
C412815GW 4064GW 4064 results in decreased expression of CYSLTR1 mRNA26655953
D007975Leukotriene B4[LY 171883 binds to and results in decreased activity of CYSLTR1 protein] which results in decreased abundance of Leukotriene B48014878
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CYSLTR1 mRNA18951874
C054217ICI 198615ICI 198615 binds to and results in decreased activity of CYSLTR1 protein9797038
C054217ICI 198615ICI 198615 inhibits the reaction [CYSLTR1 protein results in increased susceptibility to BAY u9773]9797038
C054217ICI 198615ICI 198615 inhibits the reaction [CYSLTR1 protein results in increased susceptibility to Leukotriene D4]9797038
C054217ICI 198615ICI 198615 results in decreased activity of CYSLTR1 protein8111568
C054217ICI 198615ICI 198615 binds to and results in decreased activity of CYSLTR1 protein18500362
C067425iralukastiralukast binds to CYSLTR1 protein10825389
C067425iralukastiralukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]10825389
D007545IsoproterenolIsoproterenol results in increased expression of CYSLTR1 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CYSLTR1 mRNA23086925
D020910KetorolacKetorolac inhibits the reaction [IL4 results in increased expression of CYSLTR1 mRNA]19767084
D017999Leukotriene E4Leukotriene E4 results in increased activity of CYSLTR1 protein11834255
D017999Leukotriene E4Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein10462554|1285384
D017999Leukotriene E4[Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium10462554|1285384
D017999Leukotriene E4Leukotriene E4 binds to CYSLTR1 protein8384568
D017999Leukotriene E4montelukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]9620942
D017999Leukotriene E4zafirlukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]9620942
D017999Leukotriene E4Leukotriene E4 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]11705452
D017997Leukotriene C4acivicin inhibits the reaction [LY 171883 inhibits the reaction [Leukotriene C4 results in increased activity of CYSLTR1 protein]]1651863
D017997Leukotriene C4acivicin inhibits the reaction [zafirlukast inhibits the reaction [Leukotriene C4 results in increased activity of CYSLTR1 protein]]1651863
D017997Leukotriene C4acivicin promotes the reaction [Leukotriene C4 results in increased activity of CYSLTR1 protein]1651863
D017997Leukotriene C4Leukotriene C4 results in increased activity of CYSLTR1 protein1651863
D017997Leukotriene C4LY 171883 inhibits the reaction [Leukotriene C4 results in increased activity of CYSLTR1 protein]1651863
D017997Leukotriene C4zafirlukast inhibits the reaction [Leukotriene C4 results in increased activity of CYSLTR1 protein]1651863
D017997Leukotriene C4CGP 57698 inhibits the reaction [Leukotriene C4 binds to CYSLTR1 protein]10825389
D017997Leukotriene C4Leukotriene C4 binds to and results in increased activity of CYSLTR1 protein10391245|1046255
D017997Leukotriene C4[Leukotriene C4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium10391245|1046255
D017997Leukotriene C4Leukotriene C4 binds to CYSLTR1 protein10825389|1199689
D017997Leukotriene C4MEN91507 inhibits the reaction [Leukotriene C4 binds to CYSLTR1 protein]11996896
D017997Leukotriene C4pobilukast inhibits the reaction [Leukotriene C4 binds to CYSLTR1 protein]10825389
D017997Leukotriene C4pranlukast inhibits the reaction [Leukotriene C4 binds to CYSLTR1 protein]10825389|1199689
D017997Leukotriene C4CYSLTR1 protein binds to and affects the susceptibility to Leukotriene C411932261
D017997Leukotriene C4Leukotriene C4 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]11705452
D017998Leukotriene D4BAY u9773 inhibits the reaction [CYSLTR1 protein results in increased susceptibility to Leukotriene D4]9797038
D017998Leukotriene D4BAY u9773 inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]18651869
D017998Leukotriene D4CYSLTR1 protein results in increased susceptibility to Leukotriene D49797038
D017998Leukotriene D4FPL 55712 inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]9620942
D017998Leukotriene D4ICI 198615 inhibits the reaction [CYSLTR1 protein results in increased susceptibility to Leukotriene D4]9797038
D017998Leukotriene D4Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein18651869|9620942
D017998Leukotriene D4LY 171883 inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]9620942
D017998Leukotriene D4montelukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]18651869
D017998Leukotriene D4zafirlukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]18651869|9620942
D017998Leukotriene D4alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]14718577
D017998Leukotriene D4BAY u9773 inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]14718577
D017998Leukotriene D4BAY u9773 inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]11093801
D017998Leukotriene D4BAY u9773 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]10825389
D017998Leukotriene D4CGP 57698 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]10825389
D017998Leukotriene D4CYSLTR1 protein promotes the reaction [Leukotriene D4 results in increased abundance of Calcium]15990778
D017998Leukotriene D4CYSLTR1 protein results in increased susceptibility to Leukotriene D49647482
D017998Leukotriene D4iralukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]10825389
D017998Leukotriene D4Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein10391245|1046255
D017998Leukotriene D4[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium10391245|1046255
D017998Leukotriene D4Leukotriene D4 binds to CYSLTR1 protein10825389|1199689
D017998Leukotriene D4Leukotriene D4 results in increased activity of CYSLTR1 protein18704935
D017998Leukotriene D4[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium18704935
D017998Leukotriene D4[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein18704935
D017998Leukotriene D4[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of IL6 protein18704935
D017998Leukotriene D4[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of TNF protein18704935
D017998Leukotriene D4LY 171883 inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]14718577
D017998Leukotriene D4MEN91507 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]11996896
D017998Leukotriene D4montelukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]10391245|1471857
D017998Leukotriene D4montelukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]10462554|1285384
D017998Leukotriene D4montelukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]11996896
D017998Leukotriene D4pobilukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]9620942
D017998Leukotriene D4pobilukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]10462554
D017998Leukotriene D4pobilukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]10825389
D017998Leukotriene D4pranlukast inhibits the reaction [CYSLTR1 protein results in increased susceptibility to Leukotriene D4]9647482
D017998Leukotriene D4pranlukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]10391245|9620942
D017998Leukotriene D4pranlukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]10462554
D017998Leukotriene D4pranlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]10825389|1199689
D017998Leukotriene D4verlukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]10391245|1471857
D017998Leukotriene D4verlukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]8014876
D017998Leukotriene D4verlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]8384568
D017998Leukotriene D4zafirlukast inhibits the reaction [CYSLTR1 protein promotes the reaction [Leukotriene D4 results in increased abundance of Calcium]]15990778
D017998Leukotriene D4zafirlukast inhibits the reaction [CYSLTR1 protein results in increased susceptibility to Leukotriene D4]9647482
D017998Leukotriene D4zafirlukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]10391245|1471857
D017998Leukotriene D4zafirlukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]10462554|1285384
D017998Leukotriene D4zafirlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]10825389|1199689
D017998Leukotriene D4zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein]18704935
D017998Leukotriene D4zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of IL6 protein]18704935
D017998Leukotriene D4zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of TNF protein]18704935
D017998Leukotriene D4CYSLTR1 protein binds to and affects the susceptibility to Leukotriene D411932261
D017998Leukotriene D4Leukotriene C4 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]11705452
D017998Leukotriene D4Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein11705452|1579279
D017998Leukotriene D4[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium11705452|1579279
D017998Leukotriene D4Leukotriene E4 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]11705452
D017998Leukotriene D4pranlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]11705452
D017998Leukotriene D4verlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]11705452
D017998Leukotriene D4zafirlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]11705452
D017998Leukotriene D4Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein15888248
C044660LY 171883acivicin inhibits the reaction [LY 171883 inhibits the reaction [Leukotriene C4 results in increased activity of CYSLTR1 protein]]1651863
C044660LY 171883LY 171883 binds to and results in decreased activity of CYSLTR1 protein1651863|8482329
C044660LY 171883LY 171883 inhibits the reaction [Leukotriene C4 results in increased activity of CYSLTR1 protein]1651863
C044660LY 171883LY 171883 inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]9620942
C044660LY 171883LY 171883 binds to and results in increased activity of CYSLTR1 protein14718577
C044660LY 171883LY 171883 inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]14718577
C044660LY 171883LY 171883 binds to and results in decreased activity of CYSLTR1 protein8014878
C044660LY 171883[LY 171883 binds to and results in decreased activity of CYSLTR1 protein] which results in decreased abundance of Leukotriene B48014878
C471346MEN91507MEN91507 inhibits the reaction [Leukotriene C4 binds to CYSLTR1 protein]11996896
C471346MEN91507MEN91507 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]11996896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CYSLTR1 mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CYSLTR1 mRNA23649840
C093875montelukastmontelukast binds to and results in decreased activity of CYSLTR1 protein18651869|9580604
C093875montelukastmontelukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]18651869
C093875montelukastalpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [montelukast binds to and results in decreased activity of CYSLTR1 protein]14718577
C093875montelukastmontelukast binds to and results in decreased activity of CYSLTR1 protein10851239|1100627
C093875montelukastmontelukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]10391245|1471857
C093875montelukastmontelukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]10462554|1285384
C093875montelukastmontelukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]11996896
C093875montelukastmontelukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]9620942
C093875montelukastmontelukast inhibits the reaction [[Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]20083671
C093875montelukastmontelukast inhibits the reaction [[Uridine Diphosphate metabolite results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein]20083671
C093875montelukastmontelukast inhibits the reaction [Streptozocin results in increased expression of CYSLTR1 mRNA]27702591
C093875montelukastmontelukast inhibits the reaction [Streptozocin results in increased expression of CYSLTR1 protein]27702591
C093875montelukastmontelukast results in decreased expression of CYSLTR1 mRNA19544365
C093875montelukastmontelukast binds to and results in decreased activity of CYSLTR1 protein17895592|1803791
C093875montelukastmontelukast results in decreased activity of CYSLTR1 protein10471986
C523799MRK 003CYSLTR1 results in increased susceptibility to MRK 00319903844
C065551N-(4-((5-(((cyclopentyloxy)carbonyl)amino)benzo(b)thien-3-yl)methyl)-3-methoxybenzoyl)benzenesulfonamideN-(4-((5-(((cyclopentyloxy)carbonyl)amino)benzo(b)thien-3-yl)methyl)-3-methoxybenzoyl)benzenesulfonamide binds to and results in decreased activity of CYSLTR1 protein2167983
C065550N-(4((6-(((cyclopentyloxy)carbonyl)amino)benzimidazol-1-yl)methyl)-3-methoxybenzoyl)benzenesulfonamideN-(4((6-(((cyclopentyloxy)carbonyl)amino)benzimidazol-1-yl)methyl)-3-methoxybenzoyl)benzenesulfonamide binds to and results in decreased activity of CYSLTR1 protein2167983
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CYSLTR1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CYSLTR1 mRNA"25554681
D010100OxygenOxygen deficiency results in increased expression of CYSLTR1 mRNA20880076
D010261ParaoxonParaoxon results in increased expression of CYSLTR1 mRNA17223147
C037431phthalimidephthalimide analog binds to and results in decreased activity of CYSLTR1 protein12031336
C052393pobilukastpobilukast binds to and results in decreased activity of CYSLTR1 protein9580604
C052393pobilukastpobilukast binds to and results in decreased activity of CYSLTR1 protein9152370
C052393pobilukastpobilukast binds to CYSLTR1 protein10825389
C052393pobilukastpobilukast inhibits the reaction [Leukotriene C4 binds to CYSLTR1 protein]10825389
C052393pobilukastpobilukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]9620942
C052393pobilukastpobilukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]10462554
C052393pobilukastpobilukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]10825389
C052393pobilukastpobilukast results in decreased activity of CYSLTR1 protein8111568
D059808PolyphenolsPolyphenols results in decreased expression of CYSLTR1 mRNA16293270
C047681pranlukastpranlukast binds to and results in decreased activity of CYSLTR1 protein10509933|9580604
C047681pranlukastpranlukast binds to and results in decreased activity of CYSLTR1 protein10851239|1565031
C047681pranlukast[pranlukast binds to and results in decreased activity of CYSLTR1 protein] which affects the abundance of Calcium10509933
C047681pranlukastpranlukast binds to CYSLTR1 protein10825389
C047681pranlukastpranlukast inhibits the reaction [CYSLTR1 protein results in increased susceptibility to Leukotriene D4]9647482
C047681pranlukastpranlukast inhibits the reaction [Leukotriene C4 binds to CYSLTR1 protein]10825389|1199689
C047681pranlukastpranlukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]10391245|9620942
C047681pranlukastpranlukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]10462554
C047681pranlukastpranlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]10825389|1199689
C047681pranlukastpranlukast binds to and results in decreased activity of CYSLTR1 protein11705452|1711240
C047681pranlukastpranlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]11705452
C047681pranlukastpranlukast binds to and results in decreased activity of CYSLTR1 protein18236018|1912973
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of CYSLTR1 mRNA21427059
C067525S(alpha)-methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acidS(alpha)-methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acid binds to and results in decreased activity of CYSLTR1 protein8482329
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CYSLTR1 mRNA19073995
D013311Streptozocinmontelukast inhibits the reaction [Streptozocin results in increased expression of CYSLTR1 mRNA]27702591
D013311Streptozocinmontelukast inhibits the reaction [Streptozocin results in increased expression of CYSLTR1 protein]27702591
D013311StreptozocinStreptozocin results in increased expression of CYSLTR1 mRNA27702591
D013311StreptozocinStreptozocin results in increased expression of CYSLTR1 protein27702591
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYSLTR1 mRNA19933214
D013806TheophyllineTheophylline results in decreased expression of CYSLTR1 mRNA18951874
D014530Uridine Diphosphatemontelukast inhibits the reaction [[Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]20083671
D014530Uridine Diphosphatemontelukast inhibits the reaction [[Uridine Diphosphate metabolite results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein]20083671
D014530Uridine DiphosphateUridine Diphosphate binds to and results in increased activity of CYSLTR1 protein20083671
D014530Uridine Diphosphate[Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium20083671
D014530Uridine Diphosphate[Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein20083671
D014530Uridine Diphosphatezafirlukast inhibits the reaction [[Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]20083671
D014530Uridine Diphosphatezafirlukast inhibits the reaction [[Uridine Diphosphate metabolite results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein]20083671
D014635Valproic AcidValproic Acid results in decreased expression of CYSLTR1 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CYSLTR1 gene25560391
C059141verlukastalpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [verlukast binds to and results in decreased activity of CYSLTR1 protein]14718577
C059141verlukastverlukast binds to and results in decreased activity of CYSLTR1 protein10851239|1143244
C059141verlukastverlukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]10391245|1471857
C059141verlukastverlukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]8014876
C059141verlukastverlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]8384568
C059141verlukastverlukast binds to and results in decreased activity of CYSLTR1 protein11705452
C059141verlukastverlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]11705452
C059141verlukastverlukast binds to and results in decreased activity of CYSLTR1 protein18037915
D014750VincristineVincristine results in decreased expression of CYSLTR1 mRNA23649840
C062735zafirlukastacivicin inhibits the reaction [zafirlukast inhibits the reaction [Leukotriene C4 results in increased activity of CYSLTR1 protein]]1651863
C062735zafirlukastzafirlukast binds to and results in decreased activity of CYSLTR1 protein10509933|1651863
C062735zafirlukastzafirlukast inhibits the reaction [Leukotriene C4 results in increased activity of CYSLTR1 protein]1651863
C062735zafirlukastzafirlukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]18651869|9620942
C062735zafirlukastalpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [zafirlukast binds to and results in decreased activity of CYSLTR1 protein]14718577
C062735zafirlukastzafirlukast binds to and results in decreased activity of CYSLTR1 protein10851239|1100627
C062735zafirlukast[zafirlukast binds to and results in decreased activity of CYSLTR1 protein] which affects the abundance of Calcium10509933
C062735zafirlukastzafirlukast binds to CYSLTR1 protein10825389
C062735zafirlukastzafirlukast inhibits the reaction [CYSLTR1 protein promotes the reaction [Leukotriene D4 results in increased abundance of Calcium]]15990778
C062735zafirlukastzafirlukast inhibits the reaction [CYSLTR1 protein results in increased susceptibility to Leukotriene D4]9647482
C062735zafirlukastzafirlukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]10391245|1471857
C062735zafirlukastzafirlukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]10462554|1285384
C062735zafirlukastzafirlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]10825389|1199689
C062735zafirlukastzafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein]18704935
C062735zafirlukastzafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of IL6 protein]18704935
C062735zafirlukastzafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of TNF protein]18704935
C062735zafirlukastzafirlukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]9620942
C062735zafirlukastzafirlukast inhibits the reaction [[Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]20083671
C062735zafirlukastzafirlukast inhibits the reaction [[Uridine Diphosphate metabolite results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein]20083671
C062735zafirlukastzafirlukast binds to and results in decreased activity of CYSLTR1 protein11705452
C062735zafirlukastzafirlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]11705452
C062735zafirlukastzafirlukast binds to and results in decreased activity of CYSLTR1 protein9934474
D015054ZymosanCYSLTR1 protein affects the susceptibility to Zymosan11932261

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001631cysteinyl leukotriene receptor activity-IBA21873635  
GO:0004966galanin receptor activity-IBA21873635  
GO:0004974leukotriene receptor activity-IEA-  
GO:0005515protein binding-IPI21203429  
GO:0008528G-protein coupled peptide receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002437inflammatory response to antigenic stimulus-IEA-  
GO:0006816calcium ion transport-IEA-  
GO:0006935chemotaxis-IEA-  
GO:0006952defense response-TAS10391245  
GO:0007166cell surface receptor signaling pathway-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-TAS10391245  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0007585respiratory gaseous exchange-TAS10391245  
GO:0061737leukotriene signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016020membrane-TAS10391245  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-391903Eicosanoid ligand-binding receptorsTAS
R-HSA-391906Leukotriene receptorsTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27990118Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies. (2016)Thompson MDFront Pharmacol