Gene: SEPT9

10801
AF17q25|MSF|MSF1|NAPB|PNUTL4|SINT1|SeptD1
septin 9
protein-coding
17q25.3
Ensembl:ENSG00000184640 MIM:604061 Vega:OTTHUMG00000177327 UniprotKB:Q9UHD8
NG_011683.1
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.088e-1 (AD)  7.756e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2411109chr17:77336374 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs4788985chr17:77317253 (GRCh38.p7)A>Gnicotine dependence|alcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14183922chr17:75371532SEPT91.080e-9Maternal smoking in pregnancy27040690
cg07827420chr17:75371764SEPT94.330e-10Maternal smoking in pregnancy27040690
cg00871371chr17:75371476SEPT95.760e-8Maternal smoking in pregnancy27040690
cg09481866chr17:75373040SEPT96.840e-10Maternal smoking in pregnancy27040690
cg21830368chr17:75373327SEPT91.900e-8Maternal smoking in pregnancy27040690
cg14183922chr17:75371532SEPT93.980e-11Maternal smoking in pregnancy27040690
cg07827420chr17:75371764SEPT97.070e-10Maternal smoking in pregnancy27040690
cg00871371chr17:75371476SEPT92.580e-9Maternal smoking in pregnancy27040690
cg14183922chr17:75371532SEPT91.030e-9Maternal smoking in pregnancy27040690
cg07827420chr17:75371764SEPT91.480e-8Maternal smoking in pregnancy27040690
cg00871371chr17:75371476SEPT94.370e-10Maternal smoking in pregnancy27040690
cg27627381chr17:75452100SEPT92.000e-21Smoking27651444
cg14183922chr17:75371532SEPT95.000e-21Smoking27651444
cg20772590chr17:75446431SEPT91.600e-17Smoking27651444
cg00324097chr17:75446549SEPT98.600e-10Smoking27651444
cg07827420chr17:75371764SEPT96.200e-8Smoking27651444
cg10611580chr17:75319942SEPT99.600e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SHISA50.85
ATN10.847
TFE30.841
TRAF70.84
NUCB10.837
TMED90.833
PACSIN20.833
FURIN0.832
P4HB0.83
G6PD0.829

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.722
OR4F29-0.707
SH2D1A-0.214
CTNNA3-0.192
C5orf64-0.174
MYL1-0.152
AMPD1-0.151
SPRR2E-0.148
TNFRSF13B-0.147
TSPAN8-0.146

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SEPT9 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of SEPT9 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SEPT9 gene27153756
D000452AldrinAldrin results in increased expression of SEPT9 mRNA18579281
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SEPT9 mRNA16483693
D001151ArsenicArsenic affects the expression of SEPT9 mRNA18414638
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SEPT9 protein20097212
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SEPT9 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SEPT9 mRNA"19150397
C038328BEP protocolBEP protocol results in increased expression of SEPT9 mRNA18987330
D004958EstradiolEstradiol results in increased expression of SEPT9 mRNA23019147
C551172bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in decreased expression of SEPT9 mRNA"20162321
C006780bisphenol Abisphenol A results in increased methylation of SEPT9 promoter27312807
C006780bisphenol Abisphenol A affects the expression of SEPT9 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SEPT9 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SEPT9 mRNA28628672
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased phosphorylation of SEPT9 protein22174045
D002065BuspironeBuspirone results in decreased expression of SEPT9 mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SEPT9 mRNA15003993
C018475butyraldehydebutyraldehyde results in decreased expression of SEPT9 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SEPT9 protein24527689
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SEPT9 mRNA27939986
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SEPT9 protein27939986
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased methylation of SEPT9 gene27939986
D002251Carbon Tetrachloridedecitabine inhibits the reaction [Carbon Tetrachloride results in decreased expression of SEPT9 protein]27939986
D002251Carbon TetrachlorideDNMT3A protein affects the reaction [Carbon Tetrachloride results in decreased expression of SEPT9 protein]27939986
C100187chloropicrinchloropicrin affects the expression of SEPT9 mRNA26352163
D019327Copper SulfateCopper Sulfate results in decreased expression of SEPT9 mRNA19549813
D019327Copper SulfateCopper Sulfate results in increased expression of SEPT9 mRNA18579281
D003375CoumestrolCoumestrol results in increased expression of SEPT9 mRNA19167446
D016572CyclosporineCyclosporine results in decreased methylation of SEPT9 promoter27989131
C014347decitabinedecitabine inhibits the reaction [Carbon Tetrachloride results in decreased expression of SEPT9 protein]27939986
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SEPT9 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SEPT9 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SEPT9 mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of SEPT9 mRNA28302478
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of SEPT9 protein20935162
D004052Diethylnitrosamine[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of SEPT9 protein20935162
D004298DopamineDopamine results in decreased expression of SEPT9 protein24675778
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SEPT9 protein23301498
D018120FinasterideFinasteride results in increased expression of SEPT9 mRNA24136188
D005472FluorouracilFluorouracil affects the expression of SEPT9 mRNA20421339
D005485FlutamideFlutamide results in increased expression of SEPT9 mRNA24136188
C039281furanfuran results in increased methylation of SEPT9 gene22079235
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SEPT9 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SEPT9 mRNA28628672
C057531jasplakinolidejasplakinolide inhibits the reaction [SEPT9 protein affects the expression of CDH1 protein]20388789
C057531jasplakinolidejasplakinolide inhibits the reaction [SEPT9 protein affects the expression of CDH2 protein]20388789
C057531jasplakinolidejasplakinolide inhibits the reaction [SEPT9 protein affects the expression of VIM protein]20388789
C057531jasplakinolidejasplakinolide inhibits the reaction [SEPT9 protein affects the localization of SNAI1 protein]20388789
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SEPT9 mRNA23086925
C410337K 7174K 7174 results in decreased expression of SEPT9 mRNA24086573
D007854LeadLead results in decreased expression of SEPT9 mRNA19921347
C013598methoxyacetic acidmethoxyacetic acid affects the expression of SEPT9 mRNA20421339
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SEPT9 protein25809596
C028577monobutyl phthalatemonobutyl phthalate affects the expression of SEPT9 mRNA20421339
C028577monobutyl phthalatemonobutyl phthalate affects the expression of SEPT9 mRNA20864626
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SEPT9 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SEPT9 mRNA"25620056
C016030pantogabpantogab results in decreased expression of SEPT9 mRNA17379144
D010634Phenobarbital[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of SEPT9 protein20935162
D011441PropylthiouracilPropylthiouracil results in increased expression of SEPT9 mRNA24780913
D012969Sodium FluorideSodium Fluoride results in decreased expression of SEPT9 protein28918527
D012999SomanSoman results in decreased expression of SEPT9 mRNA19281266
D012999SomanSoman results in increased expression of SEPT9 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SEPT9 gene]20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SEPT9 mRNA20819909
D013849ThimerosalThimerosal results in decreased expression of SEPT9 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SEPT9 mRNA22363418|2806579
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of SEPT9 gene26756918
D014212TretinoinTretinoin affects the expression of SEPT9 mRNA20421339
D014635Valproic AcidValproic Acid affects the expression of SEPT9 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of SEPT9 mRNA20421339

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IBA21873635  
GO:0003924GTPase activity-TAS10339604  
GO:0005515protein binding-IPI15485874  16007136  16424018  17922164  25416956  
GO:0005525GTP binding-IEA-  
GO:0032947protein-containing complex scaffold activity-IBA21873635  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0000281mitotic cytokinesis-IBA21873635  
GO:0000921septin ring assembly-IBA21873635  
GO:0007049cell cycle-IEA-  
GO:0034613cellular protein localization-IBA21873635  
GO:0051291protein heterooligomerization-IDA15485874  
GO:0051301cell division-IEA-  
GO:0060271cilium assembly-IBA21873635  
GO:1902857positive regulation of non-motile cilium assembly-IMP23572511  
GO ID GO Term Qualifier Evidence PubMed
GO:0001725stress fiber-IDA15485874  
GO:0005737cytoplasm-TAS10339604  
GO:0005874microtubule-IDA15485874  
GO:0005930axoneme-IDA23572511  
GO:0005940septin ring-IBA21873635  
GO:0015629actin cytoskeleton-IDA-  
GO:0015630microtubule cytoskeleton-IBA21873635  
GO:0031105septin complex-IBA21873635  
GO:0031105septin complex-IDA23572511  
GO:0032153cell division site-IBA21873635  
GO:0032160septin filament array-IBA21873635  
GO:0048471perinuclear region of cytoplasm-IDA15485874  
GO:0097730non-motile cilium-IDA23572511  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal