Gene: GJB6

10804
CX30|DFNA3|DFNA3B|DFNB1B|ECTD2|ED2|EDH|HED|HED2
gap junction protein beta 6
protein-coding
13q12.11
Ensembl:ENSG00000121742 MIM:604418 Vega:OTTHUMG00000016515 UniprotKB:O95452
NG_008323.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.801e-1 (AD)  8.489e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs877098chr13:20224101 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
METTL7A0.913
ETNPPL0.913
GJA10.911
GPAM0.902
EGFR0.899
SLC1A20.898
SPON10.895
CABLES10.884
ATP13A40.882
SLC4A40.882

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DUSP27-0.379
LRRC55-0.374
PLEKHA8P1-0.369
L3MBTL4-0.365
TBC1D8B-0.363
SOGA3-0.361
PAQR9-0.36
SH3BP5-0.355
VLDLR-0.355
HTR7-0.355

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GJB6 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of GJB6 mRNA"20406850
C0144643,4-dichloroaniline"3,4-dichloroaniline results in decreased expression of GJB6 mRNA"24172598
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of GJB6 mRNA24140754
D020106AcrylamideAcrylamide results in increased expression of GJB6 mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of GJB6 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GJB6 mRNA16483693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of GJB6 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GJB6 mRNA21569818
C006780bisphenol Abisphenol A results in decreased expression of GJB6 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of GJB6 mRNA21457566
D002211CapsaicinCapsaicin results in increased expression of GJB6 mRNA20349343
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of GJB6 mRNA25031359
D004237DiuronDiuron metabolite results in increased expression of GJB6 mRNA24172598
D004237DiuronDiuron results in increased expression of GJB6 mRNA21551480
D019833GenisteinGenistein results in increased expression of GJB6 mRNA25031359
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GJB6 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GJB6 mRNA26752646
D007649KetamineKetamine results in increased expression of GJB6 mRNA20080153
C008261lead acetatelead acetate results in increased expression of GJB6 mRNA22641619
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GJB6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GJB6 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of GJB6 mRNA19167457
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of GJB6 mRNA17616710
D010069Oxadiazoles[Oxadiazoles analog co-treated with FGF2 protein] results in increased expression of GJB6 mRNA23212921
D017239PaclitaxelPaclitaxel results in increased expression of GJB6 mRNA18754875
D052638Particulate MatterParticulate Matter results in increased expression of GJB6 mRNA28341207
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GJB6 mRNA19710929
D011374ProgesteroneProgesterone affects the expression of GJB6 mRNA17251523
D011374ProgesteroneProgesterone results in decreased expression of GJB6 mRNA22238285
D011441PropylthiouracilPropylthiouracil results in decreased expression of GJB6 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GJB6 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GJB6 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of GJB6 mRNA23557971
D014212TretinoinTretinoin results in increased expression of GJB6 mRNA21934132
D014635Valproic AcidValproic Acid results in increased expression of GJB6 mRNA24383497
D014635Valproic AcidValproic Acid results in decreased expression of GJB6 mRNA23665938
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GJB6 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0007154cell communication-IEA-  
GO:0007568aging-IEA-  
GO:0007605sensory perception of sound-IEA-  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0042471ear morphogenesis-IEA-  
GO:0048839inner ear development-IEA-  
GO:0051602response to electrical stimulus-IEA-  
GO:0071333cellular response to glucose stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IEA-  
GO:0005922connexin complex-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0016324apical plasma membrane-IEA-  
GO:0030054cell junction-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-157858Gap junction trafficking and regulationTAS
R-HSA-190828Gap junction traffickingTAS
R-HSA-190861Gap junction assemblyTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal