Gene: SDCCAG8

10806
BBS16|CCCAP|CCCAP SLSN7|HSPC085|NPHP10|NY-CO-8|SLSN7|hCCCAP
serologically defined colon cancer antigen 8
protein-coding
1q43-q44
Ensembl:ENSG00000054282 MIM:613524 Vega:OTTHUMG00000039996 UniprotKB:Q86SQ7
NG_027811.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.153e-1 (AD)  1.844e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf1230.881
COA50.878
AMZ20.878
AIG10.876
MTIF30.874
GNPTG0.873
NAP1L40.872
CETN20.871
GABARAPL20.87
ZFPL10.868

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.757
OR4F29-0.756
MTRNR2L6-0.332
MTRNR2L9-0.316
MTRNR2L10-0.3
MTRNR2L3-0.293
FER1L6-0.291
RNF223-0.281
KRT73-0.278
C8orf74-0.269

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SDCCAG8 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDCCAG8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDCCAG8 mRNA"27188386
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SDCCAG8 mRNA16483693
D001280AtrazineAtrazine results in increased expression of SDCCAG8 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SDCCAG8 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SDCCAG8 mRNA19770486
D004958EstradiolEstradiol affects the expression of SDCCAG8 mRNA22574217
C006780bisphenol Abisphenol A results in increased expression of SDCCAG8 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of SDCCAG8 mRNA25979313
D002273CarcinogensCarcinogens results in decreased expression of SDCCAG8 mRNA22269147
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SDCCAG8 gene20938992
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SDCCAG8 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of SDCCAG8 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SDCCAG8 mRNA19770486
D005472FluorouracilFluorouracil results in increased expression of SDCCAG8 mRNA16510598
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SDCCAG8 gene20938992
D007213IndomethacinIndomethacin results in decreased expression of SDCCAG8 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SDCCAG8 mRNA25613284
C008261lead acetatelead acetate results in increased expression of SDCCAG8 mRNA20542052
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SDCCAG8 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SDCCAG8 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SDCCAG8 mRNA23649840
D015741MetriboloneMetribolone results in increased expression of SDCCAG8 mRNA17010196
D009153MutagensMutagens results in decreased expression of SDCCAG8 mRNA22269147
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SDCCAG8 mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SDCCAG8 mRNA20971185
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SDCCAG8 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SDCCAG8 mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of SDCCAG8 mRNA23557933
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of SDCCAG8 mRNA19244175
D012643SeleniumSelenium results in decreased expression of SDCCAG8 mRNA19244175
C017947sodium arsenitesodium arsenite results in decreased expression of SDCCAG8 mRNA28595984
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SDCCAG8 mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SDCCAG8 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SDCCAG8 mRNA21354282
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SDCCAG8 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SDCCAG8 mRNA20133372
C012589trichostatin Atrichostatin A results in increased expression of SDCCAG8 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SDCCAG8 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of SDCCAG8 mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDCCAG8 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SDCCAG8 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of SDCCAG8 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SDCCAG8 mRNA23179753|2438349
C034028vanadyl sulfatevanadyl sulfate results in decreased expression of SDCCAG8 mRNA16330358
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of SDCCAG8 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of SDCCAG8 mRNA19244175
C111237vorinostatvorinostat results in increased expression of SDCCAG8 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI20835237  22190034  22940612  26638075  27173435  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-TAS-  
GO:0001764neuron migration-IBA21873635  
GO:0001764neuron migration-IEA-  
GO:0007098centrosome cycle-IEA-  
GO:0010389regulation of G2/M transition of mitotic cell cycle-TAS-  
GO:0030010establishment of cell polarity-IBA21873635  
GO:0030010establishment of cell polarity-ISS-  
GO:0031023microtubule organizing center organization-IBA21873635  
GO:0035148tube formation-IBA21873635  
GO:0035148tube formation-ISS-  
GO:0097711ciliary basal body-plasma membrane docking-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005813centrosome-IBA21873635  
GO:0005813centrosome-IDA21399614  
GO:0005814centriole-IBA21873635  
GO:0005814centriole-IDA20835237  
GO:0005829cytosol-TAS-  
GO:0005911cell-cell junction-IDA20835237  
GO:0034451centriolar satellite-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionTAS
R-HSA-380259Loss of Nlp from mitotic centrosomesTAS
R-HSA-380270Recruitment of mitotic centrosome proteins and complexesTAS
R-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosomeTAS
R-HSA-380287Centrosome maturationTAS
R-HSA-380320Recruitment of NuMA to mitotic centrosomesTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5620912Anchoring of the basal body to the plasma membraneTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-8854518AURKA Activation by TPX2TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29455858A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. (2018 Mar 1)Sung YJAm J Hum Genet