Gene: HSPH1

10808
HSP105|HSP105A|HSP105B|NY-CO-25
heat shock protein family H (Hsp110) member 1
protein-coding
13q12.3
Ensembl:ENSG00000120694 MIM:610703 Vega:OTTHUMG00000016685 UniprotKB:Q92598
NG_053051.1
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.162e-1 (AD)  6.399e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4943157chr13:31152041 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FKBP40.944
DNAJA40.927
DNAJA10.916
CACYBP0.914
STIP10.913
HSPA40.907
SIAH20.894
DNAJB60.894
HSPA4L0.888
HSP90AA10.888

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.507
OR4F29-0.482
KLRF1-0.403
KLRB1-0.398
CEACAM4-0.392
ALDH1L1-AS2-0.387
IL18RAP-0.372
CC2D2B-0.368
KLF17-0.366
ASB4-0.359

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB12695Phenethyl IsothiocyanateSmall Molecule2257-09-2InvestigationalTarget
ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in decreased expression of HSPH1 mRNA"26377693
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of HSPH1 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of HSPH1 mRNA"28903501
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of HSPH1 mRNA"20453058
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of HSPH1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of HSPH1 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HSPH1 mRNA"15215175
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of HSPH1 mRNA"20206263
C0194992-nitrofluorene2-nitrofluorene results in increased expression of HSPH1 mRNA15890375
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of HSPH1 protein26194647
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of HSPH1 mRNA18544908
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPH1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPH1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPH1 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of HSPH1 mRNA"19561079
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of HSPH1 mRNA"21346803
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of HSPH1 mRNA19191707
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HSPH1 mRNA15890375
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of HSPH1 mRNA14583596
C0297284-phenylenediamine4-phenylenediamine results in increased expression of HSPH1 mRNA23999411
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPH1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPH1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPH1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of HSPH1 mRNA21420995|2223033
D000082AcetaminophenAcetaminophen results in increased expression of HSPH1 mRNA11264010|1174374
D000082AcetaminophenPPARA protein affects the reaction [Acetaminophen results in increased expression of HSPH1 mRNA]12958197
D000082AcetaminophenPTGS2 protein affects the reaction [Acetaminophen results in increased expression of HSPH1 mRNA]11743745
D000082AcetaminophenAcetaminophen results in increased expression of HSPH1 mRNA17202762
D020106AcrylamideAcrylamide results in increased expression of HSPH1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HSPH1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HSPH1 mRNA15890375
D000393Air PollutantsAir Pollutants analog results in increased expression of HSPH1 mRNA21757418
D015766Albendazole[Ivermectin co-treated with Albendazole] results in increased expression of HSPH1 mRNA16861626
C103303alitretinoinalitretinoin results in decreased expression of HSPH1 mRNA16648578
D003913DextroamphetamineDextroamphetamine results in increased expression of HSPH1 mRNA12558987
C006632arsenic trioxidearsenic trioxide results in increased expression of HSPH1 mRNA17530438|1941714
D017636Asbestos, Amphibole"Asbestos, Amphibole results in increased expression of HSPH1 protein"20855422
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of HSPH1 mRNA"25351596
D016589AstemizoleAstemizole results in decreased expression of HSPH1 mRNA20221588
D001280AtrazineAtrazine results in decreased expression of HSPH1 mRNA22378314
C017037aurinaurin results in increased expression of HSPH1 mRNA25477506
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in increased expression of HSPH1 mRNA24356939
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of HSPH1 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HSPH1 mRNA15034205|2156981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HSPH1 mRNA22300585
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HSPH1 mRNA25566086
D004958EstradiolEstradiol results in increased expression of HSPH1 mRNA20106945
C044887beta-methylcholinebeta-methylcholine affects the expression of HSPH1 mRNA21179406
C095105bexarotenebexarotene results in decreased expression of HSPH1 mRNA16648578
C006780bisphenol Abisphenol A results in decreased methylation of HSPH1 promoter27312807
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of HSPH1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of HSPH1 mRNA25181051
C025703bleomycetinbleomycetin results in decreased expression of HSPH1 mRNA21040473
D000069286BortezomibBortezomib results in increased expression of HSPH1 mRNA17898295
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSPH1 mRNA22079614
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of HSPH1 mRNA15336504
D002101Cacodylic AcidCacodylic Acid results in decreased expression of HSPH1 mRNA17441966
D002101Cacodylic AcidOGG1 protein inhibits the reaction [Cacodylic Acid results in decreased expression of HSPH1 mRNA]17441966
D002104CadmiumCadmium results in increased expression of HSPH1 mRNA21120746|2428428
D019256Cadmium ChlorideCadmium Chloride results in increased expression of HSPH1 mRNA11171528|1508126
D019256Cadmium ChlorideCadmium Chloride results in increased expression of HSPH1 mRNA19010381
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of HSPH1 promoter22457795
C037123cadmium sulfatecadmium sulfate results in increased expression of HSPH1 mRNA21783983
D002220CarbamazepineCarbamazepine affects the expression of HSPH1 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HSPH1 mRNA15056808|2733941
C043211carvedilolcarvedilol results in increased expression of HSPH1 protein20403466
D002509CephaloridineCephaloridine results in increased expression of HSPH1 mRNA18500788
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of HSPH1 protein21791222
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPH1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of HSPH1 mRNA26272509
C100187chloropicrinchloropicrin results in increased expression of HSPH1 mRNA26352163
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of HSPH1 mRNA27344345
D002793Cholic Acids[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of HSPH1 mRNA27344345
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of HSPH1 mRNA28472532
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of HSPH1 mRNA23999411
C020722cinnamyl alcoholcinnamyl alcohol results in increased expression of HSPH1 mRNA23999411
D002994ClofibrateClofibrate results in increased expression of HSPH1 mRNA23811191
C018021cobaltous chloridecobaltous chloride results in increased expression of HSPH1 mRNA19320972|1937684
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of HSPH1 mRNA24690739
D003300Copper[Organoselenium Compounds binds to Copper] which results in increased expression of HSPH1 mRNA25167922
D003300CopperCopper results in increased expression of HSPH1 mRNA16629173
D003300CopperCopper results in increased expression of HSPH1 mRNA25058597
D019327Copper SulfateCopper Sulfate results in increased expression of HSPH1 mRNA19549813
D019327Copper SulfateCopper Sulfate results in decreased expression of HSPH1 mRNA18579281
C030973cupric oxidecupric oxide results in increased expression of HSPH1 mRNA22077320
D003520CyclophosphamideCyclophosphamide metabolite results in increased expression of HSPH1 mRNA24356939
D016572CyclosporineCyclosporine results in decreased expression of HSPH1 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of HSPH1 mRNA20106945|2556210
C515055darinaparsindarinaparsin results in increased expression of HSPH1 mRNA19417148
D003676Deferoxamine[Deferoxamine results in decreased abundance of Iron] which results in decreased expression of HSPH1 mRNA12393473
D013759DronabinolDronabinol results in decreased expression of HSPH1 mRNA16039398|1845417
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of HSPH1 protein23352502
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of HSPH1 mRNA"25908611
C020735dibutyldichlorotindibutyldichlorotin results in increased expression of HSPH1 mRNA24356939
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of HSPH1 mRNA27614199
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate affects the expression of HSPH1 mRNA21318169
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of HSPH1 mRNA21318169
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of HSPH1 mRNA21527772
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of HSPH1 mRNA15890375
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of HSPH1 mRNA15890375
D004139DinitrofluorobenzeneDinitrofluorobenzene results in increased expression of HSPH1 mRNA23999411
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of HSPH1 mRNA24690739
D004237DiuronDiuron results in decreased expression of HSPH1 mRNA21551480
D004317DoxorubicinDMD protein affects the reaction [Doxorubicin results in decreased expression of HSPH1 mRNA]17888722
D004317DoxorubicinDoxorubicin results in decreased expression of HSPH1 mRNA17888722
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of HSPH1 mRNA"23811387
C512195elesclomolelesclomol results in increased expression of HSPH1 mRNA18723479
C070609EMD 53998EMD 53998 analog results in increased expression of HSPH1 mRNA24977338
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of HSPH1 mRNA19118595
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HSPH1 protein23301498
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of HSPH1 mRNA27344345
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HSPH1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HSPH1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HSPH1 mRNA17942748
D005054EugenolEugenol results in increased expression of HSPH1 mRNA23999411
D011345FenofibrateFenofibrate results in increased expression of HSPH1 mRNA21318169
D011345FenofibratePPARA protein affects the reaction [Fenofibrate results in increased expression of HSPH1 mRNA]21318169
D005411Flame RetardantsFlame Retardants results in increased expression of HSPH1 mRNA27219277
D005485FlutamideFlutamide results in decreased expression of HSPH1 mRNA24793618
D005485FlutamideFlutamide results in increased expression of HSPH1 mRNA24136188
C039281furanfuran results in increased expression of HSPH1 mRNA24183702
C106014geduningedunin results in increased expression of HSPH1 mRNA17010675
D019833GenisteinGenistein results in increased expression of HSPH1 mRNA17341692
D006037GlyoxalGlyoxal results in increased expression of HSPH1 mRNA23999411
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers results in increased expression of HSPH1 mRNA27219277
D006427Hemin[Hemin results in increased abundance of Iron] which results in increased expression of HSPH1 mRNA12393473
C089796hexabromocyclododecanehexabromocyclododecane affects the expression of HSPH1 protein24680724
C492448ICG 001ICG 001 results in increased expression of HSPH1 mRNA26191083
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of HSPH1 mRNA"26377693
C027185indirubinindirubin results in decreased expression of HSPH1 mRNA15056799
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSPH1 mRNA25613284
D007501Iron[Deferoxamine results in decreased abundance of Iron] which results in decreased expression of HSPH1 mRNA12393473
D007501Iron[Hemin results in increased abundance of Iron] which results in increased expression of HSPH1 mRNA12393473
D007501Iron[Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of HSPH1 mRNA22198552
C036643isoeugenolisoeugenol results in increased expression of HSPH1 mRNA23999411
D007545IsoproterenolIsoproterenol results in increased expression of HSPH1 mRNA21335049
D007559Ivermectin[Ivermectin co-treated with Albendazole] results in increased expression of HSPH1 mRNA16861626
C544151jinfukangjinfukang results in decreased expression of HSPH1 mRNA27392435
D019344Lactic AcidLactic Acid results in increased expression of HSPH1 mRNA23999411
D007854LeadLead affects the splicing of HSPH1 mRNA28903495
C008261lead acetatelead acetate affects the expression of HSPH1 mRNA21829687
C008261lead acetatelead acetate results in decreased expression of HSPH1 mRNA25270620
C045463leflunomideleflunomide results in increased expression of HSPH1 mRNA24136188
C052901lemongrass oillemongrass oil affects the expression of HSPH1 mRNA25976427
C052901lemongrass oillemongrass oil results in increased expression of HSPH1 mRNA25660481
C018584linaloollinalool results in increased expression of HSPH1 mRNA20536181
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of HSPH1 mRNA"24972896
D008070Lipopolysaccharides[usnic acid co-treated with Lipopolysaccharides] results in increased expression of HSPH1 mRNA22777745
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPH1 mRNA"27188386
D008701MethapyrileneMethapyrilene results in increased expression of HSPH1 mRNA15890375
C002950methylformamidemethylformamide analog results in increased expression of HSPH1 mRNA17040096
C002950methylformamidemethylformamide results in increased expression of HSPH1 mRNA17040096
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of HSPH1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPH1 mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of HSPH1 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of HSPH1 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of HSPH1 promoter"26251327
D008777MethyltestosteroneMethyltestosterone results in decreased expression of HSPH1 mRNA29191790
C437683motexafin gadoliniummotexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HSPH1 mRNA]16357179
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of HSPH1 mRNA16357179
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of HSPH1 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of HSPH1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of HSPH1 mRNA"25620056
D009285NaphthoquinonesNaphthoquinones results in increased expression of HSPH1 mRNA23811387
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of HSPH1 mRNA27344345
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of HSPH1 mRNA20551477
C498045NCX 4040NCX 4040 results in increased expression of HSPH1 mRNA20188076
C051752nefazodonenefazodone results in increased expression of HSPH1 mRNA24136188
D009532NickelNickel results in increased expression of HSPH1 mRNA24768652|2558310
D009532Nickel[Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of HSPH1 mRNA22198552
C012655nimesulidenimesulide results in increased expression of HSPH1 mRNA24136188
D016566Organoselenium Compounds[Organoselenium Compounds binds to Copper] which results in increased expression of HSPH1 mRNA25167922
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] affects the expression of HSPH1 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of HSPH1 mRNA26516004
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of HSPH1 mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of HSPH1 protein25616259
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HSPH1 mRNA19162173|2131816
C058305phenethyl isothiocyanateHSPH1 protein binds to phenethyl isothiocyanate21838287
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of HSPH1 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of HSPH1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of HSPH1 mRNA19270015
D010634PhenobarbitalPhenobarbital results in increased expression of HSPH1 mRNA19270015|1948288
D010634PhenobarbitalPhenobarbital affects the expression of HSPH1 mRNA19162173
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of HSPH1 mRNA15890375|2248451
C006253pirinixic acidpirinixic acid results in decreased expression of HSPH1 mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of HSPH1 mRNA20059764|2131816
C006253pirinixic acidpirinixic acid results in increased expression of HSPH1 protein20059764
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of HSPH1 mRNA]20059764|2131816
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of HSPH1 protein]20059764
C006253pirinixic acidpirinixic acid results in increased expression of HSPH1 mRNA15890375|1916217
D010894PiroxicamPiroxicam results in decreased expression of HSPH1 mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of HSPH1 mRNA23557933
D010938Plant OilsPlant Oils results in increased expression of HSPH1 mRNA23370395
D011192Potassium DichromatePotassium Dichromate results in increased expression of HSPH1 protein18563748
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of HSPH1 mRNA19162173|2131816
D011374ProgesteroneProgesterone results in decreased expression of HSPH1 mRNA23018184
C045950propiconazolepropiconazole results in increased expression of HSPH1 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of HSPH1 mRNA24780913
C100573prostaglandin A1prostaglandin A1 analog results in increased metabolism of HSPH1 protein19800325
C010423pyrithione zincpyrithione zinc results in increased expression of HSPH1 mRNA21424779
D011794QuercetinQuercetin results in increased expression of HSPH1 mRNA21632981
C009166retinol acetateretinol acetate results in increased expression of HSPH1 mRNA16772331
D019438RitonavirRitonavir results in increased expression of HSPH1 protein26626330
D012402RotenoneRotenone results in decreased expression of HSPH1 mRNA23186747
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of HSPH1 mRNA"16678137
D012715Sesame OilSesame Oil results in increased expression of HSPH1 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of HSPH1 protein25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of HSPH1 mRNA25351596
D012834SilverSilver results in increased expression of HSPH1 mRNA26014281|2895954
D012834SilverSilver results in increased expression of HSPH1 mRNA27131904
D012835Silver NitrateSilver Nitrate analog results in increased expression of HSPH1 mRNA22831968
C017947sodium arsenitesodium arsenite results in increased expression of HSPH1 mRNA18812580
C016104sodium bichromatesodium bichromate results in increased expression of HSPH1 mRNA25993096
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in increased expression of HSPH1 mRNA23999411
D053260SootSoot results in decreased expression of HSPH1 mRNA26551751
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of HSPH1 mRNA16214533
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HSPH1 mRNA"18579281
D013629TamoxifenTamoxifen affects the expression of HSPH1 mRNA17555576
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of HSPH1 mRNA26496021
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of HSPH1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HSPH1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HSPH1 mRNA15056799
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of HSPH1 mRNA]15034205
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HSPH1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HSPH1 mRNA15034205|1794274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HSPH1 mRNA16960034
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSPH1 mRNA25613284
D013792ThalidomideThalidomide analog results in increased expression of HSPH1 mRNA20525221
D019284ThapsigarginThapsigargin results in increased expression of HSPH1 protein24648495
D013883ThiostreptonThiostrepton results in increased expression of HSPH1 mRNA22321511
C009495titanium dioxidetitanium dioxide results in decreased expression of HSPH1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of HSPH1 mRNA27404394
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of HSPH1 mRNA27865774
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of HSPH1 mRNA22363418|2806579
D019772Topotecan[oxaliplatin co-treated with Topotecan] affects the expression of HSPH1 mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of HSPH1 mRNA23228038
D014212TretinoinTretinoin results in decreased expression of HSPH1 mRNA24977338
D014212TretinoinTretinoin results in increased expression of HSPH1 mRNA20488242
D014241TrichloroethyleneTrichloroethylene results in increased expression of HSPH1 mRNA19448997
C050414tripterinetripterine results in increased expression of HSPH1 mRNA17010675
C057693troglitazonetroglitazone results in increased expression of HSPH1 mRNA19631733
C080163trovafloxacintrovafloxacin results in decreased expression of HSPH1 mRNA24136188
D014414Tungsten[Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of HSPH1 mRNA22198552
D014520UrethaneUrethane results in increased expression of HSPH1 mRNA28818685
C073339usnic acid[usnic acid co-treated with Lipopolysaccharides] results in increased expression of HSPH1 mRNA22777745
C406224valdecoxibvaldecoxib results in increased expression of HSPH1 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of HSPH1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of HSPH1 mRNA23179753|2915479
D014635Valproic AcidValproic Acid affects the expression of HSPH1 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of HSPH1 mRNA21318169
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of HSPH1 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of HSPH1 mRNA19465080
D014752Vinyl ChlorideVinyl Chloride results in decreased expression of HSPH1 mRNA18579281
D014800VitalliumVitallium analog results in increased expression of HSPH1 mRNA23825117
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of HSPH1 mRNA18593933
D015032ZincZinc results in increased expression of HSPH1 mRNA25058597
D019345Zinc Acetatemotexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HSPH1 mRNA]16357179
D019345Zinc AcetateZinc Acetate results in increased expression of HSPH1 mRNA16357179

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000774adenyl-nucleotide exchange factor activity-IDA24318877  
GO:0000774adenyl-nucleotide exchange factor activity-TAS-  
GO:0005515protein binding-IPI17024176  23349634  24318877  25036637  
GO:0005524ATP binding-IEA-  
GO:0043014alpha-tubulin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006898receptor-mediated endocytosis-TAS-  
GO:0006986response to unfolded protein-TAS9931472  
GO:0045345positive regulation of MHC class I biosynthetic process-TAS12952910  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0051085chaperone cofactor-dependent protein refolding-IEA-  
GO:0051135positive regulation of NK T cell activation-TAS12952910  
GO:0061098positive regulation of protein tyrosine kinase activity-IEA-  
GO:1900034regulation of cellular response to heat-TAS-  
GO:1903748negative regulation of establishment of protein localization to mitochondrion-IEA-  
GO:1903751negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide-IEA-  
GO:1903753negative regulation of p38MAPK cascade-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS12952910  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA9931472  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA21231916  
GO:0005829cytosol-TAS-  
GO:0005874microtubule-IEA-  
GO:0032991protein-containing complex-IDA23349634  
GO:0070062extracellular exosome-HDA20458337  
GO:0071682endocytic vesicle lumen-TAS-  
KEGG ID KEGG Term
hsa04141Protein processing in endoplasmic reticulum
Reactome ID Reactome Term Evidence
R-HSA-2173782Binding and Uptake of Ligands by Scavenger ReceptorsTAS
R-HSA-2173782Binding and Uptake of Ligands by Scavenger ReceptorsIEA
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3000484Scavenging by Class F ReceptorsTAS
R-HSA-3000484Scavenging by Class F ReceptorsIEA
R-HSA-3371453Regulation of HSF1-mediated heat shock responseTAS
R-HSA-3371556Cellular response to heat stressTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5653656Vesicle-mediated transportIEA
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal