Gene: CGA

1081
CG-ALPHA|FSHA|GPHA1|GPHa|HCG|LHA|TSHA
glycoprotein hormones, alpha polypeptide
protein-coding
6q14.3
Ensembl:ENSG00000135346 MIM:118850 Vega:OTTHUMG00000015161 UniprotKB:P01215
NC_000006.12
PubMed
ND
12   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.882e-1 (AD)  4.802e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRL0.79
GH10.774
LHB0.64
TSHB0.58
POMC0.562
FSHB0.478
UGT1A70.437
KRT150.435
CSTA0.407
BOD1L20.406

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYF6-0.22
MYPN-0.196
GSTM1-0.189
L3MBTL3-0.183
STX19-0.182
ZNF518B-0.178
CDK1-0.178
AKR1C1-0.177
NEB-0.177
CNGB3-0.175

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"[Egtazic Acid co-treated with 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester] inhibits the reaction [[CGA protein co-treated with Atrazine] results in increased expression of STAR mRNA]"27554787
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CGA mRNA"27291303
C1202272-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [cypermethrin results in increased expression of CGA mRNA]"29149324
C1202272-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [DDT results in increased expression of CGA mRNA]"24814263
C1202272-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Methoxychlor results in increased expression of CGA mRNA]"24814263
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CGA mRNA"19114083
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [[CGA protein co-treated with FSHB protein co-treated with rosiglitazone] results in increased expression of NR1H3 mRNA]20926582
C0163923,3'-diindolylmethane"3,3'-diindolylmethane results in increased expression of CGA mRNA"27092574
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CGA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CGA mRNA"27188386
C1163224-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine[4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine co-treated with CGA protein] results in increased expression of CYP11A1 mRNA21352547
C1163224-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine inhibits the reaction [CGA protein results in increased expression of FSHR mRNA]21352547
C1163224-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine inhibits the reaction [CGA protein results in increased expression of LHCGR mRNA]21352547
C1163224-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine inhibits the reaction [CGA protein results in increased expression of STAR mRNA]21352547
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CGA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CGA mRNA"27188386
C1197378-prenylnaringenin8-prenylnaringenin results in decreased expression of CGA mRNA16522720
D000079AcetaldehydeAminoglutethimide inhibits the reaction [CGA protein results in increased abundance of Acetaldehyde]22285649
D000079AcetaldehydeCGA protein results in increased abundance of Acetaldehyde22285649
D000079AcetaldehydeCGA protein results in increased abundance of Acetaldehyde22285649
D000079Acetaldehyde[CGA protein results in increased abundance of Acetaldehyde] which results in decreased expression of ALDH1A1 mRNA22285649
D000079Acetaldehyde[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of ALDH1A1 mRNA22285649
D000079Acetaldehyde[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of ALDH1A2 mRNA22285649
D000079Acetaldehyde[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of ALDH1A7 mRNA22285649
D000079Acetaldehyde[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of ALDH2 mRNA22285649
D000079Acetaldehyde[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of ALDH3A2 mRNA22285649
D000079Acetaldehyde[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of ALDH7A1 mRNA22285649
D000079Acetaldehyde[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of ALDH9A1 mRNA22285649
D000079Acetaldehyde[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of CYP11A1 mRNA22285649
D000079Acetaldehyde[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of CYP17A1 mRNA22285649
D000079Acetaldehyde[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of CYP19A1 mRNA22285649
D000079Acetaldehyde[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of HSD17B1 mRNA22285649
D000079Acetaldehyde[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of HSD3B1 mRNA22285649
D000079Acetaldehyde[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of STAR mRNA22285649
D000242Cyclic AMPCGA protein affects the secretion of Cyclic AMP23071612
D000242Cyclic AMP[CGA protein affects the secretion of Cyclic AMP] which results in increased secretion of Progesterone23071612
D000242Cyclic AMP[CGA protein co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Cyclic AMP23071612
D000242Cyclic AMPCGA protein results in increased abundance of Cyclic AMP20378682|2164263
D000242Cyclic AMP[CGA protein results in increased activity of FSHR protein] which results in increased abundance of Cyclic AMP26895433
D000242Cyclic AMPColforsin promotes the reaction [CGA protein results in increased abundance of Cyclic AMP]20378682
D000242Cyclic AMPDDT promotes the reaction [[CGA protein results in increased activity of FSHR protein] which results in increased abundance of Cyclic AMP]26895433
D000242Cyclic AMPColforsin inhibits the reaction [ESR2 gene mutant form inhibits the reaction [CGA protein results in increased abundance of Cyclic AMP]]20378682
D000242Cyclic AMPESR2 gene mutant form inhibits the reaction [CGA protein results in increased abundance of Cyclic AMP]20378682
D000242Cyclic AMP[ESR2 gene mutant form results in decreased expression of LHCGR protein] inhibits the reaction [CGA protein results in increased abundance of Cyclic AMP]20378682
D000242Cyclic AMP[Flufenamic Acid results in decreased abundance of Cyclic AMP] which results in decreased expression of CGA mRNA8404651
D000447AldehydesAldehydes results in increased expression of CGA mRNA25014914
D000616AminoglutethimideAminoglutethimide inhibits the reaction [CGA protein results in increased abundance of Acetaldehyde]22285649
D000638AmiodaroneAmiodarone results in increased expression of CGA mRNA3427795
C006632arsenic trioxidearsenic trioxide results in increased expression of CGA mRNA20458559
D001280AtrazineAtrazine results in increased expression of CGA mRNA18461179
D001280Atrazine[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of AREG mRNA]23583632
D001280Atrazine[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of EREG mRNA]23583632
D001280Atrazine[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of PGR mRNA]23583632
D001280Atrazinebisindolylmaleimide I inhibits the reaction [[CGA protein co-treated with Atrazine] results in increased expression of STAR mRNA]27554787
D001280Atrazine[CGA protein affects the susceptibility to Atrazine] which results in increased expression of SCARB1 mRNA27554787
D001280Atrazine[CGA protein affects the susceptibility to Atrazine] which results in increased expression of STAR mRNA27554787
D001280Atrazine[CGA protein co-treated with Atrazine] results in increased expression of STAR mRNA27554787
D001280Atrazine"[Egtazic Acid co-treated with 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester] inhibits the reaction [[CGA protein co-treated with Atrazine] results in increased expression of STAR mRNA]"27554787
D001280AtrazineU 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of AREG mRNA]]23583632
D001280AtrazineU 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of EREG mRNA]]23583632
D001280AtrazineU 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of PGR mRNA]]23583632
D001564Benzo(a)pyreneBenzo(a)pyrene inhibits the reaction [CGA results in increased abundance of Testosterone]21737371
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CGA mRNA24361490
D004958Estradiol[CGA protein co-treated with FSHB protein] affects the abundance of Estradiol22451503
D004958EstradiolCGA protein results in increased abundance of Estradiol19501113|2037868
D004958EstradiolEstradiol results in increased expression of CGA protein19580841
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of CGA protein]19580841
D004958Estradiolmono-(2-ethylhexyl)phthalate inhibits the reaction [CGA protein results in increased abundance of Estradiol]19501113
D004958EstradiolEstradiol affects the reaction [Dieldrin results in decreased expression of CGA mRNA]23041725
D004958EstradiolESR2 gene mutant form inhibits the reaction [CGA protein results in increased abundance of Estradiol]20378682
D004958EstradiolEstradiol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CGA mRNA]21187122
D004958EstradiolEstradiol results in decreased expression of CGA mRNA16522720|1661438
C099952bifenthrinbifenthrin results in increased secretion of CGA protein24938463
C099952bifenthrinfulvestrant inhibits the reaction [bifenthrin results in increased secretion of CGA protein]24938463
C099952bifenthrinbifenthrin analog inhibits the reaction [CGA protein results in increased abundance of Progesterone]21871944
C099952bifenthrinbifenthrin analog inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]21871944
C099952bifenthrinbifenthrin analog inhibits the reaction [CGA results in increased expression of CYP11A1 mRNA]21871944
C099952bifenthrinbifenthrin analog inhibits the reaction [CGA results in increased expression of DBI mRNA]21871944
C099952bifenthrinbifenthrin analog inhibits the reaction [CGA results in increased expression of PTGS2 mRNA]21871944
C099952bifenthrinbifenthrin analog inhibits the reaction [CGA results in increased expression of STAR mRNA]21871944
C099952bifenthrinbifenthrin analog inhibits the reaction [CGA results in increased expression of TSPO mRNA]21871944
C099952bifenthrinbifenthrin inhibits the reaction [CGA protein results in increased expression of AREG mRNA]21251947
C099952bifenthrinbifenthrin inhibits the reaction [CGA protein results in increased expression of CCNE1 mRNA]21251947
C099952bifenthrinbifenthrin inhibits the reaction [CGA protein results in increased expression of CDKN1A mRNA]21251947
C099952bifenthrinbifenthrin inhibits the reaction [CGA protein results in increased expression of CEBPB mRNA]21251947
C099952bifenthrinbifenthrin inhibits the reaction [CGA protein results in increased expression of CYP11A1 mRNA]21251947
C099952bifenthrinbifenthrin inhibits the reaction [CGA protein results in increased expression of CYP19A1 mRNA]21251947
C099952bifenthrinbifenthrin inhibits the reaction [CGA protein results in increased expression of EREG mRNA]21251947
C099952bifenthrinbifenthrin inhibits the reaction [CGA protein results in increased expression of PGR mRNA]21251947
C099952bifenthrinbifenthrin inhibits the reaction [CGA protein results in increased expression of PTGS2 mRNA]21251947
C099952bifenthrinbifenthrin inhibits the reaction [CGA protein results in increased expression of RUNX1 mRNA]21251947
C099952bifenthrinbifenthrin inhibits the reaction [CGA protein results in increased expression of STAR mRNA]21251947
C099952bifenthrinbifenthrin inhibits the reaction [CGA protein results in increased expression of SULT1E1 mRNA]21251947
C099952bifenthrinbifenthrin inhibits the reaction [CGA protein results in increased expression of TGFB1 mRNA]21251947
C099952bifenthrinbifenthrin inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]21251947
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [cypermethrin results in increased expression of CGA mRNA]29149324
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [[CGA protein co-treated with Atrazine] results in increased expression of STAR mRNA]27554787
C006780bisphenol Abisphenol A results in increased expression of CGA mRNA25784278
C006780bisphenol Abisphenol A results in increased expression of CGA mRNA20647052
C006780bisphenol Abisphenol A results in decreased expression of CGA mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CGA mRNA22079614
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CGA mRNA21467749|8404651
C027561butylbenzyl phthalatebutylbenzyl phthalate inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]25016925
C027561butylbenzyl phthalatebutylbenzyl phthalate inhibits the reaction [CGA protein results in increased secretion of Progesterone]25016925
C018475butyraldehydebutyraldehyde results in increased expression of CGA mRNA26079696
D020148Butyric AcidButyric Acid results in decreased stability of CGA mRNA1693837
D020148Butyric AcidButyric Acid results in increased expression of CGA mRNA1693837
D020148Butyric AcidButyric Acid results in increased expression of CGA protein1693836|1693837
D020148Butyric Acid[Theophylline co-treated with Butyric Acid] results in increased expression of CGA mRNA1693836
D020148Butyric AcidTheophylline inhibits the reaction [Butyric Acid results in decreased stability of CGA mRNA]1693837
D020148Butyric AcidTheophylline promotes the reaction [Butyric Acid results in increased expression of CGA protein]1693836|1693837
D019256Cadmium ChlorideCadmium Chloride results in decreased activity of CGA protein18040592
D019256Cadmium ChlorideCadmium Chloride affects the methylation of CGA promoter22457795
D005576ColforsinColforsin results in increased expression of CGA mRNA24747804
D005576ColforsinColforsin promotes the reaction [CGA protein results in increased abundance of Cyclic AMP]20378682
D005576ColforsinColforsin results in increased secretion of CGA protein16503475
D005576ColforsinColforsin inhibits the reaction [ESR2 gene mutant form inhibits the reaction [CGA protein results in increased abundance of Cyclic AMP]]20378682
D005576ColforsinColforsin results in increased expression of CGA mRNA8404651
D003300CopperCopper deficiency results in increased expression of CGA mRNA26033743
D003484CyanamideCyanamide inhibits the reaction [CGA protein results in increased expression of BMP7 mRNA]22285649
D003484CyanamideCyanamide inhibits the reaction [CGA protein results in increased expression of CCND2 mRNA]22285649
D003484CyanamideCyanamide inhibits the reaction [CGA protein results in increased expression of CYP17A1 mRNA]22285649
D003484CyanamideCyanamide inhibits the reaction [CGA protein results in increased expression of CYP19A1 mRNA]22285649
D003484CyanamideCyanamide inhibits the reaction [CGA protein results in increased expression of FSHR mRNA]22285649
D003484CyanamideCyanamide inhibits the reaction [CGA protein results in increased expression of LHCGR mRNA]22285649
C017160cypermethrin"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [cypermethrin results in increased expression of CGA mRNA]"29149324
C017160cypermethrinbisindolylmaleimide I inhibits the reaction [cypermethrin results in increased expression of CGA mRNA]29149324
C017160cypermethrincypermethrin results in increased expression of CGA mRNA29149324
D003634DDTDDT promotes the reaction [[CGA protein results in increased activity of FSHR protein] which results in increased abundance of Cyclic AMP]26895433
D003634DDT"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [DDT results in increased expression of CGA mRNA]"24814263
D003634DDTDDT results in increased expression of CGA mRNA24814263
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of CGA mRNA23640034
D003907DexamethasoneDexamethasone results in increased expression of CGA mRNA24747804
D003993Dibutyl PhthalateDibutyl Phthalate inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]25016925
D003993Dibutyl PhthalateDibutyl Phthalate inhibits the reaction [CGA protein results in increased secretion of Progesterone]25016925
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene affects the reaction [CGA protein results in increased expression of AR mRNA]27391359
D004026DieldrinDieldrin results in decreased expression of CGA mRNA23041725
D004026DieldrinEstradiol affects the reaction [Dieldrin results in decreased expression of CGA mRNA]23041725
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]25016925
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate inhibits the reaction [CGA protein results in increased secretion of Progesterone]25016925
D002117CalcitriolCalcitriol results in decreased expression of CGA mRNA16002434
D004533Egtazic Acid"[Egtazic Acid co-treated with 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester] inhibits the reaction [[CGA protein co-treated with Atrazine] results in increased expression of STAR mRNA]"27554787
D060754EquolEquol results in decreased expression of CGA mRNA23220561
C074283estradiol 3-benzoateestradiol 3-benzoate results in decreased expression of CGA mRNA15223135
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CGA mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CGA mRNA17942748
D015025Zearalenonefulvestrant inhibits the reaction [Zearalenone results in increased expression of CGA protein]19580841
D015025ZearalenoneZearalenone results in increased expression of CGA protein19580841
D015025Zearalenone[Zearalenone co-treated with CGA protein] results in decreased expression of ATP1A1 protein25058043
D015025Zearalenone[Zearalenone co-treated with CGA protein] results in decreased expression of CALR protein25058043
D015025Zearalenone[Zearalenone co-treated with CGA protein] results in decreased expression of CD36 protein25058043
D015025Zearalenone[Zearalenone co-treated with CGA protein] results in decreased expression of HSD17B11 protein25058043
D015025Zearalenone[Zearalenone co-treated with CGA protein] results in decreased expression of MGLL protein25058043
D015025Zearalenone[Zearalenone co-treated with CGA protein] results in decreased expression of P4HB protein25058043
D015025Zearalenone[Zearalenone co-treated with CGA protein] results in decreased expression of SMPDL3B protein25058043
D015025Zearalenone[Zearalenone co-treated with CGA protein] results in decreased expression of SYAP1 protein25058043
D015025Zearalenone[Zearalenone co-treated with CGA protein] results in increased expression of ACTR3 protein25058043
D015025Zearalenone[Zearalenone co-treated with CGA protein] results in increased expression of AHSA1 protein25058043
D015025Zearalenone[Zearalenone co-treated with CGA protein] results in increased expression of DNM1L protein25058043
D015025Zearalenone[Zearalenone co-treated with CGA protein] results in increased expression of PDCD6IP protein25058043
D015025Zearalenone[Zearalenone co-treated with CGA protein] results in increased expression of PHGDH protein25058043
D015025Zearalenone[Zearalenone co-treated with CGA protein] results in increased expression of TLN1 protein25058043
D015025Zearalenone[Zearalenone co-treated with CGA protein] results in increased expression of YKT6 protein25058043
D005411Flame RetardantsFlame Retardants promotes the reaction [CGA protein results in increased secretion of Testosterone]21642635
D005411Flame RetardantsFlame Retardants results in decreased expression of CGA mRNA21767471
D005439Flufenamic Acid[Flufenamic Acid results in decreased abundance of Cyclic AMP] which results in decreased expression of CGA mRNA8404651
D005485FlutamideFlutamide results in increased expression of CGA mRNA23220561
C070081fulvestrantfulvestrant inhibits the reaction [bifenthrin results in increased secretion of CGA protein]24938463
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of CGA protein]19580841
C070081fulvestrantfulvestrant inhibits the reaction [Zearalenone results in increased expression of CGA protein]19580841
C089796hexabromocyclododecane[hexabromocyclododecane co-treated with CGA protein] results in decreased expression of AR mRNA25447410
C089796hexabromocyclododecane[hexabromocyclododecane co-treated with CGA protein] results in decreased expression of CYP11A1 mRNA25447410
C089796hexabromocyclododecane[hexabromocyclododecane co-treated with CGA protein] results in decreased expression of HSD17B3 mRNA25447410
C089796hexabromocyclododecane[hexabromocyclododecane co-treated with CGA protein] results in decreased expression of LHCGR mRNA25447410
C089796hexabromocyclododecane[hexabromocyclododecane co-treated with CGA protein] results in decreased expression of NR0B1 mRNA25447410
C089796hexabromocyclododecane[hexabromocyclododecane co-treated with CGA protein] results in decreased expression of NR5A1 mRNA25447410
C089796hexabromocyclododecane[hexabromocyclododecane co-treated with CGA protein] results in decreased expression of SCARB1 mRNA25447410
C089796hexabromocyclododecane[hexabromocyclododecane co-treated with CGA protein] results in decreased expression of TSPO mRNA25447410
C089796hexabromocyclododecane[hexabromocyclododecane co-treated with CGA protein] results in increased degradation of STAR protein25447410
C089796hexabromocyclododecanehexabromocyclododecane inhibits the reaction [[FSHB protein co-treated with CGA protein] results in increased expression of AREG mRNA]24071787
C089796hexabromocyclododecanehexabromocyclododecane inhibits the reaction [[FSHB protein co-treated with CGA protein] results in increased expression of EREG mRNA]24071787
C089796hexabromocyclododecanehexabromocyclododecane inhibits the reaction [[FSHB protein co-treated with CGA protein] results in increased expression of PGR mRNA]24071787
C533761hexabromodiphenyl ether 154hexabromodiphenyl ether 154 results in decreased expression of CGA mRNA21767471
D007213IndomethacinIndomethacin results in increased expression of CGA mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CGA mRNA25613284
D0150561-Methyl-3-isobutylxanthine[CGA protein co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Cyclic AMP23071612
D007654KetoconazoleKetoconazole results in decreased expression of CGA mRNA25808816
C008261lead acetatelead acetate inhibits the reaction [CGA protein results in increased abundance of Progesterone]11213355|1264777
C008261lead acetatelead acetate results in decreased activity of CGA protein11213355
D008727MethotrexateCGA protein affects the susceptibility to Methotrexate16217747
D008731MethoxychlorMethoxychlor affects the reaction [CGA protein results in increased expression of AR mRNA]27391359
D008731Methoxychlor"2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Methoxychlor results in increased expression of CGA mRNA]"24814263
D008731MethoxychlorMethoxychlor results in increased expression of CGA mRNA24814263
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate inhibits the reaction [CGA protein results in increased abundance of Estradiol]19501113
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate inhibits the reaction [CGA protein results in increased abundance of Progesterone]27181934
C483758N(6)-phenyl-cAMPN(6)-phenyl-cAMP results in increased expression of CGA mRNA20663796
C029938nickel sulfatenickel sulfate results in increased expression of CGA mRNA18651567
D009538NicotineNicotine results in increased expression of CGA mRNA23825647
C025256nonylphenolnonylphenol affects the reaction [CGA protein results in increased expression of CYP11A1 protein]19883722
C025256nonylphenolnonylphenol affects the reaction [CGA protein results in increased expression of STAR protein]19883722
C025256nonylphenolnonylphenol inhibits the reaction [CGA protein results in increased secretion of Testosterone]19883722
D015282OctreotideOctreotide results in decreased secretion of CGA protein1518435
C046012pentanalpentanal results in increased expression of CGA mRNA26079696
D015232Dinoprostonebutylbenzyl phthalate inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]25016925
D015232DinoprostoneCGA protein results in increased secretion of Dinoprostone25016925
D015232DinoprostoneDibutyl Phthalate inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]25016925
D015232DinoprostoneDiethylhexyl Phthalate inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]25016925
D015232Dinoprostonebifenthrin analog inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]21871944
D015232Dinoprostonebifenthrin inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]21251947
D015232DinoprostoneCGA protein results in increased secretion of Dinoprostone21251947
D010624PhenelzinePhenelzine inhibits the reaction [Triiodothyronine results in decreased expression of CGA mRNA]20148560
D010624PhenelzinePhenelzine results in increased expression of CGA mRNA20148560
D010624PhenelzineTriiodothyronine inhibits the reaction [Phenelzine results in increased expression of CGA mRNA]20148560
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CGA mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CGA mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of CGA mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of CGA mRNA21334430
C009006potassium perchloratepotassium perchlorate results in increased expression of CGA mRNA24747804
D011374ProgesteroneADM protein modified form inhibits the reaction [ADM protein inhibits the reaction [CGA protein results in increased secretion of Progesterone]]18401014
D011374Progesteronebutylbenzyl phthalate inhibits the reaction [CGA protein results in increased secretion of Progesterone]25016925
D011374ProgesteroneCFL1 protein affects the reaction [CGA protein results in increased secretion of Progesterone]20610540
D011374Progesterone[CGA protein affects the secretion of Cyclic AMP] which results in increased secretion of Progesterone23071612
D011374Progesterone[CGA protein co-treated with FSHB protein] results in increased abundance of Progesterone20926582
D011374Progesterone[CGA protein co-treated with FSHB protein] results in increased secretion of Progesterone19228890
D011374ProgesteroneCGA protein results in increased secretion of Progesterone19228890|2061054
D011374ProgesteroneDibutyl Phthalate inhibits the reaction [CGA protein results in increased secretion of Progesterone]25016925
D011374ProgesteroneDiethylhexyl Phthalate inhibits the reaction [CGA protein results in increased secretion of Progesterone]25016925
D011374ProgesteroneTO-901317 inhibits the reaction [[CGA protein co-treated with FSHB protein] results in increased abundance of Progesterone]20926582
D011374ProgesteroneCGA protein results in increased abundance of Progesterone11213355|1264777
D011374Progesteronelead acetate inhibits the reaction [CGA protein results in increased abundance of Progesterone]11213355|1264777
D011374Progesteronemono-(2-ethylhexyl)phthalate inhibits the reaction [CGA protein results in increased abundance of Progesterone]27181934
D011374ProgesteroneProgesterone results in decreased expression of CGA mRNA19690047
D011374ProgesteroneADM protein inhibits the reaction [CGA protein results in increased secretion of Progesterone]18401014
D011374Progesteronebifenthrin analog inhibits the reaction [CGA protein results in increased abundance of Progesterone]21871944
D011374ProgesteroneCGA protein results in increased abundance of Progesterone21458522|2187194
D011374ProgesteroneCGA protein results in increased secretion of Progesterone18401014
C005556propionaldehydepropionaldehyde results in increased expression of CGA mRNA26079696
C432165pyrazolanthronepyrazolanthrone results in increased expression of CGA mRNA24747804
C089730rosiglitazone2-chloro-5-nitrobenzanilide inhibits the reaction [[CGA protein co-treated with FSHB protein co-treated with rosiglitazone] results in increased expression of NR1H3 mRNA]20926582
C089730rosiglitazone[CGA protein co-treated with FSHB protein co-treated with rosiglitazone] results in increased expression of ABCG1 mRNA20926582
C089730rosiglitazone[CGA protein co-treated with FSHB protein co-treated with rosiglitazone] results in increased expression of NR1H3 mRNA20926582
C089730rosiglitazonerosiglitazone inhibits the reaction [[CGA protein co-treated with FSHB protein] results in increased expression of SCARB1 mRNA]20926582
C089730rosiglitazonerosiglitazone inhibits the reaction [[CGA protein co-treated with FSHB protein] results in increased expression of STAR mRNA]20926582
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CGA mRNA23806026
D012834SilverSilver results in decreased expression of CGA mRNA28959546
C017947sodium arseniteCGA protein inhibits the reaction [sodium arsenite results in decreased expression of SORD protein]16483355
C017947sodium arseniteCGA protein results in decreased susceptibility to sodium arsenite20146381
D012969Sodium FluorideSodium Fluoride results in increased expression of CGA mRNA27257137
D014284TriiodothyroninePhenelzine inhibits the reaction [Triiodothyronine results in decreased expression of CGA mRNA]20148560
D014284TriiodothyronineTriiodothyronine inhibits the reaction [Phenelzine results in increased expression of CGA mRNA]20148560
D014284TriiodothyronineTriiodothyronine results in decreased expression of CGA mRNA20148560
D013605T-2 Toxin[T-2 Toxin co-treated with CGA protein] results in decreased activity of CYP11A1 protein25962641
D013605T-2 Toxin[T-2 Toxin co-treated with CGA protein] results in decreased activity of CYP17A1 protein25962641
D013605T-2 Toxin[T-2 Toxin co-treated with CGA protein] results in decreased activity of STAR protein25962641
D013605T-2 Toxin[T-2 Toxin co-treated with CGA protein] results in decreased expression of CYP11A1 mRNA25962641
D013605T-2 Toxin[T-2 Toxin co-treated with CGA protein] results in decreased expression of STAR mRNA25962641
D013629TamoxifenTamoxifen results in decreased expression of CGA mRNA25123088
D013654TaurineTaurine results in increased expression of CGA mRNA16579726
D013654TaurineTaurine affects the reaction [CGA protein results in increased secretion of Testosterone]19921479
C087114tebuconazoletebuconazole results in decreased expression of CGA mRNA26852204
D013739TestosteroneBenzo(a)pyrene inhibits the reaction [CGA results in increased abundance of Testosterone]21737371
D013739Testosterone[CGA protein co-treated with FSHB protein] affects the abundance of Testosterone22451503
D013739TestosteroneCGA protein results in increased secretion of Testosterone19228890|2164263
D013739TestosteroneCGA results in increased abundance of Testosterone21737371
D013739TestosteroneFlame Retardants promotes the reaction [CGA protein results in increased secretion of Testosterone]21642635
D013739TestosteroneFSHB protein promotes the reaction [CGA protein results in increased secretion of Testosterone]19228890
D013739TestosteroneCGA protein promotes the reaction [CRH protein results in increased secretion of Testosterone]23133512
D013739TestosteroneCGA protein results in increased abundance of Testosterone21458522
D013739TestosteroneCGA protein results in increased secretion of Testosterone19883722|1992147
D013739Testosteronenonylphenol inhibits the reaction [CGA protein results in increased secretion of Testosterone]19883722
D013739TestosteroneTaurine affects the reaction [CGA protein results in increased secretion of Testosterone]19921479
C004648testosterone enanthatetestosterone enanthate results in decreased expression of CGA mRNA25603467
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CGA mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CGA mRNA24793433
D013749TetrachlorodibenzodioxinCGA protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ESR1 protein]12128104
D013749TetrachlorodibenzodioxinCGA protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NR3C1 protein]12128104
D013749TetrachlorodibenzodioxinCGA protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLAT protein]12128104
D013749TetrachlorodibenzodioxinCGA protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLAU protein]12128104
D013749TetrachlorodibenzodioxinCGA protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 protein]12128104
D013749TetrachlorodibenzodioxinCGA protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINE1 protein]12128104
D013749TetrachlorodibenzodioxinCGA protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of NR3C1 protein]12128104
D013749TetrachlorodibenzodioxinEstradiol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CGA mRNA]21187122
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [PTGS2 protein results in increased expression of CGA mRNA]12128104
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [PTGS2 protein results in increased expression of CGA protein]12128104
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CGA mRNA22493514
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CGA mRNA21187122
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CGA mRNA25613284
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of CGA mRNA21467749
D019284ThapsigarginThapsigargin results in increased expression of CGA mRNA21694771
D013806Theophylline[Theophylline co-treated with Butyric Acid] results in increased expression of CGA mRNA1693836
D013806TheophyllineTheophylline inhibits the reaction [Butyric Acid results in decreased stability of CGA mRNA]1693837
D013806TheophyllineTheophylline promotes the reaction [Butyric Acid results in increased expression of CGA protein]1693836|1693837
D013806TheophyllineTheophylline results in increased expression of CGA protein1693837
D013806TheophyllineTheophylline results in increased stability of CGA mRNA1693837
D013849ThimerosalThimerosal results in increased expression of CGA mRNA24675092
D013890ThioureaThiourea results in increased expression of CGA mRNA9356215
C423915TO-901317TO-901317 inhibits the reaction [[CGA protein co-treated with FSHB protein] results in increased abundance of Progesterone]20926582
C423915TO-901317[TO-901317 co-treated with CGA protein co-treated with FSHB protein] results in increased expression of ABCA1 mRNA20926582
C423915TO-901317[TO-901317 co-treated with CGA protein co-treated with FSHB protein] results in increased expression of ABCG1 mRNA20926582
C423915TO-901317TO-901317 inhibits the reaction [[CGA protein co-treated with FSHB protein] results in increased expression of CYP11A1 mRNA]20926582
C423915TO-901317TO-901317 inhibits the reaction [[CGA protein co-treated with FSHB protein] results in increased expression of SCARB1 mRNA]20926582
C423915TO-901317TO-901317 inhibits the reaction [[CGA protein co-treated with FSHB protein] results in increased expression of STAR mRNA]20926582
C012589trichostatin Atrichostatin A results in decreased expression of CGA mRNA24747804
C012589trichostatin Atrichostatin A results in increased expression of CGA mRNA24935251
C113580U 0126U 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of AREG mRNA]]23583632
C113580U 0126U 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of EREG mRNA]]23583632
C113580U 0126U 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of PGR mRNA]]23583632
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CGA mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of CGA mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of CGA mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CGA gene25560391
C025643vinclozolinvinclozolin results in increased expression of CGA mRNA17980475

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005179hormone activity-IMP11207219  
GO:0005515protein binding-IPI11222739  15662415  22802634  
GO:0016913follicle-stimulating hormone activity-IDA2494176  24692546  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-TAS-  
GO:0007186G-protein coupled receptor signaling pathway-IDA24692546  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0008284positive regulation of cell proliferation-NAS20613903  
GO:0010469regulation of signaling receptor activity-IDA24692546  
GO:0010893positive regulation of steroid biosynthetic process-IDA2494176  
GO:0016486peptide hormone processing-TAS-  
GO:0030335positive regulation of cell migration-NAS20613903  
GO:0045944positive regulation of transcription by RNA polymerase II-NAS20613903  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA2494176  24692546  
GO:0005796Golgi lumen-TAS-  
GO:0016914follicle-stimulating hormone complex-IDA2494176  24692546  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
hsa04912GnRH signaling pathway
hsa05320Autoimmune thyroid disease
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-193048Androgen biosynthesisTAS
R-HSA-193993Mineralocorticoid biosynthesisTAS
R-HSA-196071Metabolism of steroid hormonesTAS
R-HSA-209776Amine-derived hormonesTAS
R-HSA-209822Glycoprotein hormonesTAS
R-HSA-209952Peptide hormone biosynthesisTAS
R-HSA-209968Thyroxine biosynthesisTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375281Hormone ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsTAS
R-HSA-8866910TFAP2 (AP-2) family regulates transcription of growth factors and their receptorsTAS
R-HSA-8957322Metabolism of steroidsTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS
R-HSA-975576N-glycan antennae elongation in the medial/trans-GolgiTAS
R-HSA-975578Reactions specific to the complex N-glycan synthesis pathwayTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26903161[Clinical Analysis of 22 Cases of Pulmonary Large Cell Neuroendocrine Cancer]. (2016 Feb)Qian ZZhongguo Fei Ai Za Zhi
20801521Development of a risk score for geographic atrophy in complications of the age-related macular degeneration prevention trial. (2011 Feb)Ying GSOphthalmology
17922186Polymorphisms in three base excision repair genes and breast cancer risk in Thai women. (2008 Sep)Sangrajrang SBreast Cancer Res Treat
15583729Plasma fibrinogen concentration predicts the risk of myocardial infarction differently in various parts of Europe: effects of beta-fibrinogen genotype and environmental factors. The HIFMECH Study. (2004 Dec)Mannila MNThromb Haemost
27126040Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. (2016 Apr 29)Zhernakova AScience
29413048Distinct clinicopathologic features, genomic characteristics and survival of central and peripheral pulmonary large cell neuroendocrine carcinoma: From different origin cells? (2018 Feb)Zhou FLung Cancer
16924699[Association of single nucleotide polymorphisms and haplotypes in DNA repair gene XRCC1 with susceptibility of breast cancer]. (2006 Jul)Jin MJZhejiang Da Xue Xue Bao Yi Xue Ban
18709642Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African Americans. (2008 Nov 1)Chang JSInt J Cancer
2404624Is physiologic sympathoadrenal catecholamine release exocytotic in humans? (1990 Jan)Takiyyuddin MACirculation
17355790[Correlations of single nucleotide polymorphisms of DNA repair gene XRCC1 to risk of colorectal cancer]. (2007 Mar)Jin MJAi Zheng
20450548[Clinical features of pulmonary malignancies in patients younger than 30 years of age]. (2010 Apr)Zhao JZhongguo Yi Xue Ke Xue Yuan Xue Bao
8777245Umbilical cord dopamine beta-hydroxylase, chromogranin A and met-enkephalin after conditions associated with chronic intrauterine stress. (1996)Van Reempts PJBiol Neonate