Gene: CPLX2

10814
921-L|CPX-2|CPX2|Hfb1
complexin 2
protein-coding
5q35.2
Ensembl:ENSG00000145920 MIM:605033 Vega:OTTHUMG00000130665 UniprotKB:Q6PUV4
NC_000005.10
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.985e-1 (AD)  9.134e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16460727chr5:175297349CPLX2Promoter2.912e-7Alcohol use disorders26763658
cg19649083chr5:175295119CPLX2Promoter2.459e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNAB20.964
PACSIN10.964
CAMK2A0.958
ATXN7L30.954
STX1B0.95
DMTN0.949
IQSEC30.948
SCAMP50.946
KCNH30.943
IQSEC10.943

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.651
OR4F29-0.599
TFPI2-0.467
C9orf135-0.463
DNAI2-0.447
SGMS2-0.444
WWTR1-0.428
RAI14-0.428
ARHGEF5-0.426
KIAA0040-0.426

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in decreased expression of CPLX2 mRNA"26377693
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CPLX2 mRNA"19114083
D020106AcrylamideAcrylamide binds to and affects the metabolism of CPLX2 protein17698512
D020106AcrylamideAcrylamide results in decreased expression of CPLX2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CPLX2 gene27153756
C000188alachloralachlor results in increased expression of CPLX2 mRNA12419858
D000638AmiodaroneAmiodarone results in increased expression of CPLX2 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CPLX2 mRNA16483693
D001151ArsenicArsenic affects the methylation of CPLX2 gene25304211
C015001arsenitearsenite results in increased methylation of CPLX2 promoter23974009
D001280AtrazineAtrazine results in decreased expression of CPLX2 mRNA25929836
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CPLX2 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CPLX2 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CPLX2 mRNA26001963
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CPLX2 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CPLX2 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of CPLX2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CPLX2 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of CPLX2 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CPLX2 gene20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CPLX2 mRNA27858113
D003024ClozapineClozapine results in decreased expression of CPLX2 mRNA17266109
D003033Coal TarCoal Tar results in decreased expression of CPLX2 mRNA27858113
D003300CopperCopper promotes the reaction [[PSEN1 gene mutant form co-treated with APP gene mutant form co-treated with MAPT gene mutant form] results in decreased expression of CPLX2 protein]25352456
D003471CuprizoneCuprizone results in decreased expression of CPLX2 mRNA26577399
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CPLX2 mRNA]27941970
D003976DiazinonDiazinon results in increased methylation of CPLX2 gene22964155
C000944dicrotophosdicrotophos results in increased expression of CPLX2 mRNA28302478
D000431EthanolEthanol results in decreased expression of CPLX2 mRNA28986285
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CPLX2 gene20938992
C069837fullerene C60fullerene C60 results in decreased expression of CPLX2 mRNA19167457
D002112CalcifediolCalcifediol deficiency results in decreased expression of CPLX2 mRNA17293106
C016517indole-3-carbinolindole-3-carbinol affects the expression of CPLX2 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CPLX2 mRNA25613284
C544151jinfukangjinfukang results in increased expression of CPLX2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CPLX2 mRNA26752646
D007657Ketone BodiesKetone Bodies results in decreased expression of CPLX2 mRNA16807920
D008694MethamphetamineMethamphetamine results in increased expression of CPLX2 protein19826936
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CPLX2 gene20938992
C030667methylazoxymethanolmethylazoxymethanol results in increased expression of CPLX2 mRNA17107856
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CPLX2 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CPLX2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CPLX2 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of CPLX2 mRNA19812364
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CPLX2 protein26879310
D010622PhencyclidinePhencyclidine results in decreased expression of CPLX2 mRNA17266109
D010795Phthalic AcidsPhthalic Acids results in decreased expression of CPLX2 mRNA21061450
D010795Phthalic AcidsPhthalic Acids results in increased expression of CPLX2 mRNA21061450
D010936Plant ExtractsPlant Extracts results in decreased expression of CPLX2 mRNA23557933
C005556propionaldehydepropionaldehyde results in decreased expression of CPLX2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of CPLX2 mRNA24780913
D012524SarinSarin results in decreased expression of CPLX2 protein28973502
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CPLX2 mRNA25895662
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CPLX2 mRNA25613284
D024505TocopherolsTocopherols results in increased expression of CPLX2 mRNA17654050
C012589trichostatin Atrichostatin A results in decreased expression of CPLX2 mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of CPLX2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CPLX2 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of CPLX2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of CPLX2 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased methylation of CPLX2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CPLX2 gene25560391
C025643vinclozolinvinclozolin affects the expression of CPLX2 mRNA19015723
D015034Zinc OxideZinc Oxide analog results in decreased expression of CPLX2 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000149SNARE binding-IBA21873635  
GO:0017075syntaxin-1 binding-IBA21873635  
GO:0017075syntaxin-1 binding-IEA-  
GO:0048306calcium-dependent protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006904vesicle docking involved in exocytosis-TAS7553862  
GO:0007399nervous system development-IEA-  
GO:0016079synaptic vesicle exocytosis-IBA21873635  
GO:0016079synaptic vesicle exocytosis-IEA-  
GO:0017157regulation of exocytosis-TAS15217342  
GO:0030154cell differentiation-IEA-  
GO:0031915positive regulation of synaptic plasticity-ISS-  
GO:0043303mast cell degranulation-IEA-  
GO:0046928regulation of neurotransmitter secretion-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IEA-  
GO:0030425dendrite-IEA-  
GO:0031201SNARE complex-IBA21873635  
GO:0042629mast cell granule-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043195terminal bouton-IBA21873635  
GO:0070033synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex-IEA-  
GO:0070554synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex-TAS15217342  
GO:0098793presynapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21426264Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. (2012 Feb)Fernandez-Castillo NWorld J Biol Psychiatry