Gene: CPLX1

10815
CPX-I|CPX1|EIEE63
complexin 1
protein-coding
4p16.3
Ensembl:ENSG00000168993 MIM:605032 Vega:OTTHUMG00000160005 UniprotKB:O14810
NC_000004.12
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.911e-1 (AD)  3.983e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCN1B0.945
CEND10.94
NRGN0.937
CABP10.936
MYPOP0.935
REEP20.935
BRSK20.933
DGKZ0.933
KCNAB20.932
STX1B0.932

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.638
OR4F29-0.6
WWTR1-0.488
IGF2BP2-0.483
TFPI2-0.483
KIAA0040-0.483
C9orf135-0.459
REST-0.457
C1orf87-0.456
CLEC2B-0.455

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of CPLX1 mRNA"23829299
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of CPLX1 mRNA"23829299
D000082AcetaminophenAcetaminophen results in decreased expression of CPLX1 mRNA22230336
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CPLX1 mRNA22129741
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of CPLX1 mRNA"22863853
D001280AtrazineAtrazine results in decreased expression of CPLX1 mRNA25929836
D001280AtrazineAtrazine results in increased expression of CPLX1 mRNA22378314
D001374AzacitidineAzacitidine results in increased expression of CPLX1 mRNA20823114
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of CPLX1 mRNA20823114
C006780bisphenol Abisphenol A results in decreased expression of CPLX1 mRNA17706920
C006780bisphenol ALHB protein affects the reaction [bisphenol A results in decreased expression of CPLX1 mRNA]17706920
C006780bisphenol Abisphenol A results in decreased expression of CPLX1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of CPLX1 promoter22457795
C084597chlorcyclizinechlorcyclizine results in increased expression of CPLX1 mRNA21058326
D003042CocaineCocaine affects the expression of CPLX1 mRNA20187946
D003300CopperCopper promotes the reaction [[PSEN1 gene mutant form co-treated with APP gene mutant form co-treated with MAPT gene mutant form] results in decreased expression of CPLX1 protein]25352456
D016572CyclosporineCyclosporine results in decreased expression of CPLX1 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of CPLX1 mRNA21632981|2556210
C089595cylindrospermopsincylindrospermopsin results in increased expression of CPLX1 mRNA24921660
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of CPLX1 mRNA20823114
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CPLX1 mRNA22129741
C540355fenamidonefenamidone results in decreased expression of CPLX1 mRNA27029645
C039281furanfuran results in increased expression of CPLX1 mRNA25539665
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CPLX1 mRNA22129741
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CPLX1 mRNA26752646
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of CPLX1 mRNA17532186
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of CPLX1 protein17532186
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of CPLX1 mRNA20823114
D008694MethamphetamineMethamphetamine results in increased expression of CPLX1 protein19826936
C523799MRK 003MRK 003 results in increased expression of CPLX1 mRNA21169257
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CPLX1 mRNA27935865
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of CPLX1 mRNA17532186
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of CPLX1 protein17532186
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CPLX1 mRNA16221955
D010936Plant ExtractsPlant Extracts results in decreased expression of CPLX1 mRNA23557933
C045950propiconazolepropiconazole results in increased expression of CPLX1 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of CPLX1 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CPLX1 mRNA19465110
C009495titanium dioxidetitanium dioxide results in decreased expression of CPLX1 mRNA23131501
D024505TocopherolsTocopherols results in increased expression of CPLX1 mRNA17654050
C012589trichostatin Atrichostatin A results in decreased expression of CPLX1 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CPLX1 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of CPLX1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CPLX1 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of CPLX1 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of CPLX1 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CPLX1 gene25560391
C025643vinclozolinvinclozolin affects the expression of CPLX1 mRNA19015723
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CPLX1 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000149SNARE binding-IBA21873635  
GO:0005326neurotransmitter transporter activity-IEA-  
GO:0005515protein binding-IPI21785412  21785414  
GO:0017075syntaxin-1 binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006887exocytosis-TAS7553862  
GO:0007268chemical synaptic transmission-TAS7553862  
GO:0016079synaptic vesicle exocytosis-IBA21873635  
GO:0016079synaptic vesicle exocytosis-IEA-  
GO:0017157regulation of exocytosis-TAS15217342  
GO:0030073insulin secretion-IEA-  
GO:0046928regulation of neurotransmitter secretion-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0030425dendrite-IEA-  
GO:0031201SNARE complex-IBA21873635  
GO:0043025neuronal cell body-IEA-  
GO:0043195terminal bouton-IBA21873635  
GO:0070032synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex-IEA-  
GO:0070554synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex-TAS15217342  
GO:0098793presynapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-181429Serotonin Neurotransmitter Release CycleTAS
R-HSA-181430Norepinephrine Neurotransmitter Release CycleTAS
R-HSA-210500Glutamate Neurotransmitter Release CycleTAS
R-HSA-212676Dopamine Neurotransmitter Release CycleTAS
R-HSA-264642Acetylcholine Neurotransmitter Release CycleTAS
R-HSA-888590GABA synthesis, release, reuptake and degradationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21426264Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. (2012 Feb)Fernandez-Castillo NWorld J Biol Psychiatry