Gene: CEACAM3

1084
CD66D|CEA|CGM1|W264|W282
carcinoembryonic antigen related cell adhesion molecule 3
protein-coding
19q13.2
Ensembl:ENSG00000170956 MIM:609142 Vega:OTTHUMG00000150142 UniprotKB:P40198
NC_000019.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.250e-1 (AD)  4.142e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7251960chr19:41802111 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLEC12A0.814
KCNJ150.808
IL2RB0.8
BPI0.796
IL18RAP0.783
TBX210.782
DPPA40.778
KLRB10.777
MROH50.775
LY90.765

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYP46A1-0.514
MAGIX-0.507
THY1-0.483
ZNF835-0.48
ASPDH-0.478
FAM43B-0.477
CHST1-0.471
EXTL1-0.471
ZNF775-0.469
LRTM2-0.469

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of CEACAM3 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CEACAM3 gene27153756
D000447AldehydesAldehydes results in decreased expression of CEACAM3 mRNA25014914
D0150571-NaphthylamineCEACAM3 gene SNP affects the susceptibility to 1-Naphthylamine25622337
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CEACAM3 mRNA16483693
D004958EstradiolESR1 protein affects the reaction [Estradiol results in decreased expression of CEACAM3 mRNA]15223131
D004958EstradiolEstradiol results in decreased expression of CEACAM3 mRNA15223131
C006780bisphenol Abisphenol A results in decreased expression of CEACAM3 mRNA15223131
C006780bisphenol AESR1 protein affects the reaction [bisphenol A results in decreased expression of CEACAM3 mRNA]15223131
C006780bisphenol Abisphenol A results in decreased expression of CEACAM3 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of CEACAM3 mRNA26079696
D002330CarmustineCarmustine results in decreased expression of CEACAM3 mRNA15980968
D003042CocaineCocaine affects the expression of CEACAM3 mRNA20187946
D019327Copper SulfateCopper Sulfate results in decreased expression of CEACAM3 mRNA19549813
C039281furanfuran results in increased methylation of CEACAM3 gene22079235
D008727MethotrexateMethotrexate results in decreased expression of CEACAM3 mRNA17400583
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to CEACAM3 promoter]20348232
C046012pentanalpentanal results in decreased expression of CEACAM3 mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CEACAM3 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of CEACAM3 gene28589171
C501413tesaglitazartesaglitazar results in increased expression of CEACAM3 mRNA21515302

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0043312neutrophil degranulation-TAS-  
GO:0050900leukocyte migration-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0035579specific granule membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal