Gene: ALDH1L1

10840
10-FTHFDH|10-fTHF|FDH|FTHFD
aldehyde dehydrogenase 1 family member L1
protein-coding
3q21.3
Ensembl:ENSG00000144908 MIM:600249 Vega:OTTHUMG00000125551 UniprotKB:O75891
NG_012260.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.123e-1 (AD)  1.554e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7617733chr3:126171901 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MRVI10.911
PLCD10.908
PBXIP10.898
RFX40.896
AHCYL10.883
AGT0.877
TP53BP20.875
SOX90.873
WLS0.868
MAOA0.867

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SAMD5-0.491
TYRP1-0.488
AGMAT-0.483
CNTN6-0.473
ZNF860-0.472
KCNS3-0.463
QRFPR-0.462
GABRG3-0.46
EPHA3-0.453
COL19A1-0.451

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00116Tetrahydrofolic acidSmall Molecule135-16-0NutraceuticalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of ALDH1L1 mRNA"19162173
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ALDH1L1 mRNA"25614096
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ALDH1L1 mRNA"19114083
C0668412,3,7,8-tetrabromodibenzo-4-dioxin"2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of ALDH1L1 protein"27604104
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ALDH1L1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ALDH1L1 mRNA"21346803
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of ALDH1L1 mRNA"21346803
C0293704-toluidine4-toluidine results in increased expression of ALDH1L1 mRNA27638505
C5213345-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate5-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate affects the expression of ALDH1L1 mRNA20932894
C0059845-methyltetrahydrofolateALDH1L1 protein results in decreased abundance of 5-methyltetrahydrofolate16627483
D000082AcetaminophenAcetaminophen results in decreased expression of ALDH1L1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ALDH1L1 mRNA17562736
D000082Acetaminophen[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of ALDH1L1 protein25499718
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ALDH1L1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ALDH1L1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ALDH1L1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ALDH1L1 mRNA19770486
D000447Aldehydes[ALDH1L1 protein co-treated with NADP] results in increased oxidation of Aldehydes23295222
D001379AzathioprineAzathioprine results in increased expression of ALDH1L1 mRNA22623647
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of ALDH1L1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ALDH1L1 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ALDH1L1 mRNA19770486
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of ALDH1L1 mRNA27685785
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in increased expression of ALDH1L1 mRNA15912405
C006780bisphenol Abisphenol A results in increased expression of ALDH1L1 mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of ALDH1L1 protein28903499
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ALDH1L1 mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ALDH1L1 mRNA17109383
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ALDH1L1 protein17109383
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ALDH1L1 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ALDH1L1 protein15650968
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ALDH1L1 mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of ALDH1L1 mRNA12851107
D002994ClofibrateClofibrate results in decreased expression of ALDH1L1 protein16470657
D002995Clofibric AcidClofibric Acid affects the expression of ALDH1L1 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in increased expression of ALDH1L1 mRNA24386269
D009249NADPALDH1L1 protein binds to NADP23295222
D009249NADP[ALDH1L1 protein co-treated with NADP] results in increased oxidation of Aldehydes23295222
D019327Copper SulfateCopper Sulfate results in decreased expression of ALDH1L1 mRNA19549813
C029892cupric chloridecupric chloride results in increased expression of ALDH1L1 mRNA17211630
C057862cyanoginosin LRcyanoginosin LR results in increased phosphorylation of ALDH1L1 protein18000846
D016572CyclosporineCyclosporine results in decreased expression of ALDH1L1 mRNA20106945|2556210
D003907DexamethasoneDexamethasone results in increased expression of ALDH1L1 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ALDH1L1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ALDH1L1 mRNA21266533|2174549
D004041Dietary FatsDietary Fats results in decreased expression of ALDH1L1 mRNA18042831
D000431EthanolEthanol results in decreased activity of ALDH1L1 protein16385189
D000431EthanolEthanol results in decreased expression of ALDH1L1 mRNA17920746
D000431EthanolFolic Acid affects the reaction [Ethanol results in decreased activity of ALDH1L1 protein]16385189
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALDH1L1 mRNA17942748
D005485FlutamideFlutamide results in increased expression of ALDH1L1 mRNA24136188
D005492Folic AcidALDH1L1 protein results in increased degradation of Folic Acid16627483
D005492Folic AcidFolic Acid affects the activity of ALDH1L1 protein16385189
D005492Folic AcidFolic Acid affects the reaction [Ethanol results in decreased activity of ALDH1L1 protein]16385189
D005897GlafenineGlafenine results in decreased expression of ALDH1L1 mRNA24136188
D017313FenretinideFenretinide results in decreased expression of ALDH1L1 mRNA28973697
C029424hydrazinehydrazine results in decreased expression of ALDH1L1 protein15370871
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ALDH1L1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ALDH1L1 mRNA28628672
C098607JP8 aviation fuelJP8 aviation fuel affects the metabolism of ALDH1L1 protein10892725
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ALDH1L1 mRNA26644586
C045463leflunomideleflunomide results in decreased expression of ALDH1L1 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ALDH1L1 mRNA"20371263
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ALDH1L1 mRNA21641980
C004925methylmercuric chloridemethylmercuric chloride affects the expression of ALDH1L1 protein27012723
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ALDH1L1 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ALDH1L1 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ALDH1L1 mRNA"25620056
C051752nefazodonenefazodone results in increased expression of ALDH1L1 mRNA24136188
D009532NickelNickel results in decreased expression of ALDH1L1 mRNA24768652|2558310
C002741N-nitrosomorpholineN-nitrosomorpholine affects the expression of ALDH1L1 protein19716841
D019319Okadaic AcidOkadaic Acid results in increased phosphorylation of ALDH1L1 protein18000846
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ALDH1L1 mRNA25729387
D010100OxygenOxygen deficiency affects the expression of ALDH1L1 protein19579223
D000073878Palm OilPalm Oil results in decreased expression of ALDH1L1 mRNA18042831
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of ALDH1L1 mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ALDH1L1 mRNA20936131
C076994perfluorooctane sulfonic acidPPARA protein promotes the reaction [perfluorooctane sulfonic acid results in decreased expression of ALDH1L1 mRNA]20936131
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ALDH1L1 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of ALDH1L1 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ALDH1L1 mRNA18467677
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of ALDH1L1 mRNA]18467677
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ALDH1L1 mRNA19162173
D010634PhenobarbitalPhenobarbital results in increased expression of ALDH1L1 mRNA19162173
D010795Phthalic AcidsPhthalic Acids results in decreased expression of ALDH1L1 mRNA15728792
C006253pirinixic acidpirinixic acid results in decreased expression of ALDH1L1 mRNA17426115
C006253pirinixic acidpirinixic acid results in decreased expression of ALDH1L1 mRNA19162173
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of ALDH1L1 mRNA27413110
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ALDH1L1 mRNA19162173
D011374ProgesteroneProgesterone results in increased expression of ALDH1L1 mRNA20726854
C005556propionaldehydepropionaldehyde results in decreased expression of ALDH1L1 mRNA26079696
D015125OxyquinolineOxyquinoline results in increased expression of ALDH1L1 mRNA21632981
D012643SeleniumSelenium affects the expression of ALDH1L1 protein19351701
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ALDH1L1 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of ALDH1L1 mRNA21457566
C016104sodium bichromatesodium bichromate results in decreased expression of ALDH1L1 mRNA25993096
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ALDH1L1 mRNA21641980
D013467Sulindac"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ALDH1L1 mRNA"20371263
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALDH1L1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ALDH1L1 mRNA19770486
D013853ThioacetamideThioacetamide results in decreased expression of ALDH1L1 mRNA23411599
C015541thionicotinamide adenine dinucleotide phosphateALDH1L1 protein binds to thionicotinamide adenine dinucleotide phosphate23295222
C009495titanium dioxidetitanium dioxide results in decreased expression of ALDH1L1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ALDH1L1 protein22609517
C066340tolcaponetolcapone results in increased expression of ALDH1L1 mRNA24136188
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ALDH1L1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of ALDH1L1 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased expression of ALDH1L1 mRNA19254012
D014303TrinitrotolueneTrinitrotoluene affects the expression of ALDH1L1 mRNA21346803
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ALDH1L1 mRNA"26743178
C057693troglitazonetroglitazone results in increased expression of ALDH1L1 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of ALDH1L1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of ALDH1L1 gene29154799
C029297vinylidene chloridevinylidene chloride results in decreased expression of ALDH1L1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003824catalytic activity-TAS10204077  
GO:0004029aldehyde dehydrogenase (NAD) activity-EXP20498374  21238436  
GO:0004029aldehyde dehydrogenase (NAD) activity-IBA21873635  
GO:0016742hydroxymethyl-, formyl- and related transferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006730one-carbon metabolic process-IEA-  
GO:0009058biosynthetic process-IEA-  
GO:000925810-formyltetrahydrofolate catabolic process-IEA-  
GO:0046655folic acid metabolic process-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa00670One carbon pool by folate
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196757Metabolism of folate and pterinesTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal