Gene info: ID 10841

Gene: FTCD

GENE ID: 10841

Synonyms: LCHC1

Description: formimidoyltransferase cyclodeaminase

Gene type: protein-coding

Location: 21q22.3

dbXrefs: Ensembl:ENSG00000160282 MIM:606806 Vega:OTTHUMG00000090488 UniprotKB:O95954

RefSeq: NG_016191.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 5

Sherlock p-value : 3.889e-1 (AD) 2.493e-1 (ND) (Frontal_Cortex)

Pascal p-value : 4.565e-1 (AD) 9.516e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
UCN	0.724
PLK1	0.709
VTN	0.7
HIC2	0.684
BRICD5	0.679
ASIC3	0.674
HSF4	0.673
OSBPL7	0.669
CPT1B	0.662
UBAP1L	0.66

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
UNC45B	-0.342
PPP1R3A	-0.34
ALG10B	-0.334
PABPC4L	-0.33
ATP1B4	-0.327
LUM	-0.324
PDE5A	-0.323
CEACAM3	-0.323
ASB9	-0.322
FER1L6	-0.319

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00114	Pyridoxal Phosphate	Small Molecule	54-47-7	Approved\|Investigational\|Nutraceutical	Target
DB00116	Tetrahydrofolic acid	Small Molecule	135-16-0	Nutraceutical	Target
DB00142	Glutamic Acid	Small Molecule	56-86-0	Approved\|Nutraceutical	Target
DB03256	(6R)-Folinic acid	Small Molecule	73951-54-9	Experimental	Target

ID	Drug Name	Action	PubMed
C490166	1-(4-methoxyphenyl)piperazine	1-(4-methoxyphenyl)piperazine results in decreased expression of FTCD mRNA	26821219
C078092	1-piperonylpiperazine	1-piperonylpiperazine results in decreased expression of FTCD mRNA	26821219
C483839	2,2',3,4,4',5',6-heptabromodiphenyl ether	"[2,2',3,4,4',5',6-heptabromodiphenyl ether co-treated with hexabromocyclododecane co-treated with tetrabromobisphenol A co-treated with tetrabromobisphenol-S-bis(2,3-dibromopropyl ether) co-treated with hexabromobenzene] results in increased expression of FTCD protein"	18258299
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FTCD mRNA"	19114083
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in decreased expression of FTCD mRNA"	20406850
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of FTCD mRNA"	25380136
C005984	5-methyltetrahydrofolate	FTCD protein results in increased abundance of 5-methyltetrahydrofolate	1574172
D000082	Acetaminophen	Acetaminophen results in decreased expression of FTCD mRNA	22230336\|2669055
D000082	Acetaminophen	Acetaminophen results in increased expression of FTCD mRNA	21420995
D000082	Acetaminophen	Acetaminophen affects the expression of FTCD protein	16687475
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of FTCD mRNA	27153756
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog results in decreased expression of FTCD protein	26597043
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of FTCD protein	26597043
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of FTCD mRNA	21298039
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of FTCD mRNA	16483693
D001280	Atrazine	Atrazine results in increased expression of FTCD mRNA	25929836
D053119	Benzophenanthridines	Benzophenanthridines analog results in decreased expression of FTCD mRNA	22120849
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of FTCD mRNA	21632023
C006780	bisphenol A	bisphenol A results in decreased expression of FTCD mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of FTCD gene	28505145
D002065	Buspirone	Buspirone results in increased expression of FTCD mRNA	24136188
C018475	butyraldehyde	butyraldehyde results in increased expression of FTCD mRNA	26079696
D002104	Cadmium	Cadmium results in increased expression of FTCD mRNA	24084258
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of FTCD mRNA	18804290
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of FTCD promoter	22457795
D002220	Carbamazepine	Carbamazepine affects the expression of FTCD mRNA	24752500
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of FTCD mRNA	27339419
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of FTCD mRNA	24612858
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of FTCD mRNA	24690739
D003300	Copper	Copper results in decreased expression of FTCD mRNA	22465980
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of FTCD mRNA	19549813
D003471	Cuprizone	Cuprizone results in increased expression of FTCD mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of FTCD mRNA	25562108
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of FTCD mRNA	21266533
D004008	Diclofenac	Diclofenac affects the expression of FTCD mRNA	24752500
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of FTCD mRNA	19041683
D019813	1,2-Dimethylhydrazine	"1,2-Dimethylhydrazine results in decreased expression of FTCD mRNA"	27840820
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of FTCD mRNA	25380136
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of FTCD mRNA	24690739
D000431	Ethanol	Ethanol results in decreased expression of FTCD protein	19609968
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FTCD mRNA	17942748
D005411	Flame Retardants	Flame Retardants results in increased expression of FTCD protein	18258299
C039281	furan	furan binds to FTCD protein	22240984
D005897	Glafenine	Glafenine results in decreased expression of FTCD mRNA	24136188
C017363	hexabromobenzene	"[2,2',3,4,4',5',6-heptabromodiphenyl ether co-treated with hexabromocyclododecane co-treated with tetrabromobisphenol A co-treated with tetrabromobisphenol-S-bis(2,3-dibromopropyl ether) co-treated with hexabromobenzene] results in increased expression of FTCD protein"	18258299
C089796	hexabromocyclododecane	"[2,2',3,4,4',5',6-heptabromodiphenyl ether co-treated with hexabromocyclododecane co-treated with tetrabromobisphenol A co-treated with tetrabromobisphenol-S-bis(2,3-dibromopropyl ether) co-treated with hexabromobenzene] results in increased expression of FTCD protein"	18258299
C410337	K 7174	K 7174 results in decreased expression of FTCD mRNA	24086573
D008694	Methamphetamine	[Methamphetamine co-treated with SCH 23390] results in increased expression of FTCD mRNA	19564919
D008694	Methamphetamine	Methamphetamine results in increased expression of FTCD mRNA	19564919
C059539	midostaurin	midostaurin results in increased expression of FTCD mRNA	20980353
C500085	muraglitazar	muraglitazar results in increased expression of FTCD mRNA	21515302
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in decreased expression of FTCD mRNA	25380136
C461488	N-benzylpiperazine	N-benzylpiperazine results in decreased expression of FTCD mRNA	26821219
C051752	nefazodone	nefazodone results in increased expression of FTCD mRNA	24136188
C012655	nimesulide	nimesulide results in increased expression of FTCD mRNA	24136188
C002741	N-nitrosomorpholine	N-nitrosomorpholine affects the expression of FTCD protein	19716841
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of FTCD mRNA	23948077
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of FTCD mRNA	18804290
C027579	periodate-oxidized adenosine	periodate-oxidized adenosine affects the expression of FTCD mRNA	17097637
D010634	Phenobarbital	Phenobarbital results in increased expression of FTCD protein	19952500
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of FTCD mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of FTCD mRNA	19482888
C006253	pirinixic acid	pirinixic acid results in decreased expression of FTCD protein	15226431
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of FTCD mRNA	23608068
C045950	propiconazole	propiconazole results in decreased expression of FTCD mRNA	21278054
C005556	propionaldehyde	propionaldehyde results in increased expression of FTCD mRNA	26079696
D011794	Quercetin	Quercetin results in decreased expression of FTCD mRNA	21632981
C059514	resveratrol	resveratrol results in increased expression of FTCD mRNA	25436977
C089730	rosiglitazone	rosiglitazone results in decreased expression of FTCD mRNA	21515302
C534628	SCH 23390	[Methamphetamine co-treated with SCH 23390] results in increased expression of FTCD mRNA	19564919
C534628	SCH 23390	SCH 23390 results in increased expression of FTCD mRNA	19564919
C009277	sodium arsenate	sodium arsenate results in decreased expression of FTCD mRNA	23922661
C016104	sodium bichromate	sodium bichromate results in decreased expression of FTCD mRNA	24612858
C016104	sodium bichromate	[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of FTCD mRNA	21632023
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid results in decreased expression of FTCD mRNA	15885361
C020806	tetrabromobisphenol A	"[2,2',3,4,4',5',6-heptabromodiphenyl ether co-treated with hexabromocyclododecane co-treated with tetrabromobisphenol A co-treated with tetrabromobisphenol-S-bis(2,3-dibromopropyl ether) co-treated with hexabromobenzene] results in increased expression of FTCD protein"	18258299
C555802	tetrabromobisphenol-S-bis(2,3-dibromopropyl ether)	"[2,2',3,4,4',5',6-heptabromodiphenyl ether co-treated with hexabromocyclododecane co-treated with tetrabromobisphenol A co-treated with tetrabromobisphenol-S-bis(2,3-dibromopropyl ether) co-treated with hexabromobenzene] results in increased expression of FTCD protein"	18258299
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FTCD mRNA	22574217
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FTCD mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FTCD mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FTCD mRNA	21215274
D013763	Tetrahydrofolates	FTCD protein results in decreased abundance of Tetrahydrofolates	1574172
D013853	Thioacetamide	Thioacetamide results in decreased expression of FTCD mRNA	23411599
D013893	Thiram	Thiram results in increased expression of FTCD mRNA	20530235
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of FTCD mRNA	21346803
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FTCD mRNA"	26179874
D014635	Valproic Acid	Valproic Acid results in decreased expression of FTCD mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of FTCD mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in increased methylation of FTCD gene	29154799
D014635	Valproic Acid	Valproic Acid results in decreased activity of FTCD protein	1574172
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of FTCD mRNA	26682919

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	25416956
GO:0005542	folic acid binding	-	IEA	-
GO:0008017	microtubule binding	-	IDA	14697341
GO:0008017	microtubule binding	-	ISS	-
GO:0030407	formimidoyltransferase activity	-	ISS	-
GO:0030409	glutamate formimidoyltransferase activity	-	IEA	-
GO:0030412	formimidoyltetrahydrofolate cyclodeaminase activity	-	EXP	12815595
GO:0030412	formimidoyltetrahydrofolate cyclodeaminase activity	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006548	histidine catabolic process	-	TAS	-
GO:0006760	folic acid-containing compound metabolic process	-	TAS	10029623
GO:0019556	histidine catabolic process to glutamate and formamide	-	IEA	-
GO:0019557	histidine catabolic process to glutamate and formate	-	IEA	-
GO:0035999	tetrahydrofolate interconversion	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000139	Golgi membrane	-	IDA	14697341
GO:0000139	Golgi membrane	-	ISS	-
GO:0005737	cytoplasm	-	TAS	10029623
GO:0005783	endoplasmic reticulum	-	ISS	-
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	-	ISS	-
GO:0005794	Golgi apparatus	-	ISS	-
GO:0005814	centriole	-	IEA	-
GO:0005829	cytosol	-	IDA	14697341
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IDA	-
GO:0030868	smooth endoplasmic reticulum membrane	-	IDA	14697341
GO:0070062	extracellular exosome	-	HDA	19056867

KEGG ID	KEGG Term
hsa00340	Histidine metabolism
hsa00670	One carbon pool by folate
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-6788656	Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism	TAS
R-HSA-70921	Histidine catabolism	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25234284	Searching for phenotypes in smoking cessation treatment. (2014 Dec)	Jimenez-Ruiz CA	Int J Clin Pract
22103680	Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study. (2011 Nov 21)	Wernimont SM	BMC Med Genet
28431293	Cigarette dependence and depressive symptoms as predictors of smoking status at five-year follow-up after a workplace smoking cessation program. (2017 Oct)	Nieva G	Addict Behav
27192133	Exploring Relationships Among Experience of Regret, Delay Discounting, and Worries About Future Effects of Smoking Among Current Smokers. (2016 Jul 28)	O'Connor RJ	Subst Use Misuse
22524403	CHRNB3 is more strongly associated with Fagerstrom test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results. (2012 Nov)	Rice JP	Addiction