Gene: CD3EAP

10849
ASE-1|ASE1|CAST|PAF49
CD3e molecule associated protein
protein-coding
19q13.32
Ensembl:ENSG00000117877 MIM:107325 Vega:OTTHUMG00000182120 UniprotKB:O15446
NC_000019.10
PubMed
0   ANCO-SNPs
ND
8   
1.924e-1 (AD)  5.472e-1 (ND)   (Frontal_Cortex)
7.431e-1 (AD)  5.689e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC27A40.87
TBC1D22B0.867
PRRT30.861
ARMC60.86
LRFN30.858
PTPRS0.858
TANGO20.857
C2CD2L0.857
FARSA0.856
TIMM500.856

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VNN2-0.519
IL18RAP-0.513
CSAG1-0.497
CLEC2B-0.495
FCGR3B-0.494
CXCR2-0.491
CST7-0.489
GNG11-0.48
KCNJ15-0.477
WEE1-0.47

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of CD3EAP mRNA"27071940
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of CD3EAP mRNA]"27071940
C0343434-aminobenzhydrazide4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in decreased expression of CD3EAP mRNA]24530881
D000082AcetaminophenAcetaminophen affects the expression of CD3EAP mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CD3EAP gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CD3EAP mRNA22100608
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CD3EAP mRNA21715664
C006780bisphenol Abisphenol A results in increased expression of CD3EAP mRNA25047013
D002185CannabidiolCannabidiol results in decreased expression of CD3EAP mRNA21542829
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of CD3EAP mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of CD3EAP mRNA19320972
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of CD3EAP mRNA20971185
C000944dicrotophosdicrotophos results in increased expression of CD3EAP mRNA28302478
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CD3EAP protein23301498
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CD3EAP mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of CD3EAP mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of CD3EAP mRNA19167457
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CD3EAP mRNA20044591
C013038hydroxyhydroquinone4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in decreased expression of CD3EAP mRNA]24530881
C013038hydroxyhydroquinonehydroxyhydroquinone results in decreased expression of CD3EAP mRNA24530881
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CD3EAP mRNA24796395
C045463leflunomideleflunomide results in decreased expression of CD3EAP mRNA28988120
D008727MethotrexateMethotrexate results in decreased expression of CD3EAP mRNA17400583
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CD3EAP mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CD3EAP mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CD3EAP mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of CD3EAP mRNA20971185
D010100OxygenOxygen deficiency results in decreased expression of CD3EAP mRNA26516004
D010416PentachlorophenolPentachlorophenol results in decreased expression of CD3EAP mRNA24642059
D011441PropylthiouracilPropylthiouracil results in increased expression of CD3EAP mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CD3EAP mRNA25895662
C016104sodium bichromatesodium bichromate results in increased expression of CD3EAP mRNA25993096
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CD3EAP mRNA"26179874
D014520UrethaneUrethane results in decreased expression of CD3EAP mRNA28818685
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CD3EAP gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0003899DNA-directed 5'-3' RNA polymerase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006361transcription initiation from RNA polymerase I promoter-TAS-  
GO:0006363termination of RNA polymerase I transcription-TAS-  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-TAS10373416  
GO:0009303rRNA transcription-TAS9426281  
GO:0045815positive regulation of gene expression, epigenetic-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000120RNA polymerase I transcription factor complex-TAS9426281  
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005694chromosome-IEA-  
GO:0005730nucleolus-TAS9426281  
GO:0005739mitochondrion-IDA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212165Epigenetic regulation of gene expressionTAS
R-HSA-212165Epigenetic regulation of gene expressionIEA
R-HSA-427413NoRC negatively regulates rRNA expressionIEA
R-HSA-5250913Positive epigenetic regulation of rRNA expressionTAS
R-HSA-5250924B-WICH complex positively regulates rRNA expressionTAS
R-HSA-5250941Negative epigenetic regulation of rRNA expressionIEA
R-HSA-73762RNA Polymerase I Transcription InitiationTAS
R-HSA-73762RNA Polymerase I Transcription InitiationIEA
R-HSA-73772RNA Polymerase I Promoter EscapeTAS
R-HSA-73777RNA Polymerase I Chain ElongationTAS
R-HSA-73854RNA Polymerase I Promoter ClearanceTAS
R-HSA-73854RNA Polymerase I Promoter ClearanceIEA
R-HSA-73863RNA Polymerase I Transcription TerminationTAS
R-HSA-73864RNA Polymerase I TranscriptionTAS
R-HSA-73864RNA Polymerase I TranscriptionIEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-74160Gene expression (Transcription)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22335888A specific diplotype defined by PPP1R13L rs1970764, CD3EAP rs967591 and ERCC1 rs11615 and lung cancer risk in a Chinese population. (2012 Jun)Yin JLung Cancer
27183913Fine-mapping markers of lung cancer susceptibility in a sub-region of chromosome 19q13.3 among Chinese. (2016 Sep 20)Yin JOncotarget
26681190Genetic Polymorphisms in XRCC1, CD3EAP, PPP1R13L, XPB, XPC, and XPF and the Risk of Chronic Benzene Poisoning in a Chinese Occupational Population. (2015)Xue PPLoS One
29108262Association of PPP1R13L and CD3EAP polymorphisms with risk and survival of non-small cell lung cancer in Chinese non-smoking females. (2017 Oct 3)Feng XOncotarget
25917613NFKB1 common variants and PPP1R13L and CD3EAP in relation to lung cancer risk in a Chinese population. (2015 Aug 1)Yin JGene
23624123Effects of PPP1R13L and CD3EAP variants on lung cancer susceptibility among nonsmoking Chinese women. (2013 Jul 25)Yin JGene
24140460HapMap-based study identifies risk sub-region on chromosome 19q13.3 in relation to lung cancer among Chinese. (2013 Dec)Yin JCancer Epidemiol
26563375Association and interaction of NFKB1 rs28362491 insertion/deletion ATTG polymorphism and PPP1R13L and CD3EAP related to lung cancer risk in a Chinese population. (2016 Apr)Yin JTumour Biol