Gene: ARID5A

10865
MRF-1|MRF1|RP11-363D14
AT-rich interaction domain 5A
protein-coding
2q11.2
Ensembl:ENSG00000196843 MIM:611583 Vega:OTTHUMG00000155229 UniprotKB:Q03989
NC_000002.12
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.034e-1 (AD)  7.846e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDKN1A0.871
GADD45B0.862
MAFF0.857
YBX30.834
NFKB20.831
CEBPD0.83
SBNO20.823
LMNA0.823
ITPKC0.818
C11orf960.811

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAPLN1-0.43
KIT-0.399
CASC15-0.369
NEUROD6-0.368
PRLHR-0.367
IGF1-0.365
MARCH4-0.362
NXPH2-0.358
SLC32A1-0.352
VWC2-0.344

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ARID5A mRNA"28903501
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in increased expression of ARID5A mRNA23792671
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ARID5A mRNA28329830
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of ARID5A mRNA19191707
D000082AcetaminophenAcetaminophen affects the expression of ARID5A mRNA17562736
C016601afimoxifeneARID5A protein inhibits the reaction [afimoxifene results in increased activity of ESR1 protein]15941852
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ARID5A mRNA22100608
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ARID5A mRNA21298039
D000638AmiodaroneAmiodarone results in increased expression of ARID5A mRNA19774075
D001280AtrazineAtrazine results in increased expression of ARID5A mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARID5A mRNA25908611
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ARID5A mRNA21569818|2222880
D004958EstradiolARID5A protein inhibits the reaction [Estradiol results in increased activity of ESR1 protein]15941852
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ARID5A mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of ARID5A mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of ARID5A mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of ARID5A mRNA26079696
D002509CephaloridineCephaloridine results in increased expression of ARID5A mRNA18500788
D003033Coal TarCoal Tar results in increased expression of ARID5A mRNA27858113
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ARID5A mRNA28628672
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ARID5A mRNA28329830
D017313FenretinideFenretinide results in increased expression of ARID5A mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ARID5A mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ARID5A mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ARID5A mRNA28628672
C544151jinfukangjinfukang results in increased expression of ARID5A mRNA27392435
D008558MelphalanMelphalan results in increased expression of ARID5A mRNA22363485
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ARID5A mRNA24810058
C500085muraglitazarmuraglitazar results in decreased expression of ARID5A mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ARID5A mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ARID5A mRNA"25554681|2562005
C031721naphthalenenaphthalene results in increased expression of ARID5A mRNA18978301
D009532NickelNickel results in increased expression of ARID5A mRNA24768652|2558310
C046012pentanalpentanal results in increased expression of ARID5A mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of ARID5A mRNA19159669
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of ARID5A mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of ARID5A mRNA19482888
D010795Phthalic AcidsPhthalic Acids results in increased expression of ARID5A mRNA21061450
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ARID5A mRNA28903501
D020849Raloxifene HydrochlorideARID5A protein inhibits the reaction [Raloxifene Hydrochloride results in increased activity of ESR1 protein]15941852
C089730rosiglitazonerosiglitazone results in decreased expression of ARID5A mRNA21515302
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of ARID5A mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ARID5A mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of ARID5A mRNA19073995
D018038Sodium SeleniteSodium Selenite results in increased expression of ARID5A mRNA18175754
D012999SomanSoman results in increased expression of ARID5A mRNA19281266
D053260SootSoot results in increased expression of ARID5A mRNA26551751
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of ARID5A mRNA"26680231
C501413tesaglitazartesaglitazar results in decreased expression of ARID5A mRNA21515302
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of ARID5A mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARID5A mRNA21570461|2637764
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ARID5A mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of ARID5A mRNA27760801
C057693troglitazonetroglitazone results in decreased expression of ARID5A mRNA21515302
D014635Valproic AcidValproic Acid results in increased expression of ARID5A mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of ARID5A gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ARID5A mRNA21427059
D024483Vitamin K 3Vitamin K 3 affects the expression of ARID5A mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IC-  
GO:0003677DNA binding-TAS15640446  
GO:0003714transcription corepressor activity-IDA15941852  
GO:0003723RNA binding-IEA-  
GO:0005515protein binding-IPI15941852  16713569  23275563  25416956  
GO:0008134transcription factor binding-IDA15941852  
GO:0030331estrogen receptor binding-IDA15941852  
GO:0043565sequence-specific DNA binding-IDA15640446  
GO:0044212transcription regulatory region DNA binding-IBA21873635  
GO:0046965retinoid X receptor binding-IDA15941852  
GO:0046966thyroid hormone receptor binding-IDA15941852  
GO:0050681androgen receptor binding-IDA15941852  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA15941852  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045087innate immune response-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-TAS15640446  
GO:0071391cellular response to estrogen stimulus-IDA15941852  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005730nucleolus-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21184583Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence. (2011 Jan)Zlojutro MAm J Med Genet B Neuropsychiatr Genet