Gene: ME3

10873
NADP-ME
malic enzyme 3
protein-coding
11q14.2
Ensembl:ENSG00000151376 MIM:604626 Vega:OTTHUMG00000167217 UniprotKB:Q16798
NC_000011.10
PubMed|SNP Mapped
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.017e-1 (AD)  6.976e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12797615chr11:86555641 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10155725chr11:86380814ME36.400e-8Smoking27651444
cg03646605chr11:86383804ME31.700e-10Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AP3B20.957
DLG30.956
ENO20.955
GPRASP10.954
ANXA60.951
MADD0.951
TRIM30.951
SUSD40.95
TBC1D250.948
ENTPD60.948

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.527
RAI14-0.522
REST-0.513
OR4F5-0.509
HEY2-0.498
WWTR1-0.493
CNN2-0.478
OR4F29-0.466
RAB13-0.452
RNF135-0.451

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of ME3 mRNA"26377693
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of ME3 mRNA"26377693
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ME3 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ME3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ME3 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ME3 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ME3 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ME3 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ME3 mRNA"23146750
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ME3 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of ME3 mRNA17202762
D020106AcrylamideAcrylamide results in decreased expression of ME3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ME3 mRNA23630614
D016604Aflatoxin B1[sulforafan co-treated with Aflatoxin B1] affects the expression of ME3 mRNA25450479
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ME3 mRNA24449571
D001151ArsenicArsenic affects the methylation of ME3 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ME3 mRNA20064835
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ME3 mRNA19619570
D004958EstradiolEstradiol results in increased expression of ME3 mRNA19619570
C006780bisphenol Abisphenol A affects the expression of ME3 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of ME3 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of ME3 mRNA25181051
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of ME3 mRNA24763279
D000068579CelecoxibCelecoxib results in decreased expression of ME3 mRNA28201806
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of ME3 mRNA26272509
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ME3 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of ME3 mRNA19320972|1937684
D003907DexamethasoneDexamethasone results in increased expression of ME3 mRNA25047013
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of ME3 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ME3 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ME3 mRNA22023808
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ME3 mRNA17602206
C118739entinostatentinostat results in decreased expression of ME3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ME3 mRNA17942748
D005485FlutamideFlutamide results in increased expression of ME3 mRNA21525395
D004397FonofosFonofos results in increased methylation of ME3 promoter22847954
C039281furanfuran results in decreased expression of ME3 mRNA25539665
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of ME3 mRNA24763279
C412815GW 4064GW 4064 results in decreased expression of ME3 mRNA26655953
D007213IndomethacinIndomethacin results in decreased expression of ME3 mRNA28201806
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ME3 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ME3 mRNA24796395
C011890kojic acidkojic acid results in decreased expression of ME3 mRNA16595896
D008345ManganeseManganese results in increased expression of ME3 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of ME3 mRNA17175027
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ME3 mRNA28001369
D009020MorphineMorphine results in increased expression of ME3 mRNA21178816
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ME3 mRNA"25554681
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of ME3 mRNA26272509
D010278ParathionParathion results in increased methylation of ME3 promoter22847954
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ME3 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of ME3 mRNA24642059
D010634PhenobarbitalPhenobarbital affects the expression of ME3 mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ME3 mRNA26272509
D012999SomanSoman results in decreased expression of ME3 mRNA19281266
D053260SootSoot results in increased expression of ME3 mRNA26551751
C016766sulforafan[sulforafan co-treated with Aflatoxin B1] affects the expression of ME3 mRNA25450479
D013629TamoxifenTamoxifen results in increased expression of ME3 mRNA25123088
C012568terbufosterbufos results in increased methylation of ME3 promoter22847954
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ME3 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ME3 mRNA19619570
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ME3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ME3 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ME3 mRNA21215274
D013853ThioacetamideThioacetamide results in decreased expression of ME3 mRNA23411599
D014212TretinoinTretinoin results in decreased expression of ME3 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ME3 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ME3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ME3 mRNA23179753|2352703
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ME3 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of ME3 mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ME3 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of ME3 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004470malic enzyme activity-IBA21873635  
GO:0004470malic enzyme activity-IDA7818469  
GO:0004471malate dehydrogenase (decarboxylating) (NAD+) activity-IEA-  
GO:0004473malate dehydrogenase (decarboxylating) (NADP+) activity-IBA21873635  
GO:0004473malate dehydrogenase (decarboxylating) (NADP+) activity-IDA7818469  
GO:0004473malate dehydrogenase (decarboxylating) (NADP+) activity-TAS-  
GO:0008948oxaloacetate decarboxylase activity-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0048037cofactor binding-TAS7818469  
GO:0051287NAD binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006090pyruvate metabolic process-IBA21873635  
GO:0006090pyruvate metabolic process-IDA7818469  
GO:0006099tricarboxylic acid cycle-TAS-  
GO:0006108malate metabolic process-IBA21873635  
GO:0006108malate metabolic process-IDA7818469  
GO:0009060aerobic respiration-TAS7818469  
GO:0055114oxidation-reduction process-IDA7818469  
GO:0072592oxygen metabolic process-TAS7818469  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-TAS7818469  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00620Pyruvate metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-71403Citric acid cycle (TCA cycle)TAS
R-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24983941Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function. (2014)Tang WPLoS One