Gene info: ID 10874

Gene: NMU

GENE ID: 10874

Synonyms: -

Description: neuromedin U

Gene type: protein-coding

Location: 4q12

dbXrefs: Ensembl:ENSG00000109255 MIM:605103 Vega:OTTHUMG00000102161 UniprotKB:P48645

RefSeq: NC_000004.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.556e-1 (AD) 6.070e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZNF385D	0.842
LHX6	0.824
NXPH2	0.806
VWC2	0.802
MYO5B	0.8
SLC32A1	0.795
CRHBP	0.788
KCNS3	0.786
RAB3B	0.771
GRIN3A	0.766

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ITPKB	-0.563
HVCN1	-0.557
REST	-0.543
TGIF1	-0.541
HEBP2	-0.541
ROM1	-0.539
RNF135	-0.532
CSF1	-0.53
STON2	-0.529
BAZ1A	-0.52

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C495626	14-deoxy-11,12-didehydroandrographolide	"14-deoxy-11,12-didehydroandrographolide results in decreased expression of NMU mRNA"	22101062
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of NMU mRNA"	19167446
C036990	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of NMU mRNA"	20816883
C549543	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in decreased expression of NMU mRNA	25716159
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NMU mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NMU mRNA"	27188386
C496492	abrine	abrine results in decreased expression of NMU mRNA	22595364
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of NMU protein	20106945
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of NMU mRNA	16483693
C015001	arsenite	arsenite results in increased methylation of NMU promoter	23974009
D001280	Atrazine	Atrazine results in decreased expression of NMU mRNA	25929836
D001280	Atrazine	Atrazine results in increased expression of NMU mRNA	22378314
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of NMU mRNA	26377693
D004958	Estradiol	Estradiol results in increased expression of NMU mRNA	19167446
C006780	bisphenol A	[bisphenol A co-treated with Genistein] results in increased methylation of NMU gene	28505145
C006780	bisphenol A	bisphenol A results in decreased expression of NMU mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of NMU gene	28505145
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of NMU mRNA	23423171
C018475	butyraldehyde	butyraldehyde results in increased expression of NMU mRNA	26079696
C584509	C646 compound	C646 compound results in decreased expression of NMU mRNA	26191083
D002104	Cadmium	Cadmium results in decreased expression of NMU mRNA	24376830
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of NMU promoter	22457795
D005576	Colforsin	Colforsin results in increased expression of NMU mRNA	23423171
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of NMU mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in increased expression of NMU mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of NMU mRNA"	19167446
D003375	Coumestrol	Coumestrol results in increased expression of NMU mRNA	19167446
D016572	Cyclosporine	Cyclosporine results in decreased expression of NMU mRNA	20106945
D003561	Cytarabine	Cytarabine results in increased expression of NMU mRNA	21198554
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of NMU mRNA	23914054
D013759	Dronabinol	Dronabinol results in increased expression of NMU mRNA	12237329
D002945	Cisplatin	NMU protein affects the susceptibility to Cisplatin	16217747
D002117	Calcitriol	Calcitriol results in decreased expression of NMU mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of NMU mRNA	21592394
C118739	entinostat	entinostat results in increased expression of NMU mRNA	27188386
D005620	Freund's Adjuvant	Freund's Adjuvant results in increased expression of NMU mRNA	20846436
C039281	furan	furan results in increased expression of NMU mRNA	27387713
D019833	Genistein	[bisphenol A co-treated with Genistein] results in increased methylation of NMU gene	28505145
C492448	ICG 001	ICG 001 results in decreased expression of NMU mRNA	26191083
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NMU mRNA	25613284
C051890	irinotecan	irinotecan affects the expression of NMU mRNA	20097248
D008466	Mechlorethamine	Mechlorethamine results in increased expression of NMU mRNA	17107856
D008694	Methamphetamine	Methamphetamine results in increased expression of NMU mRNA	19564919
C029938	nickel sulfate	nickel sulfate results in decreased expression of NMU mRNA	22714537
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of NMU mRNA	20971185
D010100	Oxygen	Oxygen deficiency results in increased expression of NMU mRNA	26516004
C006253	pirinixic acid	pirinixic acid results in increased expression of NMU mRNA	17426115
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of NMU mRNA	22714537
D011374	Progesterone	NMU protein results in increased abundance of Progesterone	23423171
C059514	resveratrol	resveratrol results in increased expression of NMU mRNA	17257620
D012524	Sarin	Sarin results in decreased expression of NMU mRNA	19522546
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of NMU mRNA	25895662
D020123	Sirolimus	Sirolimus inhibits the reaction [TP73 protein results in increased expression of NMU mRNA]	21245298
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of NMU mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of NMU mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of NMU mRNA	19693291
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NMU mRNA	25613284
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of NMU mRNA	28065790
D014212	Tretinoin	Tretinoin results in increased expression of NMU mRNA	21934132
C012589	trichostatin A	trichostatin A results in increased expression of NMU mRNA	24935251\|2718838
D014415	Tunicamycin	Tunicamycin results in decreased expression of NMU mRNA	22378314
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NMU mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of NMU mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of NMU mRNA	23179753\|2438349
C111237	vorinostat	vorinostat results in increased expression of NMU mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005102	signaling receptor binding	-	TAS	10811630
GO:0005515	protein binding	-	IPI	25416956
GO:0031839	type 1 neuromedin U receptor binding	-	IDA	10894543 11027493
GO:0031840	type 2 neuromedin U receptor binding	-	IDA	10894543
GO:0042922	neuromedin U receptor binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001659	temperature homeostasis	-	IEA	-
GO:0001696	gastric acid secretion	-	IEA	-
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	IEA	-
GO:0007218	neuropeptide signaling pathway	-	IBA	21873635
GO:0007218	neuropeptide signaling pathway	-	IDA	10894543 11027493
GO:0009648	photoperiodism	-	IEA	-
GO:0010460	positive regulation of heart rate	-	IEA	-
GO:0019233	sensory perception of pain	-	IEA	-
GO:0031652	positive regulation of heat generation	-	IEA	-
GO:0042755	eating behavior	-	IEA	-
GO:0044497	positive regulation of blood pressure in other organism	-	IEA	-
GO:0045187	regulation of circadian sleep/wake cycle, sleep	-	IEA	-
GO:0045987	positive regulation of smooth muscle contraction	-	IBA	21873635
GO:0048512	circadian behavior	-	IBA	21873635
GO:0050806	positive regulation of synaptic transmission	-	IBA	21873635
GO:0050806	positive regulation of synaptic transmission	-	IEA	-
GO:0060455	negative regulation of gastric acid secretion	-	IEA	-
GO:0097009	energy homeostasis	-	IEA	-
GO:0120061	negative regulation of gastric emptying	-	IEA	-
GO:0120069	positive regulation of stomach fundus smooth muscle contraction	-	IEA	-
GO:1902722	positive regulation of prolactin secretion	-	IEA	-
GO:1903999	negative regulation of eating behavior	-	IEA	-
GO:1904058	positive regulation of sensory perception of pain	-	IEA	-
GO:2000821	regulation of grooming behavior	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0043195	terminal bouton	-	IBA	21873635
GO:0043195	terminal bouton	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375276	Peptide ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27762075	Sex-specific linkage scans in opioid dependence. (2017 Apr)	Yang BZ	Am J Med Genet B Neuropsychiatr Genet
19147396	Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure. (2009 Aug)	Cheong SC	Oral Oncol
16627471	ADP-ribosyltransferase-specific modification of human neutrophil peptide-1. (2006 Jun 23)	Paone G	J Biol Chem