Gene: CFHR4

10877
CFHL4|FHR-4|FHR4
complement factor H related 4
protein-coding
1q31.3
Ensembl:ENSG00000134365 MIM:605337 Vega:OTTHUMG00000036647 UniprotKB:Q92496
NG_028159.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.453e-2 (AD)  9.469e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EPHA30.478
NPBWR20.457
SAMD50.449
TLL10.448
TDO20.444
POSTN0.439
PIP5KL10.436
CAPS20.434
MEPE0.432
CHRM20.43

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATOH8-0.303
RAB13-0.3
PXDC1-0.298
MAML2-0.298
TMEM176A-0.296
ROM1-0.296
HIST1H1C-0.292
FCN3-0.291
CASP7-0.288
SRGAP1-0.288

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CFHR4 mRNA"20816883
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CFHR4 mRNA"20816883
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CFHR4 mRNA28001369
D012822Silicon DioxideSilicon Dioxide analog affects the expression of CFHR4 mRNA23806026
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CFHR4 mRNA25895662

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005319lipid transporter activity-TAS9038172  
GO ID GO Term Qualifier Evidence PubMed
GO:0006869lipid transport-IEA-  
GO:0030449regulation of complement activation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21807600Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration. (2011 Jul)Hageman GSHum Genomics
18541031The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration. (2008 Jun 9)Zhang HBMC Med Genet