Gene: CFHR3

10878
CFHL3|DOWN16|FHR-3|FHR3|HLF4
complement factor H related 3
protein-coding
1q31.3
Ensembl:ENSG00000116785 MIM:605336 Vega:OTTHUMG00000035929 UniprotKB:Q02985
NG_015993.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.025e-1 (AD)  6.841e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNFAIP80.608
FRRS10.604
DPEP20.591
FAM20A0.582
SPTLC30.577
FOXD20.572
GABRP0.571
ASB90.568
PGR0.567
BNC20.564

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HRH3-0.354
PURG-0.345
CDHR2-0.345
HIPK4-0.344
PLD6-0.34
NHLH1-0.34
HTR1E-0.338
CCNF-0.338
ATP2B3-0.335
CHST1-0.334

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000393Air PollutantsAir Pollutants analog results in decreased expression of CFHR3 mRNA21757418
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CFHR3 mRNA22316170
C018475butyraldehydebutyraldehyde results in decreased expression of CFHR3 mRNA26079696
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CFHR3 mRNA27392435
D002945CisplatinCisplatin results in increased expression of CFHR3 mRNA27392435
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CFHR3 mRNA26159488
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CFHR3 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of CFHR3 mRNA16835149
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CFHR3 mRNA"24972896
D052638Particulate MatterParticulate Matter results in increased expression of CFHR3 mRNA27851901
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CFHR3 mRNA27153767
D010634PhenobarbitalPhenobarbital affects the expression of CFHR3 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of CFHR3 mRNA23091169
D011374ProgesteroneProgesterone results in increased expression of CFHR3 mRNA23012394
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CFHR3 mRNA25895662
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CFHR3 mRNA26159488
D014635Valproic AcidValproic Acid results in decreased methylation of CFHR3 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-TAS8428964  
GO:0070062extracellular exosome-HDA23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18084039Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration. (2008 Apr 1)Spencer KLHum Mol Genet
23103884Age-related macular degeneration and coronary heart disease: evaluation of genetic and environmental associations. (2013 Feb)Keilhauer CNEur J Med Genet