Gene: PROKR1

10887
GPR73|GPR73a|PK-R1|PKR1|ZAQ
prokineticin receptor 1
protein-coding
2p13.3
Ensembl:ENSG00000169618 MIM:607122 UniprotKB:Q8TCW9
NG_051312.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.943e-1 (AD)  8.791e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNTF0.549
ZNF6830.541
MBOAT10.534
GRAP20.523
RAB3IP0.517
BEST30.515
FAT40.513
LY90.503
TBX210.503
CD3G0.5

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.422
FAM71E1-0.406
YBX2-0.397
TMEM221-0.394
RECQL4-0.387
C16orf71-0.385
NAT14-0.381
RHBDL1-0.38
CCDC74B-0.379
GAS2L1-0.37

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PROKR1 mRNA19933214
D000639AmitriptylineAmitriptyline results in decreased expression of PROKR1 mRNA21820738
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PROKR1 mRNA16483693
C006780bisphenol Abisphenol A results in decreased expression of PROKR1 mRNA25181051
D002118CalciumPROKR1 protein affects the reaction [Capsaicin results in increased abundance of Calcium]16793879
D002118CalciumPROKR1 protein affects the reaction [PROK2 protein results in increased abundance of Calcium]16793879
D002211CapsaicinPROKR1 protein affects the reaction [Capsaicin results in increased abundance of Calcium]16793879
D002211CapsaicinPROKR1 protein results in increased susceptibility to Capsaicin16793879
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PROKR1 mRNA17484886
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PROKR1 mRNA23914054
D005620Freund's AdjuvantPROKR1 protein results in increased susceptibility to Freund's Adjuvant16793879
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PROKR1 mRNA21385734
C027793mustard oilPROKR1 protein results in increased susceptibility to mustard oil16793879
D010936Plant ExtractsPlant Extracts results in decreased expression of PROKR1 mRNA23557933
D011522ProtonsPROKR1 protein results in increased susceptibility to Protons16793879
D014284TriiodothyronineTriiodothyronine results in increased expression of PROKR1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PROKR1 mRNA27913140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PROKR1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PROKR1 mRNA19933214

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001602pancreatic polypeptide receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007166cell surface receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007623circadian rhythm-IBA21873635  
GO:0043066negative regulation of apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20864676Cotinine exposure increases Fallopian tube PROKR1 expression via nicotinic AChRalpha-7: a potential mechanism explaining the link between smoking and tubal ectopic pregnancy. (2010 Nov)Shaw JLAm J Pathol
21224062Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFkappaB activation resulting in a microenvironment predisposed to ectopic pregnancy. (2011 Jan)Shaw JLAm J Pathol