Gene: PPARGC1A

10891
LEM6|PGC-1(alpha)|PGC-1alpha|PGC-1v|PGC1|PGC1A|PPARGC1
PPARG coactivator 1 alpha
protein-coding
4p15.2
Ensembl:ENSG00000109819 MIM:604517 Vega:OTTHUMG00000097747 UniprotKB:Q9UBK2
NG_028250.2
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.369e-1 (AD)  7.624e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs647381chr4:24058982 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ANO50.892
CDS10.89
FGF90.89
FAM81A0.889
MEF2C0.888
PPM1L0.887
NRXN10.887
KCNQ30.886
CNTNAP20.886
ZNF250.885

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SGMS2-0.536
TGFB3-0.51
RAI14-0.508
ANXA13-0.506
SH2D1A-0.482
SNHG18-0.478
PGF-0.474
CNN2-0.471
MDFI-0.471
ROM1-0.47

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C47675610-(6'-ubiquinonyl)decyltriphenylphosphonium bromide10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [SOD2 mutant form results in increased expression of PPARGC1A protein]24563852
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of PPARGC1A mRNA"26377693
C5244781,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [PPARGC1A protein binds to CYP11A1 gene]]"18511507
C5244781,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [PPARGC1A protein binds to HSD3B gene]]"18511507
C5244781,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to PPARGC1A protein]]]"18511507
C5244781,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to PPARGC1A protein]]"18511507
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [PPARGC1A protein binds to CYP2B10 promoter]"23684557
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of PPARGC1A mRNA"22698814|2476933
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of PPARGC1A protein"24769335
C0005971361-(4-chlorophenyl)-benzo-2,5-quinone"1-(4-chlorophenyl)-benzo-2,5-quinone results in decreased expression of PPARGC1A"26004620
C0005971361-(4-chlorophenyl)-benzo-2,5-quinone"PPARGC1A protein inhibits the reaction [1-(4-chlorophenyl)-benzo-2,5-quinone results in decreased expression of CAT]"26004620
C0620781-(carboxymethylthio)tetradecane1-(carboxymethylthio)tetradecane results in decreased expression of PPARGC1A mRNA23226405
C0620781-(carboxymethylthio)tetradecane[olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of PPARGC1A mRNA23226405
C0620781-(carboxymethylthio)tetradecaneolanzapine promotes the reaction [1-(carboxymethylthio)tetradecane results in decreased expression of PPARGC1A mRNA]23226405
C0952841H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of PPARGC1A mRNA]"24041027
C0952841H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of PPARGC1A mRNA]"24041027
C0952841H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]"17179207
C0758091-stearoyl-2-arachidonoylglycerol1-stearoyl-2-arachidonoylglycerol results in increased expression of PPARGC1A mRNA23056435
C5451212-((4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy)methyl)quinoline2-((4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy)methyl)quinoline results in increased expression of PPARGC1A mRNA27247380
C5451212-((4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy)methyl)quinoline2-((4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy)methyl)quinoline results in increased expression of PPARGC1A mRNA27247380
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin results in increased expression of PPARGC1A mRNA]24041027
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of PPARGC1A mRNA]24041027
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]17179207
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]17179207
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of PPARGC1A mRNA"20406850
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [alitretinoin results in increased expression of PPARGC1A mRNA]16513826
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone results in increased expression of PPARGC1A mRNA]16513826
C0501473-(2,2,2-trimethylhydrazine)propionate"3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of PPARGC1A mRNA"27559315
C0978693-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate"3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Nebivolol results in increased expression of PPARGC1A protein]"23886954
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PPARGC1A mRNA"28973690
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PPARGC1A mRNA"27509375
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1A mRNA"27188386
C1081234-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of PPARGC1A protein]"17116659
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA]20165829
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein]20165829
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Glucose results in decreased expression of PPARGC1A mRNA]28482072
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA]20165829
C0757734-phenylbutyric acid4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein]20165829
C5705395-(3-((3-(5-methoxybenzisoxazol-3-yl)benzimidazol-1-yl)methyl)phenyl)-5-methyloxazolidinedione5-(3-((3-(5-methoxybenzisoxazol-3-yl)benzimidazol-1-yl)methyl)phenyl)-5-methyloxazolidinedione analog binds to and results in increased activity of PPARGC1A protein22070604
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [ginsenoside Rg2 results in decreased expression of PPARGC1A mRNA]"22062806
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PPARGC1A protein]]"25522270
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine promotes the reaction [tert-Butylhydroperoxide results in decreased expression of PPARGC1A protein]"25522270
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Metformin results in increased expression of PPARGC1A mRNA]"24428821
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine promotes the reaction [AICA ribonucleotide results in decreased expression of PPARGC1A mRNA]"24428821
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [AICA ribonucleotide results in increased expression of PPARGC1A mRNA]"20438809
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Aminoimidazole Carboxamide analog promotes the reaction [Lipopolysaccharides results in increased expression of PPARGC1A protein]]"19853624
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in increased expression of PPARGC1A mRNA]"20438809
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in increased expression of PPARGC1A protein"19853624
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [T-2 Toxin results in decreased expression of PPARGC1A protein]"27363784
C4732178-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate8-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate results in increased expression of PPARGC1A mRNA23056435
C0162768-bromocyclic GMP8-bromocyclic GMP results in increased expression of PPARGC1A mRNA24041027
C0162768-bromocyclic GMPtin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of PPARGC1A mRNA]24041027
D020909AcarbosePPARGC1A protein polymorphism affects the susceptibility to Acarbose15592662
D000082AcetaminophenAcetaminophen results in decreased expression of PPARGC1A mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of and affects the localization of PPARGC1A protein28827156
D000082AcetaminophenAcetaminophen affects the expression of PPARGC1A mRNA17562736
D000082AcetaminophenSRT1720 affects the reaction [Acetaminophen affects the expression of PPARGC1A protein]28827156
D000108Acetylcarnitine[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A protein20414966
D000108AcetylcarnitineAcetylcarnitine results in increased expression of PPARGC1A protein20414966
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Flavonoids results in increased expression of PPARGC1A protein]23063593
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Atorvastatin Calcium results in increased expression of PPARGC1A mRNA]21775390
D000111AcetylcysteineAcetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of PPARGC1A mRNA]26980303
C027696acipimoxacipimox results in increased expression of PPARGC1A mRNA25352640
D000241AdenosineAdenosine results in increased expression of PPARGC1A mRNA23056435
D000242Cyclic AMPCyclic AMP promotes the reaction [PPARGC1A protein binds to CYP2A5 promoter]18602936
D000242Cyclic AMPCyclic AMP results in increased expression of PPARGC1A mRNA18602936|2211707
D000242Cyclic AMPPPARGC1A mutant form inhibits the reaction [Cyclic AMP results in decreased expression of IL15RA mRNA]22117073
D000242Cyclic AMPPPARGC1A mutant form inhibits the reaction [Cyclic AMP results in increased expression of IL1RN mRNA]22117073
D000242Cyclic AMP[Dexamethasone co-treated with Cyclic AMP] results in increased expression of PPARGC1A mRNA22676303
D000242Cyclic AMPFatty Acids analog inhibits the reaction [[Dexamethasone co-treated with Cyclic AMP] results in increased expression of PPARGC1A mRNA]22676303
D000242Cyclic AMPFatty Acids analog inhibits the reaction [[Dexamethasone co-treated with Cyclic AMP] results in increased phosphorylation of PPARGC1A protein]22676303
D000242Cyclic AMPFatty Acids analog inhibits the reaction [[Glucagon co-treated with Cyclic AMP] results in increased expression of PPARGC1A mRNA]22676303
D000242Cyclic AMPFatty Acids analog inhibits the reaction [[Glucagon co-treated with Cyclic AMP] results in increased phosphorylation of PPARGC1A protein]22676303
D000242Cyclic AMP[Glucagon co-treated with Cyclic AMP] results in increased expression of PPARGC1A mRNA22676303
D000249Adenosine MonophosphateAdenosine Monophosphate results in increased expression of PPARGC1A mRNA23056435
D012435S-AdenosylhomocysteineS-Adenosylhomocysteine results in increased expression of PPARGC1A mRNA23056435
C016601afimoxifeneafimoxifene inhibits the reaction [PPARGC1A protein binds to ESRRG protein]16889744
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PPARGC1A protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PPARGC1A mRNA21632981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PPARGC1A gene27153756
C430898AGN 194204AGN 194204 results in increased expression of PPARGC1A mRNA16513826
C031143AICA ribonucleotideAICA ribonucleotide inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PPARGC1A protein]25522270
C031143AICA ribonucleotide"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine promotes the reaction [AICA ribonucleotide results in decreased expression of PPARGC1A mRNA]"24428821
C031143AICA ribonucleotideAICA ribonucleotide inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]23090186
C031143AICA ribonucleotideAICA ribonucleotide results in decreased expression of PPARGC1A mRNA24428821
C031143AICA ribonucleotide"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [AICA ribonucleotide results in increased expression of PPARGC1A mRNA]"20438809
C031143AICA ribonucleotideAICA ribonucleotide results in increased expression of PPARGC1A mRNA20438809|2249624
C031143AICA ribonucleotideDietary Fats promotes the reaction [AICA ribonucleotide results in increased expression of PPARGC1A mRNA]22496244
D000393Air PollutantsAir Pollutants results in decreased expression of PPARGC1A mRNA23649983
D000420AlbuterolAlbuterol results in increased expression of PPARGC1A mRNA17446185
D000450AldosteroneAldosterone results in increased expression of PPARGC1A mRNA19808358
D000450Aldosterone[Aldosterone binds to NR3C2 protein] which binds to PPARGC1A protein alternative form15761029
C103303alitretinoinalitretinoin results in increased expression of PPARGC1A mRNA16513826
C103303alitretinoin2-chloro-5-nitrobenzanilide inhibits the reaction [alitretinoin results in increased expression of PPARGC1A mRNA]16513826
C103303alitretinoinalitretinoin results in increased expression of PPARGC1A mRNA16513826
C103303alitretinoinPPARG protein promotes the reaction [alitretinoin results in increased expression of PPARGC1A mRNA]16513826
C103303alitretinoinRXRA protein promotes the reaction [alitretinoin results in increased expression of PPARGC1A mRNA]16513826
D000496AlloxanAlloxan results in decreased expression of PPARGC1A protein28483572
D000496Alloxanimisopasem manganese inhibits the reaction [Alloxan results in decreased expression of PPARGC1A protein]28483572
C004471allyl isothiocyanateallyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]25069801
C004471allyl isothiocyanateallyl isothiocyanate inhibits the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]25069801
D024502alpha-Tocopherolalpha-Tocopherol deficiency results in increased expression of PPARGC1A mRNA24657723
C104223aluminum lactatealuminum lactate results in decreased expression of PPARGC1A mRNA24084166|2649315
C104223aluminum lactatealuminum lactate results in decreased expression of PPARGC1A protein24084166|2649315
C104223aluminum lactateQuercetin inhibits the reaction [aluminum lactate results in decreased expression of PPARGC1A mRNA]26493151
C104223aluminum lactateQuercetin inhibits the reaction [aluminum lactate results in decreased expression of PPARGC1A protein]26493151
D000620Aminoimidazole Carboxamide"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Aminoimidazole Carboxamide analog promotes the reaction [Lipopolysaccharides results in increased expression of PPARGC1A protein]]"19853624
D000620Aminoimidazole Carboxamide[Aminoimidazole Carboxamide analog co-treated with Lipopolysaccharides] results in increased expression of PPARGC1A protein19853624
D000620Aminoimidazole CarboxamideAminoimidazole Carboxamide analog promotes the reaction [Lipopolysaccharides results in increased expression of PPARGC1A protein]19853624
D000638AmiodaroneAmiodarone results in increased expression of PPARGC1A mRNA27089845
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PPARGC1A mRNA16483693
C499916ankaflavinankaflavin results in increased expression of PPARGC1A mRNA24275089
C526219apple polyphenol extract[Dietary Sucrose co-treated with Dietary Fats co-treated with apple polyphenol extract] results in increased expression of PPARGC1A mRNA23529981
C526219apple polyphenol extract[Dietary Sucrose co-treated with Dietary Fats co-treated with apple polyphenol extract] results in increased methylation of PPARGC1A promoter23529981
C506540arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Herbicides results in increased expression of PPARGC1A mRNA]"21318024
C506540arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [triclopyr results in increased expression of PPARGC1A mRNA]"21318024
C506540arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide results in increased expression of PPARGC1A mRNA"21318024
D001151ArsenicArsenic results in increased expression of PPARGC1A mRNA21514422
D001151ArsenicArsenic results in increased expression of PPARGC1A protein21514422
C006632arsenic trioxidearsenic trioxide results in increased expression of PPARGC1A mRNA20458559
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of PPARGC1A mRNA"17331233
D001205Ascorbic AcidAscorbic Acid results in increased expression of PPARGC1A mRNA23056435
D000069059Atorvastatin CalciumAcetylcysteine inhibits the reaction [Atorvastatin Calcium results in increased expression of PPARGC1A mRNA]21775390
D000069059Atorvastatin CalciumAtorvastatin Calcium inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]22343369
D000069059Atorvastatin CalciumAtorvastatin Calcium results in decreased expression of PPARGC1A mRNA21775390
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of PPARGC1A mRNA21775390
D000069059Atorvastatin CalciumFarnesol inhibits the reaction [Atorvastatin Calcium inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]]22343369
D001280AtrazineAtrazine results in decreased expression of PPARGC1A mRNA22378314|2711463
D001280AtrazineAtrazine results in increased expression of PPARGC1A mRNA27114639
C547126AZM551248AZM551248 results in decreased expression of PPARGC1A mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of PPARGC1A mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PPARGC1A mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PPARGC1A mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PPARGC1A mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PPARGC1A mRNA"26238291
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PPARGC1A protein]20876576
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of PPARGC1A protein20860658
D001599BerberineBerberine inhibits the reaction [Ethanol results in decreased expression of PPARGC1A mRNA]25455889
D004958EstradiolEstradiol results in increased expression of PPARGC1A mRNA21632981
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of PPARGC1A mRNA17404688
D004958EstradiolEstradiol promotes the reaction [PPARGC1A protein binds to CYP2B10 promoter]23684557
D004958EstradiolEstradiol results in increased expression of PPARGC1A mRNA23056435
D001629BezafibrateBezafibrate results in increased expression of PPARGC1A mRNA17275789
D001710BiotinBiotin results in increased expression of PPARGC1A mRNA23056435
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PPARGC1A mRNA28628672
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of PPARGC1A mRNA25111128
C006780bisphenol Abisphenol A results in increased expression of PPARGC1A mRNA25514059
C006780bisphenol A[bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PPARGC1A protein modified form]28751236
C006780bisphenol Abisphenol A results in decreased expression of PPARGC1A mRNA27145005
C006780bisphenol Abisphenol A results in decreased expression of PPARGC1A mRNA25181051|2557265
C006780bisphenol Abisphenol A results in increased methylation of PPARGC1A gene25572651
D001786Blood Glucose[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PPARGC1A protein28477916
D001786Blood Glucosegenipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PPARGC1A protein]28477916
D001786Blood Glucosesirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PPARGC1A protein]]28477916
C027561butylbenzyl phthalatebutylbenzyl phthalate results in decreased expression of PPARGC1A mRNA26520405
C027561butylbenzyl phthalatebutylbenzyl phthalate affects the expression of PPARGC1A mRNA27923775
D020122tert-Butylhydroperoxide"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PPARGC1A protein]]"25522270
D020122tert-Butylhydroperoxide"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine promotes the reaction [tert-Butylhydroperoxide results in decreased expression of PPARGC1A protein]"25522270
D020122tert-ButylhydroperoxideAICA ribonucleotide inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PPARGC1A protein]25522270
D020122tert-Butylhydroperoxideresveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PPARGC1A protein]25522270
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PPARGC1A protein25522270
D020122tert-ButylhydroperoxidePPARGC1A protein results in decreased susceptibility to tert-Butylhydroperoxide17460188
D020122tert-Butylhydroperoxide"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of PPARGC1A protein]"17116659
D020122tert-ButylhydroperoxideSB 203580 inhibits the reaction [tert-Butylhydroperoxide results in increased expression of PPARGC1A protein]17116659
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PPARGC1A protein17116659
D020122tert-Butylhydroperoxidetyrphostin AG 1478 inhibits the reaction [tert-Butylhydroperoxide results in increased expression of PPARGC1A protein]17116659
C018475butyraldehydebutyraldehyde results in decreased expression of PPARGC1A mRNA26079696
D002104CadmiumCadmium results in increased acetylation of PPARGC1A protein25159133
D002104Cadmiumluzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]]25159133
D002104CadmiumMelatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]25159133
D002104Cadmiumsirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]]25159133
D002104CadmiumCadmium results in increased expression of PPARGC1A mRNA26187450
D002104CadmiumCadmium results in decreased expression of PPARGC1A mRNA24084258
D019256Cadmium ChlorideCadmium Chloride results in increased acetylation of PPARGC1A protein25159133
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PPARGC1A protein25809595
D019256Cadmium Chlorideluzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]25159133
D019256Cadmium ChlorideMelatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]25159133
D019256Cadmium Chloridesirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]25159133
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of PPARGC1A promoter22457795
C028337cadmium telluridecadmium telluride results in increased expression of PPARGC1A protein25809595
D002110CaffeineCaffeine results in increased expression of PPARGC1A mRNA17516843
D002211CapsaicinCapsaicin results in increased expression of PPARGC1A mRNA19798065
D002211CapsaicinCapsaicin promotes the reaction [Dietary Fats results in increased expression of PPARGC1A mRNA]20359164
D002220CarbamazepineCarbamazepine affects the expression of PPARGC1A mRNA24752500
D002248Carbon MonoxideCarbon Monoxide results in increased expression of PPARGC1A mRNA17179207
D002248Carbon Monoxide"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]"17179207
D002248Carbon Monoxide2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]17179207
D002248Carbon Monoxide2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]17179207
D002248Carbon MonoxideCarbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]17179207
D002248Carbon MonoxideCarbon Monoxide results in increased expression of PPARGC1A protein17179207
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PPARGC1A protein26882442
D002251Carbon TetrachlorideMelatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARGC1A protein]26882442
C043211carvedilolcarvedilol results in increased expression of PPARGC1A mRNA18971572
C054133casticincasticin results in decreased expression of PPARGC1A mRNA28444820
D002392CatechinCatechin affects the expression of PPARGC1A mRNA26363153
D002392CatechinQuercetin affects the reaction [Catechin affects the expression of PPARGC1A mRNA]26363153
C100435chicoric acidchicoric acid results in increased expression of PPARGC1A mRNA24244361
D002719ChlormethiazoleChlormethiazole affects the reaction [Ethanol results in decreased expression of PPARGC1A mRNA]24892905
D002719ChlormethiazoleChlormethiazole inhibits the reaction [Ethanol results in decreased acetylation of PPARGC1A protein]24892905
D002737ChloropreneChloroprene results in increased expression of PPARGC1A mRNA23125180
D020355Cholates"[cocoa butter co-treated with Cholesterol, Dietary co-treated with Cholates] results in increased expression of PPARGC1A mRNA"25814186
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of PPARGC1A mRNA"19509184
D002791Cholesterol, Dietary"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of PPARGC1A mRNA"19509184
D002791Cholesterol, Dietary"Cholesterol, Dietary deficiency inhibits the reaction [PPARGC1A protein binds to CYP3A11 promoter]"20926756
D002791Cholesterol, Dietary"Cholesterol, Dietary deficiency promotes the reaction [SREBF2 protein binds to PPARGC1A protein]"20926756
D002791Cholesterol, Dietary"[cocoa butter co-treated with Cholesterol, Dietary co-treated with Cholates] results in increased expression of PPARGC1A mRNA"25814186
D002794CholineCholine results in increased expression of PPARGC1A mRNA23056435
D017608Chromium CompoundsChromium Compounds results in increased expression of PPARGC1A protein21935427
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PPARGC1A mRNA28472532
C039671ciglitazoneciglitazone results in increased expression of PPARGC1A mRNA16513826
C039671ciglitazonePPARG protein promotes the reaction [ciglitazone results in increased expression of PPARGC1A mRNA]16513826
D002922CiguatoxinsCiguatoxins affects the expression of PPARGC1A mRNA18353800
D002976ClenbuterolClenbuterol results in increased expression of PPARGC1A mRNA17446185
D002976ClenbuterolPropranolol inhibits the reaction [Clenbuterol results in increased expression of PPARGC1A mRNA]17446185
D002976ClenbuterolClenbuterol results in increased expression of PPARGC1A mRNA17446185
D002994ClofibrateClofibrate results in increased expression of PPARGC1A mRNA27089845
C007095cobaltiprotoporphyrin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin results in increased expression of PPARGC1A mRNA]24041027
C007095cobaltiprotoporphyrincobaltiprotoporphyrin results in increased expression of PPARGC1A mRNA24041027
C007095cobaltiprotoporphyrinNFE2L2 mutant form inhibits the reaction [cobaltiprotoporphyrin results in increased expression of PPARGC1A mRNA]24041027
C007095cobaltiprotoporphyrincobaltiprotoporphyrin promotes the reaction [LEP gene mutant form results in decreased expression of PPARGC1A mRNA]23839791
C007095cobaltiprotoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [LEP gene mutant form results in decreased expression of PPARGC1A mRNA]]23839791
C018021cobaltous chloridecobaltous chloride results in increased expression of PPARGC1A protein22982409
C052387cocoa butter"[cocoa butter co-treated with Cholesterol, Dietary co-treated with Cholates] results in increased expression of PPARGC1A mRNA"25814186
D005576ColforsinColforsin results in increased expression of PPARGC1A mRNA16357189
D003300CopperCopper deficiency results in increased expression of PPARGC1A mRNA18993053
D003300CopperCopper deficiency results in increased expression of PPARGC1A protein18993053
D003300CopperCopper results in decreased expression of PPARGC1A mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of PPARGC1A mRNA19549813
D003348CortisoneCortisone results in increased expression of PPARGC1A mRNA23056435
D003401CreatineCreatine results in increased expression of PPARGC1A mRNA23056435
D003474CurcuminCurcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A mRNA]28951138
D003474CurcuminCurcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A protein]28951138
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PPARGC1A protein]20876576
D016572CyclosporineCyclosporine results in decreased expression of PPARGC1A mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of PPARGC1A mRNA19770486
D016572CyclosporineCyclosporine inhibits the reaction [Ionomycin results in increased expression of PPARGC1A mRNA]17516843
C093628cyproconazole[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of PPARGC1A mRNA29038839
C093628cyproconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of PPARGC1A mRNA29038839
C093628cyproconazolecyproconazole results in increased expression of PPARGC1A mRNA29038839
D003634DDTDDT promotes the reaction [PPARGC1A protein binds to CYP2B10 promoter]23684557
C031071decanoic aciddecanoic acid results in increased expression of PPARGC1A mRNA23056435
C014347decitabinedecitabine results in decreased methylation of PPARGC1A gene27923600
D003687DehydroepiandrosteroneDehydroepiandrosterone results in increased expression of PPARGC1A mRNA12659879
D015230Prostaglandin D2Prostaglandin D2 results in increased expression of PPARGC1A mRNA23056435
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PPARGC1A mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of PPARGC1A mRNA19022236|1985301
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PPARGC1A mRNA28628672
D003907Dexamethasone[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A mRNA29288687
D003907Dexamethasone[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A protein29288687
D003907DexamethasoneN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A protein]29288687
D003907Dexamethasone[PRKACA protein affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A mRNA29288687
D003907DexamethasonePRKACA protein promotes the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A mRNA]29288687
D003907DexamethasonePRKACA protein promotes the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A protein]29288687
D003907Dexamethasone[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A mRNA29288687
D003907Dexamethasone[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A protein29288687
D003907Dexamethasone[Dexamethasone co-treated with Cyclic AMP] results in increased expression of PPARGC1A mRNA22676303
D003907DexamethasoneDexamethasone results in decreased expression of PPARGC1A protein21094144
D003907DexamethasoneDexamethasone results in increased expression of PPARGC1A mRNA18972406
D003907DexamethasoneFatty Acids analog inhibits the reaction [[Dexamethasone co-treated with Cyclic AMP] results in increased expression of PPARGC1A mRNA]22676303
D003907DexamethasoneFatty Acids analog inhibits the reaction [[Dexamethasone co-treated with Cyclic AMP] results in increased phosphorylation of PPARGC1A protein]22676303
D003907DexamethasoneINS protein inhibits the reaction [Dexamethasone results in increased expression of PPARGC1A mRNA]18972406
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of PPARGC1A protein]21094144
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PPARGC1A mRNA17361019|2126653
D003994BucladesineBucladesine results in increased expression of PPARGC1A mRNA24428821
D003994BucladesineBucladesine results in increased expression of PPARGC1A protein26064446
D003994BucladesineIL22 protein inhibits the reaction [Bucladesine results in increased expression of PPARGC1A protein]26064446
D003994BucladesineMetformin inhibits the reaction [Bucladesine results in increased expression of PPARGC1A mRNA]24428821
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of PPARGC1A mRNA28962523
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased activity of PPARGC1A protein27589886
D004008DiclofenacDiclofenac affects the expression of PPARGC1A mRNA24752500
D004008DiclofenacDiclofenac results in increased expression of PPARGC1A mRNA26934552
D004041Dietary Fats"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of PPARGC1A mRNA"19509184
D004041Dietary FatsANGPTL4 protein modified form affects the reaction [Dietary Fats affects the expression of PPARGC1A mRNA]28842503
D004041Dietary FatsDietary Fats affects the expression of PPARGC1A mRNA27805061|2884250
D004041Dietary FatsDietary Fats results in decreased expression of PPARGC1A mRNA17456854|1845759
D004041Dietary FatsDietary Fats results in decreased expression of PPARGC1A protein25549548|2796028
D004041Dietary FatsDietary Fats results in increased expression of PPARGC1A mRNA18042831|2731179
D004041Dietary FatsEthanol promotes the reaction [Dietary Fats results in decreased expression of PPARGC1A protein]25549548
D004041Dietary FatsHarmine affects the reaction [Dietary Fats affects the expression of PPARGC1A mRNA]27805061
D004041Dietary FatsNFE2L2 protein affects the reaction [Dietary Fats results in increased expression of PPARGC1A mRNA]27311796
D004041Dietary FatsQuercetin inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]24586721
D004041Dietary Fatsrosiglitazone inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]17456854
D004041Dietary FatsSodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of PPARGC1A mRNA]26522834
D004041Dietary Fats[Streptozocin co-treated with Dietary Fats] results in increased expression of PPARGC1A mRNA26522834
D004041Dietary FatsCapsaicin promotes the reaction [Dietary Fats results in increased expression of PPARGC1A mRNA]20359164
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PPARGC1A mRNA20673376
D004041Dietary FatsDietary Fats promotes the reaction [AICA ribonucleotide results in increased expression of PPARGC1A mRNA]22496244
D004041Dietary FatsDietary Fats results in decreased expression of PPARGC1A mRNA21632075|2246414
D004041Dietary FatsDietary Fats results in increased expression of PPARGC1A mRNA20359164|2272001
D004041Dietary Fats[Dietary Sucrose co-treated with Dietary Fats co-treated with apple polyphenol extract] results in increased expression of PPARGC1A mRNA23529981
D004041Dietary Fats[Dietary Sucrose co-treated with Dietary Fats co-treated with apple polyphenol extract] results in increased methylation of PPARGC1A promoter23529981
D004041Dietary FatsPlant Extracts inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PPARGC1A mRNA]20673376
D004041Dietary FatsPolyphenols inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PPARGC1A mRNA]20673376
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]21632075|2522814
D004041Dietary FatsThioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]22464149
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PPARGC1A mRNA20673376
D019422Dietary Sucrose[Dietary Sucrose co-treated with Dietary Fats co-treated with apple polyphenol extract] results in increased expression of PPARGC1A mRNA23529981
D019422Dietary Sucrose[Dietary Sucrose co-treated with Dietary Fats co-treated with apple polyphenol extract] results in increased methylation of PPARGC1A promoter23529981
D019422Dietary SucrosePlant Extracts inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PPARGC1A mRNA]20673376
D019422Dietary SucrosePolyphenols inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PPARGC1A mRNA]20673376
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of PPARGC1A mRNA22672789
C010920dihydrofolatedihydrofolate results in increased expression of PPARGC1A mRNA23056435
D002117Calcitriol[Calcitriol binds to and results in increased activity of VDR protein] promotes the reaction [VDR protein binds to PPARGC1A protein]19106115
D002117Calcitriol[Calcitriol binds to and results in increased activity of VDR protein] results in decreased activity of [HNF4A protein co-treated with PPARGC1A protein]19106115
D002117CalcitriolCalcitriol inhibits the reaction [PPARGC1A protein binds to CYP7A1 mRNA]20371703
D002117CalcitriolCalcitriol inhibits the reaction [PPARGC1A protein binds to CYP7A1 promoter]19106115
D002117CalcitriolCalcitriol promotes the reaction [VDR protein binds to PPARGC1A protein]20371703
D002117Calcitriol[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]20371703
D002117CalcitriolNCOR1 protein promotes the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]]20371703
D002117CalcitriolNCOR2 protein promotes the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]]20371703
D002117CalcitriolPPARGC1A protein promotes the reaction [Calcitriol promotes the reaction [VDR protein binds to HNF4A protein]]20371703
D002117CalcitriolPPARGC1A protein promotes the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA]20371703
D002117CalcitriolU 0126 inhibits the reaction [Calcitriol inhibits the reaction [PPARGC1A protein binds to CYP7A1 mRNA]]20371703
D002117CalcitriolCalcitriol promotes the reaction [VDR protein binds to PPARGC1A protein]15908514
C118756dihydroxy-vitamin D3dihydroxy-vitamin D3 promotes the reaction [[VDR protein binds to RXRA protein] which binds to PPARGC1A protein modified form]20947021
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of PPARGC1A mRNA"22485181
D004229DithiothreitolDithiothreitol results in increased expression of PPARGC1A mRNA23056435
D004317DoxorubicinDoxorubicin results in decreased expression of and results in increased acetylation of PPARGC1A protein28456571
D004317DoxorubicinDoxorubicin results in decreased expression of PPARGC1A protein26781513
D004317DoxorubicinDoxorubicin results in increased expression of PPARGC1A protein26781513
D004317DoxorubicinErythropoietin inhibits the reaction [Doxorubicin results in decreased expression of and results in increased acetylation of PPARGC1A protein]28456571
D004317DoxorubicinPPARGC1A affects the reaction [Doxorubicin results in decreased expression of NFE2L1 protein]26781513
D004317DoxorubicinPPARGC1A affects the reaction [Doxorubicin results in decreased expression of SOD2 protein]26781513
D004317DoxorubicinPPARGC1A affects the reaction [Doxorubicin results in decreased expression of TFAM mRNA]26781513
D004317DoxorubicinPPARGC1A affects the reaction [Doxorubicin results in decreased expression of UCP2 protein]26781513
D004317DoxorubicinPPARGC1A affects the reaction [Doxorubicin results in increased expression of NFE2L1 protein]26781513
D004317DoxorubicinPPARGC1A affects the reaction [Doxorubicin results in increased expression of SOD2 protein]26781513
D004317DoxorubicinPPARGC1A affects the reaction [Doxorubicin results in increased expression of TFAM mRNA]26781513
D004317DoxorubicinPPARGC1A affects the reaction [Doxorubicin results in increased expression of UCP2 protein]26781513
D004317DoxorubicinPPARGC1A affects the susceptibility to Doxorubicin26781513
D004317DoxorubicinSIRT1 protein affects the reaction [Doxorubicin results in decreased expression of PPARGC1A protein]28456571
D004317DoxorubicinSIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of PPARGC1A protein]]28456571
D004317DoxorubicinDoxorubicin results in increased expression of PPARGC1A mRNA28710503
D004317DoxorubicinLovastatin inhibits the reaction [Doxorubicin results in increased expression of PPARGC1A mRNA]28710503
D004317DoxorubicinNSC 23766 inhibits the reaction [Doxorubicin results in increased expression of PPARGC1A mRNA]28710503
D004317DoxorubicinDoxorubicin results in decreased expression of PPARGC1A mRNA26721193|2886572
D004317DoxorubicinDoxorubicin results in decreased expression of PPARGC1A protein26678157
D015118Eicosapentaenoic AcidEicosapentaenoic Acid results in increased expression of PPARGC1A mRNA23056435
C547512eldecalcitoleldecalcitol promotes the reaction [[VDR protein binds to RXRA protein] which binds to PPARGC1A protein modified form]20947021
D004656EnalaprilEnalapril results in increased expression of PPARGC1A mRNA18765277
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of PPARGC1A mRNA20064776
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of PPARGC1A protein29175576
C045651epigallocatechin gallate[1-Methyl-4-phenylpyridinium co-treated with epigallocatechin gallate] results in increased expression of PPARGC1A mRNA22742579
C045651epigallocatechin gallate[1-Methyl-4-phenylpyridinium co-treated with epigallocatechin gallate] results in increased expression of PPARGC1A protein22742579
D004837EpinephrineEpinephrine results in decreased expression of PPARGC1A mRNA19300450
D004837EpinephrineMetoprolol inhibits the reaction [Epinephrine results in decreased expression of PPARGC1A mRNA]19300450
D004837EpinephrineEpinephrine results in increased expression of PPARGC1A mRNA22496244
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of PPARGC1A mRNA29038839
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of PPARGC1A mRNA29038839
C109476epoxiconazoleepoxiconazole results in increased expression of PPARGC1A mRNA29038839
D004921ErythropoietinErythropoietin inhibits the reaction [Doxorubicin results in decreased expression of and results in increased acetylation of PPARGC1A protein]28456571
D004921ErythropoietinSIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of PPARGC1A protein]]28456571
D000431EthanolBerberine inhibits the reaction [Ethanol results in decreased expression of PPARGC1A mRNA]25455889
D000431EthanolChlormethiazole affects the reaction [Ethanol results in decreased expression of PPARGC1A mRNA]24892905
D000431EthanolChlormethiazole inhibits the reaction [Ethanol results in decreased acetylation of PPARGC1A protein]24892905
D000431EthanolEthanol affects the localization of PPARGC1A protein27765815
D000431EthanolEthanol promotes the reaction [Dietary Fats results in decreased expression of PPARGC1A protein]25549548
D000431EthanolEthanol results in decreased acetylation of PPARGC1A protein24892905
D000431Ethanol[Ethanol results in decreased activity of SIRT1 protein] which results in increased acetylation of PPARGC1A protein18755807
D000431EthanolEthanol results in decreased expression of PPARGC1A mRNA18755807|2000785
D000431EthanolEthanol results in decreased expression of PPARGC1A protein28962519
D000431EthanolEthanol results in increased acetylation of PPARGC1A protein20007851
D000431EthanolPPARD gene mutant form inhibits the reaction [Ethanol affects the localization of PPARGC1A protein]27765815
D000431EthanolPPARGC1A protein promotes the reaction [Ethanol results in increased expression of CYP2B10 mRNA]27765815
D000431Ethanolresveratrol inhibits the reaction [[Ethanol results in decreased activity of SIRT1 protein] which results in increased acetylation of PPARGC1A protein]18755807
D000431Ethanolresveratrol inhibits the reaction [Ethanol results in decreased expression of PPARGC1A mRNA]18755807
D000431Ethanolrosiglitazone inhibits the reaction [Ethanol results in decreased expression of PPARGC1A mRNA]20007851
D000431Ethanolrosiglitazone inhibits the reaction [Ethanol results in increased acetylation of PPARGC1A protein]20007851
D000431Ethanoltetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Ethanol results in decreased expression of PPARGC1A protein]28962519
D000431EthanolEthanol results in increased acetylation of PPARGC1A protein24769256
D000431EthanolEthanol results in increased expression of PPARGC1A mRNA16098508|1879363
D000431Ethanolnaringin inhibits the reaction [Ethanol results in increased expression of PPARGC1A mRNA]18793633
D000431Ethanolresveratrol inhibits the reaction [Ethanol results in increased expression of PPARGC1A mRNA]18793633
D000431Ethanolsalvianolic acid B inhibits the reaction [Ethanol results in increased acetylation of PPARGC1A protein]24769256
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PPARGC1A mRNA18936297
D005047EtoposideEtoposide results in increased expression of PPARGC1A mRNA26259609
C422415farglitazarfarglitazar binds to and results in increased activity of PPARGC1A protein22070604
D005204FarnesolFarnesol inhibits the reaction [Atorvastatin Calcium inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]]22343369
D005227Fatty AcidsFatty Acids analog inhibits the reaction [[Dexamethasone co-treated with Cyclic AMP] results in increased expression of PPARGC1A mRNA]22676303
D005227Fatty AcidsFatty Acids analog inhibits the reaction [[Dexamethasone co-treated with Cyclic AMP] results in increased phosphorylation of PPARGC1A protein]22676303
D005227Fatty AcidsFatty Acids analog inhibits the reaction [[Glucagon co-treated with Cyclic AMP] results in increased expression of PPARGC1A mRNA]22676303
D005227Fatty AcidsFatty Acids analog inhibits the reaction [[Glucagon co-treated with Cyclic AMP] results in increased phosphorylation of PPARGC1A protein]22676303
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency results in increased expression of PPARGC1A mRNA"23333450
D011345FenofibrateFenofibrate inhibits the reaction [zoledronic acid results in decreased expression of PPARGC1A mRNA]28871336
D005419FlavonoidsAcetylcysteine inhibits the reaction [Flavonoids results in increased expression of PPARGC1A protein]23063593
D005419FlavonoidsFlavonoids results in increased expression of PPARGC1A protein23063593
D005492Folic AcidFolic Acid results in decreased expression of PPARGC1A24275386
D005632FructoseFructose results in decreased expression of PPARGC1A mRNA18063403
D005632Fructose"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of PPARGC1A mRNA"19509184
D005632FructoseFructose results in increased expression of PPARGC1A mRNA19196556|2121209
D005632FructoseFructose results in increased expression of PPARGC1A protein19196556
D005632Fructoserosiglitazone inhibits the reaction [Fructose results in increased expression of PPARGC1A protein]19196556
C069837fullerene C60fullerene C60 results in decreased expression of PPARGC1A mRNA19167457
C070081fulvestrantfulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [PPARGC1A protein binds to CYP11A1 gene]]18511507
C070081fulvestrantfulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [PPARGC1A protein binds to HSD3B gene]]18511507
C070081fulvestrantfulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to PPARGC1A protein]]]18511507
C070081fulvestrantfulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to PPARGC1A protein]]18511507
C007834genipingenipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PPARGC1A protein]28477916
C007834genipinsirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PPARGC1A protein]]28477916
C026474ginsenoside Rg2"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [ginsenoside Rg2 results in decreased expression of PPARGC1A mRNA]"22062806
C026474ginsenoside Rg2ginsenoside Rg2 results in decreased expression of PPARGC1A mRNA22062806
D005934GlucagonFatty Acids analog inhibits the reaction [[Glucagon co-treated with Cyclic AMP] results in increased expression of PPARGC1A mRNA]22676303
D005934GlucagonFatty Acids analog inhibits the reaction [[Glucagon co-treated with Cyclic AMP] results in increased phosphorylation of PPARGC1A protein]22676303
D005934Glucagon[Glucagon co-treated with Cyclic AMP] results in increased expression of PPARGC1A mRNA22676303
D005944Glucosamine4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA]20165829
D005944Glucosamine4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein]20165829
D005944GlucosamineATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA]20165829
D005944GlucosamineATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein]20165829
D005944GlucosamineGlucosamine results in decreased expression of PPARGC1A mRNA20165829
D005944GlucosamineGlucosamine results in decreased expression of PPARGC1A protein20165829
D005944Glucosaminetauroursodeoxycholic acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA]20165829
D005944Glucosaminetauroursodeoxycholic acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein]20165829
D005944Glucosamine4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA]20165829
D005944Glucosamine4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein]20165829
D005944GlucosamineATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA]20165829
D005944GlucosamineATF6 mutant form inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein]20165829
D005944GlucosamineGlucosamine results in decreased expression of PPARGC1A mRNA20165829
D005944GlucosamineGlucosamine results in decreased expression of PPARGC1A protein20165829
D005944Glucosaminetauroursodeoxycholic acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA]20165829
D005944Glucosaminetauroursodeoxycholic acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein]20165829
D005947GlucoseGlucose deficiency results in decreased expression of PPARGC1A mRNA17855661
D005947GlucoseGlucose deficiency results in increased expression of PPARGC1A mRNA26811028
D005947GlucoseGlucose results in increased acetylation of PPARGC1A protein19071085
D005947GlucoseNitroprusside inhibits the reaction [Glucose deficiency results in decreased expression of PPARGC1A mRNA]17855661
D005947Glucose[Pyruvic Acid co-treated with Glucose] results in decreased acetylation of PPARGC1A protein19071085
D005947Glucose4-phenylbutyric acid inhibits the reaction [Glucose results in decreased expression of PPARGC1A mRNA]28482072
D005947GlucoseAICA ribonucleotide inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]23090186
D005947GlucoseCEBPB protein inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]28482072
D005947GlucoseDDIT3 affects the reaction [Glucose results in decreased expression of PPARGC1A mRNA]28482072
D005947GlucoseGlucose inhibits the reaction [DDIT3 protein binds to PPARGC1A promoter]28482072
D005947GlucoseGlucose results in decreased expression of PPARGC1A mRNA28482072
D005947GlucoseGlucose results in decreased expression of PPARGC1A protein23090186|2848207
D005947GlucoseMetformin inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]23090186
D005947Glucose[SIRT1 protein co-treated with resveratrol] affects the reaction [Glucose affects the expression of PPARGC1A protein]23090186
D005947GlucoseGlucose affects the expression of PPARGC1A mRNA24349266
C004940glucuronolactoneglucuronolactone results in increased expression of PPARGC1A mRNA23056435
D005978GlutathioneGlutathione analog results in increased expression of PPARGC1A mRNA23056435
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in increased expression of PPARGC1A mRNA16206274
C425931GW 501516GW 501516 results in increased expression of PPARGC1A mRNA23056435
C425931GW 501516[GW 501516 co-treated with PPARD protein] results in increased expression of PPARGC1A mRNA17275789
C425931GW 501516GW 501516 results in increased expression of PPARGC1A mRNA17275789
D006247HarmineHarmine affects the reaction [Dietary Fats affects the expression of PPARGC1A mRNA]27805061
D006247HarmineHarmine results in increased expression of PPARGC1A protein27805061
D006540Herbicides"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [Herbicides results in increased expression of PPARGC1A mRNA]"21318024
D006540HerbicidesHerbicides results in increased expression of PPARGC1A mRNA21318024
C005499honokiol[Pyruvaldehyde co-treated with honokiol] results in increased expression of PPARGC1A protein26723916
D017313FenretinideFenretinide results in increased expression of PPARGC1A mRNA28973697
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Staurosporine] results in increased acetylation of PPARGC1A protein23293585
D006861Hydrogen Peroxideresveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in increased acetylation of PPARGC1A protein]23293585
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of PPARGC1A mRNA24349266
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of PPARGC1A protein24349266
D003900DesoxycorticosteroneDesoxycorticosterone results in increased expression of PPARGC1A mRNA23056435
C056599icariinicariin results in increased expression of PPARGC1A mRNA17883938
C056599icariinicariin results in increased expression of PPARGC1A protein17883938
C026777ICI 118551ICI 118551 results in decreased expression of PPARGC1A mRNA17446185
C082359imidaclopridimidacloprid results in decreased expression of PPARGC1A protein27960282
C121876imisopasem manganeseimisopasem manganese inhibits the reaction [Alloxan results in decreased expression of PPARGC1A protein]28483572
C121876imisopasem manganeseimisopasem manganese results in decreased expression of PPARGC1A protein28483572
C016517indole-3-carbinolindole-3-carbinol affects the expression of PPARGC1A mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PPARGC1A mRNA28628672
C002647inositol 1-phosphateinositol 1-phosphate results in increased expression of PPARGC1A mRNA23056435
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PPARGC1A mRNA25613284
D015759IonomycinCyclosporine inhibits the reaction [Ionomycin results in increased expression of PPARGC1A mRNA]17516843
D015759IonomycinIonomycin results in increased expression of PPARGC1A mRNA17516843
D015759IonomycinKN 62 affects the reaction [Ionomycin results in increased expression of PPARGC1A mRNA]17516843
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PPARGC1A mRNA28628672
D0150561-Methyl-3-isobutylxanthine[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A mRNA29288687
D0150561-Methyl-3-isobutylxanthine[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A protein29288687
D0150561-Methyl-3-isobutylxanthineN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A protein]29288687
D0150561-Methyl-3-isobutylxanthine[PRKACA protein affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A mRNA29288687
D0150561-Methyl-3-isobutylxanthinePRKACA protein promotes the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A mRNA]29288687
D0150561-Methyl-3-isobutylxanthinePRKACA protein promotes the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A protein]29288687
D0150561-Methyl-3-isobutylxanthine[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A mRNA29288687
D0150561-Methyl-3-isobutylxanthine[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A protein29288687
D007545IsoproterenolIsoproterenol results in decreased expression of PPARGC1A mRNA25045214
D007545IsoproterenolIsoproterenol results in decreased expression of PPARGC1A protein25045214
D007545IsoproterenolIsoproterenol results in increased expression of PPARGC1A mRNA19808358
D007545IsoproterenolSirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARGC1A mRNA]25045214
D007545IsoproterenolSirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARGC1A protein]25045214
D007545IsoproterenolTNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARGC1A mRNA]]25045214
D007545IsoproterenolTNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARGC1A protein]]25045214
D007555IsoxazolesIsoxazoles results in increased expression of PPARGC1A mRNA24290359
C006552kaempferolkaempferol results in increased expression of PPARGC1A mRNA17327447
D007665KetotifenKetotifen results in increased expression of PPARGC1A mRNA27089845
C063302KN 62KN 62 affects the reaction [Ionomycin results in increased expression of PPARGC1A mRNA]17516843
C030358lauric acidlauric acid results in increased expression of PPARGC1A mRNA23056435
C008261lead acetatelead acetate results in increased expression of PPARGC1A protein27236077
C008261lead acetatePPARGC1A protein affects the reaction [lead acetate results in increased expression of SIRT3 protein]27236077
C008261lead acetatePPARGC1A protein inhibits the reaction [lead acetate results in increased activity of CASP3 protein]27236077
C008261lead acetatePPARGC1A protein inhibits the reaction [lead acetate results in increased activity of CASP9 protein]27236077
C045463leflunomideleflunomide results in increased expression of PPARGC1A mRNA28988120
C432503licarin A[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A mRNA29288687
C432503licarin A[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A protein29288687
C432503licarin AN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A protein]29288687
C432503licarin APRKACA protein promotes the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A mRNA]29288687
C432503licarin APRKACA protein promotes the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A protein]29288687
C008281limonene[limonene co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein28986142
D001556LindaneLindane results in increased expression of PPARGC1A mRNA23777605
C082161lipopolysaccharide Alipopolysaccharide A results in decreased expression of PPARGC1A mRNA16061943
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of PPARGC1A mRNA"24041027
C482199lipopolysaccharide, E coli O55-B5"resveratrol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PPARGC1A mRNA]"24041027
C482199lipopolysaccharide, E coli O55-B5"tin protoporphyrin IX inhibits the reaction [resveratrol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PPARGC1A mRNA]]"24041027
C482199lipopolysaccharide, E coli O55-B5"[lipopolysaccharide, E coli O55-B5 co-treated with resveratrol] results in increased expression of PPARGC1A mRNA"24041027
C482199lipopolysaccharide, E coli O55-B5"tin protoporphyrin IX inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with resveratrol] results in increased expression of PPARGC1A mRNA]"24041027
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of PPARGC1A mRNA16847310|2187342
D008070Lipopolysaccharidespyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARGC1A mRNA]21873422
D008070Lipopolysaccharides"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Aminoimidazole Carboxamide analog promotes the reaction [Lipopolysaccharides results in increased expression of PPARGC1A protein]]"19853624
D008070Lipopolysaccharides[Aminoimidazole Carboxamide analog co-treated with Lipopolysaccharides] results in increased expression of PPARGC1A protein19853624
D008070LipopolysaccharidesAminoimidazole Carboxamide analog promotes the reaction [Lipopolysaccharides results in increased expression of PPARGC1A protein]19853624
D008070LipopolysaccharidesCurcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A mRNA]28951138
D008070LipopolysaccharidesCurcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A protein]28951138
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A mRNA28951138
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A protein28951138
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of PPARGC1A protein22610192
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PPARGC1A protein19853624
D008070Lipopolysaccharidesresveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARGC1A protein]22610192
C502354lithocholic acid acetatelithocholic acid acetate inhibits the reaction [PPARGC1A protein binds to CYP7A1 mRNA]20371703
C502354lithocholic acid acetatelithocholic acid acetate inhibits the reaction [PPARGC1A protein binds to CYP7A1 promoter]19106115
C502354lithocholic acid acetatelithocholic acid acetate promotes the reaction [VDR protein binds to PPARGC1A protein]20371703
C502354lithocholic acid acetate[lithocholic acid acetate results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]20371703
C502354lithocholic acid acetateNCOR1 protein promotes the reaction [[lithocholic acid acetate results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]]20371703
C502354lithocholic acid acetateNCOR2 protein promotes the reaction [[lithocholic acid acetate results in increased activity of [VDR protein co-treated with RXRA protein]] inhibits the reaction [PPARGC1A protein results in increased expression of CYP7A1 mRNA]]20371703
C502354lithocholic acid acetatePPARGC1A protein promotes the reaction [lithocholic acid acetate promotes the reaction [VDR protein binds to HNF4A protein]]20371703
C502354lithocholic acid acetatePPARGC1A protein promotes the reaction [[lithocholic acid acetate results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA]20371703
D019808LosartanLosartan inhibits the reaction [AGT protein results in increased expression of PPARGC1A mRNA]19109942
D019808LosartanLosartan results in increased expression of PPARGC1A mRNA18765277|1897157
D008148LovastatinLovastatin inhibits the reaction [Doxorubicin results in increased expression of PPARGC1A mRNA]28710503
C057154luzindoleluzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]25159133
C057154luzindoleluzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]]25159133
C005498magnolol[magnolol co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein28919305
C030298malic acidmalic acid results in increased expression of PPARGC1A mRNA23056435
C030290malonic acidmalonic acid results in increased expression of PPARGC1A mRNA23056435
D008345ManganeseManganese results in increased expression of PPARGC1A protein24787138
D008550Melatoninluzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]25159133
D008550Melatoninluzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]]25159133
D008550MelatoninMelatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]25159133
D008550MelatoninMelatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]25159133
D008550Melatoninsirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]25159133
D008550Melatoninsirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]]25159133
D008550MelatoninMelatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARGC1A protein]26882442
D008687MetforminMetformin results in increased expression of PPARGC1A mRNA15864539|1638048
D008687MetforminMetformin results in increased expression of PPARGC1A protein24428821
D008687MetforminPRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]16380484
D008687Metformin"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Metformin results in increased expression of PPARGC1A mRNA]"24428821
D008687MetforminMetformin inhibits the reaction [Bucladesine results in increased expression of PPARGC1A mRNA]24428821
D008687MetforminMetformin inhibits the reaction [GCG protein results in increased expression of PPARGC1A mRNA]22117073
D008687MetforminMetformin inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]23090186
D008687MetforminMetformin inhibits the reaction [PPARGC1A protein results in decreased expression of TNFSF12 mRNA]22117073
D008687MetforminMetformin inhibits the reaction [PPARGC1A protein results in increased expression of PCK1 mRNA]22117073
D008687MetforminMetformin results in increased expression of PPARGC1A mRNA24428821
D008687MetforminMetformin results in increased expression of PPARGC1A protein24428821
D008687MetforminPRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]24428821
D008687MetforminPRKAA2 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]24428821
D008687MetforminSIRT1 mutant form inhibits the reaction [Metformin results in increased expression of PPARGC1A mRNA]24428821
D008694MethamphetamineMethamphetamine results in increased expression of PPARGC1A mRNA26307267
D008715MethionineMethionine deficiency results in increased expression of PPARGC1A protein17716000
D008752Methylene ChlorideMethylene Chloride results in decreased expression of PPARGC1A mRNA28392392
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PPARGC1A mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PPARGC1A mRNA23649840
D0156551-Methyl-4-phenylpyridinium[1-Methyl-4-phenylpyridinium co-treated with epigallocatechin gallate] results in increased expression of PPARGC1A mRNA22742579
D0156551-Methyl-4-phenylpyridinium[1-Methyl-4-phenylpyridinium co-treated with epigallocatechin gallate] results in increased expression of PPARGC1A protein22742579
D008790MetoprololMetoprolol inhibits the reaction [Epinephrine results in decreased expression of PPARGC1A mRNA]19300450
D008790MetoprololMetoprolol inhibits the reaction [PPARGC1A protein binds to CPT1B promoter]19233164
D008790MetoprololMetoprolol inhibits the reaction [[[PPARGC1A protein results in increased expression of MEF2A mRNA] co-treated with [PPARGC1A protein results in increased expression of PPARA mRNA]] results in increased expression of CPT1B protein]19233164
D008790MetoprololMetoprolol promotes the reaction [USF2 protein binds to PPARGC1A protein]19233164
D015741Metribolone[Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PPARGC1A protein modified form]28751236
C517880monascinmonascin results in increased expression of PPARGC1A mRNA24275089
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate promotes the reaction [PPARA protein binds to PPARGC1A protein]20123618
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of PPARGC1A mRNA25543134
C002373monobutyryl cyclic AMPCREM protein inhibits the reaction [monobutyryl cyclic AMP results in increased expression of PPARGC1A mRNA]25381014
C002373monobutyryl cyclic AMPmonobutyryl cyclic AMP results in increased expression of PPARGC1A mRNA25381014
C523799MRK 003PPARGC1A results in decreased susceptibility to MRK 00319903844
D019814Myristic AcidMyristic Acid results in increased expression of PPARGC1A mRNA23056435
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of PPARGC1A mRNA"29244179
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of PPARGC1A mRNA"29244179
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A protein]29288687
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of PPARGC1A mRNA]16513826
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PPARGC1A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PPARGC1A mRNA"25554681
C005274naringinnaringin inhibits the reaction [Ethanol results in increased expression of PPARGC1A mRNA]18793633
C017096n-butoxyethanoln-butoxyethanol results in increased expression of PPARGC1A mRNA19812364
D000068577Nebivolol"3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Nebivolol results in increased expression of PPARGC1A protein]"23886954
D000068577NebivololNebivolol results in increased expression of PPARGC1A protein23886954
D009525NiacinNiacin results in increased expression of PPARGC1A mRNA23056435
D009532NickelNickel results in decreased expression of PPARGC1A mRNA24768652|2558310
C029938nickel sulfate[nickel sulfate co-treated with Particulate Matter] results in decreased expression of PPARGC1A mRNA23126276
C029938nickel sulfatenickel sulfate results in decreased expression of PPARGC1A mRNA23126276
D009538NicotineNicotine results in decreased expression of PPARGC1A mRNA29155039
D009573Nitrites[Nitrites co-treated with Oxygen deficiency] results in increased expression of and results in decreased acetylation of PPARGC1A protein22892143
D009573Nitrites[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA22892143
D009573NitritesPRKAA2 mutant form inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA]22892143
D009573Nitritessplitomicin inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA]22892143
D009599NitroprussideNitroprusside inhibits the reaction [Glucose deficiency results in decreased expression of PPARGC1A mRNA]17855661
D009638NorepinephrineN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of PPARGC1A mRNA]16513826
D009638NorepinephrineNorepinephrine results in increased expression of PPARGC1A mRNA16513826
D009638Norepinephrine[Propranolol co-treated with Prazosin] inhibits the reaction [Norepinephrine results in increased expression of PPARGC1A mRNA]16513826
D009638NorepinephrineNorepinephrine inhibits the reaction [Testosterone results in decreased expression of PPARGC1A mRNA]16954335
C487513NSC 23766NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of PPARGC1A mRNA]28710503
D019787Linoleic AcidLinoleic Acid results in increased expression of PPARGC1A mRNA23056435
D019787Linoleic AcidLinoleic Acid results in increased expression of PPARGC1A mRNA23056435
C076029olanzapine[olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of PPARGC1A mRNA23226405
C076029olanzapineolanzapine promotes the reaction [1-(carboxymethylthio)tetradecane results in decreased expression of PPARGC1A mRNA]23226405
C076029olanzapineolanzapine results in decreased expression of PPARGC1A mRNA23226405
D009844OligosaccharidesOligosaccharides results in increased expression of PPARGC1A protein21935427
D000069463Olive OilOlive Oil inhibits the reaction [Streptozocin results in decreased expression of PPARGC1A mRNA]25246140
D000069463Olive OilOlive Oil results in increased expression of PPARGC1A mRNA25246140
D062907Oxaloacetic AcidOxaloacetic Acid results in increased expression of PPARGC1A mRNA23056435|2681102
D062907Oxaloacetic AcidOxaloacetic Acid results in increased expression of PPARGC1A protein26811028
D010100OxygenEPAS1 gene mutant form inhibits the reaction [Oxygen deficiency results in decreased expression of PPARGC1A protein]24503013
D010100OxygenHIF1A gene mutant form inhibits the reaction [Oxygen deficiency results in decreased expression of PPARGC1A protein]24503013
D010100OxygenOxygen deficiency results in decreased expression of PPARGC1A protein24503013
D010100Oxygen[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PPARGC1A protein28477916
D010100Oxygengenipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PPARGC1A protein]28477916
D010100OxygenOxygen deficiency results in decreased expression of PPARGC1A mRNA21113404
D010100OxygenOxygen deficiency results in decreased expression of PPARGC1A protein21113404
D010100OxygenOxygen deficiency results in increased expression of PPARGC1A mRNA23539316
D010100Oxygenrosiglitazone inhibits the reaction [Oxygen deficiency results in decreased expression of PPARGC1A mRNA]21113404
D010100Oxygensirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PPARGC1A protein]]28477916
D010100Oxygen[Nitrites co-treated with Oxygen deficiency] results in increased expression of and results in decreased acetylation of PPARGC1A protein22892143
D010100Oxygen[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA22892143
D010100OxygenPRKAA2 mutant form inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA]22892143
D010100Oxygensplitomicin inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA]22892143
D010126Ozone"[Water Pollutants, Chemical co-treated with Ozone] results in decreased expression of PPARGC1A mRNA"23246600
D010126OzoneOzone results in decreased expression of PPARGC1A protein23988432
D010126OzoneOzone results in increased expression of PPARGC1A mRNA25838073
D019308Palmitic AcidPalmitic Acid results in increased expression of PPARGC1A mRNA23056435
D019308Palmitic AcidPalmitic Acid results in increased expression of PPARGC1A mRNA23056435
D000073878Palm OilPalm Oil results in increased expression of PPARGC1A mRNA18042831
D010269ParaquatAKT2 protein affects the reaction [Paraquat results in decreased expression of PPARGC1A protein]28115273
D010269ParaquatParaquat results in decreased expression of PPARGC1A protein28115273
D010269ParaquatParaquat results in increased expression of PPARGC1A protein22563483
D010269Paraquat[Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased expression of PPARGC1A protein24376630
D052638Particulate MatterParticulate Matter results in decreased expression of PPARGC1A mRNA22178795
D052638Particulate Matter[nickel sulfate co-treated with Particulate Matter] results in decreased expression of PPARGC1A mRNA23126276
D052638Particulate MatterParticulate Matter results in decreased expression of PPARGC1A mRNA21873646|2312627
D010416PentachlorophenolPentachlorophenol results in increased expression of PPARGC1A mRNA23892564
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of PPARGC1A mRNA21705711
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in decreased expression of PPARGC1A mRNA23567314
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PPARGC1A mRNA20936131|2170571
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PPARGC1A protein28288859
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PPARGC1A mRNA20936131
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PPARGC1A mRNA22154759
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PPARGC1A mRNA19616056
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PPARGC1A protein19616056
D030421Peroxynitrous AcidPeroxynitrous Acid affects the expression of PPARGC1A protein24563852
D010634PhenobarbitalPhenobarbital results in decreased expression of PPARGC1A mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of PPARGC1A mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1A mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PPARGC1A mRNA26272509
D010833Phytic Acid[resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of PPARGC1A mRNA18657603
D010846PicloramPicloram results in increased expression of PPARGC1A mRNA21318024
C004479pimagedine[Pyruvaldehyde co-treated with pimagedine] results in increased expression of PPARGC1A protein26723916
C004479pimagedine[pimagedine co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein28919305
C060836pioglitazonepioglitazone results in decreased expression of PPARGC1A mRNA22456468
C006253pirinixic acidpirinixic acid promotes the reaction [PPARA protein binds to PPARGC1A protein]20123618
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PPARGC1A mRNA19710929
C006253pirinixic acidpirinixic acid inhibits the reaction [PNPLA2 gene mutant form results in decreased expression of PPARGC1A mRNA]25285770
C006253pirinixic acidpirinixic acid promotes the reaction [PPARA protein binds to PPARGC1A protein]20123618
C006253pirinixic acidpirinixic acid promotes the reaction [PPARGC1B protein results in decreased expression of PPARGC1A mRNA]17932310
C006253pirinixic acidpirinixic acid results in increased expression of PPARGC1A mRNA17275789|1844570
D010936Plant ExtractsPlant Extracts inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PPARGC1A mRNA]20673376
D059808PolyphenolsPolyphenols inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PPARGC1A mRNA]20673376
D011189Potassium ChloridePotassium Chloride results in increased expression of PPARGC1A mRNA20438809
D011189Potassium ChloridePotassium Chloride results in increased expression of PPARGC1A protein20438809
D011192Potassium DichromatePotassium Dichromate results in increased expression of PPARGC1A mRNA18332044
D045542PQQ CofactorPQQ Cofactor results in increased expression of PPARGC1A mRNA28578007
D045542PQQ CofactorPQQ Cofactor promotes the reaction [Rotenone results in increased expression of PPARGC1A mRNA]25843018
D045542PQQ CofactorPQQ Cofactor results in increased expression of PPARGC1A mRNA25843018
D011224Prazosin[Propranolol co-treated with Prazosin] inhibits the reaction [Norepinephrine results in increased expression of PPARGC1A mRNA]16513826
D011285Pregnenolone CarbonitrilePPARGC1A protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA]21933665
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PPARGC1A mRNA28903501
D011285Pregnenolone CarbonitrilePyruvic Acid inhibits the reaction [PPARGC1A protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA]]21933665
D011285Pregnenolone CarbonitrileSIRT1 mRNA affects the reaction [Pyruvic Acid inhibits the reaction [PPARGC1A protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA]]]21933665
C045362prochlorazprochloraz results in increased expression of PPARGC1A mRNA21470553
C045362prochloraz[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of PPARGC1A mRNA29038839
C045362prochlorazprochloraz results in increased expression of PPARGC1A mRNA29038839
D011374ProgesteroneProgesterone results in increased expression of PPARGC1A mRNA23018184
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of PPARGC1A mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of PPARGC1A mRNA17404688|2305643
D011374ProgesteroneProgesterone results in increased expression of PPARGC1A mRNA23056435
C045950propiconazolepropiconazole results in decreased expression of PPARGC1A mRNA21278054
D011433Propranolol[Propranolol co-treated with Prazosin] inhibits the reaction [Norepinephrine results in increased expression of PPARGC1A mRNA]16513826
D011433PropranololPropranolol inhibits the reaction [Clenbuterol results in increased expression of PPARGC1A mRNA]17446185
D011433PropranololPropranolol results in decreased expression of PPARGC1A mRNA17446185
D011441PropylthiouracilPropylthiouracil results in decreased expression of PPARGC1A mRNA24780913
D011464EpoprostenolEpoprostenol results in increased expression of PPARGC1A mRNA23056435
C107773pterostilbenepterostilbene results in increased expression of PPARGC1A mRNA26443543
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARGC1A mRNA]21873422
C432165pyrazolanthronepyrazolanthrone results in increased expression of PPARGC1A mRNA21873422
C031280pyrazolepyrazole results in decreased expression of PPARGC1A mRNA17945193
C428725pyridabenpyridaben results in increased expression of PPARGC1A mRNA22563483
D011736PyridoxinePyridoxine results in increased expression of PPARGC1A mRNA23056435
D011736PyridoxinePyridoxine results in increased expression of PPARGC1A mRNA23056435
D011765Pyruvaldehyde[limonene co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein28986142
D011765Pyruvaldehyde[Pyruvaldehyde co-treated with honokiol] results in increased expression of PPARGC1A protein26723916
D011765Pyruvaldehyde[Pyruvaldehyde co-treated with pimagedine] results in increased expression of PPARGC1A protein26723916
D011765Pyruvaldehyde[magnolol co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein28919305
D011765Pyruvaldehyde[pimagedine co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein28919305
D019289Pyruvic Acid[Pyruvic Acid co-treated with Glucose] results in decreased acetylation of PPARGC1A protein19071085
D019289Pyruvic AcidPyruvic Acid inhibits the reaction [PPARGC1A protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA]]21933665
D019289Pyruvic AcidSIRT1 mRNA affects the reaction [Pyruvic Acid inhibits the reaction [PPARGC1A protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA]]]21933665
D011794QuercetinQuercetin results in decreased expression of PPARGC1A mRNA21632981
D011794QuercetinQuercetin affects the reaction [Catechin affects the expression of PPARGC1A mRNA]26363153
D011794QuercetinQuercetin inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]24586721
D011794QuercetinQuercetin results in increased expression of PPARGC1A mRNA19211721
D011794Quercetin[resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of PPARGC1A mRNA18657603
D011794QuercetinQuercetin inhibits the reaction [aluminum lactate results in decreased expression of PPARGC1A mRNA]26493151
D011794QuercetinQuercetin inhibits the reaction [aluminum lactate results in decreased expression of PPARGC1A protein]26493151
D017382Reactive Oxygen Species[Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased expression of PPARGC1A protein24376630
C025474rebaudioside Arebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]25554529
C059514resveratrol"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased expression of PPARGC1A mRNA]"24041027
C059514resveratrol"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PPARGC1A protein]]"25522270
C059514resveratrolHMOX1 mutant form inhibits the reaction [resveratrol results in increased expression of PPARGC1A mRNA]24041027
C059514resveratrolPPARGC1A mutant form inhibits the reaction [resveratrol results in increased expression of SIRT3 mRNA]25522270
C059514resveratrolPPARGC1A mutant form inhibits the reaction [resveratrol results in increased expression of SIRT3 protein]25522270
C059514resveratrolresveratrol affects the reaction [PRKN gene mutant form affects the expression of PPARGC1A mRNA]24582596
C059514resveratrolresveratrol affects the reaction [PRKN gene mutant form affects the expression of PPARGC1A protein]24582596
C059514resveratrolresveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PPARGC1A protein]25522270
C059514resveratrol"resveratrol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PPARGC1A mRNA]"24041027
C059514resveratrolresveratrol results in increased acetylation of PPARGC1A protein22898769
C059514resveratrolresveratrol results in increased expression of PPARGC1A21224254
C059514resveratrolresveratrol results in increased expression of PPARGC1A mRNA24041027|2458259
C059514resveratrolresveratrol results in increased expression of PPARGC1A protein16849586|2552227
C059514resveratrol"tin protoporphyrin IX inhibits the reaction [resveratrol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PPARGC1A mRNA]]"24041027
C059514resveratroltin protoporphyrin IX inhibits the reaction [resveratrol results in increased expression of PPARGC1A mRNA]24041027
C059514resveratrol"[lipopolysaccharide, E coli O55-B5 co-treated with resveratrol] results in increased expression of PPARGC1A mRNA"24041027
C059514resveratrolPPARGC1A protein affects the susceptibility to resveratrol23090186
C059514resveratrolPRKAA1 gene mutant form inhibits the reaction [resveratrol results in increased expression of PPARGC1A mRNA]25761413
C059514resveratrol[resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of PPARGC1A mRNA18657603
C059514resveratrolresveratrol inhibits the reaction [[Ethanol results in decreased activity of SIRT1 protein] which results in increased acetylation of PPARGC1A protein]18755807
C059514resveratrolresveratrol inhibits the reaction [Ethanol results in decreased expression of PPARGC1A mRNA]18755807
C059514resveratrolresveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in increased acetylation of PPARGC1A protein]23293585
C059514resveratrolresveratrol promotes the reaction [SIRT1 protein results in decreased acetylation of PPARGC1A protein]17581637
C059514resveratrolresveratrol results in decreased acetylation of and results in increased activity of PPARGC1A protein17112576
C059514resveratrolresveratrol results in decreased acetylation of PPARGC1A protein17581637
C059514resveratrolresveratrol results in decreased expression of PPARGC1A mRNA21270273|2352548
C059514resveratrolresveratrol results in decreased expression of PPARGC1A protein23525482
C059514resveratrolresveratrol results in decreased expression of PPARGC1A protein modified form23090186
C059514resveratrolresveratrol results in increased activity of PPARGC1A protein17086191
C059514resveratrol[resveratrol results in increased activity of SIRT1 protein] which results in decreased acetylation of PPARGC1A protein18755807
C059514resveratrol[resveratrol results in increased activity of SIRT1 protein] which results in increased expression of PPARGC1A protein20561979
C059514resveratrolresveratrol results in increased expression of PPARGC1A21224254
C059514resveratrolresveratrol results in increased expression of PPARGC1A mRNA17438283|1993400
C059514resveratrolresveratrol results in increased expression of PPARGC1A protein22610192|2287864
C059514resveratrol[SIRT1 protein co-treated with resveratrol] affects the reaction [Glucose affects the expression of PPARGC1A protein]23090186
C059514resveratrolSIRT1 protein promotes the reaction [resveratrol results in increased expression of PPARGC1A mRNA]19934007
C059514resveratrol"tin protoporphyrin IX inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with resveratrol] results in increased expression of PPARGC1A mRNA]"24041027
C059514resveratroltin protoporphyrin IX inhibits the reaction [resveratrol results in increased expression of PPARGC1A mRNA]24041027
C059514resveratrol"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in increased expression of PPARGC1A mRNA]"20438809
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]21632075|2522814
C059514resveratrolresveratrol inhibits the reaction [Ethanol results in increased expression of PPARGC1A mRNA]18793633
C059514resveratrolresveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARGC1A protein]22610192
C059514resveratrolresveratrol inhibits the reaction [Rotenone results in decreased expression of PPARGC1A mRNA]26770656
C059514resveratrolresveratrol inhibits the reaction [Rotenone results in decreased expression of PPARGC1A protein]26770656
C059514resveratrolresveratrol results in decreased acetylation of PPARGC1A protein17581637|2379094
C059514resveratrolresveratrol results in increased activity of PPARGC1A protein23274094
C059514resveratrol[resveratrol results in increased activity of SIRT1 protein] which results in decreased acetylation of PPARGC1A protein23422569
C059514resveratrolresveratrol results in increased expression of PPARGC1A23790948
C059514resveratrolresveratrol results in increased expression of PPARGC1A mRNA20429690|2043880
C059514resveratrolresveratrol results in increased expression of PPARGC1A protein20438809|2171568
C059514resveratrolsirtinol inhibits the reaction [resveratrol results in increased expression of PPARGC1A protein]24395567
C059514resveratrolresveratrol results in increased expression of PPARGC1A protein21739664
D012172RetinaldehydeRetinaldehyde results in increased expression of PPARGC1A mRNA23056435
D012263RibonucleosidesPRKAA1 protein affects the reaction [Ribonucleosides results in increased expression of PPARGC1A mRNA]16380484
D012263RibonucleosidesRibonucleosides results in increased expression of PPARGC1A mRNA16380484
D012293Rifampinallyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]25069801
D012293Rifampinallyl isothiocyanate inhibits the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]25069801
D012293RifampinNR1I2 protein promotes the reaction [[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]25069801
D012293Rifampin[PPARGC1A protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA25069801
D012293RifampinRifampin promotes the reaction [PPARGC1A protein binds to CYP2A6 promoter]16857725
D012293RifampinRifampin promotes the reaction [PPARGC1A protein binds to HNF4A protein]21292004
C089730rosiglitazonePPARGC1A gene polymorphism affects the susceptibility to rosiglitazone20498286
C089730rosiglitazone[rosiglitazone co-treated with Rotenone] results in increased expression of PPARGC1A protein24374061
C089730rosiglitazonerosiglitazone results in increased expression of PPARGC1A mRNA15864539|1651382
C089730rosiglitazonerosiglitazone results in increased expression of PPARGC1A protein24374061
C089730rosiglitazone2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone results in increased expression of PPARGC1A mRNA]16513826
C089730rosiglitazonePPARGC1A affects the reaction [rosiglitazone results in increased expression of CIDEA mRNA]22087241
C089730rosiglitazonePPARGC1A affects the reaction [rosiglitazone results in increased expression of COX8B mRNA]22087241
C089730rosiglitazonePPARGC1A affects the reaction [rosiglitazone results in increased expression of CPT1B mRNA]22087241
C089730rosiglitazonePPARGC1A affects the reaction [rosiglitazone results in increased expression of UCP1 mRNA]22087241
C089730rosiglitazonePPARGC1A affects the reaction [rosiglitazone results in increased expression of UCP1 protein]22087241
C089730rosiglitazonePPARGC1A protein promotes the reaction [rosiglitazone results in increased expression of PPARGC1A mRNA]16513826|1651382
C089730rosiglitazonePPARGC1A protein promotes the reaction [rosiglitazone results in increased expression of UCP1 mRNA]16513826
C089730rosiglitazone[PPARG protein co-treated with RXRA protein] promotes the reaction [rosiglitazone results in increased expression of PPARGC1A mRNA]16513826
C089730rosiglitazonePPARG protein promotes the reaction [rosiglitazone results in increased expression of PPARGC1A mRNA]16513826
C089730rosiglitazonerosiglitazone affects the expression of PPARGC1A mRNA22013433
C089730rosiglitazone[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A mRNA29288687
C089730rosiglitazone[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A protein29288687
C089730rosiglitazonerosiglitazone inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]17456854
C089730rosiglitazonerosiglitazone inhibits the reaction [Ethanol results in decreased expression of PPARGC1A mRNA]20007851
C089730rosiglitazonerosiglitazone inhibits the reaction [Ethanol results in increased acetylation of PPARGC1A protein]20007851
C089730rosiglitazonerosiglitazone inhibits the reaction [Oxygen deficiency results in decreased expression of PPARGC1A mRNA]21113404
C089730rosiglitazonerosiglitazone results in decreased expression of PPARGC1A mRNA17361034
C089730rosiglitazonerosiglitazone results in increased expression of PPARGC1A mRNA15520860|1651382
C089730rosiglitazonerosiglitazone results in increased expression of PPARGC1A protein16513826
C089730rosiglitazonerosiglitazone results in increased expression of PPARGC1A mRNA19520784
C089730rosiglitazonerosiglitazone inhibits the reaction [Fructose results in increased expression of PPARGC1A protein]19196556
C089730rosiglitazonerosiglitazone results in increased expression of PPARGC1A mRNA21373642
C089730rosiglitazoneSIRT6 affects the reaction [rosiglitazone results in increased expression of PPARGC1A mRNA]21373642
C089730rosiglitazonerosiglitazone binds to and results in increased activity of PPARGC1A protein22070604
D012402RotenoneCRTC3 protein affects the reaction [Rotenone results in increased expression of PPARGC1A mRNA]21536665
D012402Rotenone[rosiglitazone co-treated with Rotenone] results in increased expression of PPARGC1A protein24374061
D012402RotenoneRotenone results in increased expression of PPARGC1A mRNA21536665
D012402RotenoneCRTC3 protein affects the reaction [Rotenone results in increased expression of PPARGC1A mRNA]21536665
D012402RotenonePPARGC1A protein affects the reaction [Rotenone results in increased expression of COX4I1 mRNA]21536665
D012402RotenonePPARGC1A protein affects the reaction [Rotenone results in increased expression of HSPE1 mRNA]21536665
D012402RotenonePPARGC1A protein affects the reaction [Rotenone results in increased expression of NRF1 mRNA]21536665
D012402RotenoneRotenone promotes the reaction [CREB1 protein binds to PPARGC1A promoter]21536665
D012402RotenoneRotenone promotes the reaction [CRTC3 protein binds to PPARGC1A promoter]21536665
D012402RotenoneRotenone results in increased expression of PPARGC1A mRNA21536665
D012402RotenonePQQ Cofactor promotes the reaction [Rotenone results in increased expression of PPARGC1A mRNA]25843018
D012402Rotenoneresveratrol inhibits the reaction [Rotenone results in decreased expression of PPARGC1A mRNA]26770656
D012402Rotenoneresveratrol inhibits the reaction [Rotenone results in decreased expression of PPARGC1A protein]26770656
D012402RotenoneRotenone results in decreased expression of PPARGC1A mRNA26770656
D012402RotenoneRotenone results in decreased expression of PPARGC1A protein26770656
D012402RotenoneRotenone results in increased expression of PPARGC1A mRNA25843018
D000068299Salmeterol XinafoateSalmeterol Xinafoate results in increased expression of PPARGC1A mRNA17446185
C076944salvianolic acid Bsalvianolic acid B inhibits the reaction [Ethanol results in increased acetylation of PPARGC1A protein]24769256
C093642SB 203580SB 203580 inhibits the reaction [tert-Butylhydroperoxide results in increased expression of PPARGC1A protein]17116659
C480767SB219994SB219994 binds to and results in increased activity of PPARGC1A protein22070604
D012643SeleniumSelenium results in decreased expression of PPARGC1A mRNA28810182
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PPARGC1A mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PPARGC1A mRNA22300531|2535159
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PPARGC1A mRNA23221170
D020123SirolimusSirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARGC1A mRNA]25045214
D020123SirolimusSirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARGC1A protein]25045214
D020123SirolimusTNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARGC1A mRNA]]25045214
D020123SirolimusTNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of PPARGC1A protein]]25045214
C439060sirtinolsirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]25159133
C439060sirtinolsirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]]25159133
C439060sirtinolsirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PPARGC1A protein]]28477916
C439060sirtinolsirtinol inhibits the reaction [resveratrol results in increased expression of PPARGC1A protein]24395567
D012906SmokeSmoke results in decreased expression of PPARGC1A mRNA21095227
C110881S-nitro-N-acetylpenicillamine"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of PPARGC1A mRNA]"24041027
C110881S-nitro-N-acetylpenicillamineHMOX1 mutant form inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of PPARGC1A mRNA]24041027
C110881S-nitro-N-acetylpenicillamineS-nitro-N-acetylpenicillamine results in increased expression of PPARGC1A mRNA24041027
C110881S-nitro-N-acetylpenicillaminetin protoporphyrin IX inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of PPARGC1A mRNA]24041027
C110881S-nitro-N-acetylpenicillamineS-nitro-N-acetylpenicillamine results in increased expression of PPARGC1A mRNA24041027
C110881S-nitro-N-acetylpenicillaminetin protoporphyrin IX inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of PPARGC1A mRNA]24041027
C009277sodium arsenatesodium arsenate results in increased expression of PPARGC1A mRNA21795629
C017947sodium arseniteSIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [FOXO3 protein binds to PPARGC1A promoter]]25979314
C017947sodium arseniteSIRT3 protein inhibits the reaction [sodium arsenite results in decreased expression of PPARGC1A protein]25979314
C017947sodium arsenitesodium arsenite inhibits the reaction [FOXO3 protein binds to PPARGC1A promoter]25979314
C017947sodium arsenitesodium arsenite results in decreased expression of PPARGC1A protein25979314
C017947sodium arsenitesodium arsenite results in increased expression of PPARGC1A mRNA19822182
C017947sodium arsenitesodium arsenite results in decreased expression of PPARGC1A mRNA26767369|2742564
C017947sodium arsenitesodium arsenite results in decreased expression of PPARGC1A protein26767369|2742564
C009279sodium bisulfiteAcetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of PPARGC1A mRNA]26980303
C009279sodium bisulfitesodium bisulfite results in decreased expression of PPARGC1A mRNA26980303
C009279sodium bisulfitesodium bisulfite results in decreased expression of PPARGC1A protein26980303
D018038Sodium SeleniteSodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of PPARGC1A mRNA]26522834
D013109SphingomyelinsSphingomyelins results in increased expression of PPARGC1A mRNA23056435
C444426splitomicinsplitomicin inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA]22892143
C525422SRT1720SRT1720 affects the reaction [Acetaminophen affects the expression of PPARGC1A protein]28827156
D019311Staurosporine[Hydrogen Peroxide co-treated with Staurosporine] results in increased acetylation of PPARGC1A protein23293585
D019311Staurosporineresveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in increased acetylation of PPARGC1A protein]23293585
C031183stearic acidstearic acid results in increased expression of PPARGC1A mRNA23056435
C012042steviolsteviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]25554529
C012043steviosidestevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA]25554529
D013311StreptozocinSodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of PPARGC1A mRNA]26522834
D013311Streptozocin[Streptozocin co-treated with Dietary Fats] results in increased expression of PPARGC1A mRNA26522834
D013311StreptozocinStreptozocin results in decreased expression of PPARGC1A protein21381899
D013311StreptozocinStreptozocin results in increased expression of PPARGC1A mRNA23319174
D013311Streptozocintelmisartan inhibits the reaction [Streptozocin results in decreased expression of PPARGC1A protein]21381899
D013311StreptozocinOlive Oil inhibits the reaction [Streptozocin results in decreased expression of PPARGC1A mRNA]25246140
D013311StreptozocinStreptozocin results in decreased expression of PPARGC1A mRNA25246140
C020804succinylacetonesuccinylacetone results in increased expression of PPARGC1A mRNA22859313
C016766sulforafansulforafan results in increased expression of PPARGC1A protein27993529
D013458Sulfur DioxideSulfur Dioxide results in decreased expression of PPARGC1A mRNA26980303
D013458Sulfur DioxideSulfur Dioxide results in decreased expression of PPARGC1A protein26980303
D014284TriiodothyronineTriiodothyronine results in increased expression of PPARGC1A mRNA23306105
D014284TriiodothyronineTriiodothyronine results in increased expression of PPARGC1A mRNA23209300
D014284TriiodothyroninePPARGC1A protein affects the reaction [Triiodothyronine results in increased expression of CPT1A]23209300
D014284TriiodothyroninePPARGC1A protein affects the reaction [Triiodothyronine results in increased expression of PDK4]23209300
D014284TriiodothyroninePPARGC1A protein affects the susceptibility to Triiodothyronine23209300
D014284TriiodothyronineSIRT1 protein affects the reaction [Triiodothyronine results in decreased acetylation of PPARGC1A protein]23209300
D014284TriiodothyronineTriiodothyronine results in decreased acetylation of PPARGC1A protein23209300
D013605T-2 Toxin"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [T-2 Toxin results in decreased expression of PPARGC1A protein]"27363784
D013605T-2 ToxinT-2 Toxin results in decreased expression of PPARGC1A protein27363784
D013629TamoxifenTamoxifen inhibits the reaction [PPARGC1A protein binds to ESRRG protein]16889744
D013629TamoxifenTamoxifen results in increased expression of PPARGC1A mRNA27089845
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA]20165829
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein]20165829
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA]20165829
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein]20165829
C084178telmisartantelmisartan inhibits the reaction [Streptozocin results in decreased expression of PPARGC1A protein]21381899
D013739TestosteroneTestosterone results in increased expression of PPARGC1A mRNA21045173
D013739TestosteroneNorepinephrine inhibits the reaction [Testosterone results in decreased expression of PPARGC1A mRNA]16954335
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of PPARGC1A protein]21094144
D013739TestosteroneTestosterone results in decreased expression of PPARGC1A mRNA16954335
C004648testosterone enanthatetestosterone enanthate results in increased expression of PPARGC1A mRNA25603467
D013749Tetrachlorodibenzodioxinbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PPARGC1A protein]20876576
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PPARGC1A protein]20876576
D013749TetrachlorodibenzodioxinNiacinamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased acetylation of and results in decreased expression of PPARGC1A protein]20876576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased acetylation of and results in decreased expression of PPARGC1A protein20876576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PPARGC1A mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PPARGC1A mRNA20106945|2163298
D013749TetrachlorodibenzodioxinNFE2L2 gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PPARGC1A mRNA]21846477
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PPARGC1A mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [NFE2L2 gene mutant form results in increased expression of PPARGC1A mRNA]21846477
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PPARGC1A mRNA21846477
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PPARGC1A mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PPARGC1A mRNA25613284
C050950tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complextetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Ethanol results in decreased expression of PPARGC1A protein]28962519
D008063Thioctic Acid[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A protein20414966
D008063Thioctic AcidThioctic Acid results in increased expression of PPARGC1A protein20414966
D008063Thioctic AcidThioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]22464149
C055421tin mesoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [LEP gene mutant form results in decreased expression of PPARGC1A mRNA]]23839791
C032628tin protoporphyrin IXtin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of PPARGC1A mRNA]24041027
C032628tin protoporphyrin IX"tin protoporphyrin IX inhibits the reaction [resveratrol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PPARGC1A mRNA]]"24041027
C032628tin protoporphyrin IXtin protoporphyrin IX inhibits the reaction [resveratrol results in increased expression of PPARGC1A mRNA]24041027
C032628tin protoporphyrin IXtin protoporphyrin IX inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of PPARGC1A mRNA]24041027
C032628tin protoporphyrin IX"tin protoporphyrin IX inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with resveratrol] results in increased expression of PPARGC1A mRNA]"24041027
C032628tin protoporphyrin IXtin protoporphyrin IX inhibits the reaction [resveratrol results in increased expression of PPARGC1A mRNA]24041027
C032628tin protoporphyrin IXtin protoporphyrin IX inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased expression of PPARGC1A mRNA]24041027
C009495titanium dioxidetitanium dioxide results in decreased expression of PPARGC1A mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PPARGC1A mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PPARGC1A protein27319396
D014028Tobacco Smoke PollutionCurcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A mRNA]28951138
D014028Tobacco Smoke PollutionCurcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A protein]28951138
D014028Tobacco Smoke Pollution[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A mRNA28951138
D014028Tobacco Smoke Pollution[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A protein28951138
D014212TretinoinTretinoin results in increased expression of PPARGC1A mRNA16840543
C476530tricarbonylchloro(glycinato)ruthenium(II)2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of PPARGC1A mRNA]24041027
C476530tricarbonylchloro(glycinato)ruthenium(II)NFE2L2 mutant form inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of PPARGC1A mRNA]24041027
C476530tricarbonylchloro(glycinato)ruthenium(II)tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of PPARGC1A mRNA24041027
C012589trichostatin Atrichostatin A results in increased expression of PPARGC1A mRNA24935251
C032742triclopyr"arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide promotes the reaction [triclopyr results in increased expression of PPARGC1A mRNA]"21318024
C032742triclopyrtriclopyr results in increased expression of PPARGC1A mRNA21318024
C005445triphenyl phosphatetriphenyl phosphate results in increased expression of PPARGC1A mRNA23306105
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PPARGC1A mRNA"23306105
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in increased expression of PPARGC1A mRNA26562049
C031324tris(chloroethyl)phosphatetris(chloroethyl)phosphate results in increased expression of PPARGC1A mRNA27776230
C057693troglitazonePPARGC1A protein inhibits the reaction [troglitazone results in decreased expression of ATP5F1B mRNA]20860658
C057693troglitazonePPARGC1A protein inhibits the reaction [troglitazone results in decreased expression of TFAM mRNA]20860658
C057693troglitazonePPARGC1A protein results in decreased susceptibility to troglitazone20860658
C057693troglitazonetroglitazone results in decreased expression of PPARGC1A protein20860658
C057693troglitazonetroglitazone results in increased degradation of PPARGC1A protein20860658
C057693troglitazonetroglitazone results in increased expression of PPARGC1A mRNA20860658
C057693troglitazonePPARG protein promotes the reaction [troglitazone results in increased expression of PPARGC1A mRNA]16513826
C057693troglitazonetroglitazone results in increased expression of PPARGC1A mRNA16513826
C057693troglitazonetroglitazone results in increased expression of PPARGC1A mRNA14563825
D014415TunicamycinCEBPB protein inhibits the reaction [Tunicamycin results in decreased expression of PPARGC1A protein]28482072
D014415TunicamycinTunicamycin results in decreased expression of PPARGC1A mRNA28482072
D014415TunicamycinTunicamycin results in decreased expression of PPARGC1A protein28482072
D014415TunicamycinTunicamycin results in increased expression of PPARGC1A mRNA22414386
D014425TurpentineTurpentine results in decreased expression of PPARGC1A mRNA16061943
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [tert-Butylhydroperoxide results in increased expression of PPARGC1A protein]17116659
C113580U 0126U 0126 inhibits the reaction [Calcitriol inhibits the reaction [PPARGC1A protein binds to CYP7A1 mRNA]]20371703
D014535Uridine Diphosphate Glucuronic AcidUridine Diphosphate Glucuronic Acid results in increased expression of PPARGC1A mRNA23056435
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1A mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PPARGC1A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PPARGC1A mRNA27089845
D014635Valproic AcidValproic Acid results in decreased methylation of PPARGC1A gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PPARGC1A mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of PPARGC1A mRNA24489787
D014640VancomycinVancomycin results in increased expression of PPARGC1A mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PPARGC1A gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of PPARGC1A mRNA26682919
D014801Vitamin AVitamin A affects the reaction [PPARGC1A protein binds to PCK1 promoter]16317119
D012256RiboflavinRiboflavin results in increased expression of PPARGC1A mRNA23056435
D009536NiacinamideNiacinamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased acetylation of and results in decreased expression of PPARGC1A protein]20876576
D009536NiacinamideNiacinamide results in increased stability of PPARGC1A protein20876576
D009536NiacinamideNiacinamide results in increased acetylation of PPARGC1A protein19071085
D009536Niacinamide[Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [SIRT1 protein results in increased expression of PPARGC1A mRNA]23891692
D009536Niacinamide[Niacinamide results in decreased activity of SIRT1 protein] which results in increased acetylation of PPARGC1A protein23422569
D004872ErgocalciferolsErgocalciferols results in increased expression of PPARGC1A mRNA23056435
C111237vorinostatvorinostat results in increased expression of PPARGC1A mRNA27188386
D014874Water Pollutants, Chemical"[Water Pollutants, Chemical co-treated with Ozone] results in decreased expression of PPARGC1A mRNA"23246600
C488234XCT790XCT790 results in decreased expression of PPARGC1A protein19464277
D019287Zinc SulfateZinc Sulfate results in increased expression of PPARGC1A mRNA27504894
C088658zoledronic acidzoledronic acid results in decreased expression of PPARGC1A mRNA24714768|2887133
C088658zoledronic acidzoledronic acid results in decreased expression of PPARGC1A protein28871336
C088658zoledronic acidFenofibrate inhibits the reaction [zoledronic acid results in decreased expression of PPARGC1A mRNA]28871336
C088658zoledronic acidSLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in decreased expression of PPARGC1A mRNA]28871336
C088658zoledronic acidzoledronic acid results in decreased expression of PPARGC1A mRNA28871336
D015054ZymosanZymosan results in decreased expression of PPARGC1A mRNA16061943

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-ISS-  
GO:0003677DNA binding-TAS10713165  
GO:0003712transcription coregulator activity-TAS14636573  
GO:0003713transcription coactivator activity-IDA19651776  21376232  
GO:0003723RNA binding-TAS12588810  
GO:0005515protein binding-IPI12522104  17050673  18063693  19171140  19846556  19914244  
GO:0008134transcription factor binding-IBA21873635  
GO:0008134transcription factor binding-TAS12588810  
GO:0016922ligand-dependent nuclear receptor binding-IPI18798693  
GO:0030331estrogen receptor binding-IEA-  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IBA21873635  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IDA16488887  
GO:0031490chromatin DNA binding-ISS-  
GO:0031625ubiquitin protein ligase binding-IPI22064484  
GO:0042975peroxisome proliferator activated receptor binding-IEA-  
GO:0043014alpha-tubulin binding-IEA-  
GO:0043565sequence-specific DNA binding-IDA23836911  
GO:0050681androgen receptor binding-NAS15572661  
GO:1990841promoter-specific chromatin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000302response to reactive oxygen species-IEA-  
GO:0000422autophagy of mitochondrion-IEA-  
GO:0001659temperature homeostasis-TAS1258810  
GO:0001678cellular glucose homeostasis-NAS11854298  
GO:0001933negative regulation of protein phosphorylation-IEA-  
GO:0002021response to dietary excess-IEA-  
GO:0002931response to ischemia-IEA-  
GO:0006012galactose metabolic process-IEA-  
GO:0006094gluconeogenesis-NAS11854298  
GO:0006355regulation of transcription, DNA-templated-IDA23836911  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS14636573  
GO:0006397mRNA processing-TAS12588810  
GO:0007005mitochondrion organization-NAS11854298  
GO:0007005mitochondrion organization-TAS-  
GO:0007568aging-IEA-  
GO:0007586digestion-TAS10585775  
GO:0007623circadian rhythm-TAS-  
GO:0008209androgen metabolic process-IEA-  
GO:0008380RNA splicing-TAS12588810  
GO:0009409response to cold-IEA-  
GO:0010822positive regulation of mitochondrion organization-IMP25118933  
GO:0010822positive regulation of mitochondrion organization-ISS-  
GO:0014732skeletal muscle atrophy-IEA-  
GO:0014850response to muscle activity-ISS-  
GO:0014878response to electrical stimulus involved in regulation of muscle adaptation-IEA-  
GO:0014912negative regulation of smooth muscle cell migration-IEA-  
GO:0019395fatty acid oxidation-NAS11854298  
GO:0021549cerebellum development-IEA-  
GO:0022904respiratory electron transport chain-ISS-  
GO:0030521androgen receptor signaling pathway-NAS15572661  
GO:0030900forebrain development-IEA-  
GO:0032922circadian regulation of gene expression-ISS-  
GO:0034599cellular response to oxidative stress-ISS-  
GO:0035066positive regulation of histone acetylation-TAS14636573  
GO:0035865cellular response to potassium ion-IEA-  
GO:0042594response to starvation-NAS11854298  
GO:0042752regulation of circadian rhythm-ISS-  
GO:0043201response to leucine-IEA-  
GO:0043524negative regulation of neuron apoptotic process-ISS-  
GO:0045333cellular respiration-TAS11551810  
GO:0045722positive regulation of gluconeogenesis-TAS12588810  
GO:0045820negative regulation of glycolytic process-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IDA16488887  19651776  
GO:0045893positive regulation of transcription, DNA-templated-NAS15572661  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA21376232  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0046321positive regulation of fatty acid oxidation-TAS12588810  
GO:0048661positive regulation of smooth muscle cell proliferation-IEA-  
GO:0048662negative regulation of smooth muscle cell proliferation-IEA-  
GO:0050821protein stabilization-TAS14636573  
GO:0050873brown fat cell differentiation-TAS12588810  
GO:0051091positive regulation of DNA-binding transcription factor activity-IBA21873635  
GO:0051091positive regulation of DNA-binding transcription factor activity-IDA19651776  
GO:0051552flavone metabolic process-IEA-  
GO:0060612adipose tissue development-IEA-  
GO:0065003protein-containing complex assembly-TAS14636573  
GO:0071222cellular response to lipopolysaccharide-IEA-  
GO:0071250cellular response to nitrite-IEA-  
GO:0071313cellular response to caffeine-IEA-  
GO:0071332cellular response to fructose stimulus-IEA-  
GO:0071333cellular response to glucose stimulus-IEA-  
GO:0071354cellular response to interleukin-6-IEA-  
GO:0071356cellular response to tumor necrosis factor-IEA-  
GO:0071372cellular response to follicle-stimulating hormone stimulus-IEA-  
GO:0071392cellular response to estradiol stimulus-IEA-  
GO:0071456cellular response to hypoxia-IEA-  
GO:0071560cellular response to transforming growth factor beta stimulus-IEA-  
GO:0071871response to epinephrine-IEA-  
GO:0071873response to norepinephrine-IEA-  
GO:0090258negative regulation of mitochondrial fission-IEA-  
GO:0097009energy homeostasis-ISS-  
GO:0097067cellular response to thyroid hormone stimulus-IEA-  
GO:1901215negative regulation of neuron death-IGI21376232  
GO:1901558response to metformin-IEA-  
GO:1901857positive regulation of cellular respiration-IEA-  
GO:1901860positive regulation of mitochondrial DNA metabolic process-IEA-  
GO:1901863positive regulation of muscle tissue development-IEA-  
GO:1904635positive regulation of glomerular visceral epithelial cell apoptotic process-IEA-  
GO:1904637cellular response to ionomycin-IEA-  
GO:1904639cellular response to resveratrol-IEA-  
GO:1904640response to methionine-IEA-  
GO:1990845adaptive thermogenesis-IEA-  
GO:2000184positive regulation of progesterone biosynthetic process-IEA-  
GO:2000272negative regulation of signaling receptor activity-IEA-  
GO:2000310regulation of NMDA receptor activity-IEA-  
GO:2001171positive regulation of ATP biosynthetic process-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA23836911  
GO:0005634nucleus-ISS-  
GO:0005634nucleus-TAS12588810  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005665DNA-directed RNA polymerase II, core complex-TAS12588810  
GO:0005719nuclear euchromatin-IEA-  
GO:0016605PML body-IEA-  
GO:0022626cytosolic ribosome-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0097440apical dendrite-IEA-  
GO:1990843subsarcolemmal mitochondrion-IEA-  
GO:1990844interfibrillar mitochondrion-IEA-  
KEGG ID KEGG Term
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1430728MetabolismTAS
R-HSA-1592230Mitochondrial biogenesisTAS
R-HSA-1592230Mitochondrial biogenesisIEA
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-1852241Organelle biogenesis and maintenanceIEA
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2151201Transcriptional activation of mitochondrial biogenesisTAS
R-HSA-2151209Activation of PPARGC1A (PGC-1alpha) by phosphorylationIEA
R-HSA-381340Transcriptional regulation of white adipocyte differentiationTAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationIEA
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-400253Circadian ClockIEA
R-HSA-400253Circadian ClockTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878166Transcriptional regulation by RUNX2IEA
R-HSA-8878166Transcriptional regulation by RUNX2TAS
R-HSA-8939902Regulation of RUNX2 expression and activityIEA
R-HSA-8939902Regulation of RUNX2 expression and activityTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26672058Biomolecular Markers within the Core Axis of Aging and Particulate Air Pollution Exposure in the Elderly: A Cross-Sectional Study. (2016 Jul)Pieters NEnviron Health Perspect
25516156Peroxisome proliferator-activated receptors alpha and gamma are linked with alcohol consumption in mice and withdrawal and dependence in humans. (2015 Jan)Blednov YAAlcohol Clin Exp Res
25748950Association between the PPARGC1A polymorphism and aerobic capacity in Japanese middle-aged men. (2015)Nishida YIntern Med
28418876PPARGC1A rs3736265 G>A polymorphism is associated with decreased risk of type 2 diabetes mellitus and fasting plasma glucose level. (2017 Jun 6)Zhu LOncotarget
22106445HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes. (2012 Jan 1)Edwards TLAm J Epidemiol