Gene info: ID 10892

Gene: MALT1

GENE ID: 10892

Synonyms: IMD12|MLT|MLT1|PCASP1

Description: MALT1 paracaspase

Gene type: protein-coding

Location: 18q21.32

dbXrefs: Ensembl:ENSG00000172175 MIM:604860 Vega:OTTHUMG00000132761 UniprotKB:Q9UDY8

RefSeq: NG_033893.1

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.169e-1 (AD) 4.674e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs2319974	chr18:58749237 (GRCh38.p7)	A>G	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CD2AP	0.868
NUP160	0.853
SLC30A7	0.847
ZNF700	0.844
BRWD3	0.837
SMC5	0.837
XRN1	0.819
JAK2	0.818
VCL	0.814
BTAF1	0.812

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.373
OR4F29	-0.368
ASPDH	-0.322
HES5	-0.299
ARSF	-0.29
CPLX3	-0.281
HES6	-0.281
LYPD8	-0.269
CRH	-0.262
LCN1	-0.25

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of MALT1 mRNA	19933214
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MALT1 mRNA"	19114083
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of MALT1 protein	21173233
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of MALT1 mRNA"	21346803
C003898	2-anisidine	2-anisidine results in increased expression of MALT1 mRNA	28089782
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MALT1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MALT1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MALT1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MALT1 mRNA"	27188386
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of MALT1 mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of MALT1 mRNA	19770486
D001151	Arsenic	Arsenic affects the expression of MALT1 mRNA	18414638
D001151	Arsenic	Arsenic results in increased expression of MALT1 mRNA	19945496
D001205	Ascorbic Acid	[Quercetin co-treated with Ascorbic Acid] results in increased expression of MALT1 mRNA	17639512
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of MALT1 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MALT1 mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MALT1 mRNA"	19150397
C006780	bisphenol A	bisphenol A results in decreased expression of MALT1 mRNA	26364221
C006780	bisphenol A	bisphenol A affects the expression of MALT1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of MALT1 mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in decreased expression of MALT1 mRNA	26079696
C018021	cobaltous chloride	cobaltous chloride results in increased expression of MALT1 mRNA	19376846
D016572	Cyclosporine	Cyclosporine results in decreased expression of MALT1 mRNA	22147139\|2798913
D016572	Cyclosporine	Cyclosporine results in increased expression of MALT1 mRNA	20106945
D002945	Cisplatin	Cisplatin results in decreased expression of MALT1 mRNA	27392435
C000944	dicrotophos	dicrotophos results in decreased expression of MALT1 mRNA	28302478
D002117	Calcitriol	Calcitriol results in increased expression of MALT1 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of MALT1 mRNA	21592394
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of MALT1 mRNA"	22485181
D004147	Dioxins	Dioxins affects the expression of MALT1 mRNA	20463971
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MALT1 mRNA	22079256
D005472	Fluorouracil	Fluorouracil results in increased expression of MALT1 mRNA	15109396
D005472	Fluorouracil	MALT1 affects the susceptibility to Fluorouracil	15067352
C492448	ICG 001	ICG 001 results in increased expression of MALT1 mRNA	26191083
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MALT1 mRNA	25613284
C544151	jinfukang	jinfukang results in decreased expression of MALT1 mRNA	27392435
D007854	Lead	Lead affects the expression of MALT1 mRNA	28903495
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MALT1 mRNA	24056979
D008070	Lipopolysaccharides	methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of MALT1 mRNA]	24056979
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of MALT1 mRNA	21641980
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of MALT1 mRNA	21641980
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] affects the expression of MALT1 mRNA	26378955
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of MALT1 mRNA	20353558
D008727	Methotrexate	Methotrexate results in increased expression of MALT1 mRNA	17400583
C008435	methyldithiocarbamate	methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of MALT1 mRNA]	24056979
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of MALT1 mRNA	23103053
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of MALT1 mRNA	28001369
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of MALT1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of MALT1 mRNA"	25554681
C046012	pentanal	pentanal results in decreased expression of MALT1 mRNA	26079696
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of MALT1 mRNA	27153767
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MALT1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of MALT1 mRNA	26272509
D010936	Plant Extracts	Plant Extracts results in increased expression of MALT1 mRNA	23557933
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of MALT1 mRNA	21334430
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MALT1 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of MALT1 mRNA	22079256
D047428	Protein Kinase Inhibitors	Protein Kinase Inhibitors results in decreased activity of MALT1 protein	21173233
D011794	Quercetin	[Quercetin co-treated with Ascorbic Acid] results in increased expression of MALT1 mRNA	17639512
D011794	Quercetin	Quercetin results in decreased expression of MALT1 mRNA	21632981
D012643	Selenium	Selenium results in decreased expression of MALT1 mRNA	19244175
C009277	sodium arsenate	sodium arsenate results in increased expression of MALT1 mRNA	21795629
D053260	Soot	Soot results in increased expression of MALT1 mRNA	22461453\|2655175
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of MALT1 mRNA	21641980
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of MALT1 mRNA	21641980
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] affects the expression of MALT1 mRNA	26378955
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of MALT1 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of MALT1 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MALT1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MALT1 mRNA	19933214
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MALT1 mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in increased expression of MALT1 mRNA	23557971\|2776080
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of MALT1 mRNA	20133372
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MALT1 mRNA"	26179874
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MALT1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of MALT1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of MALT1 mRNA	23179753\|2493525
C088658	zoledronic acid	zoledronic acid results in increased expression of MALT1 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002020	protease binding	-	IEA	-
GO:0004197	cysteine-type endopeptidase activity	-	NAS	11090634
GO:0004842	ubiquitin-protein transferase activity	-	IDA	14695475 15125833
GO:0005515	protein binding	-	IPI	14695475 15125833 16123224 16874300 17948050 18223652 19118383 19444310 21157432 22267217 22528498 27070702
GO:0008233	peptidase activity	-	IDA	18223652
GO:0019209	kinase activator activity	contributes_to	IMP	15125833
GO:0042802	identical protein binding	-	IPI	22158899
GO:0043621	protein self-association	-	IPI	15125833

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001923	B-1 B cell differentiation	-	IEA	-
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	-
GO:0002237	response to molecule of bacterial origin	-	IEA	-
GO:0002726	positive regulation of T cell cytokine production	-	IMP	15125833
GO:0006508	proteolysis	-	IDA	18223652
GO:0006952	defense response	-	NAS	10523859
GO:0007250	activation of NF-kappaB-inducing kinase activity	-	IMP	15125833
GO:0009620	response to fungus	-	IEA	-
GO:0016567	protein ubiquitination	-	IEA	-
GO:0031398	positive regulation of protein ubiquitination	-	NAS	18223652
GO:0032743	positive regulation of interleukin-2 production	-	IMP	15125833
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	-
GO:0042098	T cell proliferation	-	IEA	-
GO:0042113	B cell activation	-	IBA	21873635
GO:0042981	regulation of apoptotic process	-	IDA	12819136
GO:0043066	negative regulation of apoptotic process	-	NAS	11090634 11096264
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	HMP	12761501
GO:0045087	innate immune response	-	IBA	21873635
GO:0045087	innate immune response	-	IEA	-
GO:0050852	T cell receptor signaling pathway	-	IBA	21873635
GO:0050852	T cell receptor signaling pathway	-	IDA	15125833
GO:0050852	T cell receptor signaling pathway	-	TAS	-
GO:0050856	regulation of T cell receptor signaling pathway	-	IEA	-
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IBA	21873635
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IMP	18223652
GO:0051168	nuclear export	-	IDA	16123224
GO:0051259	protein complex oligomerization	-	IDA	15125833
GO:2000321	positive regulation of T-helper 17 cell differentiation	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001650	fibrillar center	-	IDA	-
GO:0005634	nucleus	-	IDA	16123224
GO:0005730	nucleolus	-	IDA	-
GO:0005737	cytoplasm	-	IDA	16123224
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0032449	CBM complex	-	IDA	28628108
GO:0032449	CBM complex	-	NAS	15125833
GO:0032991	protein-containing complex	-	IDA	15125833
GO:0048471	perinuclear region of cytoplasm	-	IEA	-

KEGG ID	KEGG Term
hsa04660	T cell receptor signaling pathway
hsa04662	B cell receptor signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	IEA
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	TAS
R-HSA-1169091	Activation of NF-kappaB in B cells	IEA
R-HSA-1169091	Activation of NF-kappaB in B cells	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1280218	Adaptive Immune System	IEA
R-HSA-168249	Innate Immune System	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-202403	TCR signaling	TAS
R-HSA-202424	Downstream TCR signaling	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	IEA
R-HSA-2871837	FCERI mediated NF-kB activation	TAS
R-HSA-2871837	FCERI mediated NF-kB activation	IEA
R-HSA-5607764	CLEC7A (Dectin-1) signaling	TAS
R-HSA-5621481	C-type lectin receptors (CLRs)	TAS
R-HSA-5660668	CLEC7A/inflammasome pathway	TAS
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	IEA
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal