Gene: ADCY3

109
AC-III|AC3|BMIQ19
adenylate cyclase 3
protein-coding
2p23.3
Ensembl:ENSG00000138031 MIM:600291 Vega:OTTHUMG00000094765 UniprotKB:O60266
NC_000002.12
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.912e-1 (AD)  2.888e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TP53BP10.89
GLYR10.882
TNPO30.88
POLG0.878
GRB20.877
KPNA60.877
ARID1B0.877
IPPK0.876
POM1210.875
PCDH10.875

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.495
OR4F29-0.448
S100A14-0.333
CTNNA3-0.315
COPZ2-0.313
KLRC2-0.31
S100A1-0.308
KLRC3-0.306
MTRNR2L6-0.279
HEY2-0.274

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C021279(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester"(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester inhibits the reaction [Methamphetamine results in decreased expression of ADCY3 mRNA]"11756511
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of ADCY3 mRNA"20453058
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ADCY3 mRNA"19114083
C0185352-ethylhexyldiphenylphosphate2-ethylhexyldiphenylphosphate results in increased expression of ADCY3 mRNA26794138
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of ADCY3 mRNA"26186136
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ADCY3 mRNA16483693
D001151ArsenicArsenic affects the methylation of ADCY3 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of ADCY3 mRNA"17331233
D001280AtrazineAtrazine results in decreased expression of ADCY3 mRNA25929836
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ADCY3 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to ADCY3 promoter]19654925
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of ADCY3 mRNA]24758408
D004958EstradiolEstradiol results in increased expression of ADCY3 mRNA24758408
C044887beta-methylcholinebeta-methylcholine affects the expression of ADCY3 mRNA21179406
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ADCY3 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of ADCY3 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ADCY3 mRNA12414654
C018475butyraldehydebutyraldehyde results in decreased expression of ADCY3 mRNA26079696
D002220CarbamazepineCarbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY3 protein]19922557
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of ADCY3 mRNA18636392
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADCY3 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of ADCY3 mRNA19320972|1937684
D003300Copper[Disulfiram binds to Copper] which results in increased expression of ADCY3 mRNA24690739
D003703DemecolcineDemecolcine results in decreased expression of ADCY3 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ADCY3 mRNA28628672
D003907Dexamethasone[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of ADCY3 mRNA29288687
D003907Dexamethasone[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of ADCY3 mRNA29288687
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ADCY3 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of ADCY3 mRNA27392435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ADCY3 mRNA18164116
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of ADCY3 mRNA24690739
D000431EthanolEthanol results in increased expression of ADCY3 mRNA20655511
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADCY3 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of ADCY3 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of ADCY3 mRNA14756816
D017313FenretinideFenretinide results in increased expression of ADCY3 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ADCY3 mRNA12414654
C492448ICG 001ICG 001 results in increased expression of ADCY3 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ADCY3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ADCY3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of ADCY3 mRNA29288687
D0150561-Methyl-3-isobutylxanthine[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of ADCY3 mRNA29288687
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ADCY3 mRNA23086925|2479639
C045463leflunomideleflunomide results in decreased expression of ADCY3 mRNA28988120
C432503licarin A[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of ADCY3 mRNA29288687
D008694Methamphetamine"(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester inhibits the reaction [Methamphetamine results in decreased expression of ADCY3 mRNA]"11756511
D008694MethamphetamineMethamphetamine results in decreased expression of ADCY3 mRNA11756511
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADCY3 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of ADCY3 mRNA24449571
D009151Mustard GasMustard Gas results in decreased expression of ADCY3 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ADCY3 mRNA"25554681
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of ADCY3 mRNA18636392
D052638Particulate MatterParticulate Matter results in increased expression of ADCY3 mRNA28412507
D010416PentachlorophenolPentachlorophenol results in increased expression of ADCY3 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ADCY3 mRNA18692542
C089730rosiglitazone[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of ADCY3 mRNA29288687
D012834SilverSilver affects the expression of ADCY3 mRNA27131904
C071262SK&F 82958Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY3 protein]19922557
C071262SK&F 82958[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY3 protein19922557
C004648testosterone enanthatetestosterone enanthate affects the expression of ADCY3 mRNA25603467
D014050TolueneToluene affects the expression of ADCY3 mRNA21827849
C022884undecaneundecane results in decreased expression of ADCY3 protein17337753
D014635Valproic AcidValproic Acid affects the expression of ADCY3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of ADCY3 gene29154799
C066075vanadium pentoxidevanadium pentoxide affects the expression of ADCY3 mRNA26210822
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ADCY3 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of ADCY3 mRNA20044591
D024483Vitamin K 3Vitamin K 3 results in decreased expression of ADCY3 mRNA12414654

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004016adenylate cyclase activity-ISS-  
GO:0004016adenylate cyclase activity-TAS-  
GO:0005516calmodulin binding-IEA-  
GO:0005524ATP binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003091renal water homeostasis-TAS-  
GO:0006171cAMP biosynthetic process-IBA21873635  
GO:0006171cAMP biosynthetic process-ISS-  
GO:0007165signal transduction-TAS9920776  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-ISS-  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-TAS-  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-TAS-  
GO:0007338single fertilization-ISS-  
GO:0007340acrosome reaction-ISS-  
GO:0007608sensory perception of smell-ISS-  
GO:0008355olfactory learning-ISS-  
GO:0019933cAMP-mediated signaling-IBA21873635  
GO:0030317flagellated sperm motility-ISS-  
GO:0071377cellular response to glucagon stimulus-TAS-  
GO:1904322cellular response to forskolin-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA11549699  
GO:0005794Golgi apparatus-ISS-  
GO:0005886plasma membrane-IDA11549699  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9920776  
GO:0005929cilium-ISS-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-ISS-  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa04020Calcium signaling pathway
hsa04062Chemokine signaling pathway
hsa04114Oocyte meiosis
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04740Olfactory transduction
hsa04912GnRH signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04916Melanogenesis
hsa04962Vasopressin-regulated water reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04976Bile secretion
hsa05110Vibrio cholerae infection
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-111885Opioid SignallingTAS
R-HSA-111885Opioid SignallingIEA
R-HSA-111931PKA-mediated phosphorylation of CREBTAS
R-HSA-111933Calmodulin induced eventsTAS
R-HSA-111996Ca-dependent eventsTAS
R-HSA-111997CaM pathwayTAS
R-HSA-112040G-protein mediated eventsTAS
R-HSA-112040G-protein mediated eventsIEA
R-HSA-112043PLC beta mediated eventsTAS
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionIEA
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112315Transmission across Chemical SynapsesIEA
R-HSA-112316Neuronal SystemTAS
R-HSA-112316Neuronal SystemIEA
R-HSA-1430728MetabolismTAS
R-HSA-1489509DAG and IP3 signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-163359Glucagon signaling in metabolic regulationTAS
R-HSA-163615PKA activationTAS
R-HSA-163685Integration of energy metabolismTAS
R-HSA-164378PKA activation in glucagon signallingTAS
R-HSA-170660Adenylate cyclase activating pathwayTAS
R-HSA-170670Adenylate cyclase inhibitory pathwayTAS
R-HSA-170670Adenylate cyclase inhibitory pathwayIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-382551Transport of small moleculesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-388396GPCR downstream signallingIEA
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-418555G alpha (s) signalling eventsIEA
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-418597G alpha (z) signalling eventsIEA
R-HSA-418597G alpha (z) signalling eventsTAS
R-HSA-432040Vasopressin regulates renal water homeostasis via AquaporinsTAS
R-HSA-438064Post NMDA receptor activation eventsTAS
R-HSA-442720CREB phosphorylation through the activation of Adenylate CyclaseTAS
R-HSA-442755Activation of NMDA receptor and postsynaptic eventsTAS
R-HSA-445717Aquaporin-mediated transportTAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5610787Hedgehog 'off' stateTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-977443GABA receptor activationTAS
R-HSA-977443GABA receptor activationIEA
R-HSA-977444GABA B receptor activationTAS
R-HSA-977444GABA B receptor activationIEA
R-HSA-991365Activation of GABAB receptorsTAS
R-HSA-991365Activation of GABAB receptorsIEA
R-HSA-997269Inhibition of adenylate cyclase pathwayTAS
R-HSA-997269Inhibition of adenylate cyclase pathwayIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11. (2010 May)Edenberg HJAlcohol Clin Exp Res